YU48176B - Novi tetrahidroimidazo [1,4] benzodiazepin-2-(ti)oni i postupak njihovog dobijanja - Google Patents
Novi tetrahidroimidazo [1,4] benzodiazepin-2-(ti)oni i postupak njihovog dobijanjaInfo
- Publication number
- YU48176B YU48176B YU119491A YU119491A YU48176B YU 48176 B YU48176 B YU 48176B YU 119491 A YU119491 A YU 119491A YU 119491 A YU119491 A YU 119491A YU 48176 B YU48176 B YU 48176B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- alkyl
- hydrogen
- halo
- 6alkyl
- trifluoromethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
NOVI TETRAHIDROIMIDAZO [1,4] BENZODIAZEPIN-2-(TI)ONI I POSTUPAK NJIHOVOG DOBIJANJA - Jedinjenje formule: i njegova farmaceutski prihvatljiva kiselinska adiciona so i njegov stereohemijski izomerni oblik, u kojoj:X je O ili S; R1 je radikal formule: Alk je C1-6alkandiil; R6 je vodonik, halo ili C1-4alkil; R7 i R8 svaki nezavisno su vodonik, halo, C3-6cikloalkil, trifluorometil, 2,2,2-trifluoroetil, C1-4alkil, koji je u datom primeru supstituisan sa C1-4alkoksi; R9 je vodonik, halo ili C1-4alkil; svaki R10 je nezavisno vodonik ili C1-4alkil ili oba R10uzeta zajedno mogu da obrazuju C1-6alkandiilni radikal; n je 2,3,4,5 ili 6; R11 je vodonik ili C2-6alkenil; svaki R12 je nezavisno vodonik ili C1-4alkil ili oba R12 uzeta zajedno mogu da obrazuju C1-6alkandiil radikal; m je 0,1 ili 2; R13 je C1-6alkil, aril, arilmetil, C3-6cikloalkil ili (C3-6cik-loalkil)C1-4alkil; R2 je vodonik ili C1-6alkil; R3 je vodonik ili C1-6alkil; R4 i R5 svaki nezavisno su vodonik, C1-6alkil, halo, cijano, nitro, trifluorometil, hidroksi, C1-6alkiloksi, amino, mono- ili di(C1-6alkil)amino, C1-6alkilkarbonilamino ili arilkar-bonilamino i svaki aril je fenil koji je u datom primeru supstituisan sa 1 do 3 supstituenata nezavisno odabranih izmed-ju C1-6alkila, halo, hidroksi, C1-6alkoksi, amino, nitro i tri-fluorometila; pod uslovom da kada su R4 i R5 različiti od C1-6alkilkarbonilamino ili arilkarbonilamino, tada je R1 različiti od C3-6alkenila i (C3-6cikloalkil)C1-6alkila. - Prijava sadrži još 1 nezavisan i 5 zavisnih zahteva.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54934990A | 1990-07-06 | 1990-07-06 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU119491A YU119491A (sh) | 1994-06-10 |
| YU48176B true YU48176B (sh) | 1997-07-31 |
Family
ID=24192641
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU119491A YU48176B (sh) | 1990-07-06 | 1991-07-05 | Novi tetrahidroimidazo [1,4] benzodiazepin-2-(ti)oni i postupak njihovog dobijanja |
Country Status (29)
| Country | Link |
|---|---|
| EP (1) | EP0538297B9 (sh) |
| JP (1) | JPH05508632A (sh) |
| CN (1) | CN1034122C (sh) |
| AP (1) | AP262A (sh) |
| AT (1) | ATE205848T1 (sh) |
| AU (1) | AU644192B2 (sh) |
| CA (1) | CA2086547A1 (sh) |
| CZ (1) | CZ279900B6 (sh) |
| DE (1) | DE69132738T2 (sh) |
| DK (1) | DK0538297T3 (sh) |
| ES (1) | ES2164044T3 (sh) |
| FI (1) | FI930024A0 (sh) |
| HU (1) | HUT68382A (sh) |
| IE (1) | IE912363A1 (sh) |
| IL (1) | IL98726A (sh) |
| MA (1) | MA22205A1 (sh) |
| MX (1) | MX9100103A (sh) |
| MY (1) | MY106786A (sh) |
| NO (1) | NO300420B1 (sh) |
| NZ (1) | NZ238664A (sh) |
| OA (1) | OA09769A (sh) |
| PL (3) | PL168320B1 (sh) |
| PT (1) | PT98225B (sh) |
| SK (1) | SK278442B6 (sh) |
| TN (1) | TNSN91055A1 (sh) |
| TW (1) | TW211014B (sh) |
| WO (1) | WO1992000979A1 (sh) |
| YU (1) | YU48176B (sh) |
| ZA (1) | ZA915239B (sh) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE184787T1 (de) * | 1992-05-13 | 1999-10-15 | Wellcome Found | Therapeutische kombinationen |
| US6177435B1 (en) | 1992-05-13 | 2001-01-23 | Glaxo Wellcome Inc. | Therapeutic combinations |
| US5519021A (en) * | 1992-08-07 | 1996-05-21 | Merck & Co., Inc. | Benzoxazinones as inhibitors of HIV reverse transcriptase |
| US6420357B1 (en) | 1997-12-23 | 2002-07-16 | Instituto Biomar, S.A. | Cytotoxic alkaloid derivatives including Asmarine A and B isolated from a sponge |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8806449D0 (en) * | 1988-03-18 | 1988-04-20 | Janssen Pharmaceutica Nv | Antiviral hexahydroimiazo(1 4)benzodiazepin-2-ones |
| IL93136A (en) * | 1989-02-23 | 1995-01-24 | Janssen Pharmaceutica Nv | History of tetrahydroimidazo [1,4] benzodiazepine-2-thione, their preparation and pharmaceutical preparations containing them |
| NZ235137A (en) * | 1989-09-13 | 1992-02-25 | Janssen Pharmaceutica Nv | Tetrahydroimidazo(1,4)benzodiazepine derivatives, preparation and pharmaceutical compositions thereof |
| DE4036552C1 (sh) * | 1990-11-16 | 1992-02-06 | Boehringer Mannheim Gmbh, 6800 Mannheim, De |
-
1991
- 1991-06-21 NZ NZ238664A patent/NZ238664A/en unknown
- 1991-06-28 PL PL91297379A patent/PL168320B1/pl unknown
- 1991-06-28 AT AT91912145T patent/ATE205848T1/de not_active IP Right Cessation
- 1991-06-28 PL PL91309617A patent/PL169662B1/pl unknown
- 1991-06-28 ES ES91912145T patent/ES2164044T3/es not_active Expired - Lifetime
- 1991-06-28 JP JP91511094A patent/JPH05508632A/ja active Pending
- 1991-06-28 PL PL91309618A patent/PL169613B1/pl unknown
- 1991-06-28 DE DE69132738T patent/DE69132738T2/de not_active Expired - Fee Related
- 1991-06-28 WO PCT/EP1991/001224 patent/WO1992000979A1/en active IP Right Grant
- 1991-06-28 DK DK91912145T patent/DK0538297T3/da active
- 1991-06-28 CA CA002086547A patent/CA2086547A1/en not_active Abandoned
- 1991-06-28 HU HU9300011A patent/HUT68382A/hu unknown
- 1991-06-28 AU AU80683/91A patent/AU644192B2/en not_active Ceased
- 1991-06-28 EP EP91912145A patent/EP0538297B9/en not_active Expired - Lifetime
- 1991-07-02 MY MYPI91001205A patent/MY106786A/en unknown
- 1991-07-04 SK SK2065-91A patent/SK278442B6/sk unknown
- 1991-07-04 IL IL9872691A patent/IL98726A/en active IP Right Grant
- 1991-07-04 CZ CS912065A patent/CZ279900B6/cs unknown
- 1991-07-05 MX MX9100103A patent/MX9100103A/es not_active IP Right Cessation
- 1991-07-05 AP APAP/P/1991/000289A patent/AP262A/en active
- 1991-07-05 MA MA22478A patent/MA22205A1/fr unknown
- 1991-07-05 YU YU119491A patent/YU48176B/sh unknown
- 1991-07-05 TN TNTNSN91055A patent/TNSN91055A1/fr unknown
- 1991-07-05 ZA ZA915239A patent/ZA915239B/xx unknown
- 1991-07-05 PT PT98225A patent/PT98225B/pt not_active IP Right Cessation
- 1991-07-05 IE IE236391A patent/IE912363A1/en unknown
- 1991-07-06 CN CN91104581A patent/CN1034122C/zh not_active Expired - Fee Related
- 1991-08-02 TW TW080106042A patent/TW211014B/zh active
-
1992
- 1992-12-15 NO NO924853A patent/NO300420B1/no unknown
-
1993
- 1993-01-05 OA OA60328A patent/OA09769A/fr unknown
- 1993-01-05 FI FI930024A patent/FI930024A0/fi not_active Application Discontinuation
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