ES8202000A1 - Procedimiento para preparar pirimidil-quinazolinas - Google Patents
Procedimiento para preparar pirimidil-quinazolinasInfo
- Publication number
- ES8202000A1 ES8202000A1 ES500738A ES500738A ES8202000A1 ES 8202000 A1 ES8202000 A1 ES 8202000A1 ES 500738 A ES500738 A ES 500738A ES 500738 A ES500738 A ES 500738A ES 8202000 A1 ES8202000 A1 ES 8202000A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- quinazolines
- procedure
- reaction
- pirimidil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pretreatment Of Seeds And Plants (AREA)
- Catching Or Destruction (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE PIRIMIDIL-QUINAZOLINAS, DE FORMULA (I), Y DE SUS SALES DE ADICION DE ACIDO, EN LA QUE R1, R2 Y R3 PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE LA PIPERAZINA CON UN COMPUESTO DE FORMULA (II), SEGUIDA DE LA REACCION CON UN COMPUESTO DE FORMULA (III)), EN LAS QUE R1, R2 Y R3, TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I); X ES HALOGENO O UN GRUPO MERCAPTO, T HAL ES HALOGENO. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE, EN PRESENCIA DE UN AGENTE ACEPTOR DE ACIDO, Y A UNA TEMPERATURA ENTRE 20 Y 160 C. LOS REACTIVOS (II) Y (III) SE PUEDEN HACER REACCIONAR CON LA PIPERAZINA EN EL ORDEN INVERSO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19803011809 DE3011809A1 (de) | 1980-03-27 | 1980-03-27 | Pyrimidyl-chinazoline, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische praeparate und ihre verwendung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8202000A1 true ES8202000A1 (es) | 1982-01-16 |
| ES500738A0 ES500738A0 (es) | 1982-01-16 |
Family
ID=6098481
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES500738A Granted ES500738A0 (es) | 1980-03-27 | 1981-03-26 | Procedimiento para preparar pirimidil-quinazolinas |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0037495A1 (es) |
| JP (1) | JPS56150088A (es) |
| AR (1) | AR227542A1 (es) |
| AU (1) | AU6877481A (es) |
| CA (1) | CA1156656A (es) |
| CS (1) | CS219898B2 (es) |
| DD (1) | DD157614A5 (es) |
| DE (1) | DE3011809A1 (es) |
| DK (1) | DK115581A (es) |
| ES (1) | ES500738A0 (es) |
| FI (1) | FI810778L (es) |
| GR (1) | GR71870B (es) |
| IL (1) | IL62495A0 (es) |
| NO (1) | NO810870L (es) |
| PL (2) | PL233882A1 (es) |
| PT (1) | PT72724B (es) |
| SU (1) | SU1052158A3 (es) |
| ZA (1) | ZA812034B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61140568A (ja) * | 1984-12-14 | 1986-06-27 | Mitsui Petrochem Ind Ltd | キナゾリン誘導体及びそれを有効成分とする血圧降下剤 |
| JPS6267077A (ja) * | 1985-09-18 | 1987-03-26 | Mitsui Petrochem Ind Ltd | キナゾリン誘導体及び医薬 |
| BRPI0418639B8 (pt) * | 2004-03-15 | 2021-05-25 | Takeda Pharmaceutical | compostos inibidores de dipeptidil peptidase, assim como composição farmacêutica contendo os mesmos |
| PT1778236E (pt) * | 2004-07-02 | 2010-10-19 | Corcept Therapeutics Inc | Moduladores do receptor de glucocorticóide de pirimidina modificada |
| ES2563444T3 (es) | 2011-03-18 | 2016-03-15 | Corcept Therapeutics, Inc. | Moduladores del receptor de glucocorticoide de tipo pirimidina ciclohexilo |
| AU2019282047B2 (en) | 2018-06-04 | 2022-06-02 | Corcept Therapeutics Incorporated | Pyrimidine cyclohexenyl glucocorticoid receptor modulators |
| JP7569492B2 (ja) | 2019-12-11 | 2024-10-18 | コーセプト セラピューティクス， インコーポレイテッド | 抗精神病薬誘発性体重増加のミリコリラントによる治療方法 |
| EP4146173A4 (en) | 2020-05-06 | 2024-05-29 | Corcept Therapeutics Incorporated | FORMULATIONS OF PYRIMIDINE CYCLOHEXYL GLUCOCORTICOID RECEPTOR MODULATORS |
| AU2021268944B2 (en) | 2020-05-06 | 2024-04-18 | Corcept Therapeutics Incorporated | Polymorphs of pyrimidine cyclohexyl glucocorticoid receptor modulators |
| EP4263508A4 (en) | 2020-12-21 | 2024-11-27 | Corcept Therapeutics Incorporated | Method of preparing pyrimidine cyclohexyl glucocorticoid receptor modulators |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2007656B (en) * | 1977-11-05 | 1982-05-19 | Pfizer Ltd | Therapeutic agents |
-
1980
- 1980-03-27 DE DE19803011809 patent/DE3011809A1/de not_active Withdrawn
- 1980-12-15 GR GR64485A patent/GR71870B/el unknown
-
1981
- 1981-03-13 FI FI810778A patent/FI810778L/fi not_active Application Discontinuation
- 1981-03-13 NO NO810870A patent/NO810870L/no unknown
- 1981-03-13 DK DK115581A patent/DK115581A/da not_active Application Discontinuation
- 1981-03-20 EP EP81102088A patent/EP0037495A1/de not_active Ceased
- 1981-03-24 PT PT72724A patent/PT72724B/pt unknown
- 1981-03-25 JP JP4257181A patent/JPS56150088A/ja active Pending
- 1981-03-25 PL PL23388281A patent/PL233882A1/xx unknown
- 1981-03-25 DD DD81228589A patent/DD157614A5/de unknown
- 1981-03-25 PL PL23032081A patent/PL230320A1/xx unknown
- 1981-03-25 SU SU813261941A patent/SU1052158A3/ru active
- 1981-03-25 CS CS812182A patent/CS219898B2/cs unknown
- 1981-03-26 ZA ZA00812034A patent/ZA812034B/xx unknown
- 1981-03-26 AU AU68774/81A patent/AU6877481A/en not_active Abandoned
- 1981-03-26 CA CA000373945A patent/CA1156656A/en not_active Expired
- 1981-03-26 IL IL62495A patent/IL62495A0/xx unknown
- 1981-03-26 AR AR284752A patent/AR227542A1/es active
- 1981-03-26 ES ES500738A patent/ES500738A0/es active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| DD157614A5 (de) | 1982-11-24 |
| FI810778A7 (fi) | 1981-09-28 |
| AR227542A1 (es) | 1982-11-15 |
| EP0037495A1 (de) | 1981-10-14 |
| IL62495A0 (en) | 1981-05-20 |
| FI810778L (fi) | 1981-09-28 |
| PL230320A1 (es) | 1982-03-29 |
| JPS56150088A (en) | 1981-11-20 |
| CA1156656A (en) | 1983-11-08 |
| NO810870L (no) | 1981-09-28 |
| ES500738A0 (es) | 1982-01-16 |
| AU6877481A (en) | 1981-10-01 |
| PT72724A (de) | 1981-04-01 |
| PL233882A1 (es) | 1982-05-10 |
| DE3011809A1 (de) | 1981-10-01 |
| GR71870B (es) | 1983-07-08 |
| PT72724B (de) | 1982-03-24 |
| CS219898B2 (en) | 1983-03-25 |
| SU1052158A3 (ru) | 1983-10-30 |
| ZA812034B (en) | 1982-05-26 |
| DK115581A (da) | 1981-09-28 |
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