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WO2000062048A3 - Sensoranordnung mit elektrisch ansteuerbaren arrays - Google Patents

Sensoranordnung mit elektrisch ansteuerbaren arrays Download PDF

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Publication number
WO2000062048A3
WO2000062048A3 PCT/EP2000/003404 EP0003404W WO0062048A3 WO 2000062048 A3 WO2000062048 A3 WO 2000062048A3 EP 0003404 W EP0003404 W EP 0003404W WO 0062048 A3 WO0062048 A3 WO 0062048A3
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WO
WIPO (PCT)
Prior art keywords
array
procedures
addressing
arrays
sensor
Prior art date
Application number
PCT/EP2000/003404
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English (en)
French (fr)
Other versions
WO2000062048A2 (de
Inventor
Joerg Albers
Helmut Bernt
Reinhard Bredehorst
Rainer Hintsche
Rene Seitz
Original Assignee
Fraunhofer Ges Forschung
Joerg Albers
Helmut Bernt
Reinhard Bredehorst
Rainer Hintsche
Rene Seitz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fraunhofer Ges Forschung, Joerg Albers, Helmut Bernt, Reinhard Bredehorst, Rainer Hintsche, Rene Seitz filed Critical Fraunhofer Ges Forschung
Priority to US09/958,633 priority Critical patent/US7208077B1/en
Priority to EP00938598A priority patent/EP1200817B1/de
Priority to DE10080029T priority patent/DE10080029D2/de
Priority to DE50014414T priority patent/DE50014414D1/de
Publication of WO2000062048A2 publication Critical patent/WO2000062048A2/de
Publication of WO2000062048A3 publication Critical patent/WO2000062048A3/de

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G01N27/3277—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction being a redox reaction, e.g. detection by cyclic voltammetry

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Es wird ein elektrisches Sensorarray vorgeschlagen, das mehrere Sensorpositionen aufweist, die als jeweils ein Array (4) aus zumindest zwei Mikroelektroden bestehen. Mit diesem Array können molekulare Stoffe elektrochemisch detektiert werden, geladene Moleküle können transportiert oder gehandhabt werden. Ebenfalls möglich sind Messvorgänge, insbesondere zwischen zwei jeweiligen Adressiervorgängen, nachdem die Sensorpositionen individuell adressierbar sind und jederzeit elektrochemisch bzw. elektrisch kontrollierbar sind, zur Aufrechterhaltung einer Polarisationsspannung zwischen zwei Adressiervorgängen. Die Leitungsführung (14, 15; 16, 17) ist so ausgebildet, dass einzelne Arrays oder Gruppen von Arrays ansteuerbar sind. Für Biomolekulare Assays werden affinitätsbindende Moleküle an jeder Sensorposition oder zwischen den Mikroelektroden oder auf Hilfsflächen immobilisiert, was eine mögliche Verwendung des Arrays ist. Eine weitere liegt in der individuellen elektrischen Auslesung und der Möglichkeit, zwischen den Adressiervorgängen abgelaufene Ereignisse nachträglich zu messen, die vor der Messadressierung abgelaufen sind.
PCT/EP2000/003404 1999-04-14 2000-04-14 Sensoranordnung mit elektrisch ansteuerbaren arrays WO2000062048A2 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US09/958,633 US7208077B1 (en) 1999-04-14 2000-04-14 Sensor arrangement with electrically controllable arrays
EP00938598A EP1200817B1 (de) 1999-04-14 2000-04-14 Sensoranordnung mit elektrisch ansteuerbaren arrays
DE10080029T DE10080029D2 (de) 2000-04-14 2000-04-14 Sensoranordnung mit elektrisch ansteuerbaren Arrays
DE50014414T DE50014414D1 (de) 1999-04-14 2000-04-14 Sensoranordnung mit elektrisch ansteuerbaren arrays

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19916921.7 1999-04-14
DE19916921A DE19916921A1 (de) 1999-04-14 1999-04-14 Elektrisches Sensorarray
EPPCT/EP99/04883 1999-07-12
PCT/EP1999/004883 WO2000062047A1 (de) 1999-04-14 1999-07-12 Elektrisches sensorarray

Publications (2)

Publication Number Publication Date
WO2000062048A2 WO2000062048A2 (de) 2000-10-19
WO2000062048A3 true WO2000062048A3 (de) 2001-04-26

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/EP1999/004883 WO2000062047A1 (de) 1999-04-14 1999-07-12 Elektrisches sensorarray
PCT/EP2000/003404 WO2000062048A2 (de) 1999-04-14 2000-04-14 Sensoranordnung mit elektrisch ansteuerbaren arrays

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/004883 WO2000062047A1 (de) 1999-04-14 1999-07-12 Elektrisches sensorarray

Country Status (4)

Country Link
US (1) US7208077B1 (de)
AT (1) ATE364838T1 (de)
DE (1) DE19916921A1 (de)
WO (2) WO2000062047A1 (de)

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ATE364838T1 (de) 2007-07-15
WO2000062048A2 (de) 2000-10-19

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