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TR200603997T1 - Beşeri IL-12'yi bağlayan beşeri antikorlar ve bunları üretmek için yöntemler. - Google Patents

Beşeri IL-12'yi bağlayan beşeri antikorlar ve bunları üretmek için yöntemler.

Info

Publication number
TR200603997T1
TR200603997T1 TR2006/03997T TR200603997T TR200603997T1 TR 200603997 T1 TR200603997 T1 TR 200603997T1 TR 2006/03997 T TR2006/03997 T TR 2006/03997T TR 200603997 T TR200603997 T TR 200603997T TR 200603997 T1 TR200603997 T1 TR 200603997T1
Authority
TR
Turkey
Prior art keywords
hil
antibodies
human antibodies
human
activity
Prior art date
Application number
TR2006/03997T
Other languages
English (en)
Inventor
G. Salfeld Jochen
L. Du Fou Sarah
Paskind Michael
Banerjee Subhashis
E. Tracey Daniel
White Michael
Kaymak�Alan Zehra
Labkovsky Boris
Sakorafas Paul
Friedrich Stuart
Myles Angela
M. Veldman Geertruida
Venturini Amy
W. Warne Nicholas
Widom Angela
G. Elvin John
R. Duncan Alexander
J. Derbyshire Elaine
Carmen Sara
Smith Stephen
Las Holtet Thor
Roguska Michael
Original Assignee
Abbott Gmbh & Co. Kg
Genetics Institute, Llc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22425740&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TR200603997(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Gmbh & Co. Kg, Genetics Institute, Llc. filed Critical Abbott Gmbh & Co. Kg
Publication of TR200603997T1 publication Critical patent/TR200603997T1/tr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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Abstract

Spesifik olarak beşeri interleukin-12'ye (hIL-12) bağlanan beşeri antikorlar, tercihen rekombinan beşeri antikorlar açıklanmaktadır. Tercih edilen antikorlar hIL-12 için yüksek afiniteye sahiptir ve hIL-12 etkinliğini in vitro ve in vivo nötrleştirir. Buluşun bir antikoru tam uzunlukta bir antikor veya onun antijen bağlayıcı bir parçası olabilir. Buluşun antikorları ve antikor parçaları, örneğin hIL-12 etkinliğinin zararlı olduğu bir bozukluğu olan bir insan denekte hIL-12'yi tespit etmek ve hIL-12 etkinliğini inhibe etmek için yararlıdır. Buluşun rekombinan beşeri antikorlarını eksprese etmek için nükleik asitler, vektörler ve konak hücreler ve rekombinan beşeri antikorları sentezleme yöntemleri de buluşun çerçevesi içine girmektedir.
TR2006/03997T 1999-03-25 2000-03-24 Beşeri IL-12'yi bağlayan beşeri antikorlar ve bunları üretmek için yöntemler. TR200603997T1 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12660399P 1999-03-25 1999-03-25

Publications (1)

Publication Number Publication Date
TR200603997T1 true TR200603997T1 (tr) 2010-01-21

Family

ID=22425740

Family Applications (5)

Application Number Title Priority Date Filing Date
TR2006/03997T TR200603997T1 (tr) 1999-03-25 2000-03-24 Beşeri IL-12'yi bağlayan beşeri antikorlar ve bunları üretmek için yöntemler.
TR2001/02715T TR200102715T2 (tr) 1999-03-25 2000-03-24 Beşeri IL-12'yi bağlayan beşeri antikorlar ve bunları üretmek için yöntemler.
TR2008/02278T TR200802278T2 (tr) 1999-03-25 2000-03-24 Beşeri IL-12'yi bağlayan beşeri antikorlar ve bunları üretmek için yöntemler.
TR2005/03572T TR200503572T2 (tr) 1999-03-25 2000-03-24 Beşeri IL-12'yi bağlayan beşeri antikorlar ve bunları üretmek için yöntemler.
TR2005/01367T TR200501367T2 (tr) 1999-03-25 2000-03-24 Beşeri IL-12'yi bağlayan beşeri antikorlar ve bunları üretmek için yöntemler.

Family Applications After (4)

Application Number Title Priority Date Filing Date
TR2001/02715T TR200102715T2 (tr) 1999-03-25 2000-03-24 Beşeri IL-12'yi bağlayan beşeri antikorlar ve bunları üretmek için yöntemler.
TR2008/02278T TR200802278T2 (tr) 1999-03-25 2000-03-24 Beşeri IL-12'yi bağlayan beşeri antikorlar ve bunları üretmek için yöntemler.
TR2005/03572T TR200503572T2 (tr) 1999-03-25 2000-03-24 Beşeri IL-12'yi bağlayan beşeri antikorlar ve bunları üretmek için yöntemler.
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