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TR200102715T2 - Beşeri IL-12'yi bağlayan beşeri antikorlar ve bunları üretmek için yöntemler. - Google Patents

Beşeri IL-12'yi bağlayan beşeri antikorlar ve bunları üretmek için yöntemler.

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Publication number
TR200102715T2
TR200102715T2 TR2001/02715T TR200102715T TR200102715T2 TR 200102715 T2 TR200102715 T2 TR 200102715T2 TR 2001/02715 T TR2001/02715 T TR 2001/02715T TR 200102715 T TR200102715 T TR 200102715T TR 200102715 T2 TR200102715 T2 TR 200102715T2
Authority
TR
Turkey
Prior art keywords
hil
antibodies
methods
human antibodies
human
Prior art date
Application number
TR2001/02715T
Other languages
English (en)
Inventor
G. Salfeld Jochen
Roguska Michael
Paskind Michael
Banerjee Subhashis
Tracey Daniel
White Michael
Kaymak�Alan Zehra
Labkovsky Boris
Sakorafas Paul
Friedrich Stuart
Myles Angela
M. Veldman Geertruida
Venturini Amy
W. Warne Nicholas
Widom Angela
G. Elvin John
R. Duncan Alexander
J. Derbyshire Elaine
Carmen Sara
Smith Stephen
Las Holtet Thor
L. Du Fou Sarah
Original Assignee
Knoll Gmbh
Genetics Institute Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22425740&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TR200102715(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Knoll Gmbh, Genetics Institute Inc. filed Critical Knoll Gmbh
Publication of TR200102715T2 publication Critical patent/TR200102715T2/tr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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Abstract

Spesifik olarak beseri interleukin-12'ye (hIL-12)baglanan beseri antikorlar, tercihen rekombinan beseri antikorlar açiklanmaktadir. Tercihen edilen antikorlar hIL-12 için yüksek afiniteye sahiptir ve hIL-12 etkinligini in vitro ve in vivo nötrlestirir. Bulusun bir antikoru tam uzunlukta bir antikor veya onun antijen baglayici bir parçasi olabilir. Bulusun antikorlari ve antikor parçalari, örnegin hIL-12 etkinliginin zararli oldugu bir bozuklugu olan bir insan denekte hIL-12'yi tespit etmek ve hIL-12 etkinligini inhibe etmek için yararlidir. Bulusun rekombinan beseri antikorlarini eksperese etmek için nükleik asitler, vektörler ve konak hücreler ve rekombinan beseri antikorlari sentezleme yöntemleri de bulusun çerçevesi içine girmektedir.
TR2001/02715T 1999-03-25 2000-03-24 Beşeri IL-12'yi bağlayan beşeri antikorlar ve bunları üretmek için yöntemler. TR200102715T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12660399P 1999-03-25 1999-03-25

Publications (1)

Publication Number Publication Date
TR200102715T2 true TR200102715T2 (tr) 2002-09-23

Family

ID=22425740

Family Applications (5)

Application Number Title Priority Date Filing Date
TR2006/03997T TR200603997T1 (tr) 1999-03-25 2000-03-24 Beşeri IL-12'yi bağlayan beşeri antikorlar ve bunları üretmek için yöntemler.
TR2001/02715T TR200102715T2 (tr) 1999-03-25 2000-03-24 Beşeri IL-12'yi bağlayan beşeri antikorlar ve bunları üretmek için yöntemler.
TR2008/02278T TR200802278T2 (tr) 1999-03-25 2000-03-24 Beşeri IL-12'yi bağlayan beşeri antikorlar ve bunları üretmek için yöntemler.
TR2005/03572T TR200503572T2 (tr) 1999-03-25 2000-03-24 Beşeri IL-12'yi bağlayan beşeri antikorlar ve bunları üretmek için yöntemler.
TR2005/01367T TR200501367T2 (tr) 1999-03-25 2000-03-24 Beşeri IL-12'yi bağlayan beşeri antikorlar ve bunları üretmek için yöntemler.

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Application Number Title Priority Date Filing Date
TR2006/03997T TR200603997T1 (tr) 1999-03-25 2000-03-24 Beşeri IL-12'yi bağlayan beşeri antikorlar ve bunları üretmek için yöntemler.

Family Applications After (3)

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TR2008/02278T TR200802278T2 (tr) 1999-03-25 2000-03-24 Beşeri IL-12'yi bağlayan beşeri antikorlar ve bunları üretmek için yöntemler.
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