SMT202200136T1 - Inibitori della demetilasi lisina-specifica-1 - Google Patents

Inibitori della demetilasi lisina-specifica-1

Info

Publication number: SMT202200136T1
Authority: SM; San Marino
Prior art keywords: inhibitors; specific demethylase; lysine specific; lysine; demethylase
Prior art date: 2014-07-03

Application number

SM20220136T

Other languages

English (en)

Inventor

Zhe Nie

Toufike Kanouni

Jeffrey Alan Stafford

James Marvin Veal

Young K Chen

Original Assignee

Celgene Quanticel Research Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-07-03

Filing date

2015-06-29

Publication date

2022-05-12

2015-06-29 Application filed by Celgene Quanticel Research Inc filed Critical Celgene Quanticel Research Inc

2022-05-12 Publication of SMT202200136T1 publication Critical patent/SMT202200136T1/it

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Polyamides (AREA)

SM20220136T 2014-07-03 2015-06-29 Inibitori della demetilasi lisina-specifica-1 SMT202200136T1 (it)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201462020886P	2014-07-03	2014-07-03
EP15814038.4A EP3164380B1 (en)	2014-07-03	2015-06-29	Inhibitors of lysine specific demethylase-1
PCT/US2015/038345 WO2016003917A1 (en)	2014-07-03	2015-06-29	Inhibitors of lysine specific demethylase-1

Publications (1)

Publication Number	Publication Date
SMT202200136T1 true SMT202200136T1 (it)	2022-05-12

Family

ID=55019883

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
SM20220136T SMT202200136T1 (it)	2014-07-03	2015-06-29	Inibitori della demetilasi lisina-specifica-1
SM20230205T SMT202300205T1 (it)	2014-07-03	2015-06-29	Inibitori della demetilasi lisina-specifica-1

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
SM20230205T SMT202300205T1 (it)	2014-07-03	2015-06-29	Inibitori della demetilasi lisina-specifica-1

Country Status (29)

Country	Link
US (3)	US9902719B2 (it)
EP (2)	EP3511319B1 (it)
JP (2)	JP6663866B2 (it)
KR (1)	KR102475498B1 (it)
CN (2)	CN108530424B (it)
AU (1)	AU2015284383B2 (it)
BR (1)	BR112017000043A2 (it)
CA (1)	CA2954049A1 (it)
CL (1)	CL2016003422A1 (it)
CO (1)	CO2017000549A2 (it)
CY (1)	CY1125127T1 (it)
DK (2)	DK3511319T3 (it)
EA (2)	EA033698B1 (it)
EC (1)	ECSP17006821A (it)
ES (2)	ES2948782T3 (it)
FI (1)	FI3511319T3 (it)
HR (2)	HRP20220414T1 (it)
HU (2)	HUE058852T2 (it)
IL (2)	IL249881B (it)
LT (2)	LT3164380T (it)
MX (2)	MX395534B (it)
PL (2)	PL3164380T3 (it)
PT (2)	PT3511319T (it)
RS (2)	RS63074B1 (it)
SA (1)	SA517380651B1 (it)
SG (2)	SG11201610975RA (it)
SI (2)	SI3164380T1 (it)
SM (2)	SMT202200136T1 (it)
WO (1)	WO2016003917A1 (it)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN107849611A (zh)	2015-06-12	2018-03-27	奥瑞泽恩基因组学股份有限公司	与lsd1抑制剂相关的生物标志物及其用途
WO2017013061A1 (en)	2015-07-17	2017-01-26	Oryzon Genomics, S.A.	Biomarkers associated with lsd1 inhibitors and uses thereof
CN109195593A (zh)	2016-03-15	2019-01-11	奥莱松基因组股份有限公司	用于治疗实体瘤的lsd1抑制剂的组合
US11034991B2 (en)	2016-03-16	2021-06-15	Oryzon Genomics S.A.	Methods to determine KDM1A target engagement and chemoprobes useful therefor
US10150754B2 (en)	2016-04-19	2018-12-11	Celgene Quanticel Research, Inc.	Histone demethylase inhibitors
EP3535420A1 (en)	2016-11-03	2019-09-11	Oryzon Genomics, S.A.	Biomarkers for determining responsiveness to lsd1 inhibitors
BR112020000827A2 (pt)	2017-08-03	2020-07-21	Oryzon Genomics, S.A.	métodos de tratamento de alterações de comportamento
EP4356973A3 (en) *	2018-08-10	2024-06-26	Navire Pharma, Inc.	6-(4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-3-(2,3-dichlorophenyl)-2-methylpyrimidin-4(3h)-one derivatives and related compounds as ptpn11 (shp2) inhibitors for treating cancer
US12479845B2 (en)	2019-02-01	2025-11-25	Hanmi Pharm. Co., Ltd.	Imidazopyridine derivative compounds and use of same
AU2020216034B2 (en) *	2019-02-01	2024-12-19	Hanmi Pharm. Co., Ltd.	Imidazopyridine derivative compounds and use of same
SG11202109159VA (en)	2019-03-20	2021-10-28	Oryzon Genomics Sa	Methods of treating borderline personality disorder
ES3053813T3 (en)	2019-03-20	2026-01-26	Oryzon Genomics Sa	Methods of treating attention deficit hyperactivity disorder using kdm1a inhibitors such as the compound vafidemstat
EP3994280A1 (en)	2019-07-05	2022-05-11	Oryzon Genomics, S.A.	Biomarkers and methods for personalized treatment of small cell lung cancer using kdm1a inhibitors
US11360505B2 (en)	2020-02-11	2022-06-14	Simmonds Precision Products, Inc.	Distributed network time synchronization
CN114105950B (zh) *	2020-08-31	2022-09-06	南京明德新药研发有限公司	吡唑类化合物及其应用
EP4306520A4 (en) *	2021-03-11	2025-05-07	Medshine Discovery Inc.	THIOPHENE COMPOUND AND ITS USE
WO2022199662A1 (zh) *	2021-03-24	2022-09-29	四川汇宇制药股份有限公司	一种多环化合物及其应用
EP4319732A1 (en)	2021-04-08	2024-02-14	Oryzon Genomics, S.A.	Combinations of lsd1 inhibitors for treating myeloid cancers
CN116102533A (zh) *	2021-11-11	2023-05-12	中国科学院上海药物研究所	一种芳杂环类化合物及其应用
CN119546292A (zh)	2022-05-09	2025-02-28	奥莱松基因组股份有限公司	使用lsd1抑制剂治疗恶性周围神经鞘瘤(mpnst)的方法
JP2025516648A (ja)	2022-05-09	2025-05-30	オリゾン・ゲノミクス・ソシエダッド・アノニマ	Ｌｓｄ１阻害薬を用いるｎｆ１変異腫瘍の治療法
EP4622635A1 (en)	2022-11-24	2025-10-01	Oryzon Genomics, S.A.	Combinations of lsd1 inhibitors and menin inhibitors for treating cancer

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1963188A1 (de)	1969-12-17	1971-06-24	Bayer Ag	Neue Cyanphenyl-1,4-dihydropyridinderivate
WO2002026718A2 (en) *	2000-09-29	2002-04-04	Millennium Pharmaceutical, Inc.	Bicyclic pyrimidin-4-one based inhibitors of factor xa
US7365069B2 (en) *	2002-04-10	2008-04-29	Bexel Pharmaceuticals Inc.	Pyrimidone derivatives
JP2005170792A (ja) *	2002-11-22	2005-06-30	Mitsubishi Pharma Corp	Ｌ−プロリン誘導体およびその医薬としての用途。
JP4704914B2 (ja) *	2003-12-11	2011-06-22	田辺三菱製薬株式会社	α−アミノ酸誘導体及びその医薬用途
WO2006073167A1 (ja) *	2005-01-07	2006-07-13	Ono Pharmaceutical Co., Ltd.	ピロリジン誘導体
PL372332A1 (pl) *	2005-01-19	2006-07-24	ADAMED Sp.z o.o.	Nowe związki, pochodne kwasu 3-fenylopropionowego
WO2006129181A2 (en) *	2005-06-03	2006-12-07	Orchid Research Laboratories Limited	Preparation of 4-pyrimidone derivatives for treating inflammatory diseases
PT1924561E (pt) *	2005-09-01	2013-01-16	Lilly Co Eli	Módulo de cabeça de impressão tendo uma fiada solta e controlador de impressora para lhe fornecer dados
JP2007197324A (ja)	2006-01-23	2007-08-09	Toray Ind Inc	２，４，５−置換−１，３−アゾール誘導体
WO2008021309A1 (en)	2006-08-15	2008-02-21	Wyeth	Imidazolidin-2-one derivatives useful as pr modulators
TW200815428A (en) *	2006-08-15	2008-04-01	Wyeth Corp	Oxazolidone derivatives as PR modulators
PE20081803A1 (es)	2007-03-09	2008-12-11	Wyeth Corp	Sintesis y caracterizacion de la forma ii polimorfica de 4-(2-(4,4-dimetil-2-oxooxazolidin-3-il)tiazol-4-il)benzonitrilo
CL2008002793A1 (es) *	2007-09-20	2009-09-04	Cgi Pharmaceuticals Inc	Compuestos derivados de amidas sustituidas, inhibidores de la actividad de btk; composicion farmaceutica que los comprende; utiles en el tratamiento del cancer, trastornos oseos, enfermedades autoinmunes, entre otras
WO2009132310A1 (en) *	2008-04-25	2009-10-29	Wisconsin Alumni Research Foundation	Inhibitors of udp-galactopyranose mutase thwart mycobacterial growth
WO2011130515A1 (en)	2010-04-14	2011-10-20	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Arylthiazolyl piperidines and related compounds as modulators of survival motor neuron (smn) protein production
WO2012009475A1 (en) *	2010-07-14	2012-01-19	Oregon Health & Science University	Methods of treating cancer with inhibition of lysine-specific demethylase 1
NZ629453A (en)	2012-03-06	2016-04-29	Lupin Ltd	Thiazole derivatives as alpha 7 nachr modulators
SI3080100T1 (sl) *	2013-12-11	2023-04-28	Celgene Quanticel Research, Inc.	Inhibitorji lizin specifične demetilaze-1
JP2017505787A (ja) *	2014-02-14	2017-02-23	ザユニバーシティオブブリティッシュコロンビア	治療薬としてのヒトアンドロゲン受容体ｄｎａ結合ドメイン（ｄｂｄ）化合物およびそれらを使用する方法
AU2015253040B2 (en) *	2014-05-01	2020-04-09	Celgene Quanticel Research, Inc.	Inhibitors of lysine specific demethylase-1
FR3020945B1 (fr)	2014-05-16	2016-05-06	Oreal	Composition pour colorer les fibres keratiniques comprenant une base d'oxydation et un coupleur heteroaryle particulier
EA030946B1 (ru) *	2014-06-27	2018-10-31	Селджен Квонтисел Рисёрч, Инк.	Ингибиторы лизин-специфической деметилазы-1
CN106604997B (zh) *	2014-07-03	2021-02-19	赛尔基因昆蒂赛尔研究公司	赖氨酸特异性脱甲基酶-1的抑制剂

2015
- 2015-06-29 HU HUE15814038A patent/HUE058852T2/hu unknown
- 2015-06-29 SM SM20220136T patent/SMT202200136T1/it unknown
- 2015-06-29 WO PCT/US2015/038345 patent/WO2016003917A1/en not_active Ceased
- 2015-06-29 KR KR1020177003162A patent/KR102475498B1/ko active Active
- 2015-06-29 SI SI201531797T patent/SI3164380T1/sl unknown
- 2015-06-29 EP EP19156976.3A patent/EP3511319B1/en active Active
- 2015-06-29 MX MX2020010900A patent/MX395534B/es unknown
- 2015-06-29 EA EA201790085A patent/EA033698B1/ru not_active IP Right Cessation
- 2015-06-29 HR HRP20220414TT patent/HRP20220414T1/hr unknown
- 2015-06-29 US US15/323,277 patent/US9902719B2/en active Active
- 2015-06-29 ES ES19156976T patent/ES2948782T3/es active Active
- 2015-06-29 PL PL15814038T patent/PL3164380T3/pl unknown
- 2015-06-29 LT LTEPPCT/US2015/038345T patent/LT3164380T/lt unknown
- 2015-06-29 LT LTEP19156976.3T patent/LT3511319T/lt unknown
- 2015-06-29 RS RS20220311A patent/RS63074B1/sr unknown
- 2015-06-29 ES ES15814038T patent/ES2907676T3/es active Active
- 2015-06-29 PL PL19156976.3T patent/PL3511319T3/pl unknown
- 2015-06-29 CA CA2954049A patent/CA2954049A1/en not_active Abandoned
- 2015-06-29 SI SI201531948T patent/SI3511319T1/sl unknown
- 2015-06-29 SG SG11201610975RA patent/SG11201610975RA/en unknown
- 2015-06-29 SG SG10201802501RA patent/SG10201802501RA/en unknown
- 2015-06-29 BR BR112017000043-1A patent/BR112017000043A2/pt not_active Application Discontinuation
- 2015-06-29 CN CN201810425583.0A patent/CN108530424B/zh not_active Expired - Fee Related
- 2015-06-29 HU HUE19156976A patent/HUE062558T2/hu unknown
- 2015-06-29 RS RS20230452A patent/RS64423B1/sr unknown
- 2015-06-29 EA EA201891526A patent/EA201891526A3/ru unknown
- 2015-06-29 SM SM20230205T patent/SMT202300205T1/it unknown
- 2015-06-29 HR HRP20230595TT patent/HRP20230595T1/hr unknown
- 2015-06-29 CN CN201580047448.1A patent/CN106795103B/zh not_active Expired - Fee Related
- 2015-06-29 DK DK19156976.3T patent/DK3511319T3/da active
- 2015-06-29 MX MX2017000168A patent/MX376207B/es active IP Right Grant
- 2015-06-29 PT PT191569763T patent/PT3511319T/pt unknown
- 2015-06-29 JP JP2016575768A patent/JP6663866B2/ja not_active Expired - Fee Related
- 2015-06-29 FI FIEP19156976.3T patent/FI3511319T3/fi active
- 2015-06-29 EP EP15814038.4A patent/EP3164380B1/en active Active
- 2015-06-29 PT PT158140384T patent/PT3164380T/pt unknown
- 2015-06-29 AU AU2015284383A patent/AU2015284383B2/en not_active Ceased
- 2015-06-29 DK DK15814038.4T patent/DK3164380T3/da active
2016
- 2016-12-30 CL CL2016003422A patent/CL2016003422A1/es unknown
2017
- 2017-01-01 IL IL249881A patent/IL249881B/en active IP Right Grant
- 2017-01-02 SA SA517380651A patent/SA517380651B1/ar unknown
- 2017-01-23 CO CONC2017/0000549A patent/CO2017000549A2/es unknown
- 2017-02-01 EC ECIEPI20176821A patent/ECSP17006821A/es unknown
2018
- 2018-01-10 US US15/867,397 patent/US10100046B2/en active Active
- 2018-09-05 US US16/122,703 patent/US20190002456A1/en not_active Abandoned
2019
- 2019-02-21 JP JP2019029856A patent/JP6768857B2/ja not_active Expired - Fee Related
2020
- 2020-01-19 IL IL272130A patent/IL272130B/en active IP Right Grant
2022
- 2022-04-11 CY CY20221100269T patent/CY1125127T1/el unknown

Also Published As

Publication number	Publication date
RS64423B1 (sr)	2023-09-29
AU2015284383B2 (en)	2019-04-18
SI3164380T1 (sl)	2022-06-30
SA517380651B1 (ar)	2020-09-30
ECSP17006821A (es)	2017-03-31
ES2907676T3 (es)	2022-04-26
JP6663866B2 (ja)	2020-03-13
CA2954049A1 (en)	2016-01-07
CN108530424A (zh)	2018-09-14
JP2019108346A (ja)	2019-07-04
CY1125127T1 (el)	2024-02-16
US9902719B2 (en)	2018-02-27
WO2016003917A1 (en)	2016-01-07
IL249881A0 (en)	2017-03-30
LT3164380T (lt)	2022-06-27
PT3164380T (pt)	2022-03-02
EP3511319B1 (en)	2023-05-03
EP3164380B1 (en)	2022-02-09
HUE062558T2 (hu)	2023-11-28
CN106795103B (zh)	2019-07-12
PL3164380T3 (pl)	2022-04-04
CL2016003422A1 (es)	2017-11-10
MX395534B (es)	2025-03-25
HUE058852T2 (hu)	2022-09-28
JP6768857B2 (ja)	2020-10-14
RS63074B1 (sr)	2022-04-29
PT3511319T (pt)	2023-06-29
CN108530424B (zh)	2021-10-01
EP3511319A1 (en)	2019-07-17
KR102475498B1 (ko)	2022-12-07
ES2948782T3 (es)	2023-09-19
EA033698B1 (ru)	2019-11-18
EA201790085A1 (ru)	2017-08-31
SI3511319T1 (sl)	2023-10-30
HRP20220414T1 (hr)	2022-05-27
MX2017000168A (es)	2017-05-01
EP3164380A4 (en)	2018-07-18
LT3511319T (lt)	2023-08-25
US10100046B2 (en)	2018-10-16
CN106795103A (zh)	2017-05-31
MX2020010900A (es)	2022-09-13
SG11201610975RA (en)	2017-01-27
FI3511319T3 (fi)	2023-07-20
EA201891526A2 (ru)	2018-12-28
PL3511319T3 (pl)	2023-09-11
IL272130B (en)	2021-03-25
HRP20230595T1 (hr)	2023-09-15
JP2017525668A (ja)	2017-09-07
DK3511319T3 (da)	2023-07-31
AU2015284383A1 (en)	2017-02-02
SG10201802501RA (en)	2018-05-30
EP3164380A1 (en)	2017-05-10
DK3164380T3 (da)	2022-03-28
CO2017000549A2 (es)	2017-04-20
EA201891526A3 (ru)	2019-05-31
BR112017000043A2 (pt)	2018-07-17
MX376207B (es)	2025-03-07
KR20170018100A (ko)	2017-02-15
IL249881B (en)	2020-01-30
US20170129882A1 (en)	2017-05-11
US20190002456A1 (en)	2019-01-03
US20180127408A1 (en)	2018-05-10
IL272130A (en)	2020-03-31
SMT202300205T1 (it)	2023-09-06

Publication	Publication Date	Title
IL272130B (en)	2021-03-25	Inhibitors of specific lysine demethylase-1
IL250876A0 (en)	2017-04-30	Inhibitors of specific lysine demethylase-1
ZA201607613B (en)	2017-11-29	Inhibitors of lysine specific demethylase-1
ZA201700069B (en)	2018-04-25	Inhibitors of lysine specific demethylase-1
ZA201700072B (en)	2018-04-25	Inhibitors of lysine specific demethylase-1
PL3204352T3 (pl)	2020-12-14	Inhibitory gingipainy lizynowej
HK1234047A1 (en)	2018-02-09	Inhibitors of lysine specific demethylase-1
HK1231134A1 (en)	2017-12-15	Inhibitors of lysine specific demethylase-1
HK1231843A1 (en)	2017-12-29	Inhibitors of lysine specific demethylase-1