LT3511319T - Lizinui specifinės demetilazės-1 inhibitoriai - Google Patents

Lizinui specifinės demetilazės-1 inhibitoriai

Info

Publication number: LT3511319T
Authority: LT; Lithuania
Prior art keywords: lysine; inhibitors; specific demethylase; demethylase; specific
Prior art date: 2014-07-03

Application number

LTEP19156976.3T

Other languages

English (en)

Inventor

Young K. Chen

Toufike Kanouni

Zhe Nie

Jeffrey Alan Stafford

James Marvin Veal

Original Assignee

Celgene Quanticel Research, Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-07-03

Filing date

2015-06-29

Publication date

2023-08-25

2015-06-29 Application filed by Celgene Quanticel Research, Inc. filed Critical Celgene Quanticel Research, Inc.

2023-08-25 Publication of LT3511319T publication Critical patent/LT3511319T/lt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Polyamides (AREA)

LTEP19156976.3T 2014-07-03 2015-06-29 Lizinui specifinės demetilazės-1 inhibitoriai LT3511319T (lt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US201462020886P	2014-07-03	2014-07-03

Publications (1)

Publication Number	Publication Date
LT3511319T true LT3511319T (lt)	2023-08-25

Family

ID=55019883

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
LTEPPCT/US2015/038345T LT3164380T (lt)	2014-07-03	2015-06-29	Lizinui specifiniai demetilazės-1 inhibitoriai
LTEP19156976.3T LT3511319T (lt)	2014-07-03	2015-06-29	Lizinui specifinės demetilazės-1 inhibitoriai

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
LTEPPCT/US2015/038345T LT3164380T (lt)	2014-07-03	2015-06-29	Lizinui specifiniai demetilazės-1 inhibitoriai

Country Status (29)

Country	Link
US (3)	US9902719B2 (lt)
EP (2)	EP3511319B1 (lt)
JP (2)	JP6663866B2 (lt)
KR (1)	KR102475498B1 (lt)
CN (2)	CN108530424B (lt)
AU (1)	AU2015284383B2 (lt)
BR (1)	BR112017000043A2 (lt)
CA (1)	CA2954049A1 (lt)
CL (1)	CL2016003422A1 (lt)
CO (1)	CO2017000549A2 (lt)
CY (1)	CY1125127T1 (lt)
DK (2)	DK3511319T3 (lt)
EA (2)	EA033698B1 (lt)
EC (1)	ECSP17006821A (lt)
ES (2)	ES2948782T3 (lt)
FI (1)	FI3511319T3 (lt)
HR (2)	HRP20230595T1 (lt)
HU (2)	HUE062558T2 (lt)
IL (2)	IL249881B (lt)
LT (2)	LT3164380T (lt)
MX (2)	MX2020010900A (lt)
PL (2)	PL3164380T3 (lt)
PT (2)	PT3511319T (lt)
RS (2)	RS63074B1 (lt)
SA (1)	SA517380651B1 (lt)
SG (2)	SG11201610975RA (lt)
SI (2)	SI3164380T1 (lt)
SM (2)	SMT202300205T1 (lt)
WO (1)	WO2016003917A1 (lt)

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WO2017013061A1 (en)	2015-07-17	2017-01-26	Oryzon Genomics, S.A.	Biomarkers associated with lsd1 inhibitors and uses thereof
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KR102707409B1 (ko) *	2018-08-10	2024-09-13	나비레 파르마, 인코퍼레이티드	암 치료를 위한 ptpn11 (shp2) 저해제로서 6-(4-아미노-3-메틸-2-옥사-8-아자스피로[4.5]데칸-8-일)-3-(2,3-디클로로페닐)-2-메틸피리미딘-4(3h)-온 유도체 및 관련 화합물
CN113365996B (zh) *	2019-02-01	2024-09-03	韩美药品株式会社	咪唑吡啶衍生化合物以及药物组成物
EP3941466A1 (en)	2019-03-20	2022-01-26	Oryzon Genomics, S.A.	Methods of treating borderline personality disorder
EP3941465A1 (en)	2019-03-20	2022-01-26	Oryzon Genomics, S.A.	Methods of treating attention deficit hyperactivity disorder using kdm1a inhibitors such as the compound vafidemstat
EP3994280A1 (en)	2019-07-05	2022-05-11	Oryzon Genomics, S.A.	Biomarkers and methods for personalized treatment of small cell lung cancer using kdm1a inhibitors
US11360505B2 (en)	2020-02-11	2022-06-14	Simmonds Precision Products, Inc.	Distributed network time synchronization
CN114105950B (zh) *	2020-08-31	2022-09-06	南京明德新药研发有限公司	吡唑类化合物及其应用
WO2022199662A1 (zh) *	2021-03-24	2022-09-29	四川汇宇制药股份有限公司	一种多环化合物及其应用
CA3231846A1 (en)	2021-04-08	2022-10-13	Tamara Maes	Combinations of lsd1 inhibitors for treating myeloid cancers
CN116102533A (zh) *	2021-11-11	2023-05-12	中国科学院上海药物研究所	一种芳杂环类化合物及其应用
WO2023217758A1 (en)	2022-05-09	2023-11-16	Oryzon Genomics, S.A.	Methods of treating malignant peripheral nerve sheath tumor (mpnst) using lsd1 inhibitors
WO2023217784A1 (en)	2022-05-09	2023-11-16	Oryzon Genomics, S.A.	Methods of treating nf1-mutant tumors using lsd1 inhibitors
WO2024110649A1 (en)	2022-11-24	2024-05-30	Oryzon Genomics, S.A.	Combinations of lsd1 inhibitors and menin inhibitors for treating cancer

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SMT202000443T1 (it) *	2014-06-27	2020-09-10	Celgene Quanticel Research Inc	Inibitori della demetilasi lisina-specifica 1
US10414750B2 (en) *	2014-07-03	2019-09-17	Celgene Quanticel Research, Inc.	Inhibitors of lysine specific demethylase-1

2015
- 2015-06-29 LT LTEPPCT/US2015/038345T patent/LT3164380T/lt unknown
- 2015-06-29 MX MX2020010900A patent/MX2020010900A/es unknown
- 2015-06-29 ES ES19156976T patent/ES2948782T3/es active Active
- 2015-06-29 DK DK19156976.3T patent/DK3511319T3/da active
- 2015-06-29 HU HUE19156976A patent/HUE062558T2/hu unknown
- 2015-06-29 RS RS20220311A patent/RS63074B1/sr unknown
- 2015-06-29 DK DK15814038.4T patent/DK3164380T3/da active
- 2015-06-29 EP EP19156976.3A patent/EP3511319B1/en active Active
- 2015-06-29 US US15/323,277 patent/US9902719B2/en active Active
- 2015-06-29 HR HRP20230595TT patent/HRP20230595T1/hr unknown
- 2015-06-29 PL PL15814038T patent/PL3164380T3/pl unknown
- 2015-06-29 RS RS20230452A patent/RS64423B1/sr unknown
- 2015-06-29 PT PT191569763T patent/PT3511319T/pt unknown
- 2015-06-29 HR HRP20220414TT patent/HRP20220414T1/hr unknown
- 2015-06-29 PL PL19156976.3T patent/PL3511319T3/pl unknown
- 2015-06-29 EP EP15814038.4A patent/EP3164380B1/en active Active
- 2015-06-29 SG SG11201610975RA patent/SG11201610975RA/en unknown
- 2015-06-29 EA EA201790085A patent/EA033698B1/ru not_active IP Right Cessation
- 2015-06-29 CN CN201810425583.0A patent/CN108530424B/zh not_active Expired - Fee Related
- 2015-06-29 JP JP2016575768A patent/JP6663866B2/ja active Active
- 2015-06-29 SM SM20230205T patent/SMT202300205T1/it unknown
- 2015-06-29 CA CA2954049A patent/CA2954049A1/en not_active Abandoned
- 2015-06-29 BR BR112017000043-1A patent/BR112017000043A2/pt not_active Application Discontinuation
- 2015-06-29 SI SI201531797T patent/SI3164380T1/sl unknown
- 2015-06-29 WO PCT/US2015/038345 patent/WO2016003917A1/en active Application Filing
- 2015-06-29 KR KR1020177003162A patent/KR102475498B1/ko active IP Right Grant
- 2015-06-29 SI SI201531948T patent/SI3511319T1/sl unknown
- 2015-06-29 EA EA201891526A patent/EA201891526A3/ru unknown
- 2015-06-29 MX MX2017000168A patent/MX2017000168A/es active IP Right Grant
- 2015-06-29 CN CN201580047448.1A patent/CN106795103B/zh not_active Expired - Fee Related
- 2015-06-29 HU HUE15814038A patent/HUE058852T2/hu unknown
- 2015-06-29 PT PT158140384T patent/PT3164380T/pt unknown
- 2015-06-29 LT LTEP19156976.3T patent/LT3511319T/lt unknown
- 2015-06-29 AU AU2015284383A patent/AU2015284383B2/en not_active Ceased
- 2015-06-29 SG SG10201802501RA patent/SG10201802501RA/en unknown
- 2015-06-29 SM SM20220136T patent/SMT202200136T1/it unknown
- 2015-06-29 FI FIEP19156976.3T patent/FI3511319T3/fi active
- 2015-06-29 ES ES15814038T patent/ES2907676T3/es active Active
2016
- 2016-12-30 CL CL2016003422A patent/CL2016003422A1/es unknown
2017
- 2017-01-01 IL IL249881A patent/IL249881B/en active IP Right Grant
- 2017-01-02 SA SA517380651A patent/SA517380651B1/ar unknown
- 2017-01-23 CO CONC2017/0000549A patent/CO2017000549A2/es unknown
- 2017-02-01 EC ECIEPI20176821A patent/ECSP17006821A/es unknown
2018
- 2018-01-10 US US15/867,397 patent/US10100046B2/en active Active
- 2018-09-05 US US16/122,703 patent/US20190002456A1/en not_active Abandoned
2019
- 2019-02-21 JP JP2019029856A patent/JP6768857B2/ja not_active Expired - Fee Related
2020
- 2020-01-19 IL IL272130A patent/IL272130B/en active IP Right Grant
2022
- 2022-04-11 CY CY20221100269T patent/CY1125127T1/el unknown

Also Published As

Publication number	Publication date
IL272130B (en)	2021-03-25
CL2016003422A1 (es)	2017-11-10
PL3164380T3 (pl)	2022-04-04
CN108530424A (zh)	2018-09-14
HRP20220414T1 (hr)	2022-05-27
US20190002456A1 (en)	2019-01-03
SMT202300205T1 (it)	2023-09-06
PT3164380T (pt)	2022-03-02
SI3511319T1 (sl)	2023-10-30
MX2017000168A (es)	2017-05-01
EA201891526A2 (ru)	2018-12-28
US20170129882A1 (en)	2017-05-11
US9902719B2 (en)	2018-02-27
JP2017525668A (ja)	2017-09-07
HUE062558T2 (hu)	2023-11-28
PL3511319T3 (pl)	2023-09-11
CN108530424B (zh)	2021-10-01
EA201891526A3 (ru)	2019-05-31
SG10201802501RA (en)	2018-05-30
ES2907676T3 (es)	2022-04-26
MX2020010900A (es)	2022-09-13
SG11201610975RA (en)	2017-01-27
CA2954049A1 (en)	2016-01-07
KR102475498B1 (ko)	2022-12-07
US20180127408A1 (en)	2018-05-10
EA033698B1 (ru)	2019-11-18
JP6663866B2 (ja)	2020-03-13
EP3511319A1 (en)	2019-07-17
SMT202200136T1 (it)	2022-05-12
RS64423B1 (sr)	2023-09-29
IL249881A0 (en)	2017-03-30
AU2015284383A1 (en)	2017-02-02
WO2016003917A1 (en)	2016-01-07
SA517380651B1 (ar)	2020-09-30
EA201790085A1 (ru)	2017-08-31
DK3164380T3 (da)	2022-03-28
CN106795103B (zh)	2019-07-12
JP2019108346A (ja)	2019-07-04
PT3511319T (pt)	2023-06-29
SI3164380T1 (sl)	2022-06-30
US10100046B2 (en)	2018-10-16
EP3164380A4 (en)	2018-07-18
EP3511319B1 (en)	2023-05-03
CN106795103A (zh)	2017-05-31
AU2015284383B2 (en)	2019-04-18
JP6768857B2 (ja)	2020-10-14
BR112017000043A2 (pt)	2018-07-17
ECSP17006821A (es)	2017-03-31
EP3164380B1 (en)	2022-02-09
KR20170018100A (ko)	2017-02-15
LT3164380T (lt)	2022-06-27
ES2948782T3 (es)	2023-09-19
EP3164380A1 (en)	2017-05-10
CY1125127T1 (el)	2024-02-16
IL272130A (en)	2020-03-31
FI3511319T3 (fi)	2023-07-20
CO2017000549A2 (es)	2017-04-20
RS63074B1 (sr)	2022-04-29
IL249881B (en)	2020-01-30
HRP20230595T1 (hr)	2023-09-15
HUE058852T2 (hu)	2022-09-28
DK3511319T3 (da)	2023-07-31

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LT3137169T (lt)	2022-04-11	Lizinui specifinės demetilazės-1 inhibitoriai
HUE050564T2 (hu)	2020-12-28	Lizinspecifikus demetiláz-1 inhibitorai
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HUE042335T2 (hu)	2019-06-28	ROR-gamma dihidropirrolopiridin inhibitorai
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DK3211743T3 (da)	2019-12-16	Ø-til-netværk-omskiftningsfremgangsmåde
BR112017000042A2 (pt)	2018-07-17	inibidores de desmetilase-1 lisina-específica
DK3006072T3 (da)	2021-10-25	Karadgang
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NL301228I2 (nl)	2023-09-13	nirsevimab
DK3186242T3 (da)	2021-12-20	Alfa-amino-beta-carboxymuconsyre-semialdehyd-decarboxylasehæmmere
DK3341379T3 (da)	2019-12-02	EZH2-hæmmere
DK3114120T3 (da)	2019-05-20	Tetrazolon-substituerede dihydropyridinon-mgat2-hæmmere
DE112015001664A5 (de)	2016-12-29	Betätigungsaktuator
DK3183340T3 (da)	2019-08-19	Termolabile exonukleaser
DK3154703T3 (da)	2020-11-16	Fuldkappe-snekkecentrifuge
DK3110439T3 (da)	2019-05-13	Pcsk9-vacciner
DE112015005041A5 (de)	2017-08-31	Gargerätevorrichtung
DE102014000623A8 (de)	2016-10-13	Halbhohlnietelement
DK3481826T3 (da)	2022-01-10	Tyrosinkinaseinhibitorer
DK3009858T3 (da)	2021-08-09	Skyradar