SMT201600052B - Compositi di triazolopiridina come inibitori di chinasi pim - Google Patents

Compositi di triazolopiridina come inibitori di chinasi pim

Info

Publication number: SMT201600052B
Authority: SM; San Marino
Prior art keywords: triazolopiridine; chinase; pim; composites; inhibitors
Prior art date: 2011-02-25

Application number

SM201600052T

Other languages

English (en)

Inventor

James F Blake

Robert Kirk Delisle

Meese Lisa A De

James M Graham

Huerou Yvan Le

Michael Lyon

John E Robinson

Eli M Wallace

Bin Wang

Rui Xu

Original Assignee

Array Biopharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-02-25

Filing date

2016-02-22

Publication date

2016-04-29

2016-02-22 Application filed by Array Biopharma Inc filed Critical Array Biopharma Inc

2016-04-29 Publication of SMT201600052B publication Critical patent/SMT201600052B/it

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Transplantation (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)

SM201600052T 2011-02-25 2016-02-22 Compositi di triazolopiridina come inibitori di chinasi pim SMT201600052B (it)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201161446902P	2011-02-25	2011-02-25
PCT/US2012/026572 WO2012154274A1 (en)	2011-02-25	2012-02-24	Triazolopyridine compounds as pim kinase inhibitors

Publications (1)

Publication Number	Publication Date
SMT201600052B true SMT201600052B (it)	2016-04-29

Family

ID=46000320

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SM201600052T SMT201600052B (it)	2011-02-25	2016-02-22	Compositi di triazolopiridina come inibitori di chinasi pim

Country Status (33)

Country	Link
US (1)	US8889704B2 (it)
EP (1)	EP2678329B1 (it)
JP (2)	JP6039585B2 (it)
KR (1)	KR101940338B1 (it)
CN (1)	CN103492377B (it)
AR (1)	AR085489A1 (it)
AU (1)	AU2012254082B2 (it)
BR (1)	BR112013021675A2 (it)
CA (1)	CA2828269C (it)
CL (1)	CL2013002446A1 (it)
CO (1)	CO6771441A2 (it)
CR (1)	CR20130460A (it)
CY (1)	CY1117197T1 (it)
DK (1)	DK2678329T3 (it)
ES (1)	ES2563152T3 (it)
HK (1)	HK1190714A1 (it)
HR (1)	HRP20160134T1 (it)
HU (1)	HUE027675T2 (it)
IL (1)	IL228108A (it)
ME (1)	ME02365B (it)
MX (1)	MX339899B (it)
PH (1)	PH12013501754A1 (it)
PL (1)	PL2678329T3 (it)
RS (1)	RS54586B1 (it)
RU (1)	RU2598846C2 (it)
SG (1)	SG192944A1 (it)
SI (1)	SI2678329T1 (it)
SM (1)	SMT201600052B (it)
TW (1)	TWI529170B (it)
UA (1)	UA111075C2 (it)
UY (1)	UY33924A (it)
WO (1)	WO2012154274A1 (it)
ZA (1)	ZA201306997B (it)

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US9278950B2 (en)	2013-01-14	2016-03-08	Incyte Corporation	Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
TWI662030B (zh)	2013-01-15	2019-06-11	英塞特控股公司	適用作ｐｉｍ激酶抑制劑之噻唑甲醯胺及吡啶甲醯胺化合物
CR20160135A (es)	2013-08-23	2016-08-05	Incyte Corp	Compuestos de carboxamida de furo y tienopiridina útiles como inhibidores de cinasas pim
US9822124B2 (en)	2014-07-14	2017-11-21	Incyte Corporation	Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors
US9580418B2 (en)	2014-07-14	2017-02-28	Incyte Corporation	Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
US9540347B2 (en)	2015-05-29	2017-01-10	Incyte Corporation	Pyridineamine compounds useful as Pim kinase inhibitors
AR105967A1 (es)	2015-09-09	2017-11-29	Incyte Corp	Sales de un inhibidor de pim quinasa
TW201718546A (zh)	2015-10-02	2017-06-01	英塞特公司	適用作pim激酶抑制劑之雜環化合物
JP7160688B2 (ja) *	2016-05-24	2022-10-25	ジェネンテック，インコーポレイテッド	Ｃｂｐ／ｅｐ３００の複素環式インヒビターおよびがんの処置におけるそれらの使用
WO2019113487A1 (en)	2017-12-08	2019-06-13	Incyte Corporation	Low dose combination therapy for treatment of myeloproliferative neoplasms
CN117959303A (zh)	2018-04-13	2024-05-03	住友制药肿瘤公司	用于治疗骨髓增殖性肿瘤和与癌症相关的纤维化的pim激酶抑制剂
CA3106470A1 (en)	2018-07-17	2020-01-23	Nippon Chemiphar Co., Ltd.	T-type calcium channel blocker
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KR20210146290A (ko)	2019-02-12	2021-12-03	스미토모 다이니폰 파마 온콜로지, 인크.	헤테로시클릭 단백질 키나제 억제제를 포함하는 제제
WO2020168927A1 (zh) *	2019-02-19	2020-08-27	四川科伦博泰生物医药股份有限公司	含氮并环化合物、其制备方法及用途
AU2020250468A1 (en)	2019-03-29	2021-11-04	Kinki University	Use of T-type calcium channel blocker for treating pruritus
CN111171023B (zh) *	2020-01-10	2021-12-21	中国药科大学	一种具有Pim1抑制活性的化合物及其制备方法与医药用途
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2012
- 2012-02-24 MX MX2013009820A patent/MX339899B/es active IP Right Grant
- 2012-02-24 DK DK12716770.8T patent/DK2678329T3/da active
- 2012-02-24 SG SG2013064324A patent/SG192944A1/en unknown
- 2012-02-24 ES ES12716770.8T patent/ES2563152T3/es active Active
- 2012-02-24 AU AU2012254082A patent/AU2012254082B2/en not_active Ceased
- 2012-02-24 CA CA2828269A patent/CA2828269C/en not_active Expired - Fee Related
- 2012-02-24 SI SI201230453A patent/SI2678329T1/sl unknown
- 2012-02-24 CN CN201280020416.9A patent/CN103492377B/zh not_active Expired - Fee Related
- 2012-02-24 RS RS20160095A patent/RS54586B1/en unknown
- 2012-02-24 KR KR1020137025297A patent/KR101940338B1/ko active Active
- 2012-02-24 BR BR112013021675A patent/BR112013021675A2/pt not_active Application Discontinuation
- 2012-02-24 AR ARP120100626A patent/AR085489A1/es active IP Right Grant
- 2012-02-24 PL PL12716770T patent/PL2678329T3/pl unknown
- 2012-02-24 HU HUE12716770A patent/HUE027675T2/en unknown
- 2012-02-24 UA UAA201311350A patent/UA111075C2/uk unknown
- 2012-02-24 WO PCT/US2012/026572 patent/WO2012154274A1/en active Application Filing
- 2012-02-24 PH PH1/2013/501754A patent/PH12013501754A1/en unknown
- 2012-02-24 EP EP12716770.8A patent/EP2678329B1/en active Active
- 2012-02-24 ME MEP-2016-35A patent/ME02365B/me unknown
- 2012-02-24 RU RU2013143292/04A patent/RU2598846C2/ru not_active IP Right Cessation
- 2012-02-24 US US14/001,657 patent/US8889704B2/en not_active Expired - Fee Related
- 2012-02-24 JP JP2013555610A patent/JP6039585B2/ja not_active Expired - Fee Related
- 2012-02-24 UY UY0001033924A patent/UY33924A/es not_active Application Discontinuation
- 2012-02-29 TW TW101106629A patent/TWI529170B/zh not_active IP Right Cessation
2013
- 2013-08-23 CL CL2013002446A patent/CL2013002446A1/es unknown
- 2013-08-25 IL IL228108A patent/IL228108A/en active IP Right Grant
- 2013-09-11 CR CR20130460A patent/CR20130460A/es unknown
- 2013-09-17 ZA ZA2013/06997A patent/ZA201306997B/en unknown
- 2013-09-18 CO CO13222097A patent/CO6771441A2/es unknown
2014
- 2014-04-23 HK HK14103851.6A patent/HK1190714A1/zh not_active IP Right Cessation
2016
- 2016-02-05 HR HRP20160134TT patent/HRP20160134T1/hr unknown
- 2016-02-16 CY CY20161100127T patent/CY1117197T1/el unknown
- 2016-02-22 SM SM201600052T patent/SMT201600052B/it unknown
- 2016-02-24 JP JP2016032675A patent/JP2016106118A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
AU2012254082A1 (en)	2013-09-26
CA2828269A1 (en)	2012-11-15
TW201245193A (en)	2012-11-16
JP6039585B2 (ja)	2016-12-07
CL2013002446A1 (es)	2014-04-11
TWI529170B (zh)	2016-04-11
CA2828269C (en)	2019-01-15
CN103492377A (zh)	2014-01-01
JP2014509322A (ja)	2014-04-17
EP2678329A1 (en)	2014-01-01
UY33924A (es)	2013-09-30
PH12013501754A1 (en)	2013-10-14
UA111075C2 (uk)	2016-03-25
AU2012254082B2 (en)	2016-12-08
RU2013143292A (ru)	2015-04-10
CY1117197T1 (el)	2017-04-05
WO2012154274A1 (en)	2012-11-15
IL228108A0 (en)	2013-09-30
RS54586B1 (en)	2016-08-31
ZA201306997B (en)	2015-05-27
EP2678329B1 (en)	2015-11-18
CR20130460A (es)	2013-10-16
JP2016106118A (ja)	2016-06-16
CO6771441A2 (es)	2013-10-15
KR101940338B1 (ko)	2019-01-18
ME02365B (me)	2016-06-20
RU2598846C2 (ru)	2016-09-27
NZ615300A (en)	2014-12-24
HUE027675T2 (en)	2016-11-28
PL2678329T3 (pl)	2016-06-30
DK2678329T3 (da)	2016-02-22
HK1190714A1 (zh)	2014-07-11
HRP20160134T1 (hr)	2016-04-08
AR085489A1 (es)	2013-10-09
BR112013021675A2 (pt)	2016-11-01
MX2013009820A (es)	2014-09-01
IL228108A (en)	2017-07-31
KR20140021577A (ko)	2014-02-20
MX339899B (es)	2016-06-16
US8889704B2 (en)	2014-11-18
ES2563152T3 (es)	2016-03-11
CN103492377B (zh)	2016-04-20
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US20140005213A1 (en)	2014-01-02
SI2678329T1 (sl)	2016-05-31

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