SK59599A3 - (4r,5s,6s,7r)-hexahydro-1-[5-(3-aminoinazole)methyl]-3-butyl- -5,6-dihydroxy-4,7-bis [phaenylmethyl]-2h-1,3-diazepin-2-one, its preparation and its use as hiv protease inhibitor - Google Patents

(4r,5s,6s,7r)-hexahydro-1-[5-(3-aminoinazole)methyl]-3-butyl- -5,6-dihydroxy-4,7-bis [phaenylmethyl]-2h-1,3-diazepin-2-one, its preparation and its use as hiv protease inhibitor Download PDF

Info

Publication number: SK59599A3
Authority: SK; Slovakia
Prior art keywords: compound; hiv; formula; compounds; reverse transcriptase
Prior art date: 1996-11-08

Application number

SK595-99A

Other languages

English (en)

Slovak (sk)

Inventor

James D Rodgers

Patrick Yuk-Sun Lam

Original Assignee

Du Pont Pharm Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-11-08

Filing date

1997-11-04

Publication date

1999-12-10

1997-11-04 Application filed by Du Pont Pharm Co filed Critical Du Pont Pharm Co

1999-12-10 Publication of SK59599A3 publication Critical patent/SK59599A3/sk

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Virology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Tropical Medicine & Parasitology (AREA)
General Chemical & Material Sciences (AREA)
AIDS & HIV (AREA)
Molecular Biology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)

SK595-99A 1996-11-08 1997-11-04 (4r,5s,6s,7r)-hexahydro-1-[5-(3-aminoinazole)methyl]-3-butyl- -5,6-dihydroxy-4,7-bis [phaenylmethyl]-2h-1,3-diazepin-2-one, its preparation and its use as hiv protease inhibitor SK59599A3 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US2974696P	1996-11-08	1996-11-08
US74710396A	1996-11-08	1996-11-08
PCT/US1997/020036 WO1998020009A1 (en)	1996-11-08	1997-11-04	(4r,5s,6s,7r)-hexahydro-1- [5-(3-aminoinazole)methyl] -3-butyl-5,6-dihydroxy-4,7-bis [phaenylmethyl] -2h-1,3-diazepin-2-one, its preparation and its use as hiv protease inhibitor

Publications (1)

Publication Number	Publication Date
SK59599A3 true SK59599A3 (en)	1999-12-10

Family

ID=26705295

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK595-99A SK59599A3 (en)	1996-11-08	1997-11-04	(4r,5s,6s,7r)-hexahydro-1-[5-(3-aminoinazole)methyl]-3-butyl- -5,6-dihydroxy-4,7-bis [phaenylmethyl]-2h-1,3-diazepin-2-one, its preparation and its use as hiv protease inhibitor

Country Status (19)

Country	Link
EP (1)	EP0937066A1 (lv)
JP (1)	JP2001503429A (lv)
KR (1)	KR20000053123A (lv)
CN (1)	CN1235601A (lv)
AU (1)	AU722489B2 (lv)
BR (1)	BR9712755A (lv)
CA (1)	CA2270963A1 (lv)
CZ (1)	CZ157499A3 (lv)
EA (1)	EA001154B1 (lv)
EE (1)	EE9900187A (lv)
HU (1)	HUP9904143A3 (lv)
IL (1)	IL129726A0 (lv)
LV (1)	LV12374B (lv)
NO (1)	NO992229L (lv)
NZ (1)	NZ335919A (lv)
PL (1)	PL333412A1 (lv)
SI (1)	SI9720071A (lv)
SK (1)	SK59599A3 (lv)
WO (1)	WO1998020009A1 (lv)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2001518094A (ja) *	1997-03-31	2001-10-09	デュポンファーマシューティカルズカンパニー	Ｈｉｖプロテアーゼ阻害剤として有用なインダゾール−環式尿素
US6194391B1 (en) *	1998-06-24	2001-02-27	Emory University	3′-azido-2′,3′-dideoxyuridine administration to treat HIV and related test protocol
FR2810039B1 (fr)	2000-06-13	2007-05-25	Centre Nat Rech Scient	Composes urees cycliques et leur procede de preparation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5610294A (en) *	1991-10-11	1997-03-11	The Du Pont Merck Pharmaceutical Company	Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors
AU2871592A (en) *	1991-10-11	1993-05-03	Du Pont Merck Pharmaceutical Company, The	Cyclic ureas and analogues useful as retroviral protease inhibitiors

1997
- 1997-11-04 EP EP97945596A patent/EP0937066A1/en not_active Ceased
- 1997-11-04 AU AU51033/98A patent/AU722489B2/en not_active Ceased
- 1997-11-04 JP JP52168298A patent/JP2001503429A/ja active Pending
- 1997-11-04 WO PCT/US1997/020036 patent/WO1998020009A1/en not_active Application Discontinuation
- 1997-11-04 PL PL97333412A patent/PL333412A1/xx unknown
- 1997-11-04 SI SI9720071A patent/SI9720071A/sl unknown
- 1997-11-04 IL IL12972697A patent/IL129726A0/xx unknown
- 1997-11-04 EE EEP199900187A patent/EE9900187A/xx unknown
- 1997-11-04 BR BR9712755-8A patent/BR9712755A/pt unknown
- 1997-11-04 EA EA199900451A patent/EA001154B1/ru not_active IP Right Cessation
- 1997-11-04 KR KR1019990704049A patent/KR20000053123A/ko not_active Application Discontinuation
- 1997-11-04 CZ CZ991574A patent/CZ157499A3/cs unknown
- 1997-11-04 CN CN97199418A patent/CN1235601A/zh active Pending
- 1997-11-04 NZ NZ335919A patent/NZ335919A/xx unknown
- 1997-11-04 SK SK595-99A patent/SK59599A3/sk unknown
- 1997-11-04 CA CA002270963A patent/CA2270963A1/en not_active Abandoned
- 1997-11-04 HU HU9904143A patent/HUP9904143A3/hu unknown
1999
- 1999-04-29 LV LVP-99-75A patent/LV12374B/lv unknown
- 1999-05-07 NO NO992229A patent/NO992229L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
PL333412A1 (en)	1999-12-06
KR20000053123A (ko)	2000-08-25
EA001154B1 (ru)	2000-10-30
IL129726A0 (en)	2000-02-29
SI9720071A (sl)	1999-12-31
CN1235601A (zh)	1999-11-17
EP0937066A1 (en)	1999-08-25
WO1998020009A1 (en)	1998-05-14
BR9712755A (pt)	1999-10-19
LV12374A (lv)	1999-11-20
CA2270963A1 (en)	1998-05-14
EE9900187A (et)	1999-12-15
JP2001503429A (ja)	2001-03-13
NO992229L (no)	1999-06-07
HUP9904143A2 (hu)	2000-06-28
AU722489B2 (en)	2000-08-03
AU5103398A (en)	1998-05-29
NO992229D0 (no)	1999-05-07
HUP9904143A3 (en)	2002-11-28
NZ335919A (en)	2000-09-29
CZ157499A3 (cs)	1999-11-17
EA199900451A1 (ru)	1999-12-29
LV12374B (lv)	2000-04-20

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