NZ335919A - (4r,5s,6s,7r)-hexahydro-1-[5-(3-aminoinazole)methyl]-3-butyl-5 ,6-dihydroxy-4,7-bis[phaenylmethyl]-2h-1,3-diazepin-2-one, its preparation and its use as hiv protease inhibitor - Google Patents
(4r,5s,6s,7r)-hexahydro-1-[5-(3-aminoinazole)methyl]-3-butyl-5 ,6-dihydroxy-4,7-bis[phaenylmethyl]-2h-1,3-diazepin-2-one, its preparation and its use as hiv protease inhibitorInfo
- Publication number
- NZ335919A NZ335919A NZ335919A NZ33591997A NZ335919A NZ 335919 A NZ335919 A NZ 335919A NZ 335919 A NZ335919 A NZ 335919A NZ 33591997 A NZ33591997 A NZ 33591997A NZ 335919 A NZ335919 A NZ 335919A
- Authority
- NZ
- New Zealand
- Prior art keywords
- butyl
- hiv protease
- phaenylmethyl
- aminoinazole
- diazepin
- Prior art date
Links
- 229940122440 HIV protease inhibitor Drugs 0.000 title 1
- 239000004030 hiv protease inhibitor Substances 0.000 title 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000009007 Diagnostic Kit Methods 0.000 abstract 1
- 108010010369 HIV Protease Proteins 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical group 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Chemical & Material Sciences (AREA)
- AIDS & HIV (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2974696P | 1996-11-08 | 1996-11-08 | |
| US74710396A | 1996-11-08 | 1996-11-08 | |
| PCT/US1997/020036 WO1998020009A1 (en) | 1996-11-08 | 1997-11-04 | (4r,5s,6s,7r)-hexahydro-1- [5-(3-aminoinazole)methyl] -3-butyl-5,6-dihydroxy-4,7-bis [phaenylmethyl] -2h-1,3-diazepin-2-one, its preparation and its use as hiv protease inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ335919A true NZ335919A (en) | 2000-09-29 |
Family
ID=26705295
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ335919A NZ335919A (en) | 1996-11-08 | 1997-11-04 | (4r,5s,6s,7r)-hexahydro-1-[5-(3-aminoinazole)methyl]-3-butyl-5 ,6-dihydroxy-4,7-bis[phaenylmethyl]-2h-1,3-diazepin-2-one, its preparation and its use as hiv protease inhibitor |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0937066A1 (xx) |
| JP (1) | JP2001503429A (xx) |
| KR (1) | KR20000053123A (xx) |
| CN (1) | CN1235601A (xx) |
| AU (1) | AU722489B2 (xx) |
| BR (1) | BR9712755A (xx) |
| CA (1) | CA2270963A1 (xx) |
| CZ (1) | CZ157499A3 (xx) |
| EA (1) | EA001154B1 (xx) |
| EE (1) | EE9900187A (xx) |
| HU (1) | HUP9904143A3 (xx) |
| IL (1) | IL129726A0 (xx) |
| LV (1) | LV12374B (xx) |
| NO (1) | NO992229L (xx) |
| NZ (1) | NZ335919A (xx) |
| PL (1) | PL333412A1 (xx) |
| SI (1) | SI9720071A (xx) |
| SK (1) | SK59599A3 (xx) |
| WO (1) | WO1998020009A1 (xx) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001518094A (ja) * | 1997-03-31 | 2001-10-09 | デュポン ファーマシューティカルズ カンパニー | Ｈｉｖプロテアーゼ阻害剤として有用なインダゾール−環式尿素 |
| US6194391B1 (en) * | 1998-06-24 | 2001-02-27 | Emory University | 3′-azido-2′,3′-dideoxyuridine administration to treat HIV and related test protocol |
| FR2810039B1 (fr) | 2000-06-13 | 2007-05-25 | Centre Nat Rech Scient | Composes urees cycliques et leur procede de preparation |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5610294A (en) * | 1991-10-11 | 1997-03-11 | The Du Pont Merck Pharmaceutical Company | Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors |
| AU2871592A (en) * | 1991-10-11 | 1993-05-03 | Du Pont Merck Pharmaceutical Company, The | Cyclic ureas and analogues useful as retroviral protease inhibitiors |
-
1997
- 1997-11-04 EP EP97945596A patent/EP0937066A1/en not_active Ceased
- 1997-11-04 AU AU51033/98A patent/AU722489B2/en not_active Ceased
- 1997-11-04 JP JP52168298A patent/JP2001503429A/ja active Pending
- 1997-11-04 WO PCT/US1997/020036 patent/WO1998020009A1/en not_active Application Discontinuation
- 1997-11-04 PL PL97333412A patent/PL333412A1/xx unknown
- 1997-11-04 SI SI9720071A patent/SI9720071A/sl unknown
- 1997-11-04 IL IL12972697A patent/IL129726A0/xx unknown
- 1997-11-04 EE EEP199900187A patent/EE9900187A/xx unknown
- 1997-11-04 BR BR9712755-8A patent/BR9712755A/pt unknown
- 1997-11-04 EA EA199900451A patent/EA001154B1/ru not_active IP Right Cessation
- 1997-11-04 KR KR1019990704049A patent/KR20000053123A/ko not_active Application Discontinuation
- 1997-11-04 CZ CZ991574A patent/CZ157499A3/cs unknown
- 1997-11-04 CN CN97199418A patent/CN1235601A/zh active Pending
- 1997-11-04 NZ NZ335919A patent/NZ335919A/xx unknown
- 1997-11-04 SK SK595-99A patent/SK59599A3/sk unknown
- 1997-11-04 CA CA002270963A patent/CA2270963A1/en not_active Abandoned
- 1997-11-04 HU HU9904143A patent/HUP9904143A3/hu unknown
-
1999
- 1999-04-29 LV LVP-99-75A patent/LV12374B/en unknown
- 1999-05-07 NO NO992229A patent/NO992229L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PL333412A1 (en) | 1999-12-06 |
| KR20000053123A (ko) | 2000-08-25 |
| EA001154B1 (ru) | 2000-10-30 |
| IL129726A0 (en) | 2000-02-29 |
| SI9720071A (sl) | 1999-12-31 |
| CN1235601A (zh) | 1999-11-17 |
| EP0937066A1 (en) | 1999-08-25 |
| WO1998020009A1 (en) | 1998-05-14 |
| BR9712755A (pt) | 1999-10-19 |
| LV12374A (lv) | 1999-11-20 |
| CA2270963A1 (en) | 1998-05-14 |
| EE9900187A (et) | 1999-12-15 |
| JP2001503429A (ja) | 2001-03-13 |
| NO992229L (no) | 1999-06-07 |
| HUP9904143A2 (hu) | 2000-06-28 |
| AU722489B2 (en) | 2000-08-03 |
| AU5103398A (en) | 1998-05-29 |
| NO992229D0 (no) | 1999-05-07 |
| HUP9904143A3 (en) | 2002-11-28 |
| CZ157499A3 (cs) | 1999-11-17 |
| SK59599A3 (en) | 1999-12-10 |
| EA199900451A1 (ru) | 1999-12-29 |
| LV12374B (en) | 2000-04-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MXPA02004415A (es) | Pirazolonas sustituidas con heterociclicas. | |
| WO1998045276A3 (en) | 4,4-disubstituted-3,4-dihydro-2(1h)-quinazolinones useful as hiv reverse transcriptase inhibitors | |
| ATE297203T1 (de) | Antithrombotische mitteln | |
| YU16899A (xx) | Aralkil i aralkiliden heterociklični laktami i imidi | |
| IE940525L (en) | Known and selected novel arylmethylenyl derivatives of¹thiazolidinones, imidazolidinones and oxazolidinones useful¹as antiallergy agents and antiinflammatory agents | |
| EE200100558A (et) | Triarüülhappe derivaat, seda sisaldav farmatseutiline kompositsioon ja ühendi raviotstarbeline kasutamine | |
| AU2001280438A1 (en) | Substituted heterocyclic amides | |
| BR0015836A (pt) | Cristal de 4-carboxiamino-2-etil-1,2,3,4-tetra-hidroquinolina como inibidor de cetp | |
| NO984470L (no) | Pyrrolopyrrolon-derivater som inhibitorer for neutrofil elastase | |
| AU2364000A (en) | Heterocyclic amides as inhibitors of factor xa | |
| ATE253359T1 (de) | Antithrombotische mittel | |
| NO963331L (no) | 5-Heteroarylindol-derivater som benzodiazepin-reseptorsete-agonister og antagonister | |
| AU2001296699A1 (en) | Condensed pyrazindione derivatives as pde inhibitors | |
| NO983444D0 (no) | Benzo(c)kinolizin derivater, deres fremstilling og anvendelse som 5<alfa>-reduktaseinhibitorer | |
| NZ335919A (en) | (4r,5s,6s,7r)-hexahydro-1-[5-(3-aminoinazole)methyl]-3-butyl-5 ,6-dihydroxy-4,7-bis[phaenylmethyl]-2h-1,3-diazepin-2-one, its preparation and its use as hiv protease inhibitor | |
| AU7470098A (en) | Antithrombotic agents | |
| MXPA03000434A (es) | Compuestos de 2-piridona triciclicos utiles como inhibidores de transcriptasa inversa del virus de inmunodeficiencia humana (vih). | |
| NO992228D0 (no) | 1-(3-aminoindazol-5-yl)-3-fenylmetyl-syklisk urea egnet som HIV protease inhibitor | |
| WO2002018363A3 (en) | 3-phenyl-propanoic acid derivatives as protein tyrosine phosphatase inhibitors | |
| AU1434201A (en) | Antithrombotic agents | |
| DE69824410D1 (en) | Antithrombosemittel | |
| WO2002078628A3 (en) | Cyanamide, alkoxyamino, and urea derivatives of 1,3-benzodiazapines as hiv reverse transcriptase inhibitors |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RENW | Renewal (renewal fees accepted) |