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LV12374A - (4R,5S,6S,7R)-Heksahidro-1-(5-(3-aminoindazol)metil)-3-butil-5,6-dioksi-4,7-bis(fenilmetil)-2H-1,3-diazepin-2-ons si savienojuma iegusana un ka HIV proteazes inhibitora pielietojums - Google Patents

(4R,5S,6S,7R)-Heksahidro-1-(5-(3-aminoindazol)metil)-3-butil-5,6-dioksi-4,7-bis(fenilmetil)-2H-1,3-diazepin-2-ons si savienojuma iegusana un ka HIV proteazes inhibitora pielietojums

Info

Publication number
LV12374A
LV12374A LV990075A LV990075A LV12374A LV 12374 A LV12374 A LV 12374A LV 990075 A LV990075 A LV 990075A LV 990075 A LV990075 A LV 990075A LV 12374 A LV12374 A LV 12374A
Authority
LV
Latvia
Prior art keywords
hiv protease
aminoindazole
diazepin
phenylmethyl
hexahydro
Prior art date
Application number
LV990075A
Other languages
English (en)
Other versions
LV12374B (lv
Inventor
James David Rodgers
Patrick Lam
Original Assignee
Du Pont Pharm Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont Pharm Co filed Critical Du Pont Pharm Co
Publication of LV12374A publication Critical patent/LV12374A/lv
Publication of LV12374B publication Critical patent/LV12374B/lv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
LVP-99-75A 1996-11-08 1999-04-29 (4r,5s,6s,7r)-heksahidro-1-[5-(3-aminoindazol)metil]-3-butil-5,6-dioksi-4,7-bis[fenilmetil]-2h-1,3-diazepin-2-ons, šī savienojuma iegūšana un kā hiv proteāzes inhibitora pielietojums LV12374B (lv)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2974696P 1996-11-08 1996-11-08
US74710396A 1996-11-08 1996-11-08
PCT/US1997/020036 WO1998020009A1 (en) 1996-11-08 1997-11-04 (4r,5s,6s,7r)-hexahydro-1- [5-(3-aminoinazole)methyl] -3-butyl-5,6-dihydroxy-4,7-bis [phaenylmethyl] -2h-1,3-diazepin-2-one, its preparation and its use as hiv protease inhibitor

Publications (2)

Publication Number Publication Date
LV12374A true LV12374A (lv) 1999-11-20
LV12374B LV12374B (lv) 2000-04-20

Family

ID=26705295

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-99-75A LV12374B (lv) 1996-11-08 1999-04-29 (4r,5s,6s,7r)-heksahidro-1-[5-(3-aminoindazol)metil]-3-butil-5,6-dioksi-4,7-bis[fenilmetil]-2h-1,3-diazepin-2-ons, šī savienojuma iegūšana un kā hiv proteāzes inhibitora pielietojums

Country Status (19)

Country Link
EP (1) EP0937066A1 (lv)
JP (1) JP2001503429A (lv)
KR (1) KR20000053123A (lv)
CN (1) CN1235601A (lv)
AU (1) AU722489B2 (lv)
BR (1) BR9712755A (lv)
CA (1) CA2270963A1 (lv)
CZ (1) CZ157499A3 (lv)
EA (1) EA001154B1 (lv)
EE (1) EE9900187A (lv)
HU (1) HUP9904143A3 (lv)
IL (1) IL129726A0 (lv)
LV (1) LV12374B (lv)
NO (1) NO992229L (lv)
NZ (1) NZ335919A (lv)
PL (1) PL333412A1 (lv)
SI (1) SI9720071A (lv)
SK (1) SK59599A3 (lv)
WO (1) WO1998020009A1 (lv)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001518094A (ja) * 1997-03-31 2001-10-09 デュポン ファーマシューティカルズ カンパニー Ｈｉｖプロテアーゼ阻害剤として有用なインダゾール−環式尿素
US6194391B1 (en) * 1998-06-24 2001-02-27 Emory University 3′-azido-2′,3′-dideoxyuridine administration to treat HIV and related test protocol
FR2810039B1 (fr) 2000-06-13 2007-05-25 Centre Nat Rech Scient Composes urees cycliques et leur procede de preparation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5610294A (en) * 1991-10-11 1997-03-11 The Du Pont Merck Pharmaceutical Company Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors
AU2871592A (en) * 1991-10-11 1993-05-03 Du Pont Merck Pharmaceutical Company, The Cyclic ureas and analogues useful as retroviral protease inhibitiors

Also Published As

Publication number Publication date
PL333412A1 (en) 1999-12-06
KR20000053123A (ko) 2000-08-25
EA001154B1 (ru) 2000-10-30
IL129726A0 (en) 2000-02-29
SI9720071A (sl) 1999-12-31
CN1235601A (zh) 1999-11-17
EP0937066A1 (en) 1999-08-25
WO1998020009A1 (en) 1998-05-14
BR9712755A (pt) 1999-10-19
CA2270963A1 (en) 1998-05-14
EE9900187A (et) 1999-12-15
JP2001503429A (ja) 2001-03-13
NO992229L (no) 1999-06-07
HUP9904143A2 (hu) 2000-06-28
AU722489B2 (en) 2000-08-03
AU5103398A (en) 1998-05-29
NO992229D0 (no) 1999-05-07
HUP9904143A3 (en) 2002-11-28
NZ335919A (en) 2000-09-29
CZ157499A3 (cs) 1999-11-17
SK59599A3 (en) 1999-12-10
EA199900451A1 (ru) 1999-12-29
LV12374B (lv) 2000-04-20

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