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NZ335919A - (4r,5s,6s,7r)-hexahydro-1-[5-(3-aminoinazole)methyl]-3-butyl-5 ,6-dihydroxy-4,7-bis[phaenylmethyl]-2h-1,3-diazepin-2-one, its preparation and its use as hiv protease inhibitor - Google Patents

(4r,5s,6s,7r)-hexahydro-1-[5-(3-aminoinazole)methyl]-3-butyl-5 ,6-dihydroxy-4,7-bis[phaenylmethyl]-2h-1,3-diazepin-2-one, its preparation and its use as hiv protease inhibitor

Info

Publication number
NZ335919A
NZ335919A NZ335919A NZ33591997A NZ335919A NZ 335919 A NZ335919 A NZ 335919A NZ 335919 A NZ335919 A NZ 335919A NZ 33591997 A NZ33591997 A NZ 33591997A NZ 335919 A NZ335919 A NZ 335919A
Authority
NZ
New Zealand
Prior art keywords
butyl
hiv protease
phaenylmethyl
aminoinazole
diazepin
Prior art date
Application number
NZ335919A
Inventor
David James Rodgers
Patrick Yuk-Sun Lam
Original Assignee
Du Pont Pharm Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont Pharm Co filed Critical Du Pont Pharm Co
Publication of NZ335919A publication Critical patent/NZ335919A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The application relates to 1-(3-aminoindazol-5-yp)-3-butyl-cyclic urea derivatives of formula (I) or pharmaceutically acceptable salt forms or prodrugs thereof, which are useful as inhibitors of HIV protease. Also included is pharmaceutical compositions and diagnostic kits comprising the compound, and methods of using the compound for treating viral infection or as an assay standard or reagent.
NZ335919A 1996-11-08 1997-11-04 (4r,5s,6s,7r)-hexahydro-1-[5-(3-aminoinazole)methyl]-3-butyl-5 ,6-dihydroxy-4,7-bis[phaenylmethyl]-2h-1,3-diazepin-2-one, its preparation and its use as hiv protease inhibitor NZ335919A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2974696P 1996-11-08 1996-11-08
US74710396A 1996-11-08 1996-11-08
PCT/US1997/020036 WO1998020009A1 (en) 1996-11-08 1997-11-04 (4r,5s,6s,7r)-hexahydro-1- [5-(3-aminoinazole)methyl] -3-butyl-5,6-dihydroxy-4,7-bis [phaenylmethyl] -2h-1,3-diazepin-2-one, its preparation and its use as hiv protease inhibitor

Publications (1)

Publication Number Publication Date
NZ335919A true NZ335919A (en) 2000-09-29

Family

ID=26705295

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ335919A NZ335919A (en) 1996-11-08 1997-11-04 (4r,5s,6s,7r)-hexahydro-1-[5-(3-aminoinazole)methyl]-3-butyl-5 ,6-dihydroxy-4,7-bis[phaenylmethyl]-2h-1,3-diazepin-2-one, its preparation and its use as hiv protease inhibitor

Country Status (19)

Country Link
EP (1) EP0937066A1 (en)
JP (1) JP2001503429A (en)
KR (1) KR20000053123A (en)
CN (1) CN1235601A (en)
AU (1) AU722489B2 (en)
BR (1) BR9712755A (en)
CA (1) CA2270963A1 (en)
CZ (1) CZ157499A3 (en)
EA (1) EA001154B1 (en)
EE (1) EE9900187A (en)
HU (1) HUP9904143A3 (en)
IL (1) IL129726A0 (en)
LV (1) LV12374B (en)
NO (1) NO992229L (en)
NZ (1) NZ335919A (en)
PL (1) PL333412A1 (en)
SI (1) SI9720071A (en)
SK (1) SK59599A3 (en)
WO (1) WO1998020009A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998043969A1 (en) * 1997-03-31 1998-10-08 Dupont Pharmaceuticals Company Indazoles of cyclic ureas useful as hiv protease inhibitors
EP1089741A1 (en) * 1998-06-24 2001-04-11 Emory University Use of 3'-azido-2',3'-dideoxyuridine in combination with further anti-hiv drugs for the manufacture of a medicament for the treatment of hiv
FR2810039B1 (en) 2000-06-13 2007-05-25 Centre Nat Rech Scient CYCLIC UREA COMPOUNDS AND PROCESS FOR THEIR PREPARATION

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5610294A (en) * 1991-10-11 1997-03-11 The Du Pont Merck Pharmaceutical Company Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors
KR100268694B1 (en) * 1991-10-11 2000-10-16 미리암 디. 메코너헤이, 블레어큐. 퍼거슨 Cyclic ureas and analogues useful as retroviral protease inhibitors

Also Published As

Publication number Publication date
JP2001503429A (en) 2001-03-13
EA199900451A1 (en) 1999-12-29
EE9900187A (en) 1999-12-15
LV12374B (en) 2000-04-20
BR9712755A (en) 1999-10-19
NO992229L (en) 1999-06-07
CZ157499A3 (en) 1999-11-17
CN1235601A (en) 1999-11-17
WO1998020009A1 (en) 1998-05-14
CA2270963A1 (en) 1998-05-14
KR20000053123A (en) 2000-08-25
LV12374A (en) 1999-11-20
AU722489B2 (en) 2000-08-03
NO992229D0 (en) 1999-05-07
HUP9904143A2 (en) 2000-06-28
EA001154B1 (en) 2000-10-30
SI9720071A (en) 1999-12-31
PL333412A1 (en) 1999-12-06
SK59599A3 (en) 1999-12-10
HUP9904143A3 (en) 2002-11-28
EP0937066A1 (en) 1999-08-25
IL129726A0 (en) 2000-02-29
AU5103398A (en) 1998-05-29

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