SK284994B6 - Deriváty 8-azabicyklo[3.2.1]okt-2-énu, spôsob ich prípravy a ich použitie - Google Patents

Deriváty 8-azabicyklo[3.2.1]okt-2-énu, spôsob ich prípravy a ich použitie Download PDF

Info

Publication number: SK284994B6
Authority: SK; Slovakia
Prior art keywords: azabicyclo; oct; ene; methyl; thienyl
Prior art date: 1997-05-30

Application number

SK1626-99A

Other languages

English (en)

Slovak (sk)

Other versions

SK162699A3 (en

Inventor

Dan Peters

Gunnar M. Olsen

Simon Feldbaek Nielsen

Elsebet Ostergaard Nielsen

Original Assignee

Neurosearch A/S

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-05-30

Filing date

1998-05-29

Publication date

2006-04-06

1998-05-29 Application filed by Neurosearch A/S filed Critical Neurosearch A/S

2000-07-11 Publication of SK162699A3 publication Critical patent/SK162699A3/sk

2006-04-06 Publication of SK284994B6 publication Critical patent/SK284994B6/sk

Links

238000000034 method Methods 0.000 title claims abstract description 54
238000002360 preparation method Methods 0.000 title claims abstract description 16
SURHOQQBDZIWSO-UHFFFAOYSA-N 8-azabicyclo[3.2.1]oct-3-ene Chemical class N1C2CCC1C=CC2 SURHOQQBDZIWSO-UHFFFAOYSA-N 0.000 title claims description 6
150000001875 compounds Chemical class 0.000 claims abstract description 105
239000000203 mixture Substances 0.000 claims abstract description 81
-1 2-thiazolyl Chemical group 0.000 claims abstract description 49
150000003839 salts Chemical class 0.000 claims abstract description 28
125000001544 thienyl group Chemical group 0.000 claims abstract description 14
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 13
125000003682 3-furyl group Chemical group O1C([H])=C([*])C([H])=C1[H] 0.000 claims abstract description 9
125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims abstract description 5
125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims abstract description 4
239000001257 hydrogen Substances 0.000 claims abstract description 4
229910052739 hydrogen Inorganic materials 0.000 claims abstract description 4
125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 claims abstract description 3
125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 claims abstract description 3
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims abstract description 3
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims abstract description 3
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 3
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SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims description 24
239000000126 substance Substances 0.000 claims description 17
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ANCYAZAGAVYFFY-UHFFFAOYSA-N 3-(furan-2-yl)-8-methyl-8-azabicyclo[3.2.1]oct-3-ene Chemical compound CN1C(C2)CCC1C=C2C1=CC=CO1 ANCYAZAGAVYFFY-UHFFFAOYSA-N 0.000 claims description 3
DJNFHLLQBYEIJO-UHFFFAOYSA-N 8-methyl-3-thiophen-3-yl-8-azabicyclo[3.2.1]oct-3-ene Chemical compound CN1C(C2)CCC1C=C2C=1C=CSC=1 DJNFHLLQBYEIJO-UHFFFAOYSA-N 0.000 claims description 3
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125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 3
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JNTUJVNMCQZBLW-UHFFFAOYSA-N 2-(8-methyl-8-azabicyclo[3.2.1]oct-3-en-3-yl)-1,3-thiazole Chemical compound CN1C(C2)CCC1C=C2C1=NC=CS1 JNTUJVNMCQZBLW-UHFFFAOYSA-N 0.000 claims description 2
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SK1626-99A 1997-05-30 1998-05-29 Deriváty 8-azabicyklo[3.2.1]okt-2-énu, spôsob ich prípravy a ich použitie SK284994B6 (sk)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
DK62797		1997-05-30
DK150297		1997-12-19
DK40898		1998-03-24
DK53498		1998-04-16
PCT/DK1998/000225 WO1998054181A1 (en)	1997-05-30	1998-05-29	8-azabicyclo(3,2,1)oct-2-ene and octane derivatives as cholinergic ligands at nicotinic ach receptors

Publications (2)

Publication Number	Publication Date
SK162699A3 SK162699A3 (en)	2000-07-11
SK284994B6 true SK284994B6 (sk)	2006-04-06

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ID=27439314

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Application Number	Title	Priority Date	Filing Date
SK1626-99A SK284994B6 (sk)	1997-05-30	1998-05-29	Deriváty 8-azabicyklo[3.2.1]okt-2-énu, spôsob ich prípravy a ich použitie

Country Status (23)

Country	Link
US (2)	US6645977B1 (cs)
EP (1)	EP0984965B1 (cs)
JP (1)	JP4447663B2 (cs)
KR (1)	KR100589872B1 (cs)
CN (1)	CN1157392C (cs)
AT (1)	ATE267199T1 (cs)
AU (1)	AU745964B2 (cs)
BR (1)	BR9809697A (cs)
CA (1)	CA2289574C (cs)
CZ (1)	CZ298824B6 (cs)
DE (1)	DE69823994T2 (cs)
DK (1)	DK0984965T3 (cs)
EE (1)	EE04057B1 (cs)
HK (1)	HK1027353A1 (cs)
HU (1)	HUP0002713A3 (cs)
IL (2)	IL132437A0 (cs)
IS (1)	IS2092B (cs)
NO (1)	NO325513B1 (cs)
NZ (1)	NZ500642A (cs)
RU (1)	RU2186780C2 (cs)
SK (1)	SK284994B6 (cs)
TR (1)	TR199902942T2 (cs)
WO (1)	WO1998054181A1 (cs)

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1998
- 1998-05-29 JP JP50013099A patent/JP4447663B2/ja not_active Expired - Fee Related
- 1998-05-29 DK DK98921378T patent/DK0984965T3/da active
- 1998-05-29 EP EP98921378A patent/EP0984965B1/en not_active Expired - Lifetime
- 1998-05-29 WO PCT/DK1998/000225 patent/WO1998054181A1/en active IP Right Grant
- 1998-05-29 DE DE69823994T patent/DE69823994T2/de not_active Expired - Lifetime
- 1998-05-29 SK SK1626-99A patent/SK284994B6/sk not_active IP Right Cessation
- 1998-05-29 BR BR9809697-4A patent/BR9809697A/pt not_active Application Discontinuation
- 1998-05-29 HU HU0002713A patent/HUP0002713A3/hu unknown
- 1998-05-29 RU RU99128075/04A patent/RU2186780C2/ru not_active IP Right Cessation
- 1998-05-29 IL IL13243798A patent/IL132437A0/xx active IP Right Grant
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- 1998-05-29 AT AT98921378T patent/ATE267199T1/de not_active IP Right Cessation
- 1998-05-29 NZ NZ500642A patent/NZ500642A/en unknown
- 1998-05-29 TR TR1999/02942T patent/TR199902942T2/xx unknown
- 1998-05-29 CZ CZ0414799A patent/CZ298824B6/cs not_active IP Right Cessation
- 1998-05-29 CN CNB988054132A patent/CN1157392C/zh not_active Expired - Fee Related
- 1998-05-29 KR KR1019997011137A patent/KR100589872B1/ko not_active IP Right Cessation
- 1998-05-29 AU AU74261/98A patent/AU745964B2/en not_active Ceased
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2000
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Also Published As

Publication number	Publication date
HUP0002713A3 (en)	2001-02-28
IS2092B (is)	2006-04-12
IS5243A (is)	1999-11-10
CN1257499A (zh)	2000-06-21
SK162699A3 (en)	2000-07-11
CA2289574A1 (en)	1998-12-03
IL132437A (en)	2006-12-10
JP2002501514A (ja)	2002-01-15
DE69823994T2 (de)	2009-09-24
EP0984965B1 (en)	2004-05-19
NO995850D0 (no)	1999-11-29
WO1998054181A1 (en)	1998-12-03
EP0984965A1 (en)	2000-03-15
CZ414799A3 (cs)	2000-02-16
CN1157392C (zh)	2004-07-14
US20040019207A1 (en)	2004-01-29
TR199902942T2 (xx)	2000-04-21
AU7426198A (en)	1998-12-30
NZ500642A (en)	2001-11-30
JP4447663B2 (ja)	2010-04-07
NO995850L (no)	1999-11-29
BR9809697A (pt)	2000-07-11
RU2186780C2 (ru)	2002-08-10
US6964972B2 (en)	2005-11-15
ATE267199T1 (de)	2004-06-15
DE69823994D1 (de)	2004-06-24
EE9900529A (et)	2000-06-15
KR20010013154A (ko)	2001-02-26
HUP0002713A2 (hu)	2001-01-29
KR100589872B1 (ko)	2006-06-15
NO325513B1 (no)	2008-05-26
HK1027353A1 (en)	2001-01-12
IL132437A0 (en)	2001-03-19
EE04057B1 (et)	2003-06-16
US6645977B1 (en)	2003-11-11
DK0984965T3 (da)	2004-09-27
CA2289574C (en)	2007-04-24
AU745964B2 (en)	2002-04-11
CZ298824B6 (cs)	2008-02-20

Publication	Publication Date	Title
EP0984965B1 (en)	2004-05-19	8-azabicyclo(3,2,1)oct-2-ene and octane derivatives as cholinergic ligands at nicotinic ach receptors
US6392045B1 (en)	2002-05-21	9-azobicyclo[3.3.1] non-2-ene derivatives as cholinergic ligands at nicotinic ACH receptors
US6352995B1 (en)	2002-03-05	Spiro-quinuclidine derivatives, their preparation and use
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