NO995850L - 8-azabisyklo(3.2.1)okt-2-en- og -oktanderivater som cholinerge ligander i nikotin-ACh-reseptorer - Google Patents

8-azabisyklo(3.2.1)okt-2-en- og -oktanderivater som cholinerge ligander i nikotin-ACh-reseptorer

Info

Publication number: NO995850L
Authority: NO; Norway
Prior art keywords: thienyl; azabicyclo; oct; ene; benzofuryl
Prior art date: 1997-05-30

Application number

NO995850A

Other languages

English (en)

Other versions

NO995850D0 (no

NO325513B1 (no

Inventor

Dan Peters

Gunnar M Olsen

Simon Feldbaek Nielsen

Elsebet Nielsen

Original Assignee

Neurosearch As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-05-30

Filing date

1999-11-29

Publication date

1999-11-29

1999-11-29 Application filed by Neurosearch As filed Critical Neurosearch As

1999-11-29 Publication of NO995850D0 publication Critical patent/NO995850D0/no

1999-11-29 Publication of NO995850L publication Critical patent/NO995850L/no

2008-05-26 Publication of NO325513B1 publication Critical patent/NO325513B1/no

Links

SURHOQQBDZIWSO-UHFFFAOYSA-N 8-azabicyclo[3.2.1]oct-3-ene Chemical compound N1C2CCC1C=CC2 SURHOQQBDZIWSO-UHFFFAOYSA-N 0.000 title abstract 2
230000001713 cholinergic effect Effects 0.000 title abstract 2
SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 title 1
108010009685 Cholinergic Receptors Proteins 0.000 title 1
102000034337 acetylcholine receptors Human genes 0.000 title 1
239000003446 ligand Substances 0.000 title 1
229960002715 nicotine Drugs 0.000 title 1
SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 title 1
TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical class CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 title 1
-1 2-(3-methoxymethyl) Chemical group 0.000 abstract 9
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
208000002193 Pain Diseases 0.000 abstract 1
125000004618 benzofuryl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 abstract 1
125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
210000003169 central nervous system Anatomy 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
208000027866 inflammatory disease Diseases 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
230000016160 smooth muscle contraction Effects 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
201000009032 substance abuse Diseases 0.000 abstract 1
231100000736 substance abuse Toxicity 0.000 abstract 1
208000011117 substance-related disease Diseases 0.000 abstract 1
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Addiction (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Pulmonology (AREA)
Psychology (AREA)
Gynecology & Obstetrics (AREA)
Anesthesiology (AREA)
Diabetes (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Rheumatology (AREA)
Hematology (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Child & Adolescent Psychology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Dermatology (AREA)

NO19995850A 1997-05-30 1999-11-29 8-azabisyklo(3.2.1)okt-2-en-derivater, farmasoytiske preparater som omfatter forbindelsene, anvendelse av forbindelsene til fremstilling av medikamenter for behandling av en sykdom som gir respons pa aktiviteten til nikotin-ACh-reseptormodulatorer, samt fremgangsmate for fremstilling av forbindelsene. NO325513B1 (no)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
DK62797		1997-05-30
DK150297		1997-12-19
DK40898		1998-03-24
DK53498		1998-04-16
PCT/DK1998/000225 WO1998054181A1 (en)	1997-05-30	1998-05-29	8-azabicyclo(3,2,1)oct-2-ene and octane derivatives as cholinergic ligands at nicotinic ach receptors

Publications (3)

Publication Number	Publication Date
NO995850D0 NO995850D0 (no)	1999-11-29
NO995850L true NO995850L (no)	1999-11-29
NO325513B1 NO325513B1 (no)	2008-05-26

Family

ID=27439314

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19995850A NO325513B1 (no)	1997-05-30	1999-11-29	8-azabisyklo(3.2.1)okt-2-en-derivater, farmasoytiske preparater som omfatter forbindelsene, anvendelse av forbindelsene til fremstilling av medikamenter for behandling av en sykdom som gir respons pa aktiviteten til nikotin-ACh-reseptormodulatorer, samt fremgangsmate for fremstilling av forbindelsene.

Country Status (23)

Country	Link
US (2)	US6645977B1 (no)
EP (1)	EP0984965B1 (no)
JP (1)	JP4447663B2 (no)
KR (1)	KR100589872B1 (no)
CN (1)	CN1157392C (no)
AT (1)	ATE267199T1 (no)
AU (1)	AU745964B2 (no)
BR (1)	BR9809697A (no)
CA (1)	CA2289574C (no)
CZ (1)	CZ298824B6 (no)
DE (1)	DE69823994T2 (no)
DK (1)	DK0984965T3 (no)
EE (1)	EE04057B1 (no)
HK (1)	HK1027353A1 (no)
HU (1)	HUP0002713A3 (no)
IL (2)	IL132437A0 (no)
IS (1)	IS2092B (no)
NO (1)	NO325513B1 (no)
NZ (1)	NZ500642A (no)
RU (1)	RU2186780C2 (no)
SK (1)	SK284994B6 (no)
TR (1)	TR199902942T2 (no)
WO (1)	WO1998054181A1 (no)

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KR20080079250A (ko)	2005-12-06	2008-08-29	뉴로서치 에이/에스	신규한 디아자바이사이클릭 아릴 유도체 및 이의 의학적용도
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1998
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Also Published As

Publication number	Publication date
HUP0002713A3 (en)	2001-02-28
IS2092B (is)	2006-04-12
IS5243A (is)	1999-11-10
CN1257499A (zh)	2000-06-21
SK162699A3 (en)	2000-07-11
CA2289574A1 (en)	1998-12-03
IL132437A (en)	2006-12-10
JP2002501514A (ja)	2002-01-15
DE69823994T2 (de)	2009-09-24
EP0984965B1 (en)	2004-05-19
NO995850D0 (no)	1999-11-29
WO1998054181A1 (en)	1998-12-03
EP0984965A1 (en)	2000-03-15
CZ414799A3 (cs)	2000-02-16
CN1157392C (zh)	2004-07-14
US20040019207A1 (en)	2004-01-29
TR199902942T2 (xx)	2000-04-21
AU7426198A (en)	1998-12-30
NZ500642A (en)	2001-11-30
JP4447663B2 (ja)	2010-04-07
BR9809697A (pt)	2000-07-11
RU2186780C2 (ru)	2002-08-10
US6964972B2 (en)	2005-11-15
ATE267199T1 (de)	2004-06-15
DE69823994D1 (de)	2004-06-24
EE9900529A (et)	2000-06-15
KR20010013154A (ko)	2001-02-26
SK284994B6 (sk)	2006-04-06
HUP0002713A2 (hu)	2001-01-29
KR100589872B1 (ko)	2006-06-15
NO325513B1 (no)	2008-05-26
HK1027353A1 (en)	2001-01-12
IL132437A0 (en)	2001-03-19
EE04057B1 (et)	2003-06-16
US6645977B1 (en)	2003-11-11
DK0984965T3 (da)	2004-09-27
CA2289574C (en)	2007-04-24
AU745964B2 (en)	2002-04-11
CZ298824B6 (cs)	2008-02-20

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