SK283147B6 - Práškový prostriedok na aplikáciu liečivých peptidov, spôsob jeho výroby a jeho použitie - Google Patents

Práškový prostriedok na aplikáciu liečivých peptidov, spôsob jeho výroby a jeho použitie Download PDF

Info

Publication number: SK283147B6
Authority: SK; Slovakia
Prior art keywords: powder; powder composition; polypeptide; melezitose; acid
Prior art date: 1994-12-22

Application number

SK812-97A

Other languages

English (en)

Slovak (sk)

Other versions

SK81297A3 (en

Inventor

Kjell B�Ckstr�M

Ann Johansson

Helena Linden

Original Assignee

Astra Aktiebolag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-12-22

Filing date

1995-12-19

Publication date

2003-03-04

1995-12-19 Application filed by Astra Aktiebolag filed Critical Astra Aktiebolag

1997-11-05 Publication of SK81297A3 publication Critical patent/SK81297A3/sk

2003-03-04 Publication of SK283147B6 publication Critical patent/SK283147B6/sk

Links

239000000203 mixture Substances 0.000 title claims abstract description 100
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239000000843 powder Substances 0.000 title claims description 112
238000009472 formulation Methods 0.000 title claims description 27
238000000034 method Methods 0.000 title claims description 12
102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 64
229920001184 polypeptide Polymers 0.000 claims abstract description 63
QWIZNVHXZXRPDR-UHFFFAOYSA-N D-melezitose Natural products O1C(CO)C(O)C(O)C(O)C1OC1C(O)C(CO)OC1(CO)OC1OC(CO)C(O)C(O)C1O QWIZNVHXZXRPDR-UHFFFAOYSA-N 0.000 claims abstract description 39
QWIZNVHXZXRPDR-WSCXOGSTSA-N melezitose Chemical compound O([C@@]1(O[C@@H]([C@H]([C@@H]1O[C@@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O)CO)CO)[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O QWIZNVHXZXRPDR-WSCXOGSTSA-N 0.000 claims abstract description 39
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DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical group C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 4
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Classifications

- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds

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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pulmonology (AREA)
Diabetes (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Otolaryngology (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Endocrinology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Zoology (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Oil, Petroleum & Natural Gas (AREA)
Toxicology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Peptides Or Proteins (AREA)

SK812-97A 1994-12-22 1995-12-19 Práškový prostriedok na aplikáciu liečivých peptidov, spôsob jeho výroby a jeho použitie SK283147B6 (sk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE9404468A SE9404468D0 (sv)	1994-12-22	1994-12-22	Powder formulations
PCT/SE1995/001541 WO1996019207A1 (en)	1994-12-22	1995-12-19	Powder formulations containing melezitose as a diluent

Publications (2)

Publication Number	Publication Date
SK81297A3 SK81297A3 (en)	1997-11-05
SK283147B6 true SK283147B6 (sk)	2003-03-04

Family

ID=20396435

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK812-97A SK283147B6 (sk)	1994-12-22	1995-12-19	Práškový prostriedok na aplikáciu liečivých peptidov, spôsob jeho výroby a jeho použitie

Country Status (34)

Country	Link
US (1)	US6004574A (de)
EP (2)	EP1224929B1 (de)
JP (1)	JPH10510828A (de)
KR (1)	KR100391873B1 (de)
CN (1)	CN1080114C (de)
AR (1)	AR002261A1 (de)
AT (2)	ATE220900T1 (de)
AU (1)	AU702898B2 (de)
BR (1)	BR9510422A (de)
CA (1)	CA2206803A1 (de)
CZ (1)	CZ288487B6 (de)
DE (2)	DE69533294T2 (de)
DK (2)	DK0799030T3 (de)
EE (1)	EE03381B1 (de)
ES (2)	ES2222306T3 (de)
FI (1)	FI972654A0 (de)
HK (1)	HK1003619A1 (de)
HU (1)	HU217975B (de)
IL (1)	IL116459A (de)
IS (1)	IS1848B (de)
MY (1)	MY114211A (de)
NO (1)	NO315966B1 (de)
NZ (1)	NZ298168A (de)
PL (1)	PL183944B1 (de)
PT (2)	PT799030E (de)
RU (1)	RU2144819C1 (de)
SA (1)	SA95160484B1 (de)
SE (1)	SE9404468D0 (de)
SK (1)	SK283147B6 (de)
TR (1)	TR199501632A1 (de)
TW (1)	TW474823B (de)
UA (1)	UA44757C2 (de)
WO (1)	WO1996019207A1 (de)
ZA (1)	ZA9510753B (de)

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US7312192B2 (en)	2001-09-07	2007-12-25	Biocon Limited	Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US6913903B2 (en)	2001-09-07	2005-07-05	Nobex Corporation	Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US6770625B2 (en)	2001-09-07	2004-08-03	Nobex Corporation	Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
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US7601688B2 (en)	2002-06-13	2009-10-13	Biocon Limited	Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
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US5506203C1 (en) *	1993-06-24	2001-02-06	Astra Ab	Systemic administration of a therapeutic preparation

1994
- 1994-12-22 SE SE9404468A patent/SE9404468D0/xx unknown
1995
- 1995-12-18 ZA ZA9510753A patent/ZA9510753B/xx unknown
- 1995-12-19 TW TW084113557A patent/TW474823B/zh not_active IP Right Cessation
- 1995-12-19 AU AU43592/96A patent/AU702898B2/en not_active Ceased
- 1995-12-19 AT AT95942342T patent/ATE220900T1/de not_active IP Right Cessation
- 1995-12-19 BR BR9510422A patent/BR9510422A/pt not_active Application Discontinuation
- 1995-12-19 US US08/617,753 patent/US6004574A/en not_active Expired - Fee Related
- 1995-12-19 PT PT95942342T patent/PT799030E/pt unknown
- 1995-12-19 ES ES01130870T patent/ES2222306T3/es not_active Expired - Lifetime
- 1995-12-19 SK SK812-97A patent/SK283147B6/sk unknown
- 1995-12-19 AT AT01130870T patent/ATE271382T1/de not_active IP Right Cessation
- 1995-12-19 DE DE69533294T patent/DE69533294T2/de not_active Expired - Fee Related
- 1995-12-19 RU RU97112496A patent/RU2144819C1/ru not_active IP Right Cessation
- 1995-12-19 HU HU9800493A patent/HU217975B/hu not_active IP Right Cessation
- 1995-12-19 EP EP01130870A patent/EP1224929B1/de not_active Expired - Lifetime
- 1995-12-19 DK DK95942342T patent/DK0799030T3/da active
- 1995-12-19 MY MYPI95003942A patent/MY114211A/en unknown
- 1995-12-19 DK DK01130870T patent/DK1224929T3/da active
- 1995-12-19 NZ NZ298168A patent/NZ298168A/en unknown
- 1995-12-19 PT PT01130870T patent/PT1224929E/pt unknown
- 1995-12-19 CA CA002206803A patent/CA2206803A1/en not_active Abandoned
- 1995-12-19 IL IL11645995A patent/IL116459A/en not_active IP Right Cessation
- 1995-12-19 DE DE69527542T patent/DE69527542T2/de not_active Expired - Fee Related
- 1995-12-19 KR KR1019970704254A patent/KR100391873B1/ko not_active Expired - Fee Related
- 1995-12-19 JP JP8519731A patent/JPH10510828A/ja active Pending
- 1995-12-19 PL PL95320751A patent/PL183944B1/pl not_active IP Right Cessation
- 1995-12-19 UA UA97073876A patent/UA44757C2/uk unknown
- 1995-12-19 ES ES95942342T patent/ES2177674T3/es not_active Expired - Lifetime
- 1995-12-19 EE EE9700135A patent/EE03381B1/xx not_active IP Right Cessation
- 1995-12-19 CN CN95196965A patent/CN1080114C/zh not_active Expired - Fee Related
- 1995-12-19 CZ CZ19971946A patent/CZ288487B6/cs not_active IP Right Cessation
- 1995-12-19 EP EP95942342A patent/EP0799030B1/de not_active Expired - Lifetime
- 1995-12-19 WO PCT/SE1995/001541 patent/WO1996019207A1/en active IP Right Grant
- 1995-12-21 AR ARP950100706A patent/AR002261A1/es active IP Right Grant
- 1995-12-21 TR TR95/01632A patent/TR199501632A1/xx unknown
- 1995-12-30 SA SA95160484A patent/SA95160484B1/ar unknown
1997
- 1997-06-03 IS IS4495A patent/IS1848B/is unknown
- 1997-06-10 NO NO19972660A patent/NO315966B1/no unknown
- 1997-06-19 FI FI972654A patent/FI972654A0/fi unknown
1998
- 1998-04-02 HK HK98102788A patent/HK1003619A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE69533294T2 (de)	2005-05-19
CN1080114C (zh)	2002-03-06
EP1224929A2 (de)	2002-07-24
SK81297A3 (en)	1997-11-05
UA44757C2 (uk)	2002-03-15
IS1848B (is)	2003-02-07
NO972660L (no)	1997-06-10
US6004574A (en)	1999-12-21
PT1224929E (pt)	2004-10-29
ES2177674T3 (es)	2002-12-16
IS4495A (is)	1997-06-03
TW474823B (en)	2002-02-01
NO315966B1 (no)	2003-11-24
HU217975B (hu)	2000-05-28
EP0799030B1 (de)	2002-07-24
ATE271382T1 (de)	2004-08-15
DK1224929T3 (da)	2004-10-04
CN1171049A (zh)	1998-01-21
RU2144819C1 (ru)	2000-01-27
MY114211A (en)	2002-08-30
TR199501632A1 (tr)	1997-03-21
HK1003619A1 (en)	1998-11-06
DK0799030T3 (da)	2002-09-16
PT799030E (pt)	2002-11-29
NZ298168A (en)	1999-08-30
EP0799030A1 (de)	1997-10-08
EE9700135A (et)	1997-12-15
WO1996019207A1 (en)	1996-06-27
IL116459A (en)	2002-11-10
AR002261A1 (es)	1998-03-11
PL320751A1 (en)	1997-10-27
BR9510422A (pt)	1998-07-07
DE69527542D1 (de)	2002-08-29
AU4359296A (en)	1996-07-10
CZ288487B6 (en)	2001-06-13
NO972660D0 (no)	1997-06-10
FI972654L (fi)	1997-06-19
JPH10510828A (ja)	1998-10-20
CZ194697A3 (en)	1997-10-15
EP1224929B1 (de)	2004-07-21
IL116459A0 (en)	1996-03-31
CA2206803A1 (en)	1996-06-27
SA95160484B1 (ar)	2005-10-01
ES2222306T3 (es)	2005-02-01
DE69533294D1 (de)	2004-08-26
KR100391873B1 (ko)	2003-10-17
ZA9510753B (en)	1996-06-24
AU702898B2 (en)	1999-03-11
PL183944B1 (pl)	2002-08-30
FI972654A0 (fi)	1997-06-19
SE9404468D0 (sv)	1994-12-22
HUT77648A (hu)	1998-07-28
ATE220900T1 (de)	2002-08-15
DE69527542T2 (de)	2003-01-30
EE03381B1 (et)	2001-04-16
EP1224929A3 (de)	2002-12-18
MX9704551A (es)	1997-10-31

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CZ287656B6 (en)	2001-01-17	Pharmaceutical preparation in the form of dry powder intended for inhalation
SI20413A (sl)	2001-06-30	Dajanje aerosoliziranega aktivnega sredstva
US20010003739A1 (en)	2001-06-14	Systemic administration of a therapeutic preparation
MXPA97004551A (en)	1998-07-03	Formulations in powder containing melecitose as a diluye
US20010025037A1 (en)	2001-09-27	Systemic administration of a therapeutic preparation