SI1404811T1 - Ogljikov monoksid izboljša rezultate pri presaditvi tkiva in organov ter prepreči apoptozo - Google Patents
Ogljikov monoksid izboljša rezultate pri presaditvi tkiva in organov ter prepreči apoptozoInfo
- Publication number
- SI1404811T1 SI1404811T1 SI200230772T SI200230772T SI1404811T1 SI 1404811 T1 SI1404811 T1 SI 1404811T1 SI 200230772 T SI200230772 T SI 200230772T SI 200230772 T SI200230772 T SI 200230772T SI 1404811 T1 SI1404811 T1 SI 1404811T1
- Authority
- SI
- Slovenia
- Prior art keywords
- carbon monoxide
- tissue
- results
- prevents apoptosis
- organs
- Prior art date
Links
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 title abstract 2
- 229910002091 carbon monoxide Inorganic materials 0.000 title abstract 2
- 210000000056 organ Anatomy 0.000 title abstract 2
- 238000002054 transplantation Methods 0.000 title abstract 2
- 230000006907 apoptotic process Effects 0.000 title 1
- 238000000034 method Methods 0.000 abstract 3
- 230000004083 survival effect Effects 0.000 abstract 2
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
- A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Zoology (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- Transplantation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30028901P | 2001-06-21 | 2001-06-21 | |
US33434001P | 2001-11-29 | 2001-11-29 | |
US33797401P | 2001-12-07 | 2001-12-07 | |
PCT/US2002/019687 WO2003000114A2 (en) | 2001-06-21 | 2002-06-21 | Carbon monoxide improves outcomes in tissue and organ transplants and suppresses apoptosis |
EP02747932A EP1404811B1 (en) | 2001-06-21 | 2002-06-21 | Carbon monoxide improves outcomes in tissue and organ transplants and suppresses apoptosis |
Publications (1)
Publication Number | Publication Date |
---|---|
SI1404811T1 true SI1404811T1 (sl) | 2009-04-30 |
Family
ID=27404726
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200230772T SI1404811T1 (sl) | 2001-06-21 | 2002-06-21 | Ogljikov monoksid izboljša rezultate pri presaditvi tkiva in organov ter prepreči apoptozo |
Country Status (26)
Country | Link |
---|---|
US (2) | US7238469B2 (sl) |
EP (2) | EP2033514A3 (sl) |
JP (1) | JP4521183B2 (sl) |
KR (1) | KR20040032115A (sl) |
CN (1) | CN100502650C (sl) |
AT (1) | ATE413883T1 (sl) |
AU (2) | AU2002318377B2 (sl) |
BG (1) | BG108492A (sl) |
BR (1) | BR0210599A (sl) |
CA (1) | CA2451266A1 (sl) |
CY (1) | CY1108798T1 (sl) |
CZ (1) | CZ20033448A3 (sl) |
DE (1) | DE60229848D1 (sl) |
DK (1) | DK1404811T3 (sl) |
ES (1) | ES2316583T3 (sl) |
HK (1) | HK1067380A1 (sl) |
HU (1) | HUP0400371A3 (sl) |
MX (1) | MXPA03012031A (sl) |
NO (1) | NO20035637L (sl) |
NZ (1) | NZ562962A (sl) |
PL (1) | PL367544A1 (sl) |
PT (1) | PT1404811E (sl) |
SG (1) | SG147305A1 (sl) |
SI (1) | SI1404811T1 (sl) |
SK (1) | SK15942003A3 (sl) |
WO (1) | WO2003000114A2 (sl) |
Families Citing this family (41)
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US8128963B2 (en) * | 1996-09-27 | 2012-03-06 | The Trustees Of Columbia University In The City Of New York | Methods for treating ischemic disorders using carbon monoxide |
US7678390B2 (en) | 1999-04-01 | 2010-03-16 | Yale University | Carbon monoxide as a biomarker and therapeutic agent |
GB0111872D0 (en) | 2001-05-15 | 2001-07-04 | Northwick Park Inst For Medica | Therapeutic agents and methods |
CN100502650C (zh) * | 2001-06-21 | 2009-06-24 | 贝思·伊斯雷尔·迪科尼斯医药中心 | 一氧化碳改善组织和器官移植结局并抑制细胞凋亡 |
US20080026984A1 (en) * | 2002-02-04 | 2008-01-31 | Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda | Methods for treating inflammatory disease by administering aldehydes and derivatives thereof |
US7968605B2 (en) * | 2002-02-04 | 2011-06-28 | ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda. | Methods for treating inflammatory disease by administering aldehydes and derivatives thereof |
WO2003066067A2 (en) * | 2002-02-04 | 2003-08-14 | Alfama - Investigaçao E Desenvolvimento De Produtos Farmaceuticos Lda. | Use of co-releasing compounds for the manufacture of a medicament for the treatment of inflammatory diseases |
SG148850A1 (en) | 2002-02-13 | 2009-01-29 | Beth Israel Hospital | Methods of treating vascular disease |
CA2482260A1 (en) | 2002-04-15 | 2003-10-30 | Beth Israel Deaconess Medical Center Inc. | Use of heme oxygenase-1 and products of heme degradation |
PL373002A1 (en) * | 2002-04-15 | 2005-08-08 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Methods of treating ileus |
WO2003088981A1 (en) * | 2002-04-15 | 2003-10-30 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Methods of treating necrotizing enterocolitis |
US20040052866A1 (en) * | 2002-05-17 | 2004-03-18 | Otterbein Leo E. | Methods of treating hepatitis |
MXPA04012167A (es) * | 2002-06-05 | 2005-09-21 | Univ Yale | Metodos para tratar angiogenesis, crecimeinto tumoral y metastasis. |
EA200500062A1 (ru) * | 2002-06-21 | 2005-06-30 | Юниверсити Оф Питтсбург Оф Дзе Коммонвелт Систем Оф Хайер Эдьюкейшн | Фармацевтическое применение оксида азота, гемоксигеназы-1 и продуктов деградации гема |
CA2504604A1 (en) * | 2002-11-07 | 2004-05-27 | Timothy R. Billiar | Treatment for hemorrhagic shock |
GB2395432B (en) * | 2002-11-20 | 2005-09-14 | Northwick Park Inst For Medica | Therapeutic delivery of carbon monoxide to extracorporeal and isolated organs |
US20070207217A1 (en) * | 2003-02-03 | 2007-09-06 | Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda | Method for treating a mammal by administration of a compound having the ability to release CO |
JP2007526241A (ja) * | 2003-10-22 | 2007-09-13 | フレッド ハッチンソン キャンサー リサーチ センター | 細胞においてスタシスを誘導する方法、組成物、および装置 |
EP1552840A1 (en) * | 2004-01-07 | 2005-07-13 | Aga Ab | Use of a xenon/carbon monoxide mixture for the protection of cells |
AU2006220548B2 (en) | 2005-03-07 | 2011-04-21 | Sangart, Inc. | Composition and methods for delivering carbon monoxide (CO) and nitric ozide (NO) CO to tissue using heme proteins as carriers |
US7977042B2 (en) * | 2005-07-27 | 2011-07-12 | University Of North Carolina At Charlotte | Composition and method for the restoration and preservation of transplant organs procured from DCD donors |
US20070207993A1 (en) * | 2005-12-20 | 2007-09-06 | Alfama - Investigacao E Desenvolvimetno De Productos Farmaceuticos Lda | Molybdenum carbonyl complexes for treating rheumatoid arthritis and other inflammatory diseases |
GB0601394D0 (en) | 2006-01-24 | 2006-03-01 | Hemocorm Ltd | Therapeutic delivery of carbon monoxide |
JP5697335B2 (ja) | 2006-11-07 | 2015-04-08 | ザ ジェネラル ホスピタル コーポレイション | 血管作動性酸素運搬体に誘導される血管収縮の減弱 |
KR101899271B1 (ko) | 2009-05-27 | 2018-09-14 | 이노 테라퓨틱스 엘엘씨 | 인덱싱된 밸브와 압축 캐니스터 조립체를 칼라에 결합하고 플런저 조립체로 선형 작동시켜 약물 전달 조절용 장치와 유체 소통상태가 되게 하는 방법 및 장치 |
CA3130908A1 (en) | 2009-06-30 | 2010-12-30 | Mallinckrodt Hospital Products IP Limited | Methods of treating term and near-term neonates having hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension |
BR112013017933B1 (pt) | 2011-01-14 | 2021-02-23 | Children's Hospital Los Angeles | composição líquida e métodos para sua fabricação |
US8927750B2 (en) | 2011-02-04 | 2015-01-06 | Universitaet Zu Koeln | Acyloxy- and phosphoryloxy-butadiene-Fe(CO)3 complexes as enzyme-triggered co-releasing molecules |
AU2012228972A1 (en) | 2011-03-16 | 2013-10-24 | Dynasil Biomedical Corporation | Methods and materials for prolonging useful storage of red blood cell preparations and platelet preparations |
WO2012145520A2 (en) | 2011-04-19 | 2012-10-26 | Alfama, Inc. | Carbon monoxide releasing molecules and uses thereof |
WO2012170843A1 (en) * | 2011-06-10 | 2012-12-13 | Geno Llc | Pressurized vessel of nitric oxide (no) |
EP2734235B1 (en) | 2011-07-21 | 2017-03-22 | Alfama, Inc. | Ruthenium carbon monoxide releasing molecules and uses thereof |
CA2844660A1 (en) | 2011-08-09 | 2013-02-14 | Leo E. Otterbein | Methods of treating dna damage |
ES2981406T3 (es) | 2013-03-15 | 2024-10-08 | Mallinckrodt Pharmaceuticals Ireland Ltd | Administración y monitorización de óxido nítrico en fluidos ex vivo |
US9629358B2 (en) | 2013-03-15 | 2017-04-25 | Mallinckrodt Hospital Products IP Limited | Administration and monitoring of nitric oxide in ex vivo fluids |
TW201618795A (zh) * | 2014-04-15 | 2016-06-01 | 波泰里斯股份有限公司 | 用以改良器官功能及延長器官移植物壽命之系統及方法 |
WO2017027810A2 (en) | 2015-08-12 | 2017-02-16 | The General Hospital Corporation | Compositions and methods that promote hypoxia or the hypoxia response for treatment and prevention of mitochondrial dysfunction and oxidative stress disorders |
CN105288599A (zh) * | 2015-10-22 | 2016-02-03 | 徐州医学院 | 血红素氧化酶-2在制备抑制器官移植免疫排斥制剂中的应用 |
EP3672403A4 (en) | 2017-08-25 | 2021-05-19 | Mallinckrodt Hospital Products IP Limited | PROCESSES FOR IMPROVING ORGAN SUSTAINABILITY |
EP3524290A1 (en) | 2018-02-09 | 2019-08-14 | Julius-Maximilians-Universitaet Wuerzburg | Method and system for monitoring carbon monoxide (co) administration to ex-vivo fluids |
CN116076484A (zh) * | 2022-11-30 | 2023-05-09 | 武汉大学 | 一种修复肾脏损伤的低温携氧机械灌注液及其应用 |
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CN100502650C (zh) * | 2001-06-21 | 2009-06-24 | 贝思·伊斯雷尔·迪科尼斯医药中心 | 一氧化碳改善组织和器官移植结局并抑制细胞凋亡 |
WO2003066067A2 (en) * | 2002-02-04 | 2003-08-14 | Alfama - Investigaçao E Desenvolvimento De Produtos Farmaceuticos Lda. | Use of co-releasing compounds for the manufacture of a medicament for the treatment of inflammatory diseases |
SG148850A1 (en) * | 2002-02-13 | 2009-01-29 | Beth Israel Hospital | Methods of treating vascular disease |
WO2003088981A1 (en) * | 2002-04-15 | 2003-10-30 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Methods of treating necrotizing enterocolitis |
PL373002A1 (en) * | 2002-04-15 | 2005-08-08 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Methods of treating ileus |
CA2482260A1 (en) * | 2002-04-15 | 2003-10-30 | Beth Israel Deaconess Medical Center Inc. | Use of heme oxygenase-1 and products of heme degradation |
US20040052866A1 (en) * | 2002-05-17 | 2004-03-18 | Otterbein Leo E. | Methods of treating hepatitis |
MXPA04012167A (es) * | 2002-06-05 | 2005-09-21 | Univ Yale | Metodos para tratar angiogenesis, crecimeinto tumoral y metastasis. |
EA200500062A1 (ru) * | 2002-06-21 | 2005-06-30 | Юниверсити Оф Питтсбург Оф Дзе Коммонвелт Систем Оф Хайер Эдьюкейшн | Фармацевтическое применение оксида азота, гемоксигеназы-1 и продуктов деградации гема |
CA2504604A1 (en) * | 2002-11-07 | 2004-05-27 | Timothy R. Billiar | Treatment for hemorrhagic shock |
US20050255178A1 (en) * | 2004-02-04 | 2005-11-17 | Bloch Kenneth D | Enhancing the effectiveness of an inhaled therapeutic gas |
-
2002
- 2002-06-21 CN CNB028163443A patent/CN100502650C/zh not_active Expired - Fee Related
- 2002-06-21 AT AT02747932T patent/ATE413883T1/de not_active IP Right Cessation
- 2002-06-21 NZ NZ562962A patent/NZ562962A/en not_active IP Right Cessation
- 2002-06-21 SK SK1594-2003A patent/SK15942003A3/sk not_active Application Discontinuation
- 2002-06-21 MX MXPA03012031A patent/MXPA03012031A/es active IP Right Grant
- 2002-06-21 AU AU2002318377A patent/AU2002318377B2/en not_active Ceased
- 2002-06-21 PL PL02367544A patent/PL367544A1/xx unknown
- 2002-06-21 BR BR0210599-3A patent/BR0210599A/pt not_active IP Right Cessation
- 2002-06-21 SG SG200601852-7A patent/SG147305A1/en unknown
- 2002-06-21 DK DK02747932T patent/DK1404811T3/da active
- 2002-06-21 ES ES02747932T patent/ES2316583T3/es not_active Expired - Lifetime
- 2002-06-21 KR KR10-2003-7016702A patent/KR20040032115A/ko active IP Right Grant
- 2002-06-21 CA CA002451266A patent/CA2451266A1/en not_active Abandoned
- 2002-06-21 CZ CZ20033448A patent/CZ20033448A3/cs unknown
- 2002-06-21 HU HU0400371A patent/HUP0400371A3/hu unknown
- 2002-06-21 PT PT02747932T patent/PT1404811E/pt unknown
- 2002-06-21 WO PCT/US2002/019687 patent/WO2003000114A2/en active Application Filing
- 2002-06-21 SI SI200230772T patent/SI1404811T1/sl unknown
- 2002-06-21 US US10/177,930 patent/US7238469B2/en not_active Expired - Lifetime
- 2002-06-21 JP JP2003506568A patent/JP4521183B2/ja not_active Expired - Fee Related
- 2002-06-21 EP EP08168801A patent/EP2033514A3/en not_active Withdrawn
- 2002-06-21 DE DE60229848T patent/DE60229848D1/de not_active Expired - Lifetime
- 2002-06-21 EP EP02747932A patent/EP1404811B1/en not_active Revoked
-
2003
- 2003-12-17 NO NO20035637A patent/NO20035637L/no not_active Application Discontinuation
- 2003-12-22 BG BG108492A patent/BG108492A/xx unknown
-
2004
- 2004-09-10 HK HK04107560.1A patent/HK1067380A1/xx not_active IP Right Cessation
-
2006
- 2006-04-10 US US11/401,722 patent/US20070202083A1/en not_active Abandoned
-
2008
- 2008-09-18 AU AU2008221551A patent/AU2008221551A1/en not_active Ceased
-
2009
- 2009-02-09 CY CY20091100145T patent/CY1108798T1/el unknown
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