SI1231918T1 - Novel composition based on a thiazolidinedione and metformin and use - Google Patents

Novel composition based on a thiazolidinedione and metformin and use

Info

Publication number: SI1231918T1
Authority: SI; Slovenia
Prior art keywords: thiazolidinedione; metformin; composition based; novel composition; novel
Prior art date: 1999-11-16

Application number

SI200030697T

Other languages

English (en)

Inventor

Karen Lewis

Nicola Jayne Lilliott

Donald MACKENZIE

Original Assignee

Smithkline Beecham Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-11-16

Filing date

2000-11-16

Publication date

2005-08-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27447849&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI1231918(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1999-11-16 Priority claimed from GBGB9927119.9A external-priority patent/GB9927119D0/en

1999-11-16 Priority claimed from GBGB9927120.7A external-priority patent/GB9927120D0/en

2000-05-31 Priority claimed from GB0013240A external-priority patent/GB0013240D0/en

2000-05-31 Priority claimed from GB0013236A external-priority patent/GB0013236D0/en

2000-11-16 Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc

2005-08-31 Publication of SI1231918T1 publication Critical patent/SI1231918T1/xx

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Obesity (AREA)
Hematology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)

SI200030697T 1999-11-16 2000-11-16 Novel composition based on a thiazolidinedione and metformin and use SI1231918T1 (en)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
GBGB9927119.9A GB9927119D0 (en)	1999-11-16	1999-11-16	Novel composition and use
GBGB9927120.7A GB9927120D0 (en)	1999-11-16	1999-11-16	Novel composition and use
GB0013240A GB0013240D0 (en)	2000-05-31	2000-05-31	Novel composition and use
GB0013236A GB0013236D0 (en)	2000-05-31	2000-05-31	Novel composition and use
EP00976156A EP1231918B1 (en)	1999-11-16	2000-11-16	Novel composition based on a thiazolidinedione and metformin and use
PCT/GB2000/004368 WO2001035941A2 (en)	1999-11-16	2000-11-16	Novel composition based on a thiazolidinedione and metformin and use

Publications (1)

Publication Number	Publication Date
SI1231918T1 true SI1231918T1 (en)	2005-08-31

Family

ID=27447849

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI200030697T SI1231918T1 (en)	1999-11-16	2000-11-16	Novel composition based on a thiazolidinedione and metformin and use

Country Status (40)

Country	Link
US (1)	US8236345B2 (es)
EP (3)	EP1231918B1 (es)
JP (2)	JP4865975B2 (es)
KR (1)	KR100760063B1 (es)
CN (1)	CN1222290C (es)
AP (1)	AP1389A (es)
AR (2)	AR030920A1 (es)
AT (1)	ATE292466T1 (es)
AU (3)	AU775654B2 (es)
BG (1)	BG65616B1 (es)
BR (1)	BR0015605A (es)
CA (1)	CA2388846A1 (es)
CO (1)	CO5300392A1 (es)
CZ (1)	CZ302500B6 (es)
DE (1)	DE60019329T2 (es)
DK (1)	DK1231918T3 (es)
DZ (1)	DZ3251A1 (es)
EA (1)	EA004878B1 (es)
ES (1)	ES2240199T3 (es)
HK (1)	HK1049788B (es)
HR (1)	HRP20020416B1 (es)
HU (1)	HU229960B1 (es)
IL (3)	IL149618A0 (es)
MA (1)	MA25567A1 (es)
ME (1)	ME00318B (es)
MX (1)	MXPA02005005A (es)
MY (1)	MY125516A (es)
NO (1)	NO329926B1 (es)
NZ (1)	NZ518946A (es)
OA (1)	OA12513A (es)
PE (1)	PE20011011A1 (es)
PL (1)	PL200943B1 (es)
PT (1)	PT1231918E (es)
RS (1)	RS51343B (es)
SI (1)	SI1231918T1 (es)
SK (1)	SK286985B6 (es)
TW (1)	TWI240626B (es)
UA (1)	UA73150C2 (es)
UY (1)	UY26439A1 (es)
WO (1)	WO2001035941A2 (es)

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EP1429740A4 (en) *	2001-07-10	2005-01-26	Kos Life Sciences Inc	CORE FORMULATION WITH TROGLITAZONE AND A BIGUANIDE
GB0203296D0 (en) *	2002-02-12	2002-03-27	Glaxo Group Ltd	Novel composition
AU2002356419A1 (en) *	2002-06-17	2003-12-31	Themis Laboratories Private Limited	Multilayer tablets containing thiazolidinedione and biguanides and methods for producing them
WO2004006921A1 (ja) *	2002-07-11	2004-01-22	Takeda Pharmaceutical Company Limited	被覆製剤の製造法
US8637512B2 (en) *	2002-07-29	2014-01-28	Glaxo Group Limited	Formulations and method of treatment
US7785627B2 (en)	2002-09-20	2010-08-31	Watson Pharmaceuticals, Inc.	Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US9060941B2 (en)	2002-09-20	2015-06-23	Actavis, Inc.	Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
EP1539144B1 (en) *	2002-09-20	2014-12-24	Andrx Labs Llc	Multistage formulation containing a biguanide and a thiazolidinedione derivative
US8084058B2 (en)	2002-09-20	2011-12-27	Watson Pharmaceuticals, Inc.	Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US7959946B2 (en)	2002-09-20	2011-06-14	Watson Pharmaceuticals, Inc.	Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
UA80991C2 (en) *	2002-10-07	2007-11-26		Solid preparation containing an insulin resistance improving drug and an active ingredient useful as a remedy for diabetes
MXPA05007883A (es)	2003-01-29	2005-09-21	Takeda Pharmaceutical	Proceso para producir una preparacion recubierta.
FR2858556B1 (fr) *	2003-08-06	2006-03-10	Galenix Innovations	Composition pharmaceutique solide dispersible et/ou orodispersible non pelliculee contenant au moins le principe actif metformine, et procede de preparation
EP1738754B1 (en) *	2004-04-14	2015-07-15	Takeda Pharmaceutical Company Limited	Solid pharmaceutical preparation
WO2006011397A1 (ja) *	2004-07-27	2006-02-02	Kowa Company., Ltd.	糖尿病の予防または治療のための薬剤
KR20080007371A (ko)	2005-04-26	2008-01-18	다이닛본 스미토모 세이야꾸 가부시끼가이샤	비구아니드 화합물 함유 과립성 제제
MY149306A (en) *	2005-12-22	2013-08-30	Takeda Pharmaceutical	Solid preparation containing an insulin sensitizer
FR2896159B1 (fr)	2006-01-13	2008-09-12	Merck Sante Soc Par Actions Si	Combinaison de derives de triazine et d'agents sensibilisateurs a l'insuline.
JP4893750B2 (ja)	2006-12-26	2012-03-07	富士通株式会社	データ圧縮装置およびデータ復元装置
GEP20125410B (en)	2007-02-01	2012-02-27	Takeda Pharmaceutical	Solid preparation comprising alogliptin and pioglitazone
DK2120878T3 (da)	2007-02-09	2014-11-03	Alphapharm Pty Ltd	Doseringsform indeholdende to aktive farmaceutiske ingredienser i forskellige fysiske former
TR200803177A2 (tr) *	2008-05-06	2009-11-23	Bi̇li̇m İlaç Sanayi̇ Ti̇caret A.Ş.	Antihiperglisemik etkili metformîn - pioglitazon formülasyonu.
PE20151924A1 (es)	2008-08-12	2016-01-13	Zinfandel Pharmaceuticals Inc	Metodo de identificacion de factores de riesgo de la enfermedad
US8846315B2 (en)	2008-08-12	2014-09-30	Zinfandel Pharmaceuticals, Inc.	Disease risk factors and methods of use
FR2951945B1 (fr) *	2009-11-05	2013-08-09	Sanofi Aventis	Composition pharmaceutique
EP2498758B1 (en) *	2009-11-13	2018-07-25	AstraZeneca AB	Bilayer tablet formulations
EP2441442A1 (en)	2010-10-08	2012-04-18	LEK Pharmaceuticals d.d.	A pharmaceutical composition comprising a thiazolidinedione
US9480663B2 (en)	2011-01-07	2016-11-01	Elcelyx Therapeutics, Inc.	Biguanide compositions and methods of treating metabolic disorders
US11759441B2 (en)	2011-01-07	2023-09-19	Anji Pharmaceuticals Inc.	Biguanide compositions and methods of treating metabolic disorders
US11974971B2 (en)	2011-01-07	2024-05-07	Anji Pharmaceuticals Inc.	Compositions and methods for treating metabolic disorders
WO2013103384A1 (en)	2012-01-06	2013-07-11	Elcelyx Therapeutics, Inc.	Biguanide compositions and methods of treating metabolic disorders
CN103597071A (zh)	2011-01-07	2014-02-19	埃尔舍利克斯治疗公司	基于化学感应受体配体的治疗
US9211263B2 (en)	2012-01-06	2015-12-15	Elcelyx Therapeutics, Inc.	Compositions and methods of treating metabolic disorders
US8796338B2 (en)	2011-01-07	2014-08-05	Elcelyx Therapeutics, Inc	Biguanide compositions and methods of treating metabolic disorders
US9572784B2 (en)	2011-01-07	2017-02-21	Elcelyx Therapeutics, Inc.	Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk
EA201391017A1 (ru)	2011-01-10	2014-04-30	Зинфандел Фармасьютикалз, Инк.	Способы и готовые лекарственные формы для лечения болезни альцгеймера
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2000
- 2000-11-15 MY MYPI20005360A patent/MY125516A/en unknown
- 2000-11-15 AR ARP000106019A patent/AR030920A1/es active IP Right Grant
- 2000-11-16 HU HU0204122A patent/HU229960B1/hu unknown
- 2000-11-16 OA OA1200200145A patent/OA12513A/en unknown
- 2000-11-16 DZ DZ003251A patent/DZ3251A1/fr active
- 2000-11-16 PE PE2000001226A patent/PE20011011A1/es not_active Application Discontinuation
- 2000-11-16 KR KR1020027006271A patent/KR100760063B1/ko active IP Right Grant
- 2000-11-16 EP EP00976156A patent/EP1231918B1/en not_active Expired - Lifetime
- 2000-11-16 RS YUP-388/02A patent/RS51343B/sr unknown
- 2000-11-16 DK DK00976156T patent/DK1231918T3/da active
- 2000-11-16 EP EP04078538A patent/EP1520581A1/en not_active Withdrawn
- 2000-11-16 ME MEP-2008-340A patent/ME00318B/me unknown
- 2000-11-16 SI SI200030697T patent/SI1231918T1/xx unknown
- 2000-11-16 NZ NZ518946A patent/NZ518946A/en not_active IP Right Cessation
- 2000-11-16 EP EP07120386A patent/EP1913945A3/en not_active Withdrawn
- 2000-11-16 AT AT00976156T patent/ATE292466T1/de active
- 2000-11-16 JP JP2001537934A patent/JP4865975B2/ja not_active Expired - Lifetime
- 2000-11-16 CZ CZ20021679A patent/CZ302500B6/cs not_active IP Right Cessation
- 2000-11-16 UA UA2002064826A patent/UA73150C2/uk unknown
- 2000-11-16 CA CA002388846A patent/CA2388846A1/en not_active Abandoned
- 2000-11-16 MX MXPA02005005A patent/MXPA02005005A/es active IP Right Grant
- 2000-11-16 UY UY26439A patent/UY26439A1/es not_active IP Right Cessation
- 2000-11-16 ES ES00976156T patent/ES2240199T3/es not_active Expired - Lifetime
- 2000-11-16 CN CNB008178224A patent/CN1222290C/zh not_active Expired - Lifetime
- 2000-11-16 WO PCT/GB2000/004368 patent/WO2001035941A2/en active Application Filing
- 2000-11-16 IL IL14961800A patent/IL149618A0/xx unknown
- 2000-11-16 DE DE60019329T patent/DE60019329T2/de not_active Expired - Lifetime
- 2000-11-16 BR BR0015605-1A patent/BR0015605A/pt not_active Application Discontinuation
- 2000-11-16 EA EA200200571A patent/EA004878B1/ru not_active IP Right Cessation
- 2000-11-16 AP APAP/P/2002/002505A patent/AP1389A/en active
- 2000-11-16 PL PL355331A patent/PL200943B1/pl unknown
- 2000-11-16 PT PT00976156T patent/PT1231918E/pt unknown
- 2000-11-16 SK SK679-2002A patent/SK286985B6/sk not_active IP Right Cessation
- 2000-11-16 AU AU14040/01A patent/AU775654B2/en not_active Expired
- 2000-11-20 CO CO00088045A patent/CO5300392A1/es not_active Application Discontinuation
- 2000-12-04 TW TW089125730A patent/TWI240626B/zh not_active IP Right Cessation
2002
- 2002-05-13 IL IL149618A patent/IL149618A/en unknown
- 2002-05-14 HR HR20020416A patent/HRP20020416B1/xx not_active IP Right Cessation
- 2002-05-15 MA MA26640A patent/MA25567A1/fr unknown
- 2002-05-15 NO NO20022334A patent/NO329926B1/no not_active IP Right Cessation
- 2002-05-29 BG BG106747A patent/BG65616B1/bg unknown
2003
- 2003-01-29 HK HK03100745.5A patent/HK1049788B/zh not_active IP Right Cessation
2004
- 2004-11-04 AU AU2004226955A patent/AU2004226955B2/en not_active Expired
2006
- 2006-12-05 AR ARP060105370A patent/AR057970A2/es active IP Right Grant
2007
- 2007-07-18 US US11/779,546 patent/US8236345B2/en not_active Expired - Fee Related
2008
- 2008-03-17 IL IL190220A patent/IL190220A0/en unknown
- 2008-08-18 AU AU2008207375A patent/AU2008207375A1/en not_active Abandoned
2011
- 2011-08-11 JP JP2011175883A patent/JP5282130B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
AU2004226955B2 (en)	2008-08-28
HK1049788B (zh)	2005-11-04
EA200200571A1 (ru)	2002-12-26
NO329926B1 (no)	2011-01-24
CA2388846A1 (en)	2001-05-25
IL149618A (en)	2008-07-08
HRP20020416A2 (en)	2004-08-31
BG106747A (en)	2003-01-31
EP1913945A3 (en)	2008-04-30
PL355331A1 (en)	2004-04-19
IL149618A0 (en)	2002-12-01
TWI240626B (en)	2005-10-01
SK286985B6 (sk)	2009-08-06
CZ302500B6 (cs)	2011-06-22
JP5282130B2 (ja)	2013-09-04
EP1231918A2 (en)	2002-08-21
AR030920A1 (es)	2003-09-03
KR100760063B1 (ko)	2007-09-18
EA004878B1 (ru)	2004-08-26
PT1231918E (pt)	2005-08-31
PL200943B1 (pl)	2009-02-27
NZ518946A (en)	2003-10-31
DE60019329T2 (de)	2006-03-09
EP1913945A2 (en)	2008-04-23
AU1404001A (en)	2001-05-30
EP1520581A1 (en)	2005-04-06
US20070275054A1 (en)	2007-11-29
PE20011011A1 (es)	2001-10-28
MXPA02005005A (es)	2003-10-14
DE60019329D1 (de)	2005-05-12
MY125516A (en)	2006-08-30
UY26439A1 (es)	2001-07-31
SK6792002A3 (en)	2002-09-10
IL190220A0 (en)	2008-11-03
HK1049788A1 (en)	2003-05-30
JP4865975B2 (ja)	2012-02-01
UA73150C2 (uk)	2005-06-15
EP1231918B1 (en)	2005-04-06
CO5300392A1 (es)	2003-07-31
DK1231918T3 (da)	2005-08-01
HRP20020416B1 (en)	2011-04-30
MEP34008A (en)	2011-02-10
RS51343B (sr)	2011-02-28
US8236345B2 (en)	2012-08-07
KR20030019300A (ko)	2003-03-06
CN1222290C (zh)	2005-10-12
JP2011252007A (ja)	2011-12-15
BG65616B1 (bg)	2009-03-31
AR057970A2 (es)	2007-12-26
OA12513A (en)	2006-05-29
NO20022334D0 (no)	2002-05-15
AU2008207375A1 (en)	2008-09-11
MA25567A1 (fr)	2002-10-01
HUP0204122A3 (en)	2006-01-30
AU2004226955A1 (en)	2004-12-02
HUP0204122A2 (hu)	2003-03-28
ES2240199T3 (es)	2005-10-16
BR0015605A (pt)	2002-07-09
JP2003514012A (ja)	2003-04-15
DZ3251A1 (fr)	2001-05-25
AP1389A (en)	2005-04-14
WO2001035941A8 (en)	2002-08-29
YU38802A (sh)	2005-03-15
WO2001035941A3 (en)	2002-05-23
CN1414852A (zh)	2003-04-30
ME00318B (me)	2011-05-10
WO2001035941A2 (en)	2001-05-25
ATE292466T1 (de)	2005-04-15
AP2002002505A0 (en)	2002-06-30
AU775654B2 (en)	2004-08-12
NO20022334L (no)	2002-07-09
HU229960B1 (hu)	2015-03-30

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