HRP20020416B1 - Novi pripravak i upotreba - Google Patents

Novi pripravak i upotreba

Info

Publication number: HRP20020416B1
Authority: HR; Croatia
Prior art keywords: new preparation; thiazolidinedione; pharmaceutically acceptable; pharmaceutical composition; acceptable carrier
Prior art date: 1999-11-16

Application number

HR20020416A

Other languages

English (en)

Croatian (hr)

Inventor

Lewis Karen

Jayne Lilliott Nicola

Colin Mackenzie Donald

Original Assignee

Smithkline Beecham P.L.C.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-11-16

Filing date

2000-11-16

Publication date

2011-04-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27447849&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20020416(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1999-11-16 Priority claimed from GBGB9927120.7A external-priority patent/GB9927120D0/en

1999-11-16 Priority claimed from GBGB9927119.9A external-priority patent/GB9927119D0/en

2000-05-31 Priority claimed from GB0013236A external-priority patent/GB0013236D0/en

2000-05-31 Priority claimed from GB0013240A external-priority patent/GB0013240D0/en

2000-11-16 Application filed by Smithkline Beecham P.L.C. filed Critical Smithkline Beecham P.L.C.

2004-08-31 Publication of HRP20020416A2 publication Critical patent/HRP20020416A2/hr

2011-04-30 Publication of HRP20020416B1 publication Critical patent/HRP20020416B1/xx

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Obesity (AREA)
Hematology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)

HR20020416A 1999-11-16 2000-11-16 Novi pripravak i upotreba HRP20020416B1 (hr)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
GBGB9927120.7A GB9927120D0 (en)	1999-11-16	1999-11-16	Novel composition and use
GBGB9927119.9A GB9927119D0 (en)	1999-11-16	1999-11-16	Novel composition and use
GB0013236A GB0013236D0 (en)	2000-05-31	2000-05-31	Novel composition and use
GB0013240A GB0013240D0 (en)	2000-05-31	2000-05-31	Novel composition and use
PCT/GB2000/004368 WO2001035941A2 (en)	1999-11-16	2000-11-16	Novel composition based on a thiazolidinedione and metformin and use

Publications (2)

Publication Number	Publication Date
HRP20020416A2 HRP20020416A2 (en)	2004-08-31
HRP20020416B1 true HRP20020416B1 (hr)	2011-04-30

Family

ID=27447849

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20020416A HRP20020416B1 (hr)	1999-11-16	2000-11-16	Novi pripravak i upotreba

Country Status (40)

Country	Link
US (1)	US8236345B2 (xx)
EP (3)	EP1520581A1 (xx)
JP (2)	JP4865975B2 (xx)
KR (1)	KR100760063B1 (xx)
CN (1)	CN1222290C (xx)
AP (1)	AP1389A (xx)
AR (2)	AR030920A1 (xx)
AT (1)	ATE292466T1 (xx)
AU (3)	AU775654B2 (xx)
BG (1)	BG65616B1 (xx)
BR (1)	BR0015605A (xx)
CA (1)	CA2388846A1 (xx)
CO (1)	CO5300392A1 (xx)
CZ (1)	CZ302500B6 (xx)
DE (1)	DE60019329T2 (xx)
DK (1)	DK1231918T3 (xx)
DZ (1)	DZ3251A1 (xx)
EA (1)	EA004878B1 (xx)
ES (1)	ES2240199T3 (xx)
HK (1)	HK1049788B (xx)
HR (1)	HRP20020416B1 (xx)
HU (1)	HU229960B1 (xx)
IL (3)	IL149618A0 (xx)
MA (1)	MA25567A1 (xx)
ME (1)	ME00318B (xx)
MX (1)	MXPA02005005A (xx)
MY (1)	MY125516A (xx)
NO (1)	NO329926B1 (xx)
NZ (1)	NZ518946A (xx)
OA (1)	OA12513A (xx)
PE (1)	PE20011011A1 (xx)
PL (1)	PL200943B1 (xx)
PT (1)	PT1231918E (xx)
RS (1)	RS51343B (xx)
SI (1)	SI1231918T1 (xx)
SK (1)	SK286985B6 (xx)
TW (1)	TWI240626B (xx)
UA (1)	UA73150C2 (xx)
UY (1)	UY26439A1 (xx)
WO (1)	WO2001035941A2 (xx)

Families Citing this family (39)

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ATE367151T1 (de) *	2000-05-01	2007-08-15	Aeropharm Technology Llc	Kernformulierung
JP2004536842A (ja) *	2001-07-10	2004-12-09	エアロファームテクノロジーインコーポレイテッド	トログリタゾンおよびビグアナイドを含むコア製剤
GB0203296D0 (en) *	2002-02-12	2002-03-27	Glaxo Group Ltd	Novel composition
US8911781B2 (en) *	2002-06-17	2014-12-16	Inventia Healthcare Private Limited	Process of manufacture of novel drug delivery system: multilayer tablet composition of thiazolidinedione and biguanides
AU2003281181A1 (en) *	2002-07-11	2004-02-02	Takeda Pharmaceutical Company Limited	Process for producing coated preparation
US8637512B2 (en) *	2002-07-29	2014-01-28	Glaxo Group Limited	Formulations and method of treatment
US7785627B2 (en) *	2002-09-20	2010-08-31	Watson Pharmaceuticals, Inc.	Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
CN100544717C (zh) *	2002-09-20	2009-09-30	华生制药公司	含有双胍和噻唑烷二酮衍生物的药物剂型
US9060941B2 (en)	2002-09-20	2015-06-23	Actavis, Inc.	Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US8084058B2 (en)	2002-09-20	2011-12-27	Watson Pharmaceuticals, Inc.	Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US7959946B2 (en)	2002-09-20	2011-06-14	Watson Pharmaceuticals, Inc.	Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
UA80991C2 (en) *	2002-10-07	2007-11-26		Solid preparation containing an insulin resistance improving drug and an active ingredient useful as a remedy for diabetes
NZ541749A (en)	2003-01-29	2009-06-26	Takeda Pharmaceutical	Process for producing coated preparation comprising pioglitazone hydrochloride and a coating material
FR2858556B1 (fr) *	2003-08-06	2006-03-10	Galenix Innovations	Composition pharmaceutique solide dispersible et/ou orodispersible non pelliculee contenant au moins le principe actif metformine, et procede de preparation
CA2562391A1 (en) *	2004-04-14	2005-10-27	Takeda Pharmaceutical Company Limited	Solid pharmaceutical preparation
EP1772149A1 (en) *	2004-07-27	2007-04-11	Kowa Company. Ltd.	Drug for prevention or treatment of diabetes
CA2607419C (en)	2005-04-26	2014-06-17	Dainippon Sumitomo Pharma Co., Ltd.	Granular preparation containing biguanide compound
CA2633149C (en) *	2005-12-22	2015-06-30	Takeda Pharmaceutical Company Limited	Solid preparation containing an insulin sensitizer
FR2896159B1 (fr)	2006-01-13	2008-09-12	Merck Sante Soc Par Actions Si	Combinaison de derives de triazine et d'agents sensibilisateurs a l'insuline.
WO2008078390A1 (ja)	2006-12-26	2008-07-03	Fujitsu Limited	データ圧縮装置およびデータ復元装置
HRP20110094T8 (en)	2007-02-01	2011-07-31	Takeda Pharmaceutical Company Limited	Solid preparation comprising alogliptin and pioglitazone
PT2120878E (pt)	2007-02-09	2014-11-05	Alphapharm Pty Ltd	Forma farmacêutica contendo duas ou mais substancias ativas em diferentes formas físicas
TR200803177A2 (tr) *	2008-05-06	2009-11-23	Bi̇li̇m İlaç Sanayi̇ Ti̇caret A.Ş.	Antihiperglisemik etkili metformîn - pioglitazon formülasyonu.
AU2009282114B2 (en)	2008-08-12	2016-04-07	Zinfandel Pharmaceuticals, Inc.	Method of identifying disease risk factors
US8846315B2 (en)	2008-08-12	2014-09-30	Zinfandel Pharmaceuticals, Inc.	Disease risk factors and methods of use
FR2951945B1 (fr) *	2009-11-05	2013-08-09	Sanofi Aventis	Composition pharmaceutique
HRP20181347T1 (hr) *	2009-11-13	2018-10-19	Astrazeneca Ab	Formulacije dvoslojne tablete
EP2441442A1 (en)	2010-10-08	2012-04-18	LEK Pharmaceuticals d.d.	A pharmaceutical composition comprising a thiazolidinedione
US9480663B2 (en)	2011-01-07	2016-11-01	Elcelyx Therapeutics, Inc.	Biguanide compositions and methods of treating metabolic disorders
US9572784B2 (en)	2011-01-07	2017-02-21	Elcelyx Therapeutics, Inc.	Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk
US8796338B2 (en)	2011-01-07	2014-08-05	Elcelyx Therapeutics, Inc	Biguanide compositions and methods of treating metabolic disorders
US11759441B2 (en)	2011-01-07	2023-09-19	Anji Pharmaceuticals Inc.	Biguanide compositions and methods of treating metabolic disorders
US11974971B2 (en)	2011-01-07	2024-05-07	Anji Pharmaceuticals Inc.	Compositions and methods for treating metabolic disorders
US9211263B2 (en)	2012-01-06	2015-12-15	Elcelyx Therapeutics, Inc.	Compositions and methods of treating metabolic disorders
CA2823397C (en)	2011-01-07	2020-03-10	Elcelyx Therapeutics, Inc.	Chemosensory receptor ligand-based therapies
CN103501783A (zh)	2011-01-10	2014-01-08	金帆德尔制药股份有限公司	用于治疗阿尔茨海默病的方法和药物产品
KR20230095124A (ko)	2012-01-06	2023-06-28	앤지 파마 유에스 엘엘씨	바이구아나이드 조성물 및 대사 장애를 치료하는 방법
KR102231554B1 (ko)	2012-01-06	2021-03-23	앤지 파마 유에스 엘엘씨	대사 장애를 치료하는 조성물 및 방법
CN108451923B (zh) *	2018-05-31	2025-05-06	常州兰陵制药有限公司	盐酸二甲双胍速释胶囊及其制备方法

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WO1998057634A1 (en) *	1997-06-18	1998-12-23	Smithkline Beecham Plc	Treatment of diabetes with thiazolidinedione and metformin
WO1999003477A1 (en) *	1997-07-18	1999-01-28	Smithkline Beecham P.L.C.	Treatment of diabetes with thiazolidinedione, insulin secretagogue and diguanide

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AU736951C (en)	1998-03-19	2003-02-20	Bristol-Myers Squibb Company	Biphasic controlled release delivery system for high solubility pharmaceuticals and method
US6099859A (en)	1998-03-20	2000-08-08	Andrx Pharmaceuticals, Inc.	Controlled release oral tablet having a unitary core
US6117451A (en) *	1998-08-25	2000-09-12	Pharmalogix, Inc.	Direct compression metformin hydrochloride tablets
US20040102486A1 (en)	1998-11-12	2004-05-27	Smithkline Beecham Corporation	Novel method of treatment
GB9824893D0 (en)	1998-11-12	1999-01-06	Smithkline Beckman Corp	Novel method of treatment
AR023699A1 (es)	1998-11-12	2002-09-04	Smithkline Beecham Corp	Una composicion farmaceutica que comprende un estabilizador de insulina y un procedimiento para preparar una composicion farmaceutica
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NZ511614A (en)	1998-11-12	2003-12-19	Smithkline Beecham P	Modified release pharmaceutical composition containing the insulin sensitiser 5-[4-[2-(N-methyl-N-(2- pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione and the antidiabetic agent metaformin
AU1403501A (en)	1999-11-16	2001-05-30	Smithkline Beecham Plc	Novel composition and use
US6403121B1 (en)	2000-05-01	2002-06-11	Aeropharm Technology Incorporated	Core formulation
US6524621B2 (en)	2000-05-01	2003-02-25	Aeropharm Technology Inc.	Core formulation
US6780432B1 (en)	2000-05-01	2004-08-24	Aeropharm Technology, Inc.	Core formulation
US6461639B2 (en)	2000-05-01	2002-10-08	Aeropharm Technology, Inc.	Core formulation
US6296874B1 (en)	2000-05-01	2001-10-02	Aeropharm Technology Incorporated	Core formulation comprising troglitazone and abiguanide
US6451342B2 (en)	2000-05-01	2002-09-17	Aeropharm Technology Incorporated	Core formulation comprised of troglitazone and a biguanide
GB0318824D0 (en)	2003-08-11	2003-09-10	Glaxo Group Ltd	Novel composition

2000
- 2000-11-15 MY MYPI20005360A patent/MY125516A/en unknown
- 2000-11-15 AR ARP000106019A patent/AR030920A1/es active IP Right Grant
- 2000-11-16 UA UA2002064826A patent/UA73150C2/uk unknown
- 2000-11-16 AT AT00976156T patent/ATE292466T1/de active
- 2000-11-16 WO PCT/GB2000/004368 patent/WO2001035941A2/en active Application Filing
- 2000-11-16 ES ES00976156T patent/ES2240199T3/es not_active Expired - Lifetime
- 2000-11-16 EP EP04078538A patent/EP1520581A1/en not_active Withdrawn
- 2000-11-16 UY UY26439A patent/UY26439A1/es not_active IP Right Cessation
- 2000-11-16 PE PE2000001226A patent/PE20011011A1/es not_active Application Discontinuation
- 2000-11-16 DE DE60019329T patent/DE60019329T2/de not_active Expired - Lifetime
- 2000-11-16 RS YUP-388/02A patent/RS51343B/sr unknown
- 2000-11-16 KR KR1020027006271A patent/KR100760063B1/ko not_active Expired - Lifetime
- 2000-11-16 HU HU0204122A patent/HU229960B1/hu unknown
- 2000-11-16 HK HK03100745.5A patent/HK1049788B/en not_active IP Right Cessation
- 2000-11-16 BR BR0015605-1A patent/BR0015605A/pt not_active Application Discontinuation
- 2000-11-16 CZ CZ20021679A patent/CZ302500B6/cs not_active IP Right Cessation
- 2000-11-16 MX MXPA02005005A patent/MXPA02005005A/es active IP Right Grant
- 2000-11-16 OA OA1200200145A patent/OA12513A/en unknown
- 2000-11-16 PL PL355331A patent/PL200943B1/pl unknown
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2002
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WO1998057634A1 (en) *	1997-06-18	1998-12-23	Smithkline Beecham Plc	Treatment of diabetes with thiazolidinedione and metformin
WO1999003477A1 (en) *	1997-07-18	1999-01-28	Smithkline Beecham P.L.C.	Treatment of diabetes with thiazolidinedione, insulin secretagogue and diguanide

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Publication number	Publication date
AP2002002505A0 (en)	2002-06-30
HUP0204122A2 (hu)	2003-03-28
NZ518946A (en)	2003-10-31
EP1913945A2 (en)	2008-04-23
IL149618A0 (en)	2002-12-01
AU1404001A (en)	2001-05-30
AR057970A2 (es)	2007-12-26
EA200200571A1 (ru)	2002-12-26
DE60019329T2 (de)	2006-03-09
SI1231918T1 (en)	2005-08-31
DE60019329D1 (de)	2005-05-12
UA73150C2 (uk)	2005-06-15
HRP20020416A2 (en)	2004-08-31
AR030920A1 (es)	2003-09-03
CZ302500B6 (cs)	2011-06-22
TWI240626B (en)	2005-10-01
JP2003514012A (ja)	2003-04-15
MXPA02005005A (es)	2003-10-14
EA004878B1 (ru)	2004-08-26
NO20022334D0 (no)	2002-05-15
RS51343B (sr)	2011-02-28
WO2001035941A3 (en)	2002-05-23
CA2388846A1 (en)	2001-05-25
AU2004226955A1 (en)	2004-12-02
UY26439A1 (es)	2001-07-31
ME00318B (me)	2011-05-10
AU775654B2 (en)	2004-08-12
SK286985B6 (sk)	2009-08-06
KR20030019300A (ko)	2003-03-06
US8236345B2 (en)	2012-08-07
MA25567A1 (fr)	2002-10-01
NO329926B1 (no)	2011-01-24
EP1231918A2 (en)	2002-08-21
EP1520581A1 (en)	2005-04-06
WO2001035941A8 (en)	2002-08-29
SK6792002A3 (en)	2002-09-10
BR0015605A (pt)	2002-07-09
DK1231918T3 (da)	2005-08-01
JP2011252007A (ja)	2011-12-15
PE20011011A1 (es)	2001-10-28
NO20022334L (no)	2002-07-09
JP4865975B2 (ja)	2012-02-01
US20070275054A1 (en)	2007-11-29
KR100760063B1 (ko)	2007-09-18
OA12513A (en)	2006-05-29
DZ3251A1 (fr)	2001-05-25
HK1049788B (en)	2005-11-04
IL149618A (en)	2008-07-08
BG106747A (en)	2003-01-31
IL190220A0 (en)	2008-11-03
AU2004226955B2 (en)	2008-08-28
BG65616B1 (bg)	2009-03-31
ATE292466T1 (de)	2005-04-15
ES2240199T3 (es)	2005-10-16
CO5300392A1 (es)	2003-07-31
MEP34008A (en)	2011-02-10
HU229960B1 (hu)	2015-03-30
CN1222290C (zh)	2005-10-12
MY125516A (en)	2006-08-30
AP1389A (en)	2005-04-14
CN1414852A (zh)	2003-04-30
PL355331A1 (en)	2004-04-19
PT1231918E (pt)	2005-08-31
HK1049788A1 (en)	2003-05-30
WO2001035941A2 (en)	2001-05-25
EP1231918B1 (en)	2005-04-06
YU38802A (sh)	2005-03-15
JP5282130B2 (ja)	2013-09-04
AU2008207375A1 (en)	2008-09-11
PL200943B1 (pl)	2009-02-27
HUP0204122A3 (en)	2006-01-30
EP1913945A3 (en)	2008-04-30

Publication	Publication Date	Title
HRP20020416B1 (hr)	2011-04-30	Novi pripravak i upotreba
EA200601145A1 (ru)	2009-04-28	Таблетка замедленного высвобождения сенсибилизатора к инсулину и других антидиабетических агентов
HUP0300158A3 (en)	2005-04-28	Hydrochloride salts of-5-[4-[2-(n-methyl-n-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione, method for their production and pharmaceutical compositions containing them
MY135973A (en)	2008-07-31	Modified release compositions comprising 5-[4-[2-(n-methyl-n-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2, 4-dione, optionally in the form of pharmaceutically acceptable derivative
AR015120A1 (es)	2001-04-18	Composicion farmaceutica que comprende 5-[4-[2-(n-metil-n-(2-piridil)amino) etoxi]bencil]-tiazolidin-2,4-diona, un procedimiento para su preparacion, y unacomposicion para la pre-administracion farmaceutica
CY1105354T1 (el)	2010-03-03	Ένα παραγωγο θειαζολιδινοδιονης και η χρηση του σαν αντι-διαβητικο
AP1715A (en)	2007-02-28	The hydrochloride salt of 5-[ 4 -[2 -(n-methyl-n- (2-pyridyl) amino) ethoxy]benzyl]thiazolidine -2,4-dione
RS50136B (sr)	2009-03-25	Derivati tiazolidindiona i njihova upotreba kao antidijabetika
PT1349855E (pt)	2006-12-29	Sal misilato de 5-{4-[2-(n-metil-n-(2-piridil)amino)etoxi]benzil}tiazolidino-2, 4-diona
RS50137B (sr)	2009-03-25	Nova so 5-/4-/2-(n-metil-n-(2-piridil) amino)etoksi/benzil/ tiazolidin-2,4-dion hidrohlorid monohidrat
AP1814A (en)	2008-01-04	Tartrate salts of thiazolidinedione derivative.
DK1446404T3 (da)	2006-10-09	Rosiglitazonedisylater og deres anvendelse som antidiabetika
BR0112984A (pt)	2003-06-10	Sais tartarato de derivado de tiazolidinodiona
AP1785A (en)	2007-10-04	Tartrate salt of thiazolidinedione derivative.
NO20025882D0 (no)	2002-12-06	5-(4-(2-(N-metyl-N-(2-pyridyl)amino)etoksy)benzyl)-tiazolidin- 2,4-dion hydriodid som farmasöytisk middel
YU14503A (sh)	2006-01-16	Novi farmaceutski preparati
HK1068883A (en)	2005-05-06	5-[4-[2-(n-methyl-n-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione and pharmaceutical compositions comprising the same
ECSP003434A (es)	2000-07-21	Nuevos compuestos

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