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SI0937074T1 - Benzonaphthyridines as bronchial therapeutics - Google Patents

Benzonaphthyridines as bronchial therapeutics

Info

Publication number
SI0937074T1
SI0937074T1 SI9730535T SI9730535T SI0937074T1 SI 0937074 T1 SI0937074 T1 SI 0937074T1 SI 9730535 T SI9730535 T SI 9730535T SI 9730535 T SI9730535 T SI 9730535T SI 0937074 T1 SI0937074 T1 SI 0937074T1
Authority
SI
Slovenia
Prior art keywords
pct
benzonaphthyridines
bronchial therapeutics
date
sec
Prior art date
Application number
SI9730535T
Other languages
English (en)
Slovenian (sl)
Inventor
Beate Schmidt
Hermann Amschler
Wolf-R�diger ULRICH
Thomas Martin
Thomas Br
Armin Hatzelmann
Karl Sanders
Rolf Beume
Hildegard Boss
Dietrich H�FNER
Hans-Peter Kley
Karl-Josef Goebel
Dieter Flockerzi
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Publication of SI0937074T1 publication Critical patent/SI0937074T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SI9730535T 1996-11-11 1997-11-05 Benzonaphthyridines as bronchial therapeutics SI0937074T1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE19646298 1996-11-11
EP96118188 1996-11-13
DE19739056 1997-09-05
PCT/EP1997/006096 WO1998021208A1 (en) 1996-11-11 1997-11-05 Benzonaphthyridines as bronchial therapeutics
EP97950093A EP0937074B1 (de) 1996-11-11 1997-11-05 Benzonaphthyridine als bronchialtherapeutika

Publications (1)

Publication Number Publication Date
SI0937074T1 true SI0937074T1 (en) 2003-08-31

Family

ID=27216810

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9730535T SI0937074T1 (en) 1996-11-11 1997-11-05 Benzonaphthyridines as bronchial therapeutics

Country Status (31)

Country Link
US (1) US6008215A (de)
EP (1) EP0937074B1 (de)
JP (1) JP4223075B2 (de)
KR (1) KR100484045B1 (de)
CN (1) CN1090188C (de)
AT (1) ATE234300T1 (de)
AU (1) AU733129B2 (de)
BG (1) BG63695B1 (de)
BR (1) BR9713338B1 (de)
CA (1) CA2270964C (de)
CY (1) CY2476B1 (de)
CZ (1) CZ288752B6 (de)
DE (1) DE69719778T2 (de)
DK (1) DK0937074T3 (de)
EA (1) EA001551B1 (de)
EE (1) EE03829B1 (de)
ES (1) ES2195189T3 (de)
GE (1) GEP20012390B (de)
HK (1) HK1022151A1 (de)
HU (1) HU226981B1 (de)
ID (1) ID22042A (de)
IL (1) IL129054A (de)
NO (1) NO312764B1 (de)
NZ (1) NZ334976A (de)
PL (1) PL189641B1 (de)
PT (1) PT937074E (de)
RS (1) RS49607B (de)
SI (1) SI0937074T1 (de)
SK (1) SK283269B6 (de)
TR (1) TR199900856T2 (de)
WO (1) WO1998021208A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1075477T3 (da) 1998-05-05 2003-06-30 Altana Pharma Ag Nye benzonaphthyridin-N-oxider
US6436952B1 (en) 1998-08-31 2002-08-20 Byk Gulden Lomberg Chemische Fabrik Gmbh Benzonaphthyridine-N-oxides comprising a PDE3 and PDE4 inhibiting activity
IT1303272B1 (it) * 1998-10-29 2000-11-06 Zambon Spa Derivati triciclici inibitori della fosfodiesterasi 4
PT1147103E (pt) 1999-01-15 2005-08-31 Altana Pharma Ag Fenantridina-n-oxidos com actividade inibitoria de pde-iv
SK286946B6 (sk) * 1999-01-15 2009-08-06 Nycomed Gmbh Fenylfenantridínové zlúčeniny, farmaceutický prostriedok s ich obsahom a ich použitie
EP1163226B1 (de) * 1999-01-15 2007-03-14 ALTANA Pharma AG Polysubstituted 6-phenylphenanthridines mit pde-iv hemmender wirkung
PT1147087E (pt) 1999-01-15 2005-09-30 Altana Pharma Ag Feantridina-n-oxidos com actividade de inibicao de pde-iv
TR200201317T2 (tr) * 1999-08-21 2002-11-21 Byk Gulden Lomberg Chemische Fabrik Gmbh Sinerjistik kombinasyon.
NL1017973C2 (nl) * 2000-05-10 2002-11-08 Tristem Trading Cyprus Ltd Inrichting.
EP1377574B1 (de) 2001-02-21 2005-01-19 Byk Gulden Lomberg Chemische Fabrik GmbH 6-phenylbenzonaphthyidine
US6479493B1 (en) 2001-08-23 2002-11-12 Cell Pathways, Inc. Methods for treatment of type I diabetes
EP1581533A2 (de) * 2002-08-17 2005-10-05 ALTANA Pharma AG Benzonaphthyridine mit pde 3/4 hemmender wirkung
PL373989A1 (en) * 2002-09-04 2005-09-19 Altana Pharma Ag Novel benzonaphthyridines
US7470704B2 (en) 2002-09-04 2008-12-30 Nycomed Gmbh Benzonaphthyridines
WO2004087211A2 (en) 2003-04-01 2004-10-14 Applied Research Systems Ars Holding N.V. Inhibitors of phosphodiesterases in infertility
CN1922170A (zh) 2004-03-03 2007-02-28 奥坦纳医药公司 新的羟基－6－杂芳基菲啶及其作为pde4
AR049419A1 (es) * 2004-03-03 2006-08-02 Altana Pharma Ag Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo
NZ549254A (en) * 2004-03-10 2010-06-25 Nycomed Gmbh Amido-substituted hydroxy-6-phenylphenanthridines and their use as PDE4 inhibitors
JP2007529471A (ja) 2004-03-17 2007-10-25 アルタナ　ファルマ　アクチエンゲゼルシャフト 新規のｎ−（アルコキシアルキル）カルバモイル置換された６−フェニル−ベンゾナフチリジン誘導体及びｐｄｅ３／４インヒビターとしてのそれらの使用
US7589205B2 (en) * 2004-09-08 2009-09-15 Nycomed Gmbh 3-thia-10-aza-phenanthrene derivatives
EP1797098B1 (de) * 2004-09-08 2011-05-04 Nycomed GmbH 3-oxa-10-aza-phenanthrene als pde4- oder pde3/4-inhibitoren
WO2006092422A1 (en) 2005-03-02 2006-09-08 Nycomed Gmbh Novel salts of 6-heterocyclyl substituted hexahydrophenanthridine derivatives
EP1948164A1 (de) 2005-10-19 2008-07-30 Ranbaxy Laboratories, Ltd. Pharmazeutische zusammensetzungen mit muscarinischen rezeptor-antagonisten
TW200808695A (en) * 2006-06-08 2008-02-16 Amgen Inc Benzamide derivatives and uses related thereto
DK2061765T3 (en) * 2006-09-01 2015-01-26 Senhwa Biosciences Inc Serine-threonine protein kinase AND PARP-MODULATOR
BRPI0911681B8 (pt) 2008-04-23 2021-05-25 Rigel Pharmaceuticals Inc composto, composição farmacêutica, e, método para ativar a via de proteína quinase ativada por 5'-amp em uma célula in vitro
AR079451A1 (es) 2009-12-18 2012-01-25 Nycomed Gmbh Compuestos 3,4,4a,10b-tetrahidro-1h-tiopirano[4,3-c]isoquinolina
CN108299429B (zh) * 2018-04-09 2021-10-08 中南大学 一类八氢苯并萘啶化合物及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3899494A (en) * 1970-05-13 1975-08-12 Sandoz Ltd Substituted 6-phenyl benzo-naphthyridines
EP0247971A3 (de) * 1986-05-29 1990-01-17 Sandoz Ag Pharmazeutische Zusammensetzungen mit, und Verwendung von Cis-6-(4-Acetanilido)-8,9-dimethoxy-2-methyl-1,2,3,4,4a,10b-hexahydrobenzo[c][1,6]naphthyridin
MY105344A (en) * 1990-05-16 1994-09-30 Byk Gulden Lomberg Chemische Fabrik New sulphonyl compounds

Also Published As

Publication number Publication date
PT937074E (pt) 2003-07-31
CY2476B1 (en) 2005-05-03
ID22042A (id) 1999-08-26
WO1998021208A1 (en) 1998-05-22
CZ167599A3 (cs) 1999-11-17
CZ288752B6 (cs) 2001-08-15
CN1236367A (zh) 1999-11-24
HUP0000426A2 (hu) 2001-02-28
KR100484045B1 (ko) 2005-04-20
BG103310A (en) 2000-05-31
SK62399A3 (en) 1999-10-08
DE69719778D1 (de) 2003-04-17
BG63695B1 (bg) 2002-09-30
SK283269B6 (sk) 2003-04-01
ES2195189T3 (es) 2003-12-01
RS49607B (sr) 2007-06-04
JP4223075B2 (ja) 2009-02-12
CN1090188C (zh) 2002-09-04
EE03829B1 (et) 2002-08-15
GEP20012390B (en) 2001-03-25
HU226981B1 (hu) 2010-04-28
EP0937074A1 (de) 1999-08-25
KR20000053100A (ko) 2000-08-25
BR9713338A (pt) 2000-05-09
NO992282L (no) 1999-05-11
PL333429A1 (en) 1999-12-06
JP2001503442A (ja) 2001-03-13
EP0937074B1 (de) 2003-03-12
DE69719778T2 (de) 2004-02-05
ATE234300T1 (de) 2003-03-15
BR9713338B1 (pt) 2009-12-01
TR199900856T2 (xx) 1999-07-21
NZ334976A (en) 2000-10-27
US6008215A (en) 1999-12-28
EA199900421A1 (ru) 1999-10-28
IL129054A0 (en) 2000-02-17
AU733129B2 (en) 2001-05-10
CA2270964C (en) 2007-07-31
EE9900105A (et) 1999-10-15
IL129054A (en) 2002-07-25
EA001551B1 (ru) 2001-04-23
NO992282D0 (no) 1999-05-11
DK0937074T3 (da) 2003-06-23
YU19499A (sh) 2001-09-28
CA2270964A1 (en) 1998-05-22
AU5317098A (en) 1998-06-03
PL189641B1 (pl) 2005-09-30
NO312764B1 (no) 2002-07-01
HUP0000426A3 (en) 2001-04-28
HK1022151A1 (en) 2000-07-28

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