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NZ334976A - Benzonaphthyridine derivatives and their use for treating airway disorders and dermatoses - Google Patents

Benzonaphthyridine derivatives and their use for treating airway disorders and dermatoses

Info

Publication number
NZ334976A
NZ334976A NZ334976A NZ33497697A NZ334976A NZ 334976 A NZ334976 A NZ 334976A NZ 334976 A NZ334976 A NZ 334976A NZ 33497697 A NZ33497697 A NZ 33497697A NZ 334976 A NZ334976 A NZ 334976A
Authority
NZ
New Zealand
Prior art keywords
dermatoses
airway disorders
treating airway
benzonaphthyridine derivatives
benzonaphthyridine
Prior art date
Application number
NZ334976A
Other languages
English (en)
Inventor
Dieter Flockerzi
Beate Gutterer
Hermann Amschler
Wolf-Ruediger Ulrich
Thomas Martin
Thomas Baer
Armin Hatzelmann
Karl Sanders
Rolf Beume
Dietrich Haefner
Hildegard Boss
Hans-Peter Kley
Karl-Joseph Goebel
Original Assignee
Byk Gulden Lomberg Chem Fab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chem Fab filed Critical Byk Gulden Lomberg Chem Fab
Publication of NZ334976A publication Critical patent/NZ334976A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrane Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NZ334976A 1996-11-11 1997-11-05 Benzonaphthyridine derivatives and their use for treating airway disorders and dermatoses NZ334976A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19646298 1996-11-11
EP96118188 1996-11-13
DE19739056 1997-09-05
PCT/EP1997/006096 WO1998021208A1 (en) 1996-11-11 1997-11-05 Benzonaphthyridines as bronchial therapeutics

Publications (1)

Publication Number Publication Date
NZ334976A true NZ334976A (en) 2000-10-27

Family

ID=27216810

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ334976A NZ334976A (en) 1996-11-11 1997-11-05 Benzonaphthyridine derivatives and their use for treating airway disorders and dermatoses

Country Status (31)

Country Link
US (1) US6008215A (xx)
EP (1) EP0937074B1 (xx)
JP (1) JP4223075B2 (xx)
KR (1) KR100484045B1 (xx)
CN (1) CN1090188C (xx)
AT (1) ATE234300T1 (xx)
AU (1) AU733129B2 (xx)
BG (1) BG63695B1 (xx)
BR (1) BR9713338B1 (xx)
CA (1) CA2270964C (xx)
CY (1) CY2476B1 (xx)
CZ (1) CZ288752B6 (xx)
DE (1) DE69719778T2 (xx)
DK (1) DK0937074T3 (xx)
EA (1) EA001551B1 (xx)
EE (1) EE03829B1 (xx)
ES (1) ES2195189T3 (xx)
GE (1) GEP20012390B (xx)
HK (1) HK1022151A1 (xx)
HU (1) HU226981B1 (xx)
ID (1) ID22042A (xx)
IL (1) IL129054A (xx)
NO (1) NO312764B1 (xx)
NZ (1) NZ334976A (xx)
PL (1) PL189641B1 (xx)
PT (1) PT937074E (xx)
RS (1) RS49607B (xx)
SI (1) SI0937074T1 (xx)
SK (1) SK283269B6 (xx)
TR (1) TR199900856T2 (xx)
WO (1) WO1998021208A1 (xx)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3928999A (en) 1998-05-05 1999-11-23 Byk Gulden Lomberg Chemische Fabrik Gmbh Novel n-oxides
US6436952B1 (en) 1998-08-31 2002-08-20 Byk Gulden Lomberg Chemische Fabrik Gmbh Benzonaphthyridine-N-oxides comprising a PDE3 and PDE4 inhibiting activity
IT1303272B1 (it) 1998-10-29 2000-11-06 Zambon Spa Derivati triciclici inibitori della fosfodiesterasi 4
CZ300366B6 (cs) * 1999-01-15 2009-05-06 Nycomed Gmbh Fenylfenanthridinová sloucenina, farmaceutický prostredek s jejím obsahem a její použití
WO2000042034A1 (en) 1999-01-15 2000-07-20 Byk Gulden Phenanthridine-n-oxides with pde-iv inhibiting activity
DE60033918D1 (de) * 1999-01-15 2007-04-26 Altana Pharma Ag Polysubstituted 6-phenylphenanthridines mit pde-iv hemmender wirkung
ES2242594T3 (es) 1999-01-15 2005-11-16 Altana Pharma Ag N-oxidos de fenantridinas con una acitvidad inhidora de pde-iv.
DE60043318D1 (de) 1999-08-21 2010-01-14 Nycomed Gmbh Synergistische kombination von pumafentrine und salmeterol
NL1017973C2 (nl) * 2000-05-10 2002-11-08 Tristem Trading Cyprus Ltd Inrichting.
ATE287403T1 (de) * 2001-02-21 2005-02-15 Byk Gulden Lomberg Chem Fab 6-phenylbenzonaphthyidine
US6479493B1 (en) 2001-08-23 2002-11-12 Cell Pathways, Inc. Methods for treatment of type I diabetes
AU2003263216A1 (en) * 2002-08-17 2004-03-11 Nycomed Gmbh Benzonaphthyridines with PDE 3/4 inhibiting activity
US7470704B2 (en) * 2002-09-04 2008-12-30 Nycomed Gmbh Benzonaphthyridines
CA2496731C (en) * 2002-09-04 2011-08-16 Altana Pharma Ag Novel benzonaphthyridines
EP1624893A2 (en) 2003-04-01 2006-02-15 Applied Research Systems ARS Holding N.V. Inhibitors of phosphodiesterases in infertility
CA2557752C (en) 2004-03-03 2012-10-02 Altana Pharma Ag Hydroxy-6-heteroaryl-phenanthridines and their use as pde4 inhibitors
AR049419A1 (es) * 2004-03-03 2006-08-02 Altana Pharma Ag Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo
WO2005087745A1 (en) * 2004-03-10 2005-09-22 Altana Pharma Ag Novel amido-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors
WO2005090345A1 (en) * 2004-03-17 2005-09-29 Altana Pharma Ag Novel n- (alkoxyalkyl) carbamoyl - substituted 6-phenyl-benzonaphthyridine derivatives and their use as pde3/4 inhibitors
JP4960870B2 (ja) * 2004-09-08 2012-06-27 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規の３−チア−１０−アザ−フェナントレン誘導体
US7838521B2 (en) * 2004-09-08 2010-11-23 Nycomed Gmbh 3-oxa-10-aza-phenanthrenes
RS51345B (en) * 2005-03-02 2011-02-28 Nycomed Gmbh (2R, 4aR, 10bR) -6- (2,6-DIMETOXYPYRIDIN-3-IL) -9-ETOXY-8-METHOXY-1,2,3,4,4a, 10b-Hexahydrophenanthridin-2-OL, HCl SO
AU2006305619A1 (en) 2005-10-19 2007-04-26 Ranbaxy Laboratories Limited Pharmaceutical compositions of muscarinic receptor antagonists
TW200808695A (en) * 2006-06-08 2008-02-16 Amgen Inc Benzamide derivatives and uses related thereto
ES2528316T3 (es) * 2006-09-01 2015-02-06 Senhwa Biosciences, Inc. Moduladores de la serina-treonina proteína quinasa y de PARP
CA2722139C (en) 2008-04-23 2017-04-11 Rigel Pharmaceuticals, Inc. Carboxamide compounds for the treatment of metabolic disorders
AR079451A1 (es) 2009-12-18 2012-01-25 Nycomed Gmbh Compuestos 3,4,4a,10b-tetrahidro-1h-tiopirano[4,3-c]isoquinolina
CN108299429B (zh) * 2018-04-09 2021-10-08 中南大学 一类八氢苯并萘啶化合物及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3899494A (en) * 1970-05-13 1975-08-12 Sandoz Ltd Substituted 6-phenyl benzo-naphthyridines
EP0247971A3 (en) * 1986-05-29 1990-01-17 Sandoz Ag Novel pharmaceutical compositions comprising and use of cis-6-(4-acetanilido)-8,9-dimethoxy-2-methyl-1,2,3,4,4a,10b-hexahydrobenzo[c][1,6]naphthyridin
MY105344A (en) * 1990-05-16 1994-09-30 Byk Gulden Lomberg Chemische Fabrik New sulphonyl compounds

Also Published As

Publication number Publication date
NO992282L (no) 1999-05-11
RS49607B (sr) 2007-06-04
GEP20012390B (en) 2001-03-25
EA001551B1 (ru) 2001-04-23
PL333429A1 (en) 1999-12-06
PL189641B1 (pl) 2005-09-30
CN1090188C (zh) 2002-09-04
CY2476B1 (en) 2005-05-03
CZ288752B6 (cs) 2001-08-15
CA2270964C (en) 2007-07-31
ID22042A (id) 1999-08-26
TR199900856T2 (xx) 1999-07-21
BR9713338A (pt) 2000-05-09
NO312764B1 (no) 2002-07-01
DE69719778D1 (de) 2003-04-17
KR20000053100A (ko) 2000-08-25
NO992282D0 (no) 1999-05-11
EA199900421A1 (ru) 1999-10-28
HUP0000426A2 (hu) 2001-02-28
AU5317098A (en) 1998-06-03
CN1236367A (zh) 1999-11-24
YU19499A (sh) 2001-09-28
IL129054A (en) 2002-07-25
SK62399A3 (en) 1999-10-08
DK0937074T3 (da) 2003-06-23
IL129054A0 (en) 2000-02-17
WO1998021208A1 (en) 1998-05-22
EP0937074A1 (en) 1999-08-25
SI0937074T1 (en) 2003-08-31
EE03829B1 (et) 2002-08-15
ATE234300T1 (de) 2003-03-15
JP2001503442A (ja) 2001-03-13
JP4223075B2 (ja) 2009-02-12
BR9713338B1 (pt) 2009-12-01
BG63695B1 (bg) 2002-09-30
SK283269B6 (sk) 2003-04-01
EE9900105A (et) 1999-10-15
PT937074E (pt) 2003-07-31
HU226981B1 (hu) 2010-04-28
US6008215A (en) 1999-12-28
ES2195189T3 (es) 2003-12-01
HUP0000426A3 (en) 2001-04-28
CA2270964A1 (en) 1998-05-22
BG103310A (en) 2000-05-31
DE69719778T2 (de) 2004-02-05
EP0937074B1 (en) 2003-03-12
CZ167599A3 (cs) 1999-11-17
AU733129B2 (en) 2001-05-10
KR100484045B1 (ko) 2005-04-20
HK1022151A1 (en) 2000-07-28

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Legal Events

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RENW Renewal (renewal fees accepted)
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ASS Change of ownership

Owner name: TAKEDA GMBH, DE

Effective date: 20150305

EXPY Patent expired