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ES2195189T3 - Benzonaftiridinas como agentes terapeuticos bronquiales. - Google Patents

Benzonaftiridinas como agentes terapeuticos bronquiales.

Info

Publication number
ES2195189T3
ES2195189T3 ES97950093T ES97950093T ES2195189T3 ES 2195189 T3 ES2195189 T3 ES 2195189T3 ES 97950093 T ES97950093 T ES 97950093T ES 97950093 T ES97950093 T ES 97950093T ES 2195189 T3 ES2195189 T3 ES 2195189T3
Authority
ES
Spain
Prior art keywords
therapeutic agents
benzonaftiridines
bronchial therapeutic
bronchial
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97950093T
Other languages
English (en)
Inventor
Beate Schmidt
Hermann Amschler
Wolf-Ruediger Ulrich
Thomas Martin
Thomas Baer
Armin Hatzelmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Altana Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma AG filed Critical Altana Pharma AG
Application granted granted Critical
Publication of ES2195189T3 publication Critical patent/ES2195189T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrane Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

ESTA INVENCION SE REFIERE A UNOS COMPUESTOS DE LA FORMULA (I) EN LA CUAL R1, R2, R3 Y R4 TIENEN LOS SIGNIFICADOS QUE CONSTAN EN LA DESCRIPCION Y SON NUEVOS AGENTES TERAPEUTICOS BRONQUIALES ACTIVOS.
ES97950093T 1996-11-11 1997-11-05 Benzonaftiridinas como agentes terapeuticos bronquiales. Expired - Lifetime ES2195189T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19646298 1996-11-11
EP96118188 1996-11-13
DE19739056 1997-09-05

Publications (1)

Publication Number Publication Date
ES2195189T3 true ES2195189T3 (es) 2003-12-01

Family

ID=27216810

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97950093T Expired - Lifetime ES2195189T3 (es) 1996-11-11 1997-11-05 Benzonaftiridinas como agentes terapeuticos bronquiales.

Country Status (31)

Country Link
US (1) US6008215A (es)
EP (1) EP0937074B1 (es)
JP (1) JP4223075B2 (es)
KR (1) KR100484045B1 (es)
CN (1) CN1090188C (es)
AT (1) ATE234300T1 (es)
AU (1) AU733129B2 (es)
BG (1) BG63695B1 (es)
BR (1) BR9713338B1 (es)
CA (1) CA2270964C (es)
CY (1) CY2476B1 (es)
CZ (1) CZ288752B6 (es)
DE (1) DE69719778T2 (es)
DK (1) DK0937074T3 (es)
EA (1) EA001551B1 (es)
EE (1) EE03829B1 (es)
ES (1) ES2195189T3 (es)
GE (1) GEP20012390B (es)
HK (1) HK1022151A1 (es)
HU (1) HU226981B1 (es)
ID (1) ID22042A (es)
IL (1) IL129054A (es)
NO (1) NO312764B1 (es)
NZ (1) NZ334976A (es)
PL (1) PL189641B1 (es)
PT (1) PT937074E (es)
RS (1) RS49607B (es)
SI (1) SI0937074T1 (es)
SK (1) SK283269B6 (es)
TR (1) TR199900856T2 (es)
WO (1) WO1998021208A1 (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1075477E (pt) 1998-05-05 2003-07-31 Altana Pharma Ag Novos n-oxidos de benzonaftiridina
JP2002523505A (ja) 1998-08-31 2002-07-30 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング Ｐｄｅ３−及びｐｄｅ−４抑制作用を有するベンゾナフチリデン−ｎ−オキシド
IT1303272B1 (it) 1998-10-29 2000-11-06 Zambon Spa Derivati triciclici inibitori della fosfodiesterasi 4
JP2002534505A (ja) 1999-01-15 2002-10-15 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング 新規フェナントリジン−ｎ−オキシド
WO2000042034A1 (en) 1999-01-15 2000-07-20 Byk Gulden Phenanthridine-n-oxides with pde-iv inhibiting activity
JP2002534506A (ja) 1999-01-15 2002-10-15 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング Ｐｄｅ−ｉｖ抑制作用を有する多重に置換された６−フェニルフェナントリジン
US6476025B1 (en) * 1999-01-15 2002-11-05 Altana Pharma Ag Phenylphennanthridines with PDE-IV inhibiting activity
BRPI0013478B8 (pt) 1999-08-21 2016-12-27 Altana Pharma Ag medicamento compreendendo inibidor pde e uso de roflumilast
NL1017973C2 (nl) * 2000-05-10 2002-11-08 Tristem Trading Cyprus Ltd Inrichting.
PT1377574E (pt) * 2001-02-21 2005-05-31 Byk Gulden Lomberg Chem Fab 6-fenilbenzonaftiridinas
US6479493B1 (en) 2001-08-23 2002-11-12 Cell Pathways, Inc. Methods for treatment of type I diabetes
AU2003263216A1 (en) * 2002-08-17 2004-03-11 Nycomed Gmbh Benzonaphthyridines with PDE 3/4 inhibiting activity
US7470704B2 (en) 2002-09-04 2008-12-30 Nycomed Gmbh Benzonaphthyridines
JP4638736B2 (ja) * 2002-09-04 2011-02-23 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規のベンゾナフチリジン
AR049419A1 (es) * 2004-03-03 2006-08-02 Altana Pharma Ag Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo
MX341474B (es) 2004-03-03 2016-08-19 Takeda Gmbh Nuevas hidroxi-6-heteroarilfenantridinas y su uso como inhibidores de la fosfodiesterasa tipo 4 ( pde4).
AU2005221832A1 (en) * 2004-03-10 2005-09-22 Nycomed Gmbh Novel amido-substituted hydroxy-6-phenylphenanthridines and their use as PDE4 inhibitors
JP2007529471A (ja) * 2004-03-17 2007-10-25 アルタナ　ファルマ　アクチエンゲゼルシャフト 新規のｎ−（アルコキシアルキル）カルバモイル置換された６−フェニル−ベンゾナフチリジン誘導体及びｐｄｅ３／４インヒビターとしてのそれらの使用
JP5009799B2 (ja) 2004-09-08 2012-08-22 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規の３−オキサ−１０−アザ−フェナントレン
CA2579000C (en) * 2004-09-08 2013-02-05 Altana Pharma Ag Novel 3-thia-10-aza-phenanthrene derivatives
CA2598860C (en) 2005-03-02 2017-01-17 Nycomed Gmbh Novel salts of 6-heterocyclyl substituted hexahydrophenanthridine derivatives
WO2007045979A1 (en) 2005-10-19 2007-04-26 Ranbaxy Laboratories Limited Pharmaceutical compositions of muscarinic receptor antagonists
TW200808695A (en) * 2006-06-08 2008-02-16 Amgen Inc Benzamide derivatives and uses related thereto
AU2007289065B2 (en) * 2006-09-01 2013-03-14 Senhwa Biosciences, Inc. Serine-threonine protein kinase and PARP modulators
BRPI0911681B8 (pt) 2008-04-23 2021-05-25 Rigel Pharmaceuticals Inc composto, composição farmacêutica, e, método para ativar a via de proteína quinase ativada por 5'-amp em uma célula in vitro
AR079451A1 (es) 2009-12-18 2012-01-25 Nycomed Gmbh Compuestos 3,4,4a,10b-tetrahidro-1h-tiopirano[4,3-c]isoquinolina
CN108299429B (zh) * 2018-04-09 2021-10-08 中南大学 一类八氢苯并萘啶化合物及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3899494A (en) * 1970-05-13 1975-08-12 Sandoz Ltd Substituted 6-phenyl benzo-naphthyridines
EP0247971A3 (en) * 1986-05-29 1990-01-17 Sandoz Ag Novel pharmaceutical compositions comprising and use of cis-6-(4-acetanilido)-8,9-dimethoxy-2-methyl-1,2,3,4,4a,10b-hexahydrobenzo[c][1,6]naphthyridin
MY105344A (en) * 1990-05-16 1994-09-30 Byk Gulden Lomberg Chemische Fabrik New sulphonyl compounds

Also Published As

Publication number Publication date
CY2476B1 (en) 2005-05-03
NZ334976A (en) 2000-10-27
CA2270964A1 (en) 1998-05-22
NO992282L (no) 1999-05-11
JP2001503442A (ja) 2001-03-13
ATE234300T1 (de) 2003-03-15
SI0937074T1 (en) 2003-08-31
ID22042A (id) 1999-08-26
EA001551B1 (ru) 2001-04-23
DE69719778D1 (de) 2003-04-17
SK62399A3 (en) 1999-10-08
EP0937074A1 (en) 1999-08-25
BR9713338B1 (pt) 2009-12-01
BG63695B1 (bg) 2002-09-30
IL129054A0 (en) 2000-02-17
EE03829B1 (et) 2002-08-15
HUP0000426A3 (en) 2001-04-28
AU5317098A (en) 1998-06-03
DE69719778T2 (de) 2004-02-05
PL189641B1 (pl) 2005-09-30
EA199900421A1 (ru) 1999-10-28
HK1022151A1 (en) 2000-07-28
US6008215A (en) 1999-12-28
DK0937074T3 (da) 2003-06-23
CN1236367A (zh) 1999-11-24
KR20000053100A (ko) 2000-08-25
EE9900105A (et) 1999-10-15
CZ288752B6 (cs) 2001-08-15
GEP20012390B (en) 2001-03-25
PT937074E (pt) 2003-07-31
CN1090188C (zh) 2002-09-04
AU733129B2 (en) 2001-05-10
SK283269B6 (sk) 2003-04-01
JP4223075B2 (ja) 2009-02-12
BR9713338A (pt) 2000-05-09
HU226981B1 (hu) 2010-04-28
BG103310A (en) 2000-05-31
PL333429A1 (en) 1999-12-06
NO312764B1 (no) 2002-07-01
RS49607B (sr) 2007-06-04
WO1998021208A1 (en) 1998-05-22
CZ167599A3 (cs) 1999-11-17
YU19499A (sh) 2001-09-28
TR199900856T2 (xx) 1999-07-21
EP0937074B1 (en) 2003-03-12
KR100484045B1 (ko) 2005-04-20
NO992282D0 (no) 1999-05-11
HUP0000426A2 (hu) 2001-02-28
IL129054A (en) 2002-07-25
CA2270964C (en) 2007-07-31

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