SG10202101830WA - Processes for preparing oligomers - Google Patents
Processes for preparing oligomersInfo
- Publication number
- SG10202101830WA SG10202101830WA SG10202101830WA SG10202101830WA SG10202101830WA SG 10202101830W A SG10202101830W A SG 10202101830WA SG 10202101830W A SG10202101830W A SG 10202101830WA SG 10202101830W A SG10202101830W A SG 10202101830WA SG 10202101830W A SG10202101830W A SG 10202101830WA
- Authority
- SG
- Singapore
- Prior art keywords
- processes
- preparing oligomers
- oligomers
- preparing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662341049P | 2016-05-24 | 2016-05-24 | |
| US201662357153P | 2016-06-30 | 2016-06-30 | |
| US201662356923P | 2016-06-30 | 2016-06-30 | |
| US201662357072P | 2016-06-30 | 2016-06-30 | |
| US201662357166P | 2016-06-30 | 2016-06-30 | |
| US201762508256P | 2017-05-18 | 2017-05-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10202101830WA true SG10202101830WA (en) | 2021-04-29 |
Family
ID=59078165
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10202101830WA SG10202101830WA (en) | 2016-05-24 | 2017-05-24 | Processes for preparing oligomers |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US10875880B2 (da) |
| EP (2) | EP3464305B1 (da) |
| JP (2) | JP7008642B2 (da) |
| KR (1) | KR102506298B1 (da) |
| CN (1) | CN109563114B (da) |
| AU (1) | AU2017269355B2 (da) |
| BR (2) | BR112018074346B1 (da) |
| CA (1) | CA3025339A1 (da) |
| CO (1) | CO2018013838A2 (da) |
| DK (1) | DK3464305T3 (da) |
| ES (1) | ES2993738T3 (da) |
| FI (1) | FI3464305T3 (da) |
| HR (1) | HRP20241428T1 (da) |
| IL (1) | IL263149B2 (da) |
| MA (2) | MA45154B1 (da) |
| MD (1) | MD3464305T2 (da) |
| MX (2) | MX384727B (da) |
| SA (1) | SA518400500B1 (da) |
| SG (1) | SG10202101830WA (da) |
| TW (2) | TWI738784B (da) |
| WO (1) | WO2017205496A1 (da) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI541024B (zh) | 2010-09-01 | 2016-07-11 | 日本新藥股份有限公司 | 反義核酸 |
| BR112018074346B1 (pt) | 2016-05-24 | 2023-01-03 | Sarepta Therapeutics, Inc. | Composto oligomérico e processo para preparar um composto oligomérico |
| SG11201809499UA (en) * | 2016-05-24 | 2018-12-28 | Sarepta Therapeutics Inc | Processes for preparing phosphorodiamidate morpholino oligomers |
| IL263044B2 (en) | 2016-05-24 | 2024-06-01 | Sarepta Therapeutics Inc | Processes for the preparation of phosphorodiamidate morpholino oligomers |
| MA45362A (fr) | 2016-05-24 | 2019-04-10 | Sarepta Therapeutics Inc | Procédés de préparation d'oligomères morpholino de phosphorodiamidate |
| US11472824B2 (en) | 2016-05-24 | 2022-10-18 | Sarepta Therapeutics, Inc. | Processes for preparing phosphorodiamidate morpholino oligomers |
| CN109152775B (zh) * | 2016-06-30 | 2022-04-26 | 萨勒普塔医疗公司 | 制备磷酸二酰胺吗啉代寡聚物的方法 |
| JP7022079B2 (ja) * | 2016-06-30 | 2022-02-17 | サレプタ セラピューティクス， インコーポレイテッド | ホスホロジアミダートモルホリノオリゴマーを調製するためのプロセス |
| MA49986A (fr) * | 2017-09-25 | 2020-07-01 | Massachusetts Inst Technology | Procédés de préparation d'oligomères morpholino phosphorodiamidate par l'intermédiaire d'une synthèse à flux rapide |
| US20210102205A1 (en) * | 2018-04-26 | 2021-04-08 | Sarepta Therapeutics, Inc. | Exon skipping oligomers and oligomer conjugates for muscular dystrophy |
| WO2024163762A2 (en) * | 2023-02-01 | 2024-08-08 | Alnylam Pharmaceuticals, Inc. | Six membered ring containing oligomers |
Family Cites Families (53)
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| US5185444A (en) | 1985-03-15 | 1993-02-09 | Anti-Gene Deveopment Group | Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages |
| US5217866A (en) | 1985-03-15 | 1993-06-08 | Anti-Gene Development Group | Polynucleotide assay reagent and method |
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| US5521063A (en) | 1985-03-15 | 1996-05-28 | Antivirals Inc. | Polynucleotide reagent containing chiral subunits and methods of use |
| US5506337A (en) | 1985-03-15 | 1996-04-09 | Antivirals Inc. | Morpholino-subunit combinatorial library and method |
| DE3687030T2 (de) | 1985-03-15 | 1993-03-11 | Eugene Stirchak | Stereoregulare polynukleotiden bindende polymere. |
| US5166315A (en) | 1989-12-20 | 1992-11-24 | Anti-Gene Development Group | Sequence-specific binding polymers for duplex nucleic acids |
| AU4225889A (en) | 1988-09-01 | 1990-04-02 | Forskningscenter Riso | Peptide synthesis method and solid support for use in the method |
| KR100386542B1 (ko) | 1993-12-29 | 2003-10-11 | 후지사와 야꾸힝 고교 가부시키가이샤 | 피라졸로피리딘아데노신길항제 |
| US6794499B2 (en) | 1997-09-12 | 2004-09-21 | Exiqon A/S | Oligonucleotide analogues |
| US7572582B2 (en) | 1997-09-12 | 2009-08-11 | Exiqon A/S | Oligonucleotide analogues |
| US7084125B2 (en) | 1999-03-18 | 2006-08-01 | Exiqon A/S | Xylo-LNA analogues |
| DE60033927T2 (de) | 1999-05-04 | 2007-11-29 | Santaris Pharma A/S | L-ribo-lna analoge |
| JP2003533986A (ja) | 2000-05-04 | 2003-11-18 | エイブイアイ バイオファーマ， インコーポレイテッド | スプライス領域アンチセンス組成物および方法 |
| WO2003020739A2 (en) | 2001-09-04 | 2003-03-13 | Exiqon A/S | Novel lna compositions and uses thereof |
| US7569575B2 (en) | 2002-05-08 | 2009-08-04 | Santaris Pharma A/S | Synthesis of locked nucleic acid derivatives |
| CA2504554A1 (en) | 2002-11-05 | 2004-05-27 | Isis Pharmaceuticals, Inc. | 2'-substituted oligomeric compounds and compositions for use in gene modulations |
| US7759513B2 (en) | 2003-02-21 | 2010-07-20 | Nigu Chemie Gmbh | Photolabile protective groups for improved processes to prepare oligonucleotide arrays |
| EP3228711A1 (en) | 2004-06-28 | 2017-10-11 | The University Of Western Australia | Antisense oligonucleotides for inducing exon skipping and methods of use thereof |
| US8067571B2 (en) | 2005-07-13 | 2011-11-29 | Avi Biopharma, Inc. | Antibacterial antisense oligonucleotide and method |
| HUE036995T2 (hu) * | 2006-05-10 | 2018-08-28 | Sarepta Therapeutics Inc | Az alegységek között kationos kötéssel rendelkezõ oligonukleotid analógok |
| US9371348B2 (en) | 2006-11-27 | 2016-06-21 | The Trustees Of The University Of Pennsylvania | Photocleavable oligonucleotide and uses thereof |
| CN101861318A (zh) | 2007-11-15 | 2010-10-13 | Avi生物制药公司 | 合成吗啉代低聚物的方法 |
| US8299206B2 (en) | 2007-11-15 | 2012-10-30 | Avi Biopharma, Inc. | Method of synthesis of morpholino oligomers |
| US8076476B2 (en) | 2007-11-15 | 2011-12-13 | Avi Biopharma, Inc. | Synthesis of morpholino oligomers using doubly protected guanine morpholino subunits |
| EP2350281B1 (en) | 2008-10-24 | 2014-05-14 | Sarepta Therapeutics, Inc. | Multiple exon skipping compositions for dmd |
| HUE028036T2 (en) | 2009-04-10 | 2016-11-28 | Ass Inst De Myologie | Tricyclic DNA anti-sense oligonucleotides, compositions and methods for treating a disease |
| NZ716534A (en) | 2009-11-12 | 2018-06-29 | Univ Western Australia | Antisense molecules and methods for treating pathologies |
| TWI463423B (zh) * | 2010-05-28 | 2014-12-01 | Poynt Corp | 用以針對基於三維形狀之廣告系統使用位置資訊的方法 |
| KR102182663B1 (ko) * | 2010-05-28 | 2020-11-25 | 사렙타 쎄러퓨틱스, 인코퍼레이티드 | 변형된 서브유니트간 결합 및/또는 말단 그룹을 갖는 올리고뉴클레오타이드 유사체 |
| TWI541024B (zh) * | 2010-09-01 | 2016-07-11 | 日本新藥股份有限公司 | 反義核酸 |
| SMT201700038T1 (it) | 2010-09-30 | 2017-03-08 | Nippon Shinyaku Co Ltd | Derivati morfolinici di acidi nucleici |
| US9078911B2 (en) * | 2011-02-08 | 2015-07-14 | The Charlotte-Mecklenburg Hospital Authority | Antisense oligonucleotides |
| WO2013026142A1 (en) | 2011-08-23 | 2013-02-28 | The Royal Institution For The Advancement Of Learning/Mcgill University | Ionic tags for synthesis of oligoribonucleotides |
| DK2581448T3 (da) | 2011-10-13 | 2015-04-27 | Ass Inst De Myologie | Tricyclo-phosphorothioat-DNA |
| HK1201514A1 (en) | 2011-11-18 | 2015-09-04 | Sarepta Therapeutics, Inc. | Functionally-modified oligonucleotides and subunits thereof |
| ES2727481T3 (es) * | 2011-11-30 | 2019-10-16 | Sarepta Therapeutics Inc | Inclusión inducida de exón en atrofia muscular espinal |
| CN108588073A (zh) * | 2011-12-28 | 2018-09-28 | 日本新药株式会社 | 反义核酸 |
| ES2741099T3 (es) | 2012-02-28 | 2020-02-10 | Agilent Technologies Inc | Método de fijación de una secuencia de recuento para una muestra de ácido nucleico |
| CN102702265A (zh) * | 2012-05-14 | 2012-10-03 | 天津特安化学科技有限公司 | 一种固相合成磷酰二胺吗啉代寡核苷酸及方法 |
| US20140329881A1 (en) * | 2013-03-14 | 2014-11-06 | Sarepta Therapeutics, Inc. | Exon skipping compositions for treating muscular dystrophy |
| BR112015023038A2 (pt) * | 2013-03-14 | 2017-11-14 | Sarepta Therapeutics Inc | composições para salto de exon para o tratamento da distrofia muscular |
| CN113633787A (zh) | 2013-03-15 | 2021-11-12 | 萨勒普塔医疗公司 | 改进的用于治疗肌营养不良的组合物 |
| CN105228999B (zh) * | 2013-05-24 | 2021-03-02 | 味之素株式会社 | 吗啉代寡核苷酸的制备方法 |
| BR112018074346B1 (pt) | 2016-05-24 | 2023-01-03 | Sarepta Therapeutics, Inc. | Composto oligomérico e processo para preparar um composto oligomérico |
| US11472824B2 (en) | 2016-05-24 | 2022-10-18 | Sarepta Therapeutics, Inc. | Processes for preparing phosphorodiamidate morpholino oligomers |
| MA45362A (fr) | 2016-05-24 | 2019-04-10 | Sarepta Therapeutics Inc | Procédés de préparation d'oligomères morpholino de phosphorodiamidate |
| SG11201809499UA (en) * | 2016-05-24 | 2018-12-28 | Sarepta Therapeutics Inc | Processes for preparing phosphorodiamidate morpholino oligomers |
| IL263044B2 (en) | 2016-05-24 | 2024-06-01 | Sarepta Therapeutics Inc | Processes for the preparation of phosphorodiamidate morpholino oligomers |
| ES2927079T3 (es) | 2016-12-19 | 2022-11-02 | Sarepta Therapeutics Inc | Conjugados de oligómero de omisión de exones para distrofia muscular |
| CN110636866B (zh) | 2016-12-19 | 2024-10-18 | 萨勒普塔医疗公司 | 用于肌肉萎缩症的外显子跳跃寡聚体缀合物 |
| NZ755422A (en) | 2016-12-19 | 2023-06-30 | Sarepta Therapeutics Inc | Exon skipping oligomer conjugates for muscular dystrophy |
| EA201991450A1 (ru) | 2017-09-22 | 2019-12-30 | Сарепта Терапьютикс, Инк. | Конъюгаты олигомеров для пропуска экзона при мышечной дистрофии |
-
2017
- 2017-05-24 BR BR112018074346-1A patent/BR112018074346B1/pt active IP Right Grant
- 2017-05-24 CA CA3025339A patent/CA3025339A1/en active Pending
- 2017-05-24 ES ES17731336T patent/ES2993738T3/es active Active
- 2017-05-24 MD MDE20190423T patent/MD3464305T2/ro unknown
- 2017-05-24 DK DK17731336.8T patent/DK3464305T3/da active
- 2017-05-24 CN CN201780037531.XA patent/CN109563114B/zh active Active
- 2017-05-24 HR HRP20241428TT patent/HRP20241428T1/hr unknown
- 2017-05-24 MX MX2018014472A patent/MX384727B/es unknown
- 2017-05-24 MA MA45154A patent/MA45154B1/fr unknown
- 2017-05-24 EP EP17731336.8A patent/EP3464305B1/en active Active
- 2017-05-24 TW TW106117189A patent/TWI738784B/zh active
- 2017-05-24 SG SG10202101830WA patent/SG10202101830WA/en unknown
- 2017-05-24 TW TW110113938A patent/TWI801843B/zh active
- 2017-05-24 JP JP2018562078A patent/JP7008642B2/ja active Active
- 2017-05-24 EP EP19174995.1A patent/EP3564248A1/en active Pending
- 2017-05-24 WO PCT/US2017/034235 patent/WO2017205496A1/en active IP Right Grant
- 2017-05-24 US US16/303,356 patent/US10875880B2/en active Active
- 2017-05-24 FI FIEP17731336.8T patent/FI3464305T3/fi active
- 2017-05-24 BR BR122022014984-7A patent/BR122022014984B1/pt active IP Right Grant
- 2017-05-24 MA MA049775A patent/MA49775A/fr unknown
- 2017-05-24 AU AU2017269355A patent/AU2017269355B2/en active Active
- 2017-05-24 MX MX2021008539A patent/MX2021008539A/es unknown
- 2017-05-24 KR KR1020187036117A patent/KR102506298B1/ko active Active
-
2018
- 2018-11-20 IL IL263149A patent/IL263149B2/en unknown
- 2018-11-24 SA SA518400500A patent/SA518400500B1/ar unknown
- 2018-12-19 CO CONC2018/0013838A patent/CO2018013838A2/es unknown
-
2020
- 2020-11-16 US US17/098,935 patent/US11384105B2/en active Active
-
2021
- 2021-07-15 JP JP2021117392A patent/JP2021176967A/ja active Pending
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