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SE9602263D0 - New amino acid derivatives - Google Patents

New amino acid derivatives

Info

Publication number
SE9602263D0
SE9602263D0 SE9602263A SE9602263A SE9602263D0 SE 9602263 D0 SE9602263 D0 SE 9602263D0 SE 9602263 A SE9602263 A SE 9602263A SE 9602263 A SE9602263 A SE 9602263A SE 9602263 D0 SE9602263 D0 SE 9602263D0
Authority
SE
Sweden
Prior art keywords
amino acid
acid derivatives
new amino
thrombin
new
Prior art date
Application number
SE9602263A
Other languages
English (en)
Inventor
David Gustafsson
Jan-Erik Nystroem
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Priority to SE9602263A priority Critical patent/SE9602263D0/sv
Publication of SE9602263D0 publication Critical patent/SE9602263D0/sv
Priority to ZA9704542A priority patent/ZA974542B/xx
Priority to IDP971884A priority patent/ID17016A/id
Priority to NZ332964A priority patent/NZ332964A/xx
Priority to DK97926356T priority patent/DK0910573T3/da
Priority to ES97926356T priority patent/ES2191840T3/es
Priority to AT97926356T priority patent/ATE231883T1/de
Priority to CZ983986A priority patent/CZ398698A3/cs
Priority to IL12732597A priority patent/IL127325A0/xx
Priority to PCT/SE1997/000989 priority patent/WO1997046577A1/en
Priority to AU31140/97A priority patent/AU723420B2/en
Priority to HU0002404A priority patent/HUP0002404A3/hu
Priority to SK1653-98A priority patent/SK165398A3/sk
Priority to TR1998/02536T priority patent/TR199802536T2/xx
Priority to DE69718791T priority patent/DE69718791T2/de
Priority to PL97330482A priority patent/PL330482A1/xx
Priority to EP97926356A priority patent/EP0910573B1/en
Priority to BR9709560A priority patent/BR9709560A/pt
Priority to US08/860,871 priority patent/US6255301B1/en
Priority to EE9800425A priority patent/EE9800425A/xx
Priority to JP50050298A priority patent/JP4237824B2/ja
Priority to CA002255625A priority patent/CA2255625A1/en
Priority to CN97196864A priority patent/CN1129604C/zh
Priority to ARP970102484A priority patent/AR008046A1/es
Priority to IS4906A priority patent/IS4906A/is
Priority to IL127325A priority patent/IL127325A/en
Priority to NO19985700A priority patent/NO317135B1/no
Priority to US09/844,427 priority patent/US6838478B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
SE9602263A 1996-06-07 1996-06-07 New amino acid derivatives SE9602263D0 (sv)

Priority Applications (28)

Application Number Priority Date Filing Date Title
SE9602263A SE9602263D0 (sv) 1996-06-07 1996-06-07 New amino acid derivatives
ZA9704542A ZA974542B (en) 1996-06-07 1997-05-23 New amino acid derivatives and their use as thrombin inhibitors.
IDP971884A ID17016A (id) 1996-06-07 1997-06-03 Turunan-turunan asam yang baru dan penggunaannya sebagai penghambat-penghambat trombin
CN97196864A CN1129604C (zh) 1996-06-07 1997-06-05 新的氨基酸衍生物及其作为凝血酶抑制剂的用途
SK1653-98A SK165398A3 (en) 1996-06-07 1997-06-05 New amino acid derivatives and their use as thrombin inhibitors
EP97926356A EP0910573B1 (en) 1996-06-07 1997-06-05 New amino acid derivatives and their use as thrombin inhibitors
ES97926356T ES2191840T3 (es) 1996-06-07 1997-06-05 Nuevos derivados de aminoacidos y su utilizacion como inhibidores de trombina.
AT97926356T ATE231883T1 (de) 1996-06-07 1997-06-05 Neuartige aminosäurederivate und deren verwendung als thrombininhibitoren
CZ983986A CZ398698A3 (cs) 1996-06-07 1997-06-05 Nový derivát aminokyseliny a jeho použití jako inhibitoru thrombinu
IL12732597A IL127325A0 (en) 1996-06-07 1997-06-05 Amino acid derivatives and their use as thrombin inhibitors
PCT/SE1997/000989 WO1997046577A1 (en) 1996-06-07 1997-06-05 New amino acid derivatives and their use as thrombin inhibitors
AU31140/97A AU723420B2 (en) 1996-06-07 1997-06-05 New amino acid derivatives and their use as thrombin inhibitors
HU0002404A HUP0002404A3 (en) 1996-06-07 1997-06-05 Amino acid derivatives, pharmaceutical compositions comprising thereof, process for preparation them and their use
NZ332964A NZ332964A (en) 1996-06-07 1997-06-05 azetidine, pyrrolidine or piperidine substituted amino acid derivatives
TR1998/02536T TR199802536T2 (xx) 1996-06-07 1997-06-05 Yeni amino asit t�revleri,trombin inhibit�rleri olarak kullan�lmalar�.
DE69718791T DE69718791T2 (de) 1996-06-07 1997-06-05 Neuartige aminosäurederivate und deren verwendung als thrombininhibitoren
PL97330482A PL330482A1 (en) 1996-06-07 1997-06-05 Novel amino acid derivatives and their application as thrombosin inhibitors
DK97926356T DK0910573T3 (da) 1996-06-07 1997-06-05 Nye aminosyrederivater og deres anvendelse som thrombininhibitorer
BR9709560A BR9709560A (pt) 1996-06-07 1997-06-05 Composto formulação farmacéutica uso de um compostoãe processo para tratamento de uma condição em que a inibição da trombina seja necessaria e para a preparação de um composto
US08/860,871 US6255301B1 (en) 1996-06-07 1997-06-05 Amino acid derivatives and their use as thrombin inhibitors
EE9800425A EE9800425A (et) 1996-06-07 1997-06-05 Uued aminohappe derivaadid ja nende kasutamine trombiini inhibiitoritena
JP50050298A JP4237824B2 (ja) 1996-06-07 1997-06-05 新規なアミノ酸誘導体およびトロンビン阻害剤としてのその使用
CA002255625A CA2255625A1 (en) 1996-06-07 1997-06-05 New amino acid derivatives and their use as thrombin inhibitors
ARP970102484A AR008046A1 (es) 1996-06-07 1997-06-06 Nuevos derivados de aminoacidos, formulacion farmaceutica que los incluye, metodos para la elaboracion de medicamentos y proceso para la preparacion dedichos derivados.
IS4906A IS4906A (is) 1996-06-07 1998-11-25 Nýjar amínósýruafleiður og notkun þeirra sem þrombínhemla
IL127325A IL127325A (en) 1996-06-07 1998-11-30 History of amino acids, process for their preparation, pharmaceutical preparations containing them and their uses in the preparation of drugs as thrombin inhibitors
NO19985700A NO317135B1 (no) 1996-06-07 1998-12-04 Nye aminosyrederivater, farmasoytisk formulering inneholdende slike derivater, fremgangsmate for og deres fremstilling, og deres anvendelse som trombininhibitorer
US09/844,427 US6838478B2 (en) 1996-06-07 2001-04-30 Amino acid derivatives and their use as thrombin inhibitors

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9602263A SE9602263D0 (sv) 1996-06-07 1996-06-07 New amino acid derivatives

Publications (1)

Publication Number Publication Date
SE9602263D0 true SE9602263D0 (sv) 1996-06-07

Family

ID=20402928

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9602263A SE9602263D0 (sv) 1996-06-07 1996-06-07 New amino acid derivatives

Country Status (26)

Country Link
US (2) US6255301B1 (sv)
EP (1) EP0910573B1 (sv)
JP (1) JP4237824B2 (sv)
CN (1) CN1129604C (sv)
AR (1) AR008046A1 (sv)
AT (1) ATE231883T1 (sv)
AU (1) AU723420B2 (sv)
BR (1) BR9709560A (sv)
CA (1) CA2255625A1 (sv)
CZ (1) CZ398698A3 (sv)
DE (1) DE69718791T2 (sv)
DK (1) DK0910573T3 (sv)
EE (1) EE9800425A (sv)
ES (1) ES2191840T3 (sv)
HU (1) HUP0002404A3 (sv)
ID (1) ID17016A (sv)
IL (2) IL127325A0 (sv)
IS (1) IS4906A (sv)
NO (1) NO317135B1 (sv)
NZ (1) NZ332964A (sv)
PL (1) PL330482A1 (sv)
SE (1) SE9602263D0 (sv)
SK (1) SK165398A3 (sv)
TR (1) TR199802536T2 (sv)
WO (1) WO1997046577A1 (sv)
ZA (1) ZA974542B (sv)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SA96170106A (ar) * 1995-07-06 2005-12-03 أسترا أكتيبولاج مشتقات حامض أميني جديدة
AR013084A1 (es) 1997-06-19 2000-12-13 Astrazeneca Ab Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados
SE9704543D0 (sv) 1997-12-05 1997-12-05 Astra Ab New compounds
NZ508005A (en) 1998-04-24 2003-05-30 Dimensional Pharm Inc Amino acid amidinohydrazones, alkoxyguanidines and aminoguanidines useful as serine protease inhibitors
SE9804313D0 (sv) 1998-12-14 1998-12-14 Astra Ab New compounds
EE200100371A (et) * 1999-01-13 2002-02-15 Astrazeneca Ab Amidinobensüülamiini derivaadid ja nende kasutamine trombiini inhibiitoritena
AR023510A1 (es) 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.
SE9902270D0 (sv) * 1999-06-16 1999-06-16 Astra Ab Pharmaceutically active compounds
SE0001803D0 (sv) 2000-05-16 2000-05-16 Astrazeneca Ab New compounds i
US6433186B1 (en) * 2000-08-16 2002-08-13 Astrazeneca Ab Amidino derivatives and their use as thormbin inhibitors
IL154077A0 (en) * 2000-08-16 2003-07-31 Astrazeneca Ab New amidino derivatives and their use as thrombin inhibitors
US7129233B2 (en) 2000-12-01 2006-10-31 Astrazeneca Ab Mandelic acid derivatives and their use as thrombin inhibitors
AR035216A1 (es) * 2000-12-01 2004-05-05 Astrazeneca Ab Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios
AR034517A1 (es) 2001-06-21 2004-02-25 Astrazeneca Ab Formulacion farmaceutica
SE0201659D0 (sv) 2002-05-31 2002-05-31 Astrazeneca Ab Modified release pharmaceutical formulation
SE0201661D0 (sv) 2002-05-31 2002-05-31 Astrazeneca Ab New salts
US7781424B2 (en) * 2003-05-27 2010-08-24 Astrazeneca Ab Modified release pharmaceutical formulation
TW200827336A (en) * 2006-12-06 2008-07-01 Astrazeneca Ab New crystalline forms
US20090061000A1 (en) * 2007-08-31 2009-03-05 Astrazeneca Ab Pharmaceutical formulation use 030
SI2242759T1 (sl) 2008-02-06 2013-01-31 Astrazeneca Ab Spojine
GB0913342D0 (en) 2009-07-31 2009-09-16 Astrazeneca Ab Compounds - 801
KR101181918B1 (ko) * 2010-11-09 2012-09-11 주식회사 세라젬 온열치료기용 상하운동 조절장치
EP3052498A1 (en) 2013-09-30 2016-08-10 Council of Scientific & Industrial Research 3,7-diazabicyclo[3.3.1]nonane carboxamides as antithrombotic agents
KR102256242B1 (ko) * 2014-02-07 2021-05-26 엑시테라 파마슈티컬스 인코퍼레이티드 치료 화합물 및 조성물
CN108530297B (zh) * 2017-03-03 2021-09-24 联化科技股份有限公司 2-氯-3-甲基苯甲酸及其中间体的制备方法

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU178398B (en) 1979-06-12 1982-04-28 Gyogyszerkutato Intezet Process for producing new agmatine derivatives of activity against haemagglutination
HU192646B (en) 1984-12-21 1987-06-29 Gyogyszerkutato Intezet Process for preparing new n-alkyl-peptide aldehydes
AU600226B2 (en) 1985-02-04 1990-08-09 Merrell Pharmaceuticals Inc. Novel peptidase inhibitors
US5187157A (en) 1987-06-05 1993-02-16 Du Pont Merck Pharmaceutical Company Peptide boronic acid inhibitors of trypsin-like proteases
EP0362002B1 (en) 1988-09-01 1995-07-26 Merrell Dow Pharmaceuticals Inc. HIV protease inhibitors
ZA897515B (en) 1988-10-07 1990-06-27 Merrell Dow Pharma Novel peptidase inhibitors
TW201303B (sv) 1990-07-05 1993-03-01 Hoffmann La Roche
CA2075154A1 (en) 1991-08-06 1993-02-07 Neelakantan Balasubramanian Peptide aldehydes as antithrombotic agents
SE9102462D0 (sv) 1991-08-28 1991-08-28 Astra Ab New isosteric peptides
ZA928581B (en) 1991-11-12 1994-05-06 Lilly Co Eli Antithrombotic agents
SE9103612D0 (sv) 1991-12-04 1991-12-04 Astra Ab New peptide derivatives
EP0629212B1 (en) 1992-03-04 1997-10-08 Gyogyszerkutato Intezet Kft. New anticoagulant peptide derivatives and pharmaceutical compositions containing the same as well as a process for the preparation thereof
TW223629B (sv) 1992-03-06 1994-05-11 Hoffmann La Roche
AU675981B2 (en) 1992-12-02 1997-02-27 Bristol-Myers Squibb Company Guanidinyl-substituted heterocyclic thrombin inhibitors
US5583146A (en) 1992-12-02 1996-12-10 Bristol-Myers Squibb Company Heterocyclic thrombin inhibitors
JPH06340619A (ja) 1993-05-03 1994-12-13 Bristol Myers Squibb Co グアニジニルまたはアミジニル置換メチルアミノ複素環トロンビン抑制剤
US5783563A (en) 1993-06-03 1998-07-21 Astra Aktiebolag Method for treatment or prophylaxis of venous thrombosis
SE9301916D0 (sv) 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
EP0648780A1 (en) 1993-08-26 1995-04-19 Bristol-Myers Squibb Company Heterocyclic thrombin inhibitors
TW394760B (en) 1993-09-07 2000-06-21 Hoffmann La Roche Novel Carboxamides, process for their preparation and pharmaceutical composition containing the same
AU1025795A (en) 1994-01-27 1995-08-03 Mitsubishi Chemical Corporation Prolineamide derivatives
US5726159A (en) 1994-03-04 1998-03-10 Eli Lilly And Company Antithrombotic agents
US5707966A (en) 1994-03-04 1998-01-13 Eli Lilly And Company Antithrombotic agents
US5705487A (en) 1994-03-04 1998-01-06 Eli Lilly And Company Antithrombotic agents
ZA951617B (en) 1994-03-04 1997-02-27 Lilly Co Eli Antithrombotic agents.
US5561146A (en) 1994-06-10 1996-10-01 Bristol-Myers Squibb Company Modified guanidino and amidino thrombin inhibitors
DE4421052A1 (de) * 1994-06-17 1995-12-21 Basf Ag Neue Thrombininhibitoren, ihre Herstellung und Verwendung
US5510369A (en) 1994-07-22 1996-04-23 Merck & Co., Inc. Pyrrolidine thrombin inhibitors
DE4443390A1 (de) 1994-12-06 1996-06-13 Basf Ag Neue dipeptidische p-Amidinobenzylamide mit N-terminalen Sulfonyl- bzw. Aminosulfonylresten
KR19980702112A (ko) 1995-02-10 1998-07-15 페라 스타르크,요헨 카르크 트롬빈 억제제
CZ245797A3 (cs) * 1995-02-17 1998-06-17 Basf Aktiengesellschaft Derivát amidinu dipeptidu jako inhibitor thrombinu
US5710130A (en) 1995-02-27 1998-01-20 Eli Lilly And Company Antithrombotic agents
US5914319A (en) 1995-02-27 1999-06-22 Eli Lilly And Company Antithrombotic agents
WO1996031504A1 (en) 1995-04-04 1996-10-10 Merck & Co., Inc. Thrombin inhibitors
US5629324A (en) 1995-04-10 1997-05-13 Merck & Co., Inc. Thrombin inhibitors
SA96170106A (ar) 1995-07-06 2005-12-03 أسترا أكتيبولاج مشتقات حامض أميني جديدة
TW541316B (en) 1995-12-21 2003-07-11 Astrazeneca Ab Prodrugs of thrombin inhibitors
JPH1095898A (ja) 1996-09-25 1998-04-14 Sumitomo Bakelite Co Ltd 難燃性樹脂組成物およびこれを用いた積層板
DE19632772A1 (de) 1996-08-14 1998-02-19 Basf Ag Neue Benzamidine
DE19632773A1 (de) 1996-08-14 1998-02-19 Basf Ag Neue Thrombininhibitoren
SE9704543D0 (sv) * 1997-12-05 1997-12-05 Astra Ab New compounds

Also Published As

Publication number Publication date
US20020019371A1 (en) 2002-02-14
DE69718791D1 (de) 2003-03-06
ES2191840T3 (es) 2003-09-16
EP0910573B1 (en) 2003-01-29
TR199802536T2 (xx) 1999-03-22
SK165398A3 (en) 1999-08-06
ZA974542B (en) 1997-12-08
EE9800425A (et) 1999-06-15
ATE231883T1 (de) 2003-02-15
WO1997046577A1 (en) 1997-12-11
NZ332964A (en) 2000-08-25
HUP0002404A3 (en) 2001-02-28
CZ398698A3 (cs) 1999-07-14
US6838478B2 (en) 2005-01-04
DE69718791T2 (de) 2003-10-23
CA2255625A1 (en) 1997-12-11
IL127325A (en) 2006-10-31
DK0910573T3 (da) 2003-06-23
NO317135B1 (no) 2004-08-23
ID17016A (id) 1997-12-04
NO985700D0 (no) 1998-12-04
IS4906A (is) 1998-11-25
US6255301B1 (en) 2001-07-03
AU723420B2 (en) 2000-08-24
JP2000512631A (ja) 2000-09-26
JP4237824B2 (ja) 2009-03-11
BR9709560A (pt) 1999-08-10
EP0910573A1 (en) 1999-04-28
IL127325A0 (en) 1999-09-22
PL330482A1 (en) 1999-05-24
AR008046A1 (es) 1999-12-09
HUP0002404A2 (hu) 2000-10-28
NO985700L (no) 1999-02-05
CN1129604C (zh) 2003-12-03
CN1226895A (zh) 1999-08-25
AU3114097A (en) 1998-01-05

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