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SE9201956D0 - Novel nicotinicacid esters - Google Patents

Novel nicotinicacid esters

Info

Publication number
SE9201956D0
SE9201956D0 SE9201956A SE9201956A SE9201956D0 SE 9201956 D0 SE9201956 D0 SE 9201956D0 SE 9201956 A SE9201956 A SE 9201956A SE 9201956 A SE9201956 A SE 9201956A SE 9201956 D0 SE9201956 D0 SE 9201956D0
Authority
SE
Sweden
Prior art keywords
saturated
nicotinicacid
esters
novel
carbon atoms
Prior art date
Application number
SE9201956A
Other languages
English (en)
Swedish (sv)
Inventor
T Lundstedt
Original Assignee
Kabi Pharmacia Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabi Pharmacia Ab filed Critical Kabi Pharmacia Ab
Priority to SE9201956A priority Critical patent/SE9201956D0/xx
Publication of SE9201956D0 publication Critical patent/SE9201956D0/xx
Priority to AT93915075T priority patent/ATE209634T1/de
Priority to AU45193/93A priority patent/AU681346B2/en
Priority to RO94-02087A priority patent/RO115725B1/ro
Priority to PT93915075T priority patent/PT673368E/pt
Priority to SK1585-94A priority patent/SK279393B6/sk
Priority to PCT/SE1993/000565 priority patent/WO1994000434A1/en
Priority to JP50226894A priority patent/JP3306827B2/ja
Priority to DK93915075T priority patent/DK0673368T3/da
Priority to HU9403786A priority patent/HU220613B1/hu
Priority to EP93915075A priority patent/EP0673368B1/en
Priority to DE69331234T priority patent/DE69331234T2/de
Priority to KR1019940704643A priority patent/KR100302216B1/ko
Priority to CZ943274A priority patent/CZ281975B6/cs
Priority to ES93915075T priority patent/ES2169044T3/es
Priority to CA002139112A priority patent/CA2139112C/en
Priority to DE69333655T priority patent/DE69333655D1/de
Priority to EP01108668A priority patent/EP1120410B1/en
Priority to NZ253823A priority patent/NZ253823A/en
Priority to AT01108668T priority patent/ATE278671T1/de
Priority to US08/362,475 priority patent/US5658910A/en
Priority to RU94046310A priority patent/RU2127732C1/ru
Priority to IL10613593A priority patent/IL106135A/en
Priority to ZA934596A priority patent/ZA934596B/xx
Priority to CN93116250A priority patent/CN1085981C/zh
Priority to EE9400400A priority patent/EE03122B1/xx
Priority to BG99289A priority patent/BG62000B1/bg
Priority to FI946085A priority patent/FI107151B/fi
Priority to NO945022A priority patent/NO302945B1/no
Priority to HU95P/P00139P priority patent/HU210875A9/hu
Priority to PH4640898A priority patent/PH31417A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
SE9201956A 1992-06-25 1992-06-25 Novel nicotinicacid esters SE9201956D0 (sv)

Priority Applications (31)

Application Number Priority Date Filing Date Title
SE9201956A SE9201956D0 (sv) 1992-06-25 1992-06-25 Novel nicotinicacid esters
DE69333655T DE69333655D1 (de) 1992-06-25 1993-06-23 Nicotinsäureester mit Wirkung auf das Zentralnervensystem und mit 5-HT-Rezeptor-Affinität
ES93915075T ES2169044T3 (es) 1992-06-25 1993-06-23 Nuevos esteres de acido nicotinico.
CA002139112A CA2139112C (en) 1992-06-25 1993-06-23 Novel nicotinic acid esters
RO94-02087A RO115725B1 (ro) 1992-06-25 1993-06-23 Esteri ai acidului nicotinic, procedee de preparare, compozitie care ii contine, si metoda de tratament
PT93915075T PT673368E (pt) 1992-06-25 1993-06-23 Esteres novos do acido nicotinico
SK1585-94A SK279393B6 (sk) 1992-06-25 1993-06-23 Estery kyseliny bisfenylpiperazínnikotínovej, spôs
PCT/SE1993/000565 WO1994000434A1 (en) 1992-06-25 1993-06-23 Novel nicotinic acid esters
JP50226894A JP3306827B2 (ja) 1992-06-25 1993-06-23 新規ニコチン酸エステル
DK93915075T DK0673368T3 (da) 1992-06-25 1993-06-23 Hidtil ukendte nicotinsyreestere
HU9403786A HU220613B1 (hu) 1992-06-25 1993-06-23 Nikotinsav-észterek, eljárás előállításukra, e vegyületeket tartalmazó gyógyászati készítmények és új eljárás a nikotinsav-észterek intermedierjeinek előállítására
EP93915075A EP0673368B1 (en) 1992-06-25 1993-06-23 Novel nicotinic acid esters
DE69331234T DE69331234T2 (de) 1992-06-25 1993-06-23 Neue nicotinsäureester
KR1019940704643A KR100302216B1 (ko) 1992-06-25 1993-06-23 새로운니코틴산에스테르화합물및그제조방법
CZ943274A CZ281975B6 (cs) 1992-06-25 1993-06-23 Estery kyseliny nikotinové a způsob jejich přípravy
AT93915075T ATE209634T1 (de) 1992-06-25 1993-06-23 Neue nicotinsäureester
EP01108668A EP1120410B1 (en) 1992-06-25 1993-06-23 Nicotinic acid esters useful as CNS agents and having affinity for 5-HT receptors
RU94046310A RU2127732C1 (ru) 1992-06-25 1993-06-23 Эфиры бис-фенилпиперазинникотиновой кислоты, способ их получения (варианты), фармацевтическая композиция и способ лечения расстройств центральной нервной системы
AU45193/93A AU681346B2 (en) 1992-06-25 1993-06-23 Novel nicotinic acid esters
NZ253823A NZ253823A (en) 1992-06-25 1993-06-23 Nicotinic acid esters; compounds, preparation and pharmaceutical compositions; intermediate therefor
AT01108668T ATE278671T1 (de) 1992-06-25 1993-06-23 Nicotinsäureester mit wirkung auf das zentralnervensystem und mit 5-ht-rezeptor- affinität
US08/362,475 US5658910A (en) 1992-06-25 1993-06-23 Nicotinic acid esters
IL10613593A IL106135A (en) 1992-06-25 1993-06-24 Nicotinic acid esters and pharmaceutical compositions containing them
ZA934596A ZA934596B (en) 1992-06-25 1993-06-25 Nicotinicacid esters
CN93116250A CN1085981C (zh) 1992-06-25 1993-06-25 烟酸酯化合物及其盐,它们的制法及含有该化合物的药物组合物
EE9400400A EE03122B1 (et) 1992-06-25 1994-11-17 Nikotiinhappe estrid, nende valmistamismeetod ja farmatseutiline kompositsioon
BG99289A BG62000B1 (bg) 1992-06-25 1994-12-22 Нови естери на никотиновата киселина
FI946085A FI107151B (fi) 1992-06-25 1994-12-23 Menetelmä uusien terapeuttisesti käyttökelpoisten 2-[4-(4,4-bis(4-fluorifenyyli)butyyli)piperatsin-1-yyli]pyridin-3-yyli-karboksyyliestrereiden valmistamiseksi
NO945022A NO302945B1 (no) 1992-06-25 1994-12-23 Nikotinsyreestere
HU95P/P00139P HU210875A9 (en) 1992-06-25 1995-05-23 Nicotinicacid esters
PH4640898A PH31417A (en) 1992-06-25 1998-06-24 Nicotinic acid esters.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9201956A SE9201956D0 (sv) 1992-06-25 1992-06-25 Novel nicotinicacid esters

Publications (1)

Publication Number Publication Date
SE9201956D0 true SE9201956D0 (sv) 1992-06-25

Family

ID=20386602

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9201956A SE9201956D0 (sv) 1992-06-25 1992-06-25 Novel nicotinicacid esters

Country Status (27)

Country Link
US (1) US5658910A (xx)
EP (2) EP1120410B1 (xx)
JP (1) JP3306827B2 (xx)
KR (1) KR100302216B1 (xx)
CN (1) CN1085981C (xx)
AT (2) ATE209634T1 (xx)
AU (1) AU681346B2 (xx)
BG (1) BG62000B1 (xx)
CA (1) CA2139112C (xx)
CZ (1) CZ281975B6 (xx)
DE (2) DE69331234T2 (xx)
DK (1) DK0673368T3 (xx)
EE (1) EE03122B1 (xx)
ES (1) ES2169044T3 (xx)
FI (1) FI107151B (xx)
HU (2) HU220613B1 (xx)
IL (1) IL106135A (xx)
NO (1) NO302945B1 (xx)
NZ (1) NZ253823A (xx)
PH (1) PH31417A (xx)
PT (1) PT673368E (xx)
RO (1) RO115725B1 (xx)
RU (1) RU2127732C1 (xx)
SE (1) SE9201956D0 (xx)
SK (1) SK279393B6 (xx)
WO (1) WO1994000434A1 (xx)
ZA (1) ZA934596B (xx)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6632823B1 (en) * 1997-12-22 2003-10-14 Merck & Co., Inc. Substituted pyridine compounds useful as modulators of acetylcholine receptors
US7045519B2 (en) * 1998-06-19 2006-05-16 Chiron Corporation Inhibitors of glycogen synthase kinase 3
AU4956699A (en) 1998-06-19 2000-01-05 Chiron Corporation Inhibitors of glycogen synthase kinase 3
AU2019265268C1 (en) 2018-05-09 2022-08-04 Lg Chem, Ltd. Novel compound exhibiting enteropeptidase inhibitory activity

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8701375D0 (sv) * 1987-04-02 1987-04-02 Leo Ab Novel pyridyl- and pyrimidyl derivatives
SE9201239D0 (sv) * 1992-04-21 1992-04-21 Kabi Pharmacia Ab Agents for treating substance abuse disorders
SE9202265D0 (sv) * 1992-07-31 1992-07-31 Kabi Pharmacia Ab Novel- pyridyl and pyrimidylpiperazine derivatives

Also Published As

Publication number Publication date
EP0673368B1 (en) 2001-11-28
PH31417A (en) 1998-10-29
NO945022L (no) 1995-02-13
CA2139112C (en) 2006-03-21
HU9403786D0 (en) 1995-02-28
PT673368E (pt) 2002-05-31
JPH07508517A (ja) 1995-09-21
ZA934596B (en) 1994-02-14
HU220613B1 (hu) 2002-03-28
IL106135A (en) 1999-01-26
NO302945B1 (no) 1998-05-11
FI107151B (fi) 2001-06-15
HU210875A9 (en) 1995-08-28
EP1120410A1 (en) 2001-08-01
SK279393B6 (sk) 1998-11-04
CA2139112A1 (en) 1994-01-06
RO115725B1 (ro) 2000-05-30
FI946085A0 (fi) 1994-12-23
RU94046310A (ru) 1996-10-27
IL106135A0 (en) 1993-10-20
DE69331234T2 (de) 2002-08-08
DK0673368T3 (da) 2002-03-18
WO1994000434A1 (en) 1994-01-06
DE69331234D1 (de) 2002-01-10
EE03122B1 (et) 1998-10-15
NO945022D0 (no) 1994-12-23
KR100302216B1 (ko) 2001-11-22
BG99289A (bg) 1995-09-29
NZ253823A (en) 1996-01-26
EP0673368A1 (en) 1995-09-27
CZ327494A3 (en) 1995-09-13
HUT71406A (en) 1995-11-28
BG62000B1 (bg) 1998-12-30
JP3306827B2 (ja) 2002-07-24
FI946085L (fi) 1994-12-23
AU4519393A (en) 1994-01-24
DE69333655D1 (de) 2004-11-11
KR950702186A (ko) 1995-06-19
ATE209634T1 (de) 2001-12-15
ATE278671T1 (de) 2004-10-15
AU681346B2 (en) 1997-08-28
RU2127732C1 (ru) 1999-03-20
CN1086811A (zh) 1994-05-18
SK158594A3 (en) 1995-07-11
EP1120410B1 (en) 2004-10-06
CZ281975B6 (cs) 1997-04-16
US5658910A (en) 1997-08-19
ES2169044T3 (es) 2002-07-01
CN1085981C (zh) 2002-06-05

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