SE8001338L - "monacolin k"-framstellning - Google Patents

"monacolin k"-framstellning

Info

Publication number: SE8001338L
Authority: SE; Sweden
Prior art keywords: sank; monascus; ferm; monacolin; ifo
Prior art date: 1979-05-11

Application number

SE8001338A

Other languages

English (en)

Other versions

SE467975B (sv

Inventor

K Tanzawa

S Iwado

Y Tsujita

M Kuroda

K Furuya

Original Assignee

Sankyo Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-05-11

Filing date

1980-02-20

Publication date

1980-11-12

1980-02-20 Application filed by Sankyo Co filed Critical Sankyo Co

1980-11-12 Publication of SE8001338L publication Critical patent/SE8001338L/sv

1992-10-12 Publication of SE467975B publication Critical patent/SE467975B/sv

Classifications

- A—HUMAN NECESSITIES
- A22—BUTCHERING; MEAT TREATMENT; PROCESSING POULTRY OR FISH
- A22C—PROCESSING MEAT, POULTRY, OR FISH
- A22C25/00—Processing fish ; Curing of fish; Stunning of fish by electric current; Investigating fish by optical means
- A22C25/16—Removing fish-bones; Filleting fish
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Microbiology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Obesity (AREA)
Diabetes (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Hematology (AREA)
Food Science & Technology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Plant Substances (AREA)

SE8001338A 1979-05-11 1980-02-20 Framstaellning av monakolin k SE467975B (sv)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP5792779A JPS55150898A (en)	1979-05-11	1979-05-11	Preparation of a new physiologically active substance mb-530b
KR1019800001707A KR830002329B1 (ko)	1979-05-11	1980-04-29	모나콜린 k의 제조방법

Publications (2)

Publication Number	Publication Date
SE8001338L true SE8001338L (sv)	1980-11-12
SE467975B SE467975B (sv)	1992-10-12

Family

ID=26399012

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
SE8001338A SE467975B (sv)	1979-05-11	1980-02-20	Framstaellning av monakolin k
SE8701483A SE468482B (sv)	1979-05-11	1987-04-09	Framstaellning av monakolin k

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
SE8701483A SE468482B (sv)	1979-05-11	1987-04-09	Framstaellning av monakolin k

Country Status (17)

Country	Link
US (1)	US4323648A (sv)
JP (1)	JPS55150898A (sv)
KR (1)	KR830002329B1 (sv)
AT (1)	AT372975B (sv)
AU (1)	AU534647B2 (sv)
BE (1)	BE882325A (sv)
CA (1)	CA1129795A (sv)
CH (1)	CH645891A5 (sv)
DE (2)	DE3006215A1 (sv)
DK (1)	DK148807C (sv)
ES (1)	ES8104409A1 (sv)
FR (1)	FR2456141A1 (sv)
GB (1)	GB2049664B (sv)
IE (1)	IE49749B1 (sv)
IT (1)	IT1133075B (sv)
NL (1)	NL8001697A (sv)
SE (2)	SE467975B (sv)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5925599B2 (ja) *	1979-02-20	1984-06-19	三共株式会社	新生理活性物質モナコリンｋおよびその製造法
ES8105781A1 (es) *	1979-07-27	1981-06-16	Sankyo Co	Un procedimiento para la preparacion de sales y esteres, de monacolina k utiles como agentes antitlipercolesteremicos.
US4444784A (en) *	1980-08-05	1984-04-24	Merck & Co., Inc.	Antihypercholesterolemic compounds
US4351844A (en) *	1980-02-04	1982-09-28	Merck & Co., Inc.	Hypocholesterolemic hydrogenation products and process of preparation
JPS56142236A (en)	1980-04-08	1981-11-06	Sankyo Co Ltd	Ml-236a and mb-530a derivative
DK149080C (da) *	1980-06-06	1986-07-28	Sankyo Co	Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre
US4343814A (en) *	1980-11-17	1982-08-10	Merck & Co., Inc.	Hypocholesterolemic fermentation products
JPS5835144A (ja) *	1981-08-27	1983-03-01	Sankyo Co Ltd	Ｍｂ−５３０ｂ誘導体およびその製造法
JPS5855443A (ja) *	1981-09-25	1983-04-01	Sankyo Co Ltd	オクタヒドロナフタリン誘導体およびその製造法
US4678806A (en) *	1986-09-02	1987-07-07	Merck & Co., Inc.	Prodrugs of antihypercholesterolemic compounds
US4865977A (en) *	1987-03-13	1989-09-12	Shell Oil Company	Increasing monascus pigment production
DE3801588A1 (de) *	1988-01-21	1989-08-10	Hoechst Ag	Verfahren zur herstellung von farbstoffen und/oder wirkstoffen in der wasserarmen, sterilen wirbelschicht
KR960004032B1 (ko) *	1992-10-26	1996-03-25	롯데제과주식회사	신균주 모나스커스 앵카 732y3(kccm10014)
HU210867B (en) *	1992-11-04	1995-10-30	Biogal Gyogyszergyar	Method for extraction and purification of mevinolin from culture medium
BG61613B1 (bg) *	1994-06-24	1998-01-30	Анна Куюмджиева	Щам моnаsсus рurрurеus-продуцент на пигмент и биоактивни продукти
US7238348B2 (en)	1996-09-30	2007-07-03	Beijing Peking University Wbl Corporation Ltd.	Method of treatment of osteoporosis with compositions of red rice fermentation products
US6046022A (en)	1996-09-30	2000-04-04	Peking University	Methods and compositions employing red rice fermentation products
US6258361B1 (en)	1996-10-21	2001-07-10	Akio Yoshihara	Agent for recovering hematopoietic function and processed food both containing treated product of peanut seed coats
US6391583B1 (en)	1998-12-18	2002-05-21	Wisconsin Alumni Research Foundation	Method of producing antihypercholesterolemic agents
WO2002085398A1 (en) *	2001-04-19	2002-10-31	Taipei-Veterans General Hospital	Lithospermic acid-containing composition
US20030086987A1 (en) *	2001-08-30	2003-05-08	Ming-Shi Shiao	Salvianolic acid B
KR100379075B1 (en) *	2002-03-07	2003-04-08	Jinis Biopharmaceuticals Co	Method for producing low cholesterol animal food product and food product therefrom
TWI262949B (en) *	2002-08-15	2006-10-01	Food Industry Res & Dev Inst	Monascus purpureus mutants and their use in preparing fermentation products having hypotensive activity
DE102004062386B4 (de) *	2003-12-24	2010-06-24	Food Industry Research And Development Institute	Monacolin K-Biosynthese-Gene
KR100710500B1 (ko) *	2005-05-18	2007-04-24	고려대학교 산학협력단	홍국균을 이용한 모나콜린 ｋ 생산방법
US20120171311A1 (en) *	2007-06-01	2012-07-05	Opheim Joar A	Substances for reducing occurrence of major cardiac events comprising epa or derivatives thereof, optionally, dha or derivatives thereof and monacolin k
US20120172425A1 (en) *	2007-06-01	2012-07-05	Opheim Joar A	Red yeast rice extract high in monacolin k content
US20120171285A1 (en) *	2007-06-01	2012-07-05	Opheim Joar A	Substances for reducing occurrence of major cardiac events comprising omega-3 polyunsaturated fatty acid or derivatives thereof and high-monacolin k content red yeast rice extract
US20100119600A1 (en)	2007-06-01	2010-05-13	Joar Opheim	Substances for reducing occurrence of major cardiac events comprising red yeast rice extract and omega-3 polyunsaturated fatty acid or derivative thereof
CN101317660B (zh) *	2008-06-23	2012-10-24	谢键泓	一种提高红曲洛伐他汀在水中溶解度的方法及应用
US9078849B2 (en)	2009-04-08	2015-07-14	Nanyang Polytechnic	Plant extract comprising statins and preparation techniques and uses thereof
CN116083252B (zh) *	2023-04-12	2023-06-27	北京一品堂医药科技有限公司	一种高产降脂天然莫拉可林k的红曲米发酵制备方法
CN116925926B (zh) *	2023-07-14	2024-02-02	中国农业大学	富硒红色红曲霉发酵生产洛伐他汀的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5612114B2 (sv) *	1974-06-07	1981-03-18
JPS5925599B2 (ja) *	1979-02-20	1984-06-19	三共株式会社	新生理活性物質モナコリンｋおよびその製造法
AU535944B2 (en) *	1979-06-15	1984-04-12	Merck & Co., Inc.	Hypocholestermic fermentation products from aspergillus

1979
- 1979-05-11 JP JP5792779A patent/JPS55150898A/ja active Pending
1980
- 1980-02-20 DK DK73180A patent/DK148807C/da not_active IP Right Cessation
- 1980-02-20 CH CH136780A patent/CH645891A5/de not_active IP Right Cessation
- 1980-02-20 DE DE19803006215 patent/DE3006215A1/de active Granted
- 1980-02-20 DE DE3051097A patent/DE3051097C2/de not_active Expired - Lifetime
- 1980-02-20 SE SE8001338A patent/SE467975B/sv not_active IP Right Cessation
- 1980-03-04 GB GB8007240A patent/GB2049664B/en not_active Expired
- 1980-03-19 AT AT0148280A patent/AT372975B/de not_active IP Right Cessation
- 1980-03-19 BE BE0/199871A patent/BE882325A/fr not_active IP Right Cessation
- 1980-03-20 ES ES80489751A patent/ES8104409A1/es not_active Expired
- 1980-03-20 IE IE577/80A patent/IE49749B1/en not_active IP Right Cessation
- 1980-03-20 FR FR8006203A patent/FR2456141A1/fr active Granted
- 1980-03-20 CA CA348,220A patent/CA1129795A/en not_active Expired
- 1980-03-21 IT IT67445/80A patent/IT1133075B/it active
- 1980-03-21 NL NL8001697A patent/NL8001697A/nl not_active Application Discontinuation
- 1980-03-21 AU AU56678/80A patent/AU534647B2/en not_active Expired
- 1980-04-04 US US06/137,821 patent/US4323648A/en not_active Expired - Lifetime
- 1980-04-29 KR KR1019800001707A patent/KR830002329B1/ko active
1987
- 1987-04-09 SE SE8701483A patent/SE468482B/sv not_active IP Right Cessation

Also Published As

Publication number	Publication date
SE8701483L (sv)	1987-04-09
SE8701483D0 (sv)	1987-04-09
GB2049664A (en)	1980-12-31
DE3051097C2 (sv)	1990-02-08
DE3006215C2 (sv)	1989-01-05
US4323648A (en)	1982-04-06
ATA148280A (de)	1983-04-15
AU534647B2 (en)	1984-02-09
KR830002875A (ko)	1983-05-31
KR830002329B1 (ko)	1983-10-22
CH645891A5 (de)	1984-10-31
DK148807B (da)	1985-10-07
FR2456141B1 (sv)	1983-11-18
NL8001697A (nl)	1980-11-13
DK73180A (da)	1980-11-12
SE467975B (sv)	1992-10-12
CA1129795A (en)	1982-08-17
IT1133075B (it)	1986-07-09
IE49749B1 (en)	1985-12-11
GB2049664B (en)	1983-01-12
JPS55150898A (en)	1980-11-25
AU5667880A (en)	1980-11-13
BE882325A (fr)	1980-09-19
ES489751A0 (es)	1981-04-16
IT8067445A0 (it)	1980-03-21
IE800577L (en)	1980-11-11
DK148807C (da)	1986-04-28
DE3006215A1 (de)	1980-11-27
AT372975B (de)	1983-12-12
SE468482B (sv)	1993-01-25
FR2456141A1 (fr)	1980-12-05
ES8104409A1 (es)	1981-04-16

Publication	Publication Date	Title
SE8001338L (sv)	1980-11-12	"monacolin k"-framstellning
ES2103516T3 (es)	1997-09-16	Procedimiento para reticular.
CA2066561A1 (en)	1992-02-10	Methods for rapid microbial detection
ES8103171A1 (es)	1981-02-16	Un procedimiento de preparacion de monacolina k.
AU541097B2 (en)	1984-12-13	Novel derivatives of c-076 compounds
LU90379I2 (fr)	1999-05-31	Tetravac
ATE63338T1 (de)	1991-05-15	Verfahren zur herstellung von 6hydroxynikotins\|ure.
AU3834789A (en)	1990-01-05	Process for the preparation of gamma and delta lactones
ATE5726T1 (de)	1984-01-15	Verfahren zur herstellung von antibiotikum c15003 p3.
SE7509571L (sv)	1976-03-01	Sett att framstella nya rifamyciner identifierade som rifamycin p, rifamycin q, rifamycin r och rifamycin u
UA27128C2 (uk)	2000-02-28	Спосіб затримки росту бактерій в середовищах спиртової фермеhтації
ES8302097A1 (es)	1983-01-01	Un metodo para producir enduracidina
AU542720B2 (en)	1985-03-07	2,9-dioxatricyclo(4,3,1,0,3,7)decanes
KR850003165A (ko)	1985-06-13	항생물질 착화물
KR910014398A (ko)	1991-08-31	항생제 데옥시물룬도칸딘, 이의 제조방법 및 약제로서의 이의 용도
ES475179A1 (es)	1979-05-16	Un metodo mejorado para producir antibiotico c-15003 p-4.
KR890014457A (ko)	1989-10-23	신규 아족시 화합물 및 그의 제조방법
KR920009986A (ko)	1992-06-26	다이네마이신 c 항종양 항생제
JPS56151494A (en)	1981-11-24	Isolation of polyamine
KR840007437A (ko)	1984-12-07	항생제 a 51568 인자 a 및 b의 제조방법
GB1382329A (en)	1975-01-29	Method of cultivating microorganisms
JPS56121495A (en)	1981-09-24	Preparation of benzodiazepine derivative
KR910014509A (ko)	1991-08-31	항생성 알리사마이신, 이의 제조방법 및 용도
DE59108700D1 (de)	1997-06-12	Verfahren zur herstellung von 17-oxosteroiden
DK0794193T3 (da)	2000-12-04	Substans MK7634, fremgangsmåde til fremstilling heraf samt anthelmintisk middel indeholdende denne substans

Legal Events

Date	Code	Title	Description
1995-01-31	NAL	Patent in force	Ref document number: 8001338-6 Format of ref document f/p: F
2000-05-02	NUG	Patent has lapsed	Ref document number: 8001338-6 Format of ref document f/p: F

Date

Code

Title

Description

1995-01-31

NAL

Patent in force

Ref document number: 8001338-6

Format of ref document f/p: F

2000-05-02

NUG

Patent has lapsed