IT8067445A0 - Procedimento per la preparazione della monacolina k. - Google Patents

Procedimento per la preparazione della monacolina k.

Info

Publication number: IT8067445A0
Authority: IT; Italy
Prior art keywords: monacolina; procedure; preparation
Prior art date: 1979-05-11

Application number

IT8067445A

Other languages

English (en)

Other versions

IT1133075B (it

Inventor

Kazuhiko Tanzawa Seigo Iwado

Yoshio Tsujita Masao Kuroda

Kouhei Furuya

Original Assignee

Sankyo Co

Giappone

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-05-11

Filing date

1980-03-21

Publication date

1980-03-21

1980-03-21 Application filed by Sankyo Co, Giappone filed Critical Sankyo Co

1980-03-21 Publication of IT8067445A0 publication Critical patent/IT8067445A0/it

1986-07-09 Application granted granted Critical

1986-07-09 Publication of IT1133075B publication Critical patent/IT1133075B/it

Classifications

- A—HUMAN NECESSITIES
- A22—BUTCHERING; MEAT TREATMENT; PROCESSING POULTRY OR FISH
- A22C—PROCESSING MEAT, POULTRY, OR FISH
- A22C25/00—Processing fish ; Curing of fish; Stunning of fish by electric current; Investigating fish by optical means
- A22C25/16—Removing fish-bones; Filleting fish
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Obesity (AREA)
Hematology (AREA)
Diabetes (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Food Science & Technology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Plant Substances (AREA)

IT67445/80A 1979-05-11 1980-03-21 Procedimento per la preparazione della monacolina k IT1133075B (it)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP5792779A JPS55150898A (en)	1979-05-11	1979-05-11	Preparation of a new physiologically active substance mb-530b
KR1019800001707A KR830002329B1 (ko)	1979-05-11	1980-04-29	모나콜린 k의 제조방법

Publications (2)

Publication Number	Publication Date
IT8067445A0 true IT8067445A0 (it)	1980-03-21
IT1133075B IT1133075B (it)	1986-07-09

Family

ID=26399012

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT67445/80A IT1133075B (it)	1979-05-11	1980-03-21	Procedimento per la preparazione della monacolina k

Country Status (17)

Country	Link
US (1)	US4323648A (it)
JP (1)	JPS55150898A (it)
KR (1)	KR830002329B1 (it)
AT (1)	AT372975B (it)
AU (1)	AU534647B2 (it)
BE (1)	BE882325A (it)
CA (1)	CA1129795A (it)
CH (1)	CH645891A5 (it)
DE (2)	DE3051097C2 (it)
DK (1)	DK148807C (it)
ES (1)	ES489751A0 (it)
FR (1)	FR2456141A1 (it)
GB (1)	GB2049664B (it)
IE (1)	IE49749B1 (it)
IT (1)	IT1133075B (it)
NL (1)	NL8001697A (it)
SE (2)	SE467975B (it)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5925599B2 (ja) *	1979-02-20	1984-06-19	三共株式会社	新生理活性物質モナコリンｋおよびその製造法
ES493726A0 (es) *	1979-07-27	1981-06-16	Sankyo Co	Un procedimiento para la preparacion de sales y esteres, de monacolina k utiles como agentes antitlipercolesteremicos.
US4444784A (en) *	1980-08-05	1984-04-24	Merck & Co., Inc.	Antihypercholesterolemic compounds
US4351844A (en) *	1980-02-04	1982-09-28	Merck & Co., Inc.	Hypocholesterolemic hydrogenation products and process of preparation
JPS56142236A (en)	1980-04-08	1981-11-06	Sankyo Co Ltd	Ml-236a and mb-530a derivative
DK149080C (da) *	1980-06-06	1986-07-28	Sankyo Co	Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre
US4343814A (en) *	1980-11-17	1982-08-10	Merck & Co., Inc.	Hypocholesterolemic fermentation products
JPS5835144A (ja) *	1981-08-27	1983-03-01	Sankyo Co Ltd	Ｍｂ−５３０ｂ誘導体およびその製造法
JPS5855443A (ja) *	1981-09-25	1983-04-01	Sankyo Co Ltd	オクタヒドロナフタリン誘導体およびその製造法
US4678806A (en) *	1986-09-02	1987-07-07	Merck & Co., Inc.	Prodrugs of antihypercholesterolemic compounds
US4865977A (en) *	1987-03-13	1989-09-12	Shell Oil Company	Increasing monascus pigment production
DE3801588A1 (de) *	1988-01-21	1989-08-10	Hoechst Ag	Verfahren zur herstellung von farbstoffen und/oder wirkstoffen in der wasserarmen, sterilen wirbelschicht
KR960004032B1 (ko) *	1992-10-26	1996-03-25	롯데제과주식회사	신균주 모나스커스 앵카 732y3(kccm10014)
HU210867B (en) *	1992-11-04	1995-10-30	Biogal Gyogyszergyar	Method for extraction and purification of mevinolin from culture medium
BG61613B1 (bg) *	1994-06-24	1998-01-30	Анна Куюмджиева	Щам моnаsсus рurрurеus-продуцент на пигмент и биоактивни продукти
US6046022A (en) *	1996-09-30	2000-04-04	Peking University	Methods and compositions employing red rice fermentation products
US7238348B2 (en)	1996-09-30	2007-07-03	Beijing Peking University Wbl Corporation Ltd.	Method of treatment of osteoporosis with compositions of red rice fermentation products
US6258361B1 (en)	1996-10-21	2001-07-10	Akio Yoshihara	Agent for recovering hematopoietic function and processed food both containing treated product of peanut seed coats
US6391583B1 (en)	1998-12-18	2002-05-21	Wisconsin Alumni Research Foundation	Method of producing antihypercholesterolemic agents
WO2002085398A1 (en) *	2001-04-19	2002-10-31	Taipei-Veterans General Hospital	Lithospermic acid-containing composition
AU2002329931A1 (en) *	2001-08-30	2003-03-18	Taipei-Veterans General Hospital	Salvianolic acid b
KR100379075B1 (en) *	2002-03-07	2003-04-08	Jinis Biopharmaceuticals Co	Method for producing low cholesterol animal food product and food product therefrom
TWI262949B (en) *	2002-08-15	2006-10-01	Food Industry Res & Dev Inst	Monascus purpureus mutants and their use in preparing fermentation products having hypotensive activity
US7482157B2 (en) *	2003-12-24	2009-01-27	Food Industry Research & Development Institute	Monacolin K biosynthesis genes
KR100710500B1 (ko) *	2005-05-18	2007-04-24	고려대학교 산학협력단	홍국균을 이용한 모나콜린 ｋ 생산방법
US20100119600A1 (en) *	2007-06-01	2010-05-13	Joar Opheim	Substances for reducing occurrence of major cardiac events comprising red yeast rice extract and omega-3 polyunsaturated fatty acid or derivative thereof
US20120171285A1 (en) *	2007-06-01	2012-07-05	Opheim Joar A	Substances for reducing occurrence of major cardiac events comprising omega-3 polyunsaturated fatty acid or derivatives thereof and high-monacolin k content red yeast rice extract
US20120172425A1 (en) *	2007-06-01	2012-07-05	Opheim Joar A	Red yeast rice extract high in monacolin k content
US20120171311A1 (en) *	2007-06-01	2012-07-05	Opheim Joar A	Substances for reducing occurrence of major cardiac events comprising epa or derivatives thereof, optionally, dha or derivatives thereof and monacolin k
CN101317660B (zh) *	2008-06-23	2012-10-24	谢键泓	一种提高红曲洛伐他汀在水中溶解度的方法及应用
WO2010117342A1 (en) *	2009-04-08	2010-10-14	Nanyang Polytechnic	A plant extract comprising statins and preparation techniques and uses thereof
CN116083252B (zh) *	2023-04-12	2023-06-27	北京一品堂医药科技有限公司	一种高产降脂天然莫拉可林k的红曲米发酵制备方法
CN116925926B (zh) *	2023-07-14	2024-02-02	中国农业大学	富硒红色红曲霉发酵生产洛伐他汀的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5612114B2 (it) *	1974-06-07	1981-03-18
JPS5925599B2 (ja) *	1979-02-20	1984-06-19	三共株式会社	新生理活性物質モナコリンｋおよびその製造法
IL60219A (en) *	1979-06-15	1985-05-31	Merck & Co Inc	Hypocholesteremic fermentation products of the hmg-coa reductase inhibitor type,their preparation and pharmaceutical compositions containing them

1979
- 1979-05-11 JP JP5792779A patent/JPS55150898A/ja active Pending
1980
- 1980-02-20 DE DE3051097A patent/DE3051097C2/de not_active Expired - Lifetime
- 1980-02-20 DE DE19803006215 patent/DE3006215A1/de active Granted
- 1980-02-20 DK DK73180A patent/DK148807C/da not_active IP Right Cessation
- 1980-02-20 SE SE8001338A patent/SE467975B/sv not_active IP Right Cessation
- 1980-02-20 CH CH136780A patent/CH645891A5/de not_active IP Right Cessation
- 1980-03-04 GB GB8007240A patent/GB2049664B/en not_active Expired
- 1980-03-19 BE BE0/199871A patent/BE882325A/fr not_active IP Right Cessation
- 1980-03-19 AT AT0148280A patent/AT372975B/de not_active IP Right Cessation
- 1980-03-20 FR FR8006203A patent/FR2456141A1/fr active Granted
- 1980-03-20 IE IE577/80A patent/IE49749B1/en not_active IP Right Cessation
- 1980-03-20 CA CA348,220A patent/CA1129795A/en not_active Expired
- 1980-03-20 ES ES489751A patent/ES489751A0/es active Granted
- 1980-03-21 IT IT67445/80A patent/IT1133075B/it active
- 1980-03-21 AU AU56678/80A patent/AU534647B2/en not_active Expired
- 1980-03-21 NL NL8001697A patent/NL8001697A/nl not_active Application Discontinuation
- 1980-04-04 US US06/137,821 patent/US4323648A/en not_active Expired - Lifetime
- 1980-04-29 KR KR1019800001707A patent/KR830002329B1/ko active
1987
- 1987-04-09 SE SE8701483A patent/SE468482B/sv not_active IP Right Cessation

Also Published As

Publication number	Publication date
FR2456141B1 (it)	1983-11-18
AU534647B2 (en)	1984-02-09
AU5667880A (en)	1980-11-13
DE3006215A1 (de)	1980-11-27
JPS55150898A (en)	1980-11-25
DE3051097C2 (it)	1990-02-08
IE49749B1 (en)	1985-12-11
FR2456141A1 (fr)	1980-12-05
CH645891A5 (de)	1984-10-31
US4323648A (en)	1982-04-06
GB2049664A (en)	1980-12-31
SE8701483L (sv)	1987-04-09
KR830002875A (ko)	1983-05-31
KR830002329B1 (ko)	1983-10-22
DK148807B (da)	1985-10-07
NL8001697A (nl)	1980-11-13
SE468482B (sv)	1993-01-25
AT372975B (de)	1983-12-12
SE467975B (sv)	1992-10-12
GB2049664B (en)	1983-01-12
DK73180A (da)	1980-11-12
ES8104409A1 (es)	1981-04-16
DE3006215C2 (it)	1989-01-05
BE882325A (fr)	1980-09-19
SE8701483D0 (sv)	1987-04-09
ES489751A0 (es)	1981-04-16
SE8001338L (sv)	1980-11-12
IT1133075B (it)	1986-07-09
CA1129795A (en)	1982-08-17
DK148807C (da)	1986-04-28
ATA148280A (de)	1983-04-15
IE800577L (en)	1980-11-11

Publication	Publication Date	Title
IT8067445A0 (it)	1980-03-21	Procedimento per la preparazione della monacolina k.
ES498071A0 (es)	1981-12-01	Procedimiento para la preparacion de 2-acilaminometil-1h-2,3-dihidro-1,4-benzodiazepinas
IT1116742B (it)	1986-02-10	Procedimento per la preparazione di bis-immidi aromatiche
IT1084165B (it)	1985-05-25	Procedimento per la preparazione di resorcinolo
IT8019504A0 (it)	1980-01-28	Procedimento per la preparazione selettiva di isosorbite-5-nitrato.
IT1096156B (it)	1985-08-17	Procedimento per la preparazione di 1-azolil-3,3-dimetil-1-fenoss-butan-2-oni
RO77485A (ro)	1981-11-04	Procedeu pentru prepararea 1,2,3-tiadiazol-3-in-5-ilidenureelor
IT7829060A0 (it)	1978-10-24	Procedimento per la prepoarazione di alogeno-vinil-delta-butirrolattoni.
ES491139A0 (es)	1981-04-16	Procedimiento para la preparacion de 2-amino-4-halogeno-5- formil-tiazoleno.
IT7827487A0 (it)	1978-09-08	Alogeno-vinil-sostituiti. procedimento per la preparazione di tetraidrofuran-2-oni
IT7826596A0 (it)	1978-08-08	Procedimento per la preparazione di funanoni.
IT8083454A0 (it)	1980-10-23	Harzburgite e procedimento per lapreparazione della stessa.
IT8020873A0 (it)	1980-03-24	Procedimento per la preparazione di solfossidi di penicellina.
IT7820858A0 (it)	1978-03-03	Procedimento per la preparazione di tiofenoli.
IT1133021B (it)	1986-07-09	Procedimento per la preparazione di trialcossisilanoli
IT1094983B (it)	1985-08-10	Procedimento per la preparazione di 3,5 di alogeno-aniline
ES508579A0 (es)	1983-06-01	Procedimiento para la preparacion de alfa-hidroxiacidos.
IT8021231A0 (it)	1980-04-04	Procedimento per la preparazione di 2-amminopirazine sostituite.
IT7825311A0 (it)	1978-07-04	Procedimento per la preparazione di cloro-s-triazina trioni.
NO153570C (no)	1986-05-21	Fremgangsmaate for fremstilling av 2-isopropylaminopyrimidin.
IT1140964B (it)	1986-10-10	Procedimento per la preparazione di n-dialchilamminometil-s, s-diarilsul fossimidi
IT7827257A0 (it)	1978-09-01	Procedimento per la preparazione di 7-idrossisteroidi.
IT7820981A0 (it)	1978-03-07	Procedimento per la preparazione di dialogenovinil-y-butirrolattoni.
IT7828656A0 (it)	1978-10-11	Procedimento per la preparazione di bis-triazolil-stilbeni.
IT8025422A0 (it)	1980-10-17	Procedimento per la preparazione della citidin-difosfocolina.

Legal Events

Date	Code	Title	Description
1999-10-27	TA	Fee payment date (situation as of event date), data collected since 19931001	Effective date: 19970329