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KR830002875A - 모나콜린 k의 제조방법 - Google Patents

모나콜린 k의 제조방법 Download PDF

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Publication number
KR830002875A
KR830002875A KR1019800001707A KR800001707A KR830002875A KR 830002875 A KR830002875 A KR 830002875A KR 1019800001707 A KR1019800001707 A KR 1019800001707A KR 800001707 A KR800001707 A KR 800001707A KR 830002875 A KR830002875 A KR 830002875A
Authority
KR
South Korea
Prior art keywords
monascus
sank
ferm
rubber
ifo
Prior art date
Application number
KR1019800001707A
Other languages
English (en)
Other versions
KR830002329B1 (ko
Inventor
가즈히꼬 단자와
요시오 쓰지따
마사오 구로다
고오헤이 후루야
세이고 이와도
Original Assignee
가와무라 요시부미
상꾜 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP5792779A priority Critical patent/JPS55150898A/ja
Priority to SE8001338A priority patent/SE467975B/sv
Priority to DK73180A priority patent/DK148807C/da
Priority to CH136780A priority patent/CH645891A5/de
Priority to DE19803006215 priority patent/DE3006215A1/de
Priority to DE3051097A priority patent/DE3051097C2/de
Priority to GB8007240A priority patent/GB2049664B/en
Priority to BE0/199871A priority patent/BE882325A/fr
Priority to AT0148280A priority patent/AT372975B/de
Priority to IE577/80A priority patent/IE49749B1/en
Priority to FR8006203A priority patent/FR2456141A1/fr
Priority to ES489751A priority patent/ES489751A0/es
Priority to CA348,220A priority patent/CA1129795A/en
Priority to IT67445/80A priority patent/IT1133075B/it
Priority to AU56678/80A priority patent/AU534647B2/en
Priority to NL8001697A priority patent/NL8001697A/nl
Priority to US06/137,821 priority patent/US4323648A/en
Application filed by 가와무라 요시부미, 상꾜 가부시끼가이샤 filed Critical 가와무라 요시부미
Priority to KR1019800001707A priority patent/KR830002329B1/ko
Publication of KR830002875A publication Critical patent/KR830002875A/ko
Application granted granted Critical
Publication of KR830002329B1 publication Critical patent/KR830002329B1/ko
Priority to SE8701483A priority patent/SE468482B/sv

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Classifications

    • A—HUMAN NECESSITIES
    • A22—BUTCHERING; MEAT TREATMENT; PROCESSING POULTRY OR FISH
    • A22C—PROCESSING MEAT, POULTRY, OR FISH
    • A22C25/00—Processing fish ; Curing of fish; Stunning of fish by electric current; Investigating fish by optical means
    • A22C25/16—Removing fish-bones; Filleting fish
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Food Science & Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

내용 없음

Description

모나콜린 K의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 모나스쿠스 앙카(Monascus anka) SANK 10171(IFO 6540), 모나스쿠스 파아푸르스(Monascus purpureus) SANK 10271(IFO 4513), 모나스쿠스 러버(Monascus rubber) SANK 10671(FERM 4958), 모나스쿠스 비트류우스(Monascus vitreus) SANK 10960(FERM 4960), 모나스쿠스 팍시이(Monascus paxii) SANK 11172(IFO 8201), 모나스쿠스 러버 SANK 13778(FERM 4959), 모나스쿠스 러버 SANK 15177(FERM 4956) 또는 모나스쿠스 러버 SANK 18174(FERM 4957) 등의 모나스쿠스 속균 중에서 선택되는 하나 이상의 모나스쿠스 균주를 배양하여 배지로부터 모나콜린 K를 분리시키는 것을 특징으로 하는 모나콜린 K의 제조 방법.
  2. 상기 배양을 7내지 40℃의 온도 범위하에 수행함을 특징으로 하는 특허청구의 범위 제1항 기재의 방법.
  3. 상기 배양을 20내지 30℃의 온도 범위하에 수행함을 특징으로 하는 특허청구의 범위 제1항 기재의 방법.
  4. 모나스쿠스 속균이 모나스쿠스 러버 SANK 15177균주이고, 23내지 30℃의 온도 범위하에서 배양을 수행함을 특징으로 하는 특허청구의 범위 제1항 기재의 방법.
  5. 모나스쿠스 균주가 모나스쿠스 러버 SANK 10671(FERM 4958), 모나스쿠스 러버 SANK 13778(FERM 4959), 모나스쿠스 러버 SANK 15177(FERM 4956) 또는 모나스쿠스 러버 SANK 18174(FERM 4957) 중에서 선택됨을 특징으로 하는 모나스쿠스 속균의 순수한 생물학적 배양액.
  6. ※참고사항:최초출원 내용에 의하여 공개하는 것임.
KR1019800001707A 1979-05-11 1980-04-29 모나콜린 k의 제조방법 KR830002329B1 (ko)

Priority Applications (19)

Application Number Priority Date Filing Date Title
JP5792779A JPS55150898A (en) 1979-05-11 1979-05-11 Preparation of a new physiologically active substance mb-530b
DK73180A DK148807C (da) 1979-05-11 1980-02-20 Fremgangsmaade til fremstilling af monacolin k
CH136780A CH645891A5 (de) 1979-05-11 1980-02-20 Verfahren zur herstellung von monacolin k.
DE19803006215 DE3006215A1 (de) 1979-05-11 1980-02-20 Verfahren zur herstellung von monacolin k
DE3051097A DE3051097C2 (ko) 1979-05-11 1980-02-20
SE8001338A SE467975B (sv) 1979-05-11 1980-02-20 Framstaellning av monakolin k
GB8007240A GB2049664B (en) 1979-05-11 1980-03-04 Preparation of monacolin k
AT0148280A AT372975B (de) 1979-05-11 1980-03-19 Verfahren zum herstellen von monacolin k
BE0/199871A BE882325A (fr) 1979-05-11 1980-03-19 Procede de preparation de la monacoline k.
ES489751A ES489751A0 (es) 1979-05-11 1980-03-20 Un procedimiento para la preparacion de monacolina k
CA348,220A CA1129795A (en) 1979-05-11 1980-03-20 Preparation of monacolin k
FR8006203A FR2456141A1 (fr) 1979-05-11 1980-03-20 Procede de preparation de la monacoline k
IE577/80A IE49749B1 (en) 1979-05-11 1980-03-20 Preparation of monacolin k
AU56678/80A AU534647B2 (en) 1979-05-11 1980-03-21 Monacolin k
IT67445/80A IT1133075B (it) 1979-05-11 1980-03-21 Procedimento per la preparazione della monacolina k
NL8001697A NL8001697A (nl) 1979-05-11 1980-03-21 Werkwijze voor de bereiding van manocolin k.
US06/137,821 US4323648A (en) 1979-05-11 1980-04-04 Preparation of Monacolin K
KR1019800001707A KR830002329B1 (ko) 1979-05-11 1980-04-29 모나콜린 k의 제조방법
SE8701483A SE468482B (sv) 1979-05-11 1987-04-09 Framstaellning av monakolin k

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP5792779A JPS55150898A (en) 1979-05-11 1979-05-11 Preparation of a new physiologically active substance mb-530b
KR1019800001707A KR830002329B1 (ko) 1979-05-11 1980-04-29 모나콜린 k의 제조방법

Publications (2)

Publication Number Publication Date
KR830002875A true KR830002875A (ko) 1983-05-31
KR830002329B1 KR830002329B1 (ko) 1983-10-22

Family

ID=26399012

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019800001707A KR830002329B1 (ko) 1979-05-11 1980-04-29 모나콜린 k의 제조방법

Country Status (17)

Country Link
US (1) US4323648A (ko)
JP (1) JPS55150898A (ko)
KR (1) KR830002329B1 (ko)
AT (1) AT372975B (ko)
AU (1) AU534647B2 (ko)
BE (1) BE882325A (ko)
CA (1) CA1129795A (ko)
CH (1) CH645891A5 (ko)
DE (2) DE3051097C2 (ko)
DK (1) DK148807C (ko)
ES (1) ES489751A0 (ko)
FR (1) FR2456141A1 (ko)
GB (1) GB2049664B (ko)
IE (1) IE49749B1 (ko)
IT (1) IT1133075B (ko)
NL (1) NL8001697A (ko)
SE (2) SE467975B (ko)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5925599B2 (ja) * 1979-02-20 1984-06-19 三共株式会社 新生理活性物質モナコリンｋおよびその製造法
ES493726A0 (es) * 1979-07-27 1981-06-16 Sankyo Co Un procedimiento para la preparacion de sales y esteres, de monacolina k utiles como agentes antitlipercolesteremicos.
US4444784A (en) * 1980-08-05 1984-04-24 Merck & Co., Inc. Antihypercholesterolemic compounds
US4351844A (en) * 1980-02-04 1982-09-28 Merck & Co., Inc. Hypocholesterolemic hydrogenation products and process of preparation
JPS56142236A (en) 1980-04-08 1981-11-06 Sankyo Co Ltd Ml-236a and mb-530a derivative
DK149080C (da) * 1980-06-06 1986-07-28 Sankyo Co Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre
US4343814A (en) * 1980-11-17 1982-08-10 Merck & Co., Inc. Hypocholesterolemic fermentation products
JPS5835144A (ja) * 1981-08-27 1983-03-01 Sankyo Co Ltd Ｍｂ−５３０ｂ誘導体およびその製造法
JPS5855443A (ja) * 1981-09-25 1983-04-01 Sankyo Co Ltd オクタヒドロナフタリン誘導体およびその製造法
US4678806A (en) * 1986-09-02 1987-07-07 Merck & Co., Inc. Prodrugs of antihypercholesterolemic compounds
US4865977A (en) * 1987-03-13 1989-09-12 Shell Oil Company Increasing monascus pigment production
DE3801588A1 (de) * 1988-01-21 1989-08-10 Hoechst Ag Verfahren zur herstellung von farbstoffen und/oder wirkstoffen in der wasserarmen, sterilen wirbelschicht
KR960004032B1 (ko) * 1992-10-26 1996-03-25 롯데제과주식회사 신균주 모나스커스 앵카 732y3(kccm10014)
HU210867B (en) * 1992-11-04 1995-10-30 Biogal Gyogyszergyar Method for extraction and purification of mevinolin from culture medium
BG61613B1 (bg) * 1994-06-24 1998-01-30 Анна Куюмджиева Щам моnаsсus рurрurеus-продуцент на пигмент и биоактивни продукти
US6046022A (en) * 1996-09-30 2000-04-04 Peking University Methods and compositions employing red rice fermentation products
US7238348B2 (en) 1996-09-30 2007-07-03 Beijing Peking University Wbl Corporation Ltd. Method of treatment of osteoporosis with compositions of red rice fermentation products
US6258361B1 (en) 1996-10-21 2001-07-10 Akio Yoshihara Agent for recovering hematopoietic function and processed food both containing treated product of peanut seed coats
US6391583B1 (en) 1998-12-18 2002-05-21 Wisconsin Alumni Research Foundation Method of producing antihypercholesterolemic agents
WO2002085398A1 (en) * 2001-04-19 2002-10-31 Taipei-Veterans General Hospital Lithospermic acid-containing composition
AU2002329931A1 (en) * 2001-08-30 2003-03-18 Taipei-Veterans General Hospital Salvianolic acid b
KR100379075B1 (en) * 2002-03-07 2003-04-08 Jinis Biopharmaceuticals Co Method for producing low cholesterol animal food product and food product therefrom
TWI262949B (en) * 2002-08-15 2006-10-01 Food Industry Res & Dev Inst Monascus purpureus mutants and their use in preparing fermentation products having hypotensive activity
US7482157B2 (en) * 2003-12-24 2009-01-27 Food Industry Research & Development Institute Monacolin K biosynthesis genes
KR100710500B1 (ko) * 2005-05-18 2007-04-24 고려대학교 산학협력단 홍국균을 이용한 모나콜린 ｋ 생산방법
US20100119600A1 (en) * 2007-06-01 2010-05-13 Joar Opheim Substances for reducing occurrence of major cardiac events comprising red yeast rice extract and omega-3 polyunsaturated fatty acid or derivative thereof
US20120171285A1 (en) * 2007-06-01 2012-07-05 Opheim Joar A Substances for reducing occurrence of major cardiac events comprising omega-3 polyunsaturated fatty acid or derivatives thereof and high-monacolin k content red yeast rice extract
US20120172425A1 (en) * 2007-06-01 2012-07-05 Opheim Joar A Red yeast rice extract high in monacolin k content
US20120171311A1 (en) * 2007-06-01 2012-07-05 Opheim Joar A Substances for reducing occurrence of major cardiac events comprising epa or derivatives thereof, optionally, dha or derivatives thereof and monacolin k
CN101317660B (zh) * 2008-06-23 2012-10-24 谢键泓 一种提高红曲洛伐他汀在水中溶解度的方法及应用
WO2010117342A1 (en) * 2009-04-08 2010-10-14 Nanyang Polytechnic A plant extract comprising statins and preparation techniques and uses thereof
CN116083252B (zh) * 2023-04-12 2023-06-27 北京一品堂医药科技有限公司 一种高产降脂天然莫拉可林k的红曲米发酵制备方法
CN116925926B (zh) * 2023-07-14 2024-02-02 中国农业大学 富硒红色红曲霉发酵生产洛伐他汀的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5612114B2 (ko) * 1974-06-07 1981-03-18
JPS5925599B2 (ja) * 1979-02-20 1984-06-19 三共株式会社 新生理活性物質モナコリンｋおよびその製造法
IL60219A (en) * 1979-06-15 1985-05-31 Merck & Co Inc Hypocholesteremic fermentation products of the hmg-coa reductase inhibitor type,their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
FR2456141B1 (ko) 1983-11-18
AU534647B2 (en) 1984-02-09
AU5667880A (en) 1980-11-13
DE3006215A1 (de) 1980-11-27
JPS55150898A (en) 1980-11-25
DE3051097C2 (ko) 1990-02-08
IE49749B1 (en) 1985-12-11
FR2456141A1 (fr) 1980-12-05
CH645891A5 (de) 1984-10-31
IT8067445A0 (it) 1980-03-21
US4323648A (en) 1982-04-06
GB2049664A (en) 1980-12-31
SE8701483L (sv) 1987-04-09
KR830002329B1 (ko) 1983-10-22
DK148807B (da) 1985-10-07
NL8001697A (nl) 1980-11-13
SE468482B (sv) 1993-01-25
AT372975B (de) 1983-12-12
SE467975B (sv) 1992-10-12
GB2049664B (en) 1983-01-12
DK73180A (da) 1980-11-12
ES8104409A1 (es) 1981-04-16
DE3006215C2 (ko) 1989-01-05
BE882325A (fr) 1980-09-19
SE8701483D0 (sv) 1987-04-09
ES489751A0 (es) 1981-04-16
SE8001338L (sv) 1980-11-12
IT1133075B (it) 1986-07-09
CA1129795A (en) 1982-08-17
DK148807C (da) 1986-04-28
ATA148280A (de) 1983-04-15
IE800577L (en) 1980-11-11

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