RU2018108851A - Дифференцировка эмбриональных стволовых клеток человека в панкреатические эндокринные клетки - Google Patents
Дифференцировка эмбриональных стволовых клеток человека в панкреатические эндокринные клетки Download PDFInfo
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- cells
- activin
- pancreatic endoderm
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- 230000004069 differentiation Effects 0.000 title claims 5
- 210000000130 stem cell Anatomy 0.000 title claims 3
- 210000003890 endocrine cell Anatomy 0.000 title 1
- 230000009996 pancreatic endocrine effect Effects 0.000 title 1
- 210000004039 endoderm cell Anatomy 0.000 claims 14
- 108010059616 Activins Proteins 0.000 claims 11
- 102000005606 Activins Human genes 0.000 claims 11
- 239000000488 activin Substances 0.000 claims 11
- 108010023082 activin A Proteins 0.000 claims 11
- 210000004027 cell Anatomy 0.000 claims 9
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 6
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 4
- 102000012004 Ghrelin Human genes 0.000 claims 3
- 101800001586 Ghrelin Proteins 0.000 claims 3
- 102000004877 Insulin Human genes 0.000 claims 3
- 108090001061 Insulin Proteins 0.000 claims 3
- 210000001900 endoderm Anatomy 0.000 claims 3
- GNKDKYIHGQKHHM-RJKLHVOGSA-N ghrelin Chemical compound C([C@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CN)COC(=O)CCCCCCC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C1=CC=CC=C1 GNKDKYIHGQKHHM-RJKLHVOGSA-N 0.000 claims 3
- 229940125396 insulin Drugs 0.000 claims 3
- 102000051325 Glucagon Human genes 0.000 claims 2
- 108060003199 Glucagon Proteins 0.000 claims 2
- 102000005157 Somatostatin Human genes 0.000 claims 2
- 108010056088 Somatostatin Proteins 0.000 claims 2
- 230000024245 cell differentiation Effects 0.000 claims 2
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 claims 2
- 229960004666 glucagon Drugs 0.000 claims 2
- 230000000968 intestinal effect Effects 0.000 claims 2
- 210000000936 intestine Anatomy 0.000 claims 2
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 claims 2
- 229960000553 somatostatin Drugs 0.000 claims 2
- 102000006277 CDX2 Transcription Factor Human genes 0.000 claims 1
- 108010083123 CDX2 Transcription Factor Proteins 0.000 claims 1
- 101000687905 Homo sapiens Transcription factor SOX-2 Proteins 0.000 claims 1
- 102100024270 Transcription factor SOX-2 Human genes 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/04—Plant cells or tissues
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/998—Proteins not provided for elsewhere
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
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- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Botany (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Developmental Biology & Embryology (AREA)
- Materials For Medical Uses (AREA)
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Claims (18)
1. Способ повышения экспрессии соматостатина в экспрессирующих гормоны клетках, включающий обработку клеток панкреатической энтодермы активином А или активином С.
2. Способ по п.1, где экспрессия инсулина, гликагона и грелина подавлена.
3. Способ по п.1, где популяция клеток панкреатической энтодермы, обработанная активином А или активином С, экспрессирует больше соматостатина по сравнению с популяции клеток панкреатической энтодермы, не обработанной активином А или активином С.
4. Способ по п.3, где экспрессия инсулина подавляется в популяции клеток панкреатической энтодермы, обработанных активином А или активином С, по сравнению с экспрессией инсулина в популяции клеток панкреатической энтодермы, не обработанной активином А или активином C.
5. Способ по п.1, где экспрессия глюкагона в популяции клеток панкреатической энтодермы, обработанная активином А или активином С, подавляется по сравнению с экспрессией глюкагона в популяции клеток панкреатической энтодермы, не обработанной активином А или активином C.
6. Способ по п.1, где экспрессия грелина подавляется в популяции клеток панкреатической энтодермы, обработанных активином А или активином С, по сравнению с экспрессией грелина в популяции клеток панкреатической эндодермы, не обработанной активином А или активином C.
7. Способ по любому из пп.1-6, где способ включает обработку клеток панкреатической энтодермы активином А.
8. Способ по любому из пп.1-6, где способ включает обработку клеток панкреатической энтодермы активином C.
9. Способ по любому из пп.1-6, где клетки панкреатической энтодермы по существу не экспрессируют CDX2 или SOX2.
10. Способ по п.1, в котором клетки панкреатической эндодермы, обработанные активином А или активином С, получают путем поэтапной дифференцировки плюрипотентных клеток.
11. Способ по п.10, где плюрипотентные клетки, из которых клетки энтодермы поджелудочной железы являются производными, представляют собой плюрипотентные стволовые клетки человека.
12. Способ по п.1, где способ дополнительно содержит:
дифференцировку плюрипотентных стволовых клеток в конечные клетки энтодермы;
дифференцировку конечных клеток энтодермы в клетки первичной кишечной трубки;
дифференцировку клеток первичной кишечной трубки в клетки передней кишки;
дифференцировку клеток передней кишки в клетки-предшественники панкреатических клеток; и
дифференцировку клеток-предшественников панкреатических клеток в клетки панкреатической энтодермы.
13. Способ по п.12, где плюрипотентные стволовые клетки представляют собой плюрипотентные стволовые клетки человека.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261657160P | 2012-06-08 | 2012-06-08 | |
| US61/657,160 | 2012-06-08 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014153529A Division RU2650813C2 (ru) | 2012-06-08 | 2013-06-06 | Использование лигандов эпинефрина для дифференцирования клеток панкреатической эндодермы |
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| RU2018108851A true RU2018108851A (ru) | 2019-02-26 |
| RU2018108851A3 RU2018108851A3 (ru) | 2019-02-26 |
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| Application Number | Title | Priority Date | Filing Date |
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| RU2014153529A RU2650813C2 (ru) | 2012-06-08 | 2013-06-06 | Использование лигандов эпинефрина для дифференцирования клеток панкреатической эндодермы |
| RU2018108850A RU2018108850A (ru) | 2012-06-08 | 2013-06-06 | Дифференцировка эмбриональных стволовых клеток человека в панкреатические эндокринные клетки |
| RU2018108851A RU2018108851A (ru) | 2012-06-08 | 2013-06-06 | Дифференцировка эмбриональных стволовых клеток человека в панкреатические эндокринные клетки |
| RU2018108847A RU2018108847A (ru) | 2012-06-08 | 2013-06-06 | Дифференцировка эмбриональных стволовых клеток человека в панкреатические эндокринные клетки |
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| RU2014153529A RU2650813C2 (ru) | 2012-06-08 | 2013-06-06 | Использование лигандов эпинефрина для дифференцирования клеток панкреатической эндодермы |
| RU2018108850A RU2018108850A (ru) | 2012-06-08 | 2013-06-06 | Дифференцировка эмбриональных стволовых клеток человека в панкреатические эндокринные клетки |
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| RU2018108847A RU2018108847A (ru) | 2012-06-08 | 2013-06-06 | Дифференцировка эмбриональных стволовых клеток человека в панкреатические эндокринные клетки |
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| Country | Link |
|---|---|
| US (5) | US10066210B2 (ru) |
| EP (5) | EP3957714A1 (ru) |
| JP (3) | JP6469003B2 (ru) |
| KR (4) | KR102468315B1 (ru) |
| CN (4) | CN108103006A (ru) |
| AR (1) | AR091388A1 (ru) |
| AU (4) | AU2013271581B2 (ru) |
| BR (1) | BR112014030682A2 (ru) |
| CA (2) | CA2875786C (ru) |
| DK (1) | DK3450542T3 (ru) |
| ES (2) | ES2690118T3 (ru) |
| IN (1) | IN2014DN10021A (ru) |
| MX (1) | MX358590B (ru) |
| PH (4) | PH12014502661A1 (ru) |
| PL (1) | PL2859091T3 (ru) |
| RU (4) | RU2650813C2 (ru) |
| SG (2) | SG10201610313WA (ru) |
| WO (1) | WO2013184888A1 (ru) |
| ZA (3) | ZA201802251B (ru) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9080145B2 (en) | 2007-07-01 | 2015-07-14 | Lifescan Corporation | Single pluripotent stem cell culture |
| CA2695225C (en) | 2007-07-31 | 2021-06-01 | Lifescan, Inc. | Differentiation of human embryonic stem cells to pancreatic endocrine |
| RU2473684C2 (ru) | 2007-11-27 | 2013-01-27 | Лайфскен, Инк. | Дифференцировка человеческих эмбриональных стволовых клеток |
| KR101597731B1 (ko) | 2008-02-21 | 2016-02-26 | 센토코 오르토 바이오테크 인코포레이티드 | 세포 부착, 배양 및 탈리를 위한 방법, 표면 개질 플레이트 및 조성물 |
| MX2011000125A (es) | 2008-06-30 | 2011-02-25 | Centocor Ortho Biotech Inc | Diferenciacion de celulas madre pluripotentes. |
| EP2346988B1 (en) | 2008-10-31 | 2017-05-31 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells to the pancreatic endocrine lineage |
| US20100124781A1 (en) | 2008-11-20 | 2010-05-20 | Shelley Nelson | Pluripotent Stem Cell Culture on Micro-Carriers |
| US9969973B2 (en) | 2008-11-20 | 2018-05-15 | Janssen Biotech, Inc. | Methods and compositions for cell attachment and cultivation on planar substrates |
| US10076544B2 (en) | 2009-07-20 | 2018-09-18 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells |
| BR112012017761A2 (pt) | 2009-12-23 | 2015-09-15 | Centocor Ortho Biotech Inc | diferenciação das células-tronco embrionárias humanas |
| KR101928299B1 (ko) | 2010-03-01 | 2018-12-12 | 얀센 바이오테크 인코포레이티드 | 만능 줄기 세포로부터 유래된 세포의 정제 방법 |
| US9719068B2 (en) | 2010-05-06 | 2017-08-01 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
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