SG11201507510PA - Isolation of non-embryonic stem cells and uses thereof - Google Patents
Isolation of non-embryonic stem cells and uses thereofInfo
- Publication number
- SG11201507510PA SG11201507510PA SG11201507510PA SG11201507510PA SG11201507510PA SG 11201507510P A SG11201507510P A SG 11201507510PA SG 11201507510P A SG11201507510P A SG 11201507510PA SG 11201507510P A SG11201507510P A SG 11201507510PA SG 11201507510P A SG11201507510P A SG 11201507510PA
- Authority
- SG
- Singapore
- Prior art keywords
- isolation
- stem cells
- embryonic stem
- embryonic
- cells
- Prior art date
Links
- 210000001671 embryonic stem cell Anatomy 0.000 title 1
- 238000002955 isolation Methods 0.000 title 1
Classifications
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/22—Urine; Urinary tract, e.g. kidney or bladder; Intraglomerular mesangial cells; Renal mesenchymal cells; Adrenal gland
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/38—Stomach; Intestine; Goblet cells; Oral mucosa; Saliva
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/39—Pancreas; Islets of Langerhans
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- A61K35/407—Liver; Hepatocytes
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/42—Respiratory system, e.g. lungs, bronchi or lung cells
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0623—Stem cells
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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- C12N5/067—Hepatocytes
- C12N5/0672—Stem cells; Progenitor cells; Precursor cells; Oval cells
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- C12N5/0676—Pancreatic cells
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- C12N5/06—Animal cells or tissues; Human cells or tissues
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- C12N5/0679—Cells of the gastro-intestinal tract
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- C12N5/0684—Cells of the urinary tract or kidneys
- C12N5/0685—Bladder epithelial cells
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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- C12N5/0693—Tumour cells; Cancer cells
- C12N5/0695—Stem cells; Progenitor cells; Precursor cells
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- C12N2500/00—Specific components of cell culture medium
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- C12N2500/38—Vitamins
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- C12N2501/11—Epidermal growth factor [EGF]
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- C12N2501/15—Transforming growth factor beta (TGF-β)
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- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/33—Insulin
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- C12N2501/40—Regulators of development
- C12N2501/415—Wnt; Frizzeled
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- C12N2501/40—Regulators of development
- C12N2501/42—Notch; Delta; Jagged; Serrate
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- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/52—Fibronectin; Laminin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Developmental Biology & Embryology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Oncology (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361792027P | 2013-03-15 | 2013-03-15 | |
| US201361912795P | 2013-12-06 | 2013-12-06 | |
| PCT/US2014/027207 WO2014152321A1 (en) | 2013-03-15 | 2014-03-14 | Isolation of non-embryonic stem cells and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201507510PA true SG11201507510PA (en) | 2015-10-29 |
Family
ID=50639961
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201507510PA SG11201507510PA (en) | 2013-03-15 | 2014-03-14 | Isolation of non-embryonic stem cells and uses thereof |
| SG10201708332WA SG10201708332WA (en) | 2013-03-15 | 2014-03-14 | Isolation of non-embryonic stem cells and uses thereof |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201708332WA SG10201708332WA (en) | 2013-03-15 | 2014-03-14 | Isolation of non-embryonic stem cells and uses thereof |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20160060594A1 (en) |
| EP (1) | EP2970892A1 (en) |
| JP (2) | JP6602745B2 (en) |
| AU (1) | AU2014239954B2 (en) |
| CA (1) | CA2906643A1 (en) |
| SG (2) | SG11201507510PA (en) |
| TW (1) | TW201522637A (en) |
| WO (1) | WO2014152321A1 (en) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9080145B2 (en) | 2007-07-01 | 2015-07-14 | Lifescan Corporation | Single pluripotent stem cell culture |
| US9096832B2 (en) | 2007-07-31 | 2015-08-04 | Lifescan, Inc. | Differentiation of human embryonic stem cells |
| CN107574142B (en) | 2007-11-27 | 2021-07-06 | 生命扫描有限公司 | Differentiation of human embryonic stem cells |
| CA2959401C (en) | 2008-02-21 | 2021-12-07 | Centocor Ortho Biotech Inc. | Methods, surface modified plates and compositions for cell attachment, cultivation and detachment |
| KR20180018839A (en) | 2008-06-30 | 2018-02-21 | 얀센 바이오테크 인코포레이티드 | Differentiation of pluripotent stem cells |
| US9234178B2 (en) | 2008-10-31 | 2016-01-12 | Janssen Biotech, Inc. | Differentiation of human pluripotent stem cells |
| ES2584053T3 (en) | 2008-11-20 | 2016-09-23 | Janssen Biotech, Inc. | Methods and compositions for cell binding and culture in flat substrates |
| MX356756B (en) | 2008-11-20 | 2018-06-11 | Centocor Ortho Biotech Inc | Pluripotent stem cell culture on micro-carriers. |
| WO2011011300A2 (en) | 2009-07-20 | 2011-01-27 | Centocor Ortho Biotech Inc. | Differentiation of human embryonic stem cells |
| KR101773538B1 (en) | 2009-12-23 | 2017-08-31 | 얀센 바이오테크 인코포레이티드 | Differentiation of human embryonic stem cells |
| PH12012501686A1 (en) | 2010-03-01 | 2020-10-19 | Janssen Biotech Inc | Methods for purifying cells derived from pluripotent stem cells |
| CN102884176B (en) | 2010-05-12 | 2017-09-05 | 詹森生物科技公司 | Differentiation of human embryonic stem cells |
| RU2620938C2 (en) | 2010-08-31 | 2017-05-30 | Янссен Байотек, Инк. | Differentiation of human embryonic stem cells |
| US9388386B2 (en) | 2011-12-22 | 2016-07-12 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells into single hormonal insulin positive cells |
| US9434920B2 (en) | 2012-03-07 | 2016-09-06 | Janssen Biotech, Inc. | Defined media for expansion and maintenance of pluripotent stem cells |
| CN108103005A (en) | 2012-06-08 | 2018-06-01 | 詹森生物科技公司 | Differentiation of the human embryo stem cell to pancreatic endocrine cell |
| US10370644B2 (en) | 2012-12-31 | 2019-08-06 | Janssen Biotech, Inc. | Method for making human pluripotent suspension cultures and cells derived therefrom |
| SG10201709338RA (en) | 2012-12-31 | 2017-12-28 | Janssen Biotech Inc | Culturing of human embryonic stem cells at the air-liquid interface for differentiation into pancreatic endocrine cells |
| JP6529440B2 (en) | 2012-12-31 | 2019-06-12 | ヤンセン バイオテツク,インコーポレーテツド | Suspension and clustering of human pluripotent cells for differentiation to pancreatic endocrine cells |
| SG11201507510PA (en) * | 2013-03-15 | 2015-10-29 | Jackson Lab | Isolation of non-embryonic stem cells and uses thereof |
| US20160237400A1 (en) * | 2013-03-15 | 2016-08-18 | The Jackson Laboratory | Isolation of non-embryonic stem cells and uses thereof |
| CN117821369A (en) | 2014-05-16 | 2024-04-05 | 詹森生物科技公司 | Use of small molecules to enhance MAFA expression in pancreatic endocrine cells |
| CA2981708C (en) | 2015-04-03 | 2024-09-10 | Propagenix Inc. | Ex vivo proliferation of epithelial cells |
| US10100285B2 (en) | 2015-04-03 | 2018-10-16 | Propagenix Inc. | Ex vivo proliferation of epithelial cells |
| US10087417B2 (en) | 2015-04-22 | 2018-10-02 | William J. Freed | Three-dimensional model of human cortex |
| EP3307874A4 (en) * | 2015-06-12 | 2019-04-24 | Agency For Science, Technology And Research | DERIVATION OF HEPATIC STEM CELLS AND TYPES OF HEPATIC CELLS AND ASSOCIATED USES THEREOF |
| DK3347450T3 (en) | 2015-09-11 | 2021-05-31 | Propagenix Inc | EX VIVO PROLIFERATION OF EPITHEL CELLS |
| CN108884445A (en) * | 2016-03-09 | 2018-11-23 | 北京智康博药肿瘤医学研究有限公司 | Tumour cell suspension culture and correlation technique |
| CN107267437B (en) * | 2016-04-08 | 2021-01-19 | 苏州吉美瑞生医学科技有限公司 | Kit and method for isolating and obtaining lung stem cells |
| MA45479A (en) | 2016-04-14 | 2019-02-20 | Janssen Biotech Inc | DIFFERENTIATION OF PLURIPOTENT STEM CELLS IN ENDODERMAL CELLS OF MIDDLE INTESTINE |
| KR102362222B1 (en) * | 2016-05-16 | 2022-02-11 | 더 제너럴 하스피탈 코포레이션 | Human Airway Stem Cells in Lung Epithelial Engineering |
| CN110225980B (en) | 2016-11-21 | 2023-01-06 | 纳米线科技公司 | Chemical compositions and methods of use thereof |
| CA3045627C (en) | 2016-12-02 | 2024-10-01 | EMULATE, Inc. | In vitro gastrointestinal model comprising lamina propria-derived cells |
| GB2573427B (en) | 2016-12-02 | 2020-12-09 | Emulate Inc | In vitro epithelial models comprising lamina propria-derived cells |
| WO2018204913A1 (en) * | 2017-05-05 | 2018-11-08 | Tract Pharmaceuticals, Inc. | Inflammatory bowel disease stem cells, agents which target ibd stem cells, and uses related thereto |
| KR102277147B1 (en) * | 2017-12-13 | 2021-07-13 | 건국대학교 산학협력단 | Use of peptides derived from fibroblast growth factor to promote osteogenic or chondrogenic differentiation |
| EP3732285A1 (en) | 2017-12-28 | 2020-11-04 | Tract Pharmaceuticals, Inc. | Stem cell culture systems for columnar epithelial stem cells, and uses related thereto |
| WO2019141824A1 (en) * | 2018-01-18 | 2019-07-25 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Generation, proliferation and expansion of epithelial cells from primary tissue into mucosoid cultures |
| US20210147811A1 (en) * | 2018-04-09 | 2021-05-20 | Cedars-Sinai Medical Center | Methods for in vitro expansion of adult tissue stem cells |
| AU2019250859B2 (en) * | 2018-04-13 | 2025-02-20 | Shanghai Lide Biotech Co., Ltd. | Method for obtaining an animal model from conditionally reprogrammed cells and use of the animal model for screening anti-tumor drugs |
| WO2019211734A1 (en) * | 2018-04-30 | 2019-11-07 | Avita International Ltd. | Immature dental pulp stem cells and methods of use to treat bone marrow failure |
| EP3814484A4 (en) | 2018-05-10 | 2022-02-23 | Agency for Science, Technology and Research | CELL CULTURE MEDIUM |
| EP3794146B1 (en) | 2018-05-14 | 2025-12-10 | Bruker Spatial Biology, Inc. | Method for identifying a predetermined nucleotide sequence |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| CN111254118A (en) * | 2018-11-30 | 2020-06-09 | 中国科学院大连化学物理研究所 | Brain-like tissue generation method of hiPSCs source |
| WO2020132248A1 (en) * | 2018-12-21 | 2020-06-25 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for airway tissue regeneration |
| CN109652365A (en) * | 2019-02-01 | 2019-04-19 | 南京大学 | A kind of preparation method of zebrafish embryo single cell suspension |
| US20210062157A1 (en) * | 2019-08-27 | 2021-03-04 | United Therapeutics Corporation | Methods and compositions for culturing alveolar cells |
| US20240158756A1 (en) * | 2019-10-10 | 2024-05-16 | University Of Houston System | Feeder-based and feeder-free stem cell culture systems for stratified epithelial stem cells, and uses related thereto |
| CN111471643B (en) * | 2020-04-09 | 2020-12-29 | 创芯国际生物科技(广州)有限公司 | Universal culture medium and culture method for upper respiratory mucosa organoid |
| US20230203450A1 (en) | 2020-05-27 | 2023-06-29 | Otsuka Pharmaceutical Co., Ltd. | Method of producing organoid derived from lung epithelial cell or lung cancer cell |
| CN111560376B (en) * | 2020-06-15 | 2022-03-25 | 浙江大学 | siRNA for specifically inhibiting OLFM4 gene expression and application thereof |
| CN111808795A (en) * | 2020-06-28 | 2020-10-23 | 广东省医疗器械研究所 | Hepatocyte in-vitro co-culture system and construction method and application thereof |
| WO2022125438A1 (en) * | 2020-12-07 | 2022-06-16 | The Jackson Laboratory | Infectious disease mouse models |
| CN112725259B (en) * | 2021-01-07 | 2023-08-29 | 福州市皮肤病防治院 | Induction medium and induction method for differentiation of stem cells into sweat gland-like cells |
| KR102574856B1 (en) * | 2021-02-05 | 2023-09-07 | 연세대학교 산학협력단 | Composition for preventing or treating renal disease |
| CN118787657B (en) * | 2024-09-11 | 2024-12-03 | 内蒙古大学 | Application of nicotinamide adenine dinucleotide in improving cow breeding efficiency |
| CN120025968A (en) * | 2025-01-24 | 2025-05-23 | 上海华奥新生命科学有限公司 | Method for culturing bronchial epithelial stem/progenitor cells |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5464758A (en) | 1993-06-14 | 1995-11-07 | Gossen; Manfred | Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters |
| US6133027A (en) | 1996-08-07 | 2000-10-17 | City Of Hope | Inducible expression system |
| US6207455B1 (en) | 1997-05-01 | 2001-03-27 | Lung-Ji Chang | Lentiviral vectors |
| WO1998051810A1 (en) | 1997-05-13 | 1998-11-19 | University Of North Carolina At Chapel Hill | Lentivirus-based gene transfer vectors |
| US5994136A (en) | 1997-12-12 | 1999-11-30 | Cell Genesys, Inc. | Method and means for producing high titer, safe, recombinant lentivirus vectors |
| US6218181B1 (en) | 1998-03-18 | 2001-04-17 | The Salk Institute For Biological Studies | Retroviral packaging cell line |
| DE19909769A1 (en) | 1999-03-05 | 2000-09-07 | Bundesrepublik Deutschland Let | SIVagm-derived lentiviral vectors, processes for their preparation and their use for gene transfer in mammalian cells |
| US8075881B2 (en) * | 1999-08-05 | 2011-12-13 | Regents Of The University Of Minnesota | Use of multipotent adult stem cells in treatment of myocardial infarction and congestive heart failure |
| CA2402459A1 (en) | 2000-12-01 | 2002-06-06 | Central Institute For Experimental Animals | Method of producing a mouse suitable for engraftment, differentiation and proliferation of heterologous cells, mouse produced by this method and use of the mouse |
| WO2003030959A1 (en) * | 2001-10-06 | 2003-04-17 | Btg International Limited | Corneal repair device |
| US20040161419A1 (en) * | 2002-04-19 | 2004-08-19 | Strom Stephen C. | Placental stem cells and uses thereof |
| CN101310012B (en) * | 2005-10-14 | 2012-05-09 | 明尼苏达大学董事会 | Differentiation of non-embryonic stem cells into cells with pancreatic phenotype |
| EP1999253B1 (en) * | 2006-03-02 | 2019-05-22 | Viacyte, Inc. | Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production |
| ES2453373T3 (en) * | 2006-04-14 | 2014-04-07 | Wako Pure Chemical Industries, Ltd. | Procedure for introducing a plurality of solutions into a microfluidic channel |
| AU2008206884B2 (en) * | 2007-01-18 | 2012-07-05 | Glykos Finland Oy | Novel methods and reagents directed to production of cells |
| US8383349B2 (en) | 2007-03-16 | 2013-02-26 | The Board Of Trustees Of The Leland Stanford Junior University | Bone morphogenetic protein antagonist and uses thereof |
| US10227563B2 (en) * | 2008-06-06 | 2019-03-12 | Riken | Method for culture of stem cell |
| EP2297299A1 (en) * | 2008-06-25 | 2011-03-23 | INSERM - Institut National de la Santé et de la Recherche Médicale | Methods for preparing human skin substitutes from human pluripotent stem cells |
| EP2412800A1 (en) * | 2010-07-29 | 2012-02-01 | Koninklijke Nederlandse Akademie van Wetenschappen | Liver organoid, uses thereof and culture method for obtaining them |
| MX379945B (en) * | 2009-02-03 | 2025-03-11 | Koninklijke Nederlandse Akademie Van Wetenschappen | CULTURE MEDIUM FOR EPITHELIAL STEM CELLS AND ORGANOIDS THAT INCLUDE STEM CELLS. |
| GB201111244D0 (en) | 2011-06-30 | 2011-08-17 | Konink Nl Akademie Van Wetenschappen Knaw | Culture media for stem cells |
| EP2420566A4 (en) * | 2009-04-17 | 2014-01-15 | Univ Tohoku | METHOD FOR PREPARING HUMAN PULMONARY TISSUE STEM CELLS AND METHOD FOR INDUCING HUMAN ALVEOLAR EPITHELIAL CELL DIFFERENTIATION |
| US9550975B2 (en) * | 2009-07-15 | 2017-01-24 | Mari Dezawa | SSEA-3 pluripotent stem cell isolated from body tissue |
| WO2012044992A2 (en) * | 2010-09-30 | 2012-04-05 | Agency For Science, Technology And Research (A*Star) | Methods and reagents for detection and treatment of esophageal metaplasia |
| WO2012168434A1 (en) * | 2011-06-08 | 2012-12-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Partial reprogramming of somatic cells to induced tissue stem (its) cells |
| WO2014151456A2 (en) * | 2013-03-15 | 2014-09-25 | The Jackson Laboratory | Treatment of inflammatory diseases |
| SG11201507510PA (en) * | 2013-03-15 | 2015-10-29 | Jackson Lab | Isolation of non-embryonic stem cells and uses thereof |
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- 2014-03-14 JP JP2016502367A patent/JP6602745B2/en active Active
- 2014-03-14 WO PCT/US2014/027207 patent/WO2014152321A1/en not_active Ceased
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2015
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| SG10201708332WA (en) | 2017-11-29 |
| US20180179492A1 (en) | 2018-06-28 |
| WO2014152321A1 (en) | 2014-09-25 |
| US20160060594A1 (en) | 2016-03-03 |
| CA2906643A1 (en) | 2014-09-25 |
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