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RU2011101140A - Пирроло[2,3-b]пиридиновые производные в качестве ингибиторов протеинкиназ - Google Patents

Пирроло[2,3-b]пиридиновые производные в качестве ингибиторов протеинкиназ Download PDF

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Publication number
RU2011101140A
RU2011101140A RU2011101140/04A RU2011101140A RU2011101140A RU 2011101140 A RU2011101140 A RU 2011101140A RU 2011101140/04 A RU2011101140/04 A RU 2011101140/04A RU 2011101140 A RU2011101140 A RU 2011101140A RU 2011101140 A RU2011101140 A RU 2011101140A
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Prior art keywords
compound according
hydrogen
compound
fluoro
optionally substituted
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RU2011101140/04A
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RU2565071C2 (ru
Inventor
Прабха Н. ИБРАХИМ (US)
Прабха Н. Ибрахим
Дин Р. АРТИС (US)
Дин Р. Артис
Райан БРЕМЕР (US)
Райан Бремер
Шумейе МАМО (US)
Шумейе МАМО
Марика НЕСПИ (US)
Марика Неспи
Чао ЖАНГ (US)
Чао Жанг
Джиажонг ЖАНГ (US)
Джиажонг ЖАНГ
Йонг-Лианг ЖУ (US)
Йонг-Лианг Жу
Джеймс ЦАЙ (US)
Джеймс Цай
Клаус-Питер ХЕРТ (US)
Клаус-Питер ХЕРТ
Гидеон БОЛЛАГ (US)
Гидеон Боллаг
Уэйн СПЕВАК (US)
Уэйн СПЕВАК
Ханна ЧО (US)
Ханна Чо
Сэмьюэл Дж. ДЖИЛЛЕТ (US)
Сэмьюэл Дж. ДЖИЛЛЕТ
Гуоксиам ВУ (US)
Гуоксиам ВУ
Хонгьяо ЖУ (US)
Хонгьяо ЖУ
Шенгхуа ШИ (US)
Шенгхуа Ши
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Плекссикон, Инк (Us)
Плекссикон, Инк
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Application filed by Плекссикон, Инк (Us), Плекссикон, Инк filed Critical Плекссикон, Инк (Us)
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Abstract

1. Соединение, имеющее структуру формулы VIIa: ! , ! где R84 выбран из группы, состоящей из водорода, низшего алкокси, -ОН и -Cl; ! R92, R94, R95 и R96 независимо выбраны из группы, состоящей из водорода, галогена, низшего алкила, фторозамещенного низшего алкила, низшего алкокси и фторозамещенного низшего алкокси; !R99 выбран из группы, состоящей из возможно замещенного С2-6алкила, возможно замещенного арила, возможно замещенного гетероарила и -NR79R80; и ! R79 и R80 независимо представляют собой водород или возможно замещенный низший алкил, или R79 и R80 объединены с атомом азота, к которому они присоединены, с образованием возможно замещенного 5-7-членного гетероциклоалкила. ! 2. Соединение по п.1, где R92 представляет собой фторо. ! 3. Соединение по п.1, где R94 и R95 представляют собой водород. ! 4. Соединение по п.1, где R96 выбран из группы, состоящей из водорода, фторо и хлоро. ! 5. Соединение по п.4, где R96 представляет собой водород. ! 6. Соединение по п.4, где R96 представляет собой фторо. ! 7. Соединение по п.4, где R96 представляет собой хлоро. ! 8. Соединение по п.1, где R99 представляет собой возможно замещенный С2-6алкил. ! 9. Соединение по п.1, где R99 представляет собой н-пропил. ! 10. Соединение по п.1, где R99 представляет собой возможно замещенный арил. ! 11. Соединение по п.1, где R99 представляет собой возможно замещенный гетероарил. ! 12. Соединение по п.1, где R99 представляет собой -NR79R80. ! 13. Соединение по п.12, где R79 и R80 независимо представляют собой водород или возможно замещенный низший алкил. ! 14. Соединение по п.12, где R79 и R80 объединены с атомом азота, к которому они присоединены, с образованием возможно замещенного 5-7-членного гетероциклоалкила. ! 15. Соединение по п.1, где R92

Claims (18)

1. Соединение, имеющее структуру формулы VIIa:
Figure 00000001
,
где R84 выбран из группы, состоящей из водорода, низшего алкокси, -ОН и -Cl;
R92, R94, R95 и R96 независимо выбраны из группы, состоящей из водорода, галогена, низшего алкила, фторозамещенного низшего алкила, низшего алкокси и фторозамещенного низшего алкокси;
R99 выбран из группы, состоящей из возможно замещенного С2-6алкила, возможно замещенного арила, возможно замещенного гетероарила и -NR79R80; и
R79 и R80 независимо представляют собой водород или возможно замещенный низший алкил, или R79 и R80 объединены с атомом азота, к которому они присоединены, с образованием возможно замещенного 5-7-членного гетероциклоалкила.
2. Соединение по п.1, где R92 представляет собой фторо.
3. Соединение по п.1, где R94 и R95 представляют собой водород.
4. Соединение по п.1, где R96 выбран из группы, состоящей из водорода, фторо и хлоро.
5. Соединение по п.4, где R96 представляет собой водород.
6. Соединение по п.4, где R96 представляет собой фторо.
7. Соединение по п.4, где R96 представляет собой хлоро.
8. Соединение по п.1, где R99 представляет собой возможно замещенный С2-6алкил.
9. Соединение по п.1, где R99 представляет собой н-пропил.
10. Соединение по п.1, где R99 представляет собой возможно замещенный арил.
11. Соединение по п.1, где R99 представляет собой возможно замещенный гетероарил.
12. Соединение по п.1, где R99 представляет собой -NR79R80.
13. Соединение по п.12, где R79 и R80 независимо представляют собой водород или возможно замещенный низший алкил.
14. Соединение по п.12, где R79 и R80 объединены с атомом азота, к которому они присоединены, с образованием возможно замещенного 5-7-членного гетероциклоалкила.
15. Соединение по п.1, где R92 и R96 представляют собой фторо, R99 и R95 представляют собой водород, и R99 представляет собой н-пропил.
16. Соединение по п.15, где R84 представляет собой водород.
17. Соединение по п.15, где R84 представляет собой -ОН.
18. Соединение по п.15, где R84 представляет собой -Cl.
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