RU2003134632A - Двухфазные биоадгезионные композиции, абсорбирующие воду - Google Patents
Двухфазные биоадгезионные композиции, абсорбирующие воду Download PDFInfo
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- RU2003134632A RU2003134632A RU2003134632/15A RU2003134632A RU2003134632A RU 2003134632 A RU2003134632 A RU 2003134632A RU 2003134632/15 A RU2003134632/15 A RU 2003134632/15A RU 2003134632 A RU2003134632 A RU 2003134632A RU 2003134632 A RU2003134632 A RU 2003134632A
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- hydrophilic polymer
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- polymer
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- 239000000203 mixture Substances 0.000 title claims abstract 40
- 230000035587 bioadhesion Effects 0.000 title 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title 1
- 229920001477 hydrophilic polymer Polymers 0.000 claims abstract 16
- 230000000295 complement effect Effects 0.000 claims abstract 13
- 229920001600 hydrophobic polymer Polymers 0.000 claims abstract 8
- 238000004132 cross linking Methods 0.000 claims abstract 7
- 230000002209 hydrophobic effect Effects 0.000 claims abstract 6
- 239000000227 bioadhesive Substances 0.000 claims abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 3
- 239000001257 hydrogen Substances 0.000 claims abstract 3
- 238000000034 method Methods 0.000 claims 7
- 229920002554 vinyl polymer Polymers 0.000 claims 7
- 229920001515 polyalkylene glycol Polymers 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 239000002202 Polyethylene glycol Substances 0.000 claims 3
- 229920005549 butyl rubber Polymers 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 229920001223 polyethylene glycol Polymers 0.000 claims 3
- 229920002367 Polyisobutene Polymers 0.000 claims 2
- 229920001577 copolymer Polymers 0.000 claims 2
- UYMKPFRHYYNDTL-UHFFFAOYSA-N ethenamine Chemical class NC=C UYMKPFRHYYNDTL-UHFFFAOYSA-N 0.000 claims 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 2
- 150000005846 sugar alcohols Polymers 0.000 claims 2
- 229920002845 Poly(methacrylic acid) Polymers 0.000 claims 1
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 1
- 229920002125 Sokalan® Polymers 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 150000001335 aliphatic alkanes Chemical class 0.000 claims 1
- -1 alkylene glycols Chemical class 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 239000003431 cross linking reagent Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 229920001519 homopolymer Polymers 0.000 claims 1
- 239000000017 hydrogel Substances 0.000 claims 1
- 150000001451 organic peroxides Chemical class 0.000 claims 1
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical group OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 claims 1
- 239000004584 polyacrylic acid Substances 0.000 claims 1
- 229940068918 polyethylene glycol 400 Drugs 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
- 239000002250 absorbent Substances 0.000 abstract 1
- 239000000853 adhesive Substances 0.000 abstract 1
- 230000001070 adhesive effect Effects 0.000 abstract 1
- 238000012377 drug delivery Methods 0.000 abstract 1
- 210000004400 mucous membrane Anatomy 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/58—Adhesives
- A61L15/585—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/60—Liquid-swellable gel-forming materials, e.g. super-absorbents
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J123/00—Adhesives based on homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Adhesives based on derivatives of such polymers
- C09J123/02—Adhesives based on homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Adhesives based on derivatives of such polymers not modified by chemical after-treatment
- C09J123/18—Homopolymers or copolymers of hydrocarbons having four or more carbon atoms
- C09J123/20—Homopolymers or copolymers of hydrocarbons having four or more carbon atoms having four to nine carbon atoms
- C09J123/22—Copolymers of isobutene; Butyl rubber ; Homo- or copolymers of other iso-olefines
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2312/00—Crosslinking
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2666/00—Composition of polymers characterized by a further compound in the blend, being organic macromolecular compounds, natural resins, waxes or and bituminous materials, non-macromolecular organic substances, inorganic substances or characterized by their function in the composition
- C08L2666/02—Organic macromolecular compounds, natural resins, waxes or and bituminous materials
- C08L2666/14—Macromolecular compounds according to C08L59/00 - C08L87/00; Derivatives thereof
- C08L2666/20—Macromolecular compounds having nitrogen in the main chain according to C08L75/00 - C08L79/00; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L33/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- C08L33/04—Homopolymers or copolymers of esters
- C08L33/06—Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, which oxygen atoms are present only as part of the carboxyl radical
- C08L33/08—Homopolymers or copolymers of acrylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L77/00—Compositions of polyamides obtained by reactions forming a carboxylic amide link in the main chain; Compositions of derivatives of such polymers
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Materials Engineering (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Organic Chemistry (AREA)
- Materials For Medical Uses (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Medicinal Preparation (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Claims (29)
1. Биоадгезионная композиция, содержащая гидрофобную фазу и гидрофильную фазу, где гидрофобная фаза включает поперечно-сшитую гидрофобную полимерную композицию, а гидрофильная фаза содержит смесь гидрофильного полимера и комплементарного олигомера, способного к поперечному сшиванию гидрофильного полимера через водородные связи, через ионные связи или ковалентные связи.
2. Композиция по п.1, в которой поперечно-сшитой гидрофобной полимерной композицией является поперечно-сшитый бутилкаучук.
3. Композиция по п.2, в которой поперечно-сшитой гидрофобной полимерной композицией является бутилкаучук, поперечно-сшитый с полиизобутиленом.
4. Композиция по п.1, в которой гидрофильный полимер и комплементарный олигомер являются поперечно-сшитыми ковалентной связью.
5. Композиция по п.1, в которой гидрофильный полимер выбирают из группы, включающей поли(N-виниллактамы), поли(N-виниламиды), поли(N-алкилакриламиды), полиакриловую кислоту, полиметакриловую кислоту, поливиниловый спирт, поливиниламин, их сополимеры и смеси.
6. Композиция по п.5, в которой гидрофильный полимер выбирают из группы, включающей поли(N-виниллактамы), поли(N-виниламиды), поли(N-алкилакриламиды), их сополимеры и смеси.
7. Композиция по п.6, в которой гидрофильным полимером является поли(N-виниллактам).
8. Композиция по п.7, в которой гидрофильным полимером является гомополимер поли(N-виниллактама).
9. Композиция по п.8, в которой поли(N-виниллактам) выбирают из группы, включающей поливинилпирролидон, поливинилкапролактам и их смеси.
10. Композиция по п.9, в которой поли(N-виниллактамом) является поливинилпирролидон.
11. Композиция по п.9, в которой поли(N-виниллактамом) является поливинилкапролактам.
12. Композиция по п.1, в которой гидрофильный полимер имеет среднечисленную массу в интервале от приблизительно 20000 до 2000000.
13. Композиция по п.12, в которой гидрофильный полимер имеет среднечисленную молекулярную массу в интервале от приблизительно 200000 до 1000000.
14. Композиция по п.1, в которой комплементарный олигомер имеет молекулярную массу примерно от 45 до 800.
15. Композиция по п.14, в которой комплементарный олигомер имеет молекулярную массу примерно от 45 до 600.
16. Композиция по п.15, в которой комплементарный олигомер имеет молекулярную массу примерно от 300 до 600.
17. Композиция по п.1, в которой комплементарный олигомер выбирают из группы, включающей многоатомные спирты, мономерные и олигомерные алкиленгликоли, полиалкиленгликоли, полиалкиленгликоли, имеющие на концах карбоксильные группы, полиалкиленгликоли, имеющие на концах аминогруппы, неполные эфиры многоатомных спиртов, алкандиолы и карбоновые дикислоты.
18. Композиция по п.17, в которой комплементарный олигомер выбирают из группы, включающей полиалкиленгликоли и полиалкиленгликоли, имеющие на концах карбоксильные группы.
19. Композиция гидрогеля по п.18, в которой комплементарный олигомер выбирают из группы, включающей полиэтиленгликоль и полиэтиленгликоль, имеющий на концах карбоксильные группы.
20. Композиция по п.19, в которой комплементарным олигомером является полиэтиленгликоль.
21. Композиция по п.20, в которой комплементарным олигомером является полиэтиленгликоль 400.
22. Композиция по п.1, дополнительно включающая активный агент.
23. Способ получения двухфазной абсорбирующей воду биоадгезионной композиции, включающий
(а) получение поперечно-сшиваемой гидрофобной композиции, включающей гидрофобный полимер и, по крайней мере, один агент поперечного сшивания полимера; и
(b) получение гидрофильной композиции, включающей гидрофильный полимер и комплементарный олигомер, способный к поперечному сшиванию гидрофильного полимера через водородное связывание, ионное связывание и/или ковалентное связывание;
(с) смешивание поперечно-связываемой гидрофобной композиции и гидрофильной композиции; и
(d) поперечное сшивание гидрофобного полимера в смеси.
24. Способ по п.23, в котором комплементарный олигомер является эффективным для поперечного сшивания гидрофильного полимера в присутствии отверждающего агента.
25. Способ по п.24, в котором стадия (d) дополнительно включает поперечное сшивание гидрофильного полимера.
26. Способ по п.25, в котором стадию (d) проводят при температуре, эффективной для поперечного сшивания при нагревании как гидрофобного полимера, так и гидрофильного полимера.
27. Способ по п.26, в котором гидрофобным полимером является бутилкаучук и, по крайней мере, один агент содержит полиизобутилен.
28. Способ по п.27, в котором, по крайней мере, один агент дополнительно включает органическую перекись.
29. Способ по п.26, в котором отверждающим агентом является пентаэритрит-моногидроксипентаакрилат.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28802401P | 2001-05-01 | 2001-05-01 | |
| US60/288,024 | 2001-05-01 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2003134632A true RU2003134632A (ru) | 2005-01-27 |
| RU2286801C2 RU2286801C2 (ru) | 2006-11-10 |
Family
ID=23105426
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2003134632/15A RU2286801C2 (ru) | 2001-05-01 | 2002-05-01 | Двухфазные биоадгезионные композиции, абсорбирующие воду |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US6803420B2 (ru) |
| EP (2) | EP2277556B1 (ru) |
| AT (1) | ATE502657T1 (ru) |
| AU (1) | AU2002316053A1 (ru) |
| CA (1) | CA2447302C (ru) |
| DE (1) | DE60239528D1 (ru) |
| ES (1) | ES2587187T3 (ru) |
| RU (1) | RU2286801C2 (ru) |
| WO (1) | WO2002087642A2 (ru) |
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| AU2002316053A1 (en) | 2001-05-01 | 2002-11-11 | A.V. Topchiev Institute Of Petrochemical Synthesis | Two-phase, water-absorbent bioadhesive composition |
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| DE10317108A1 (de) * | 2003-04-14 | 2004-11-11 | Mutzbauer, Till S., Dr. Dr.med. | Transdermal applizierbares Beruhigungs- und Sedierungsmittel |
| EP1713523B1 (en) | 2003-09-02 | 2015-07-01 | Coloplast A/S | Adhesive composition comprising hydrophilic and hydrophobic silicone elastomers |
| EP1667619A4 (en) | 2003-09-19 | 2007-10-10 | Drugtech Corp | PHARMACEUTICAL FEEDING SYSTEM |
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| WO2005041987A1 (en) * | 2003-10-29 | 2005-05-12 | Gentis, Inc. | Polymerizable emulsions for tissue engineering |
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-
2002
- 2002-05-01 AU AU2002316053A patent/AU2002316053A1/en not_active Abandoned
- 2002-05-01 CA CA002447302A patent/CA2447302C/en not_active Expired - Lifetime
- 2002-05-01 AT AT02746327T patent/ATE502657T1/de not_active IP Right Cessation
- 2002-05-01 DE DE60239528T patent/DE60239528D1/de not_active Expired - Lifetime
- 2002-05-01 US US10/137,196 patent/US6803420B2/en not_active Expired - Lifetime
- 2002-05-01 EP EP10178994.9A patent/EP2277556B1/en not_active Expired - Lifetime
- 2002-05-01 ES ES10178994.9T patent/ES2587187T3/es not_active Expired - Lifetime
- 2002-05-01 RU RU2003134632/15A patent/RU2286801C2/ru active
- 2002-05-01 EP EP02746327A patent/EP1390084B1/en not_active Expired - Lifetime
- 2002-05-01 WO PCT/US2002/013680 patent/WO2002087642A2/en not_active Application Discontinuation
-
2004
- 2004-10-12 US US10/964,379 patent/US20050048103A1/en not_active Abandoned
- 2004-10-12 US US10/964,431 patent/US7138458B2/en not_active Expired - Lifetime
-
2007
- 2007-08-20 US US11/894,647 patent/US8753669B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002316053A1 (en) | 2002-11-11 |
| US7138458B2 (en) | 2006-11-21 |
| US20080161492A1 (en) | 2008-07-03 |
| US6803420B2 (en) | 2004-10-12 |
| US20050049365A1 (en) | 2005-03-03 |
| EP1390084B1 (en) | 2011-03-23 |
| ATE502657T1 (de) | 2011-04-15 |
| WO2002087642A2 (en) | 2002-11-07 |
| WO2002087642A3 (en) | 2003-01-09 |
| CA2447302A1 (en) | 2002-11-07 |
| US20050048103A1 (en) | 2005-03-03 |
| EP2277556A1 (en) | 2011-01-26 |
| US20030130427A1 (en) | 2003-07-10 |
| ES2587187T3 (es) | 2016-10-21 |
| US8753669B2 (en) | 2014-06-17 |
| DE60239528D1 (de) | 2011-05-05 |
| CA2447302C (en) | 2008-07-29 |
| EP1390084A2 (en) | 2004-02-25 |
| RU2286801C2 (ru) | 2006-11-10 |
| EP2277556B1 (en) | 2016-04-20 |
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| TK4A | Correction to the publication in the bulletin (patent) |
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