PT937456E - Dispersao lipossomal de eritropoietina - Google Patents
Dispersao lipossomal de eritropoietinaInfo
- Publication number
- PT937456E PT937456E PT98103111T PT98103111T PT937456E PT 937456 E PT937456 E PT 937456E PT 98103111 T PT98103111 T PT 98103111T PT 98103111 T PT98103111 T PT 98103111T PT 937456 E PT937456 E PT 937456E
- Authority
- PT
- Portugal
- Prior art keywords
- cholesterol
- cholesterols
- erythropoietin
- lecithin
- liposome based
- Prior art date
Links
- 239000006185 dispersion Substances 0.000 title 1
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 3
- 235000012000 cholesterol Nutrition 0.000 abstract 3
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 abstract 2
- 102000003951 Erythropoietin Human genes 0.000 abstract 2
- 108090000394 Erythropoietin Proteins 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 229940105423 erythropoietin Drugs 0.000 abstract 2
- 239000002502 liposome Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 abstract 2
- 102000008100 Human Serum Albumin Human genes 0.000 abstract 1
- 108091006905 Human Serum Albumin Proteins 0.000 abstract 1
- 239000002202 Polyethylene glycol Chemical class 0.000 abstract 1
- 150000001840 cholesterol esters Chemical class 0.000 abstract 1
- 150000001841 cholesterols Chemical class 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 150000002334 glycols Chemical class 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 229940067606 lecithin Drugs 0.000 abstract 1
- 235000010445 lecithin Nutrition 0.000 abstract 1
- 239000000787 lecithin Substances 0.000 abstract 1
- -1 lipid compound Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 239000006201 parenteral dosage form Substances 0.000 abstract 1
- 239000008363 phosphate buffer Substances 0.000 abstract 1
- 229920001223 polyethylene glycol Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1816—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98103111A EP0937456B1 (en) | 1998-02-23 | 1998-02-23 | Erythropoietin liposomal dispersion |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT937456E true PT937456E (pt) | 2004-10-29 |
Family
ID=8231466
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT98103111T PT937456E (pt) | 1998-02-23 | 1998-02-23 | Dispersao lipossomal de eritropoietina |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US6645522B2 (pt) |
| EP (1) | EP0937456B1 (pt) |
| JP (1) | JP4613294B2 (pt) |
| KR (1) | KR100591871B1 (pt) |
| CN (1) | CN1184958C (pt) |
| AT (1) | ATE271376T1 (pt) |
| AU (1) | AU750481B2 (pt) |
| BR (1) | BR9908202A (pt) |
| CA (1) | CA2320072C (pt) |
| CZ (1) | CZ296415B6 (pt) |
| DE (1) | DE69825137T2 (pt) |
| DK (1) | DK0937456T3 (pt) |
| ES (1) | ES2224299T3 (pt) |
| HU (1) | HUP0101026A2 (pt) |
| IL (2) | IL137808A0 (pt) |
| NO (1) | NO20004186L (pt) |
| NZ (1) | NZ506429A (pt) |
| PL (1) | PL194502B1 (pt) |
| PT (1) | PT937456E (pt) |
| RU (1) | RU2218914C2 (pt) |
| SI (1) | SI0937456T1 (pt) |
| SK (1) | SK284036B6 (pt) |
| WO (1) | WO1999042085A1 (pt) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT937456E (pt) * | 1998-02-23 | 2004-10-29 | Cilag Ag Int | Dispersao lipossomal de eritropoietina |
| US7345019B1 (en) * | 1999-04-13 | 2008-03-18 | The Kenneth S. Warren Institute, Inc. | Modulation of excitable tissue function by peripherally administered erythropoietin |
| ATE356874T1 (de) * | 1999-12-22 | 2007-04-15 | Dade Behring Marburg Gmbh | Lösungen von humanem procalcitonin |
| US7767643B2 (en) | 2000-12-29 | 2010-08-03 | The Kenneth S. Warren Institute, Inc. | Protection, restoration, and enhancement of erythropoietin-responsive cells, tissues and organs |
| US20030072737A1 (en) | 2000-12-29 | 2003-04-17 | Michael Brines | Tissue protective cytokines for the protection, restoration, and enhancement of responsive cells, tissues and organs |
| DE10219545A1 (de) * | 2002-04-26 | 2003-11-06 | Lang Florian | Regulation der Apoptose |
| ATE466085T1 (de) * | 2002-09-09 | 2010-05-15 | Hanall Pharmaceutical Co Ltd | Protease-resistente modifizierte interferon alpha polypeptide |
| JP2004115397A (ja) * | 2002-09-25 | 2004-04-15 | Fuji Photo Film Co Ltd | 血管疾患治療薬を含むリポソーム |
| PT1592416E (pt) * | 2003-02-07 | 2009-04-03 | Prometic Biosciences Inc | Ácidos gordos, glicéridos e análogos com cadeia de comprimento médio como estimulantes da eritropoiese |
| CN1822844B (zh) * | 2003-07-17 | 2012-05-09 | 大塚制药株式会社 | 含配糖物的脂质体 |
| ZA200603396B (en) * | 2003-09-29 | 2007-11-28 | Warren Pharmaceuticals Inc | Tissue protective cytokines for the treatment and prevention of sepsis and the formation of adhesions |
| EP1537876A1 (en) * | 2003-12-01 | 2005-06-08 | BioGeneriX AG | Erythropoietin solution formulation |
| WO2005115337A1 (en) * | 2004-05-24 | 2005-12-08 | Polymun Scientific Immunbiologische Forschung Gmbh | Superloaded liposomes for drug delivery |
| KR100684380B1 (ko) | 2005-05-24 | 2007-02-20 | 한국화학연구원 | 빗살형 폴리에틸렌글리콜을 결합한 리포솜 및 이의 제조방법 |
| US9119782B2 (en) | 2006-03-20 | 2015-09-01 | Mary P. McCourt | Drug delivery means |
| EP2120998B1 (en) | 2006-11-28 | 2013-08-07 | HanAll Biopharma Co., Ltd. | Modified erythropoietin polypeptides and uses thereof for treatment |
| US20100310636A1 (en) * | 2007-05-09 | 2010-12-09 | Gita Sharma | Stearically stabilized unilamilar vesicles, process for preparation thereof and use thereof |
| US20100003322A1 (en) * | 2008-07-03 | 2010-01-07 | Lai Felix S | Enteric coated hydrophobic matrix formulation |
| US20110070294A1 (en) * | 2009-09-23 | 2011-03-24 | Javeri Indu | Methods for the Administration of Drugs Using Liposomes |
| WO2011162818A2 (en) * | 2010-06-23 | 2011-12-29 | Controlled Nanovolumes, Inc. | Lecithin carrier vesicles and methods of making the same |
| EA018472B1 (ru) * | 2010-09-15 | 2013-08-30 | Открытое Акционерное Общество "Протек" | Частицы, содержащие эритропоэтин, для лечения и профилактики неврологических и гематологических заболеваний и нарушений |
| CA2905108C (en) | 2013-03-14 | 2021-12-07 | Julie HUGHES | Cholestosome vesicles for incorporation of molecules into chylomicrons |
| CN103751214A (zh) * | 2014-01-03 | 2014-04-30 | 广州市鼍龙生物技术开发有限公司 | 一种鳄鱼油纳米脂质体及其制备方法 |
| JP6155387B2 (ja) * | 2014-04-30 | 2017-06-28 | 富士フイルム株式会社 | リポソームの製造方法 |
| US11198831B2 (en) | 2019-01-31 | 2021-12-14 | Kvi Llc | Lubricant for a device |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ210501A (en) | 1983-12-13 | 1991-08-27 | Kirin Amgen Inc | Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence |
| JPS6197229A (ja) * | 1984-10-18 | 1986-05-15 | Chugai Pharmaceut Co Ltd | 安定なエリトロポエチン製剤 |
| AU598002B2 (en) * | 1986-07-15 | 1990-06-14 | Cilag Ltd. | Method of preparing single bilayered liposomes |
| JPH087219B2 (ja) | 1992-04-27 | 1996-01-29 | 雪印乳業株式会社 | リポソーム封入生理活性蛋白質の定量方法 |
| JPH06228012A (ja) | 1993-01-29 | 1994-08-16 | Dai Ichi Seiyaku Co Ltd | リポソーム製剤 |
| CA2120197A1 (en) * | 1993-04-02 | 1994-10-03 | Kenji Endo | Stable aqueous dispersions containing liposomes |
| US5874075A (en) * | 1993-10-06 | 1999-02-23 | Amgen Inc. | Stable protein: phospholipid compositions and methods |
| US6214388B1 (en) * | 1994-11-09 | 2001-04-10 | The Regents Of The University Of California | Immunoliposomes that optimize internalization into target cells |
| JP3850468B2 (ja) * | 1994-12-28 | 2006-11-29 | 中外製薬株式会社 | エリスロポエチンのリポソーム製剤 |
| US5858397A (en) * | 1995-10-11 | 1999-01-12 | University Of British Columbia | Liposomal formulations of mitoxantrone |
| PT937456E (pt) * | 1998-02-23 | 2004-10-29 | Cilag Ag Int | Dispersao lipossomal de eritropoietina |
-
1998
- 1998-02-23 PT PT98103111T patent/PT937456E/pt unknown
- 1998-02-23 AT AT98103111T patent/ATE271376T1/de active
- 1998-02-23 SI SI9830684T patent/SI0937456T1/xx unknown
- 1998-02-23 DK DK98103111T patent/DK0937456T3/da active
- 1998-02-23 DE DE69825137T patent/DE69825137T2/de not_active Expired - Lifetime
- 1998-02-23 ES ES98103111T patent/ES2224299T3/es not_active Expired - Lifetime
- 1998-02-23 EP EP98103111A patent/EP0937456B1/en not_active Expired - Lifetime
-
1999
- 1999-02-12 KR KR1020007009202A patent/KR100591871B1/ko not_active IP Right Cessation
- 1999-02-12 CZ CZ20002959A patent/CZ296415B6/cs not_active IP Right Cessation
- 1999-02-12 HU HU0101026A patent/HUP0101026A2/hu unknown
- 1999-02-12 NZ NZ506429A patent/NZ506429A/xx not_active IP Right Cessation
- 1999-02-12 WO PCT/IB1999/000249 patent/WO1999042085A1/en active IP Right Grant
- 1999-02-12 BR BR9908202-0A patent/BR9908202A/pt not_active Application Discontinuation
- 1999-02-12 AU AU21808/99A patent/AU750481B2/en not_active Ceased
- 1999-02-12 RU RU2000124317/14A patent/RU2218914C2/ru not_active IP Right Cessation
- 1999-02-12 IL IL13780899A patent/IL137808A0/xx active IP Right Grant
- 1999-02-12 CN CNB998052590A patent/CN1184958C/zh not_active Expired - Fee Related
- 1999-02-12 SK SK1222-2000A patent/SK284036B6/sk not_active IP Right Cessation
- 1999-02-12 CA CA002320072A patent/CA2320072C/en not_active Expired - Fee Related
- 1999-02-12 PL PL99342514A patent/PL194502B1/pl unknown
- 1999-02-12 JP JP2000532102A patent/JP4613294B2/ja not_active Expired - Fee Related
- 1999-02-18 US US09/252,563 patent/US6645522B2/en not_active Expired - Lifetime
-
2000
- 2000-08-10 IL IL137808A patent/IL137808A/en not_active IP Right Cessation
- 2000-08-22 NO NO20004186A patent/NO20004186L/no not_active Application Discontinuation
-
2003
- 2003-09-10 US US10/659,097 patent/US20040052838A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT937456E (pt) | Dispersao lipossomal de eritropoietina | |
| MY111841A (en) | Injectable liposomal pharmaceutical preparations | |
| EP0167062B1 (en) | Topical composition | |
| CA2259179A1 (en) | Emulsion formulations for hydrophilic active agents | |
| ES8700933A1 (es) | Un metodo para preparar esterol-liposomas | |
| ATE308327T1 (de) | Verwendung von 2-hydroxy-5-phenylazobenzoesäure- derivaten als wirkstoffe zur chemoprävention und chemotherapie von kolonkrebs | |
| IT1281337B1 (it) | Preparazione farmaceutica orale contenente ciclosporina come sostanza attiva ed un preconcentrato di emulsione multipla | |
| DE69324367D1 (de) | Kationische lipide | |
| CA2156288A1 (en) | Glycerol derivative, device and pharmaceutical composition | |
| CO4940469A1 (es) | Composicion oral de estabilidad mejorada que comprende un derivado de indolinona y una mezcla de gliceridos o esteres de polietilenglicol | |
| ATE244015T1 (de) | Formulierungen fuer faktor ix | |
| DK0876131T3 (da) | Sammensætninger til lægemiddelindgivelse til forbedret stabilitet af androgener | |
| BR9911013A (pt) | Derivados de pirazol como inibidores da p-38 map quinase | |
| WO1999027924A3 (fr) | Agnim comme agents anti-inflammatoires dans les tissus superficiels des mammiferes | |
| PT975329E (pt) | Complexos de lipidos e lipossomas de complexos de platina altamente insoluveis | |
| ATE328583T1 (de) | Hochdosierte liposomale aerosolformulierung | |
| RU2000124317A (ru) | Эритропоэтиновая липосомальная дисперсия | |
| DE69818806D1 (de) | Antimikrobielle kosmetische präparate | |
| RS50046B (sr) | Farmaceutske kompozicije tizoksanida i nitazoksanida | |
| DE69923332D1 (de) | Rückfettende ester auf basis von capryl-alkohol und isostearinsäure | |
| HUP0004058A2 (hu) | Készítmények és eljárások biológiai membránok permeabilitásának reverzibilis növelésére | |
| SE9604193L (sv) | Terapeutiska och kosmetiska kompositioner, deras användning och metod för framställning därav | |
| BR9811954A (pt) | ácidos 3-aril-succinamido-hidroxâmicos, processos para sua produção e preparações farmacêuticas contendo estas substâncias | |
| CA2177696A1 (en) | Lipid vesicles containing avocado oil unsaponifiables | |
| WO2001041706A3 (en) | Lipid nanotubules for topical delivery |