ATE244015T1 - Formulierungen fuer faktor ix - Google Patents
Formulierungen fuer faktor ixInfo
- Publication number
- ATE244015T1 ATE244015T1 AT95915040T AT95915040T ATE244015T1 AT E244015 T1 ATE244015 T1 AT E244015T1 AT 95915040 T AT95915040 T AT 95915040T AT 95915040 T AT95915040 T AT 95915040T AT E244015 T1 ATE244015 T1 AT E244015T1
- Authority
- AT
- Austria
- Prior art keywords
- factor
- formulations
- administration
- methods
- storage
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/233,663 US6372716B1 (en) | 1994-04-26 | 1994-04-26 | Formulations for factor IX |
PCT/US1995/004263 WO1995028954A1 (en) | 1994-04-26 | 1995-04-06 | Formulations for factor ix |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE244015T1 true ATE244015T1 (de) | 2003-07-15 |
Family
ID=22878181
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT95915040T ATE244015T1 (de) | 1994-04-26 | 1995-04-06 | Formulierungen fuer faktor ix |
Country Status (11)
Country | Link |
---|---|
US (1) | US6372716B1 (de) |
EP (1) | EP0758248B1 (de) |
JP (4) | JPH09512267A (de) |
AT (1) | ATE244015T1 (de) |
AU (1) | AU695084B2 (de) |
CA (1) | CA2182200C (de) |
DE (1) | DE69531204T2 (de) |
DK (1) | DK0758248T3 (de) |
ES (1) | ES2202356T3 (de) |
PT (1) | PT758248E (de) |
WO (1) | WO1995028954A1 (de) |
Families Citing this family (84)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6372716B1 (en) * | 1994-04-26 | 2002-04-16 | Genetics Institute, Inc. | Formulations for factor IX |
US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
US5770700A (en) * | 1996-01-25 | 1998-06-23 | Genetics Institute, Inc. | Liquid factor IX formulations |
US7786070B2 (en) | 1997-09-10 | 2010-08-31 | Novo Nordisk Healthcare A/G | Subcutaneous administration of coagulation factor VII |
US20080050367A1 (en) * | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
US7588766B1 (en) | 2000-05-26 | 2009-09-15 | Elan Pharma International Limited | Treatment of amyloidogenic disease |
US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
TWI239847B (en) * | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
US7790856B2 (en) * | 1998-04-07 | 2010-09-07 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
US6787523B1 (en) * | 1997-12-02 | 2004-09-07 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
US6761888B1 (en) | 2000-05-26 | 2004-07-13 | Neuralab Limited | Passive immunization treatment of Alzheimer's disease |
JP5090605B2 (ja) | 2000-05-03 | 2012-12-05 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 凝固因子viiの皮下投与 |
RU2163140C1 (ru) * | 2000-07-05 | 2001-02-20 | Гематологический научный центр РАМН | Концентрат фактора ix системы свертывания крови и способ его получения |
US7083787B2 (en) * | 2000-11-15 | 2006-08-01 | Globeimmune, Inc. | Yeast-dendritic cell vaccines and uses thereof |
US7700751B2 (en) | 2000-12-06 | 2010-04-20 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize β-amyloid peptide |
TWI255272B (en) * | 2000-12-06 | 2006-05-21 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
ES2325653T3 (es) | 2001-12-21 | 2009-09-11 | Novo Nordisk Health Care Ag | Composicion liquida de polipeptidos del factor vii. |
MY139983A (en) * | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
EP2283856B1 (de) | 2002-06-21 | 2017-09-20 | Novo Nordisk Health Care AG | Stabiliserte feste Zusammensetzungen von Faktor VIIa Polypeptiden |
HRP20050670A2 (en) * | 2003-02-01 | 2005-12-31 | WYETH Neuralab Limited | Active immunization to generate antibodies to soluble a-beta |
US7897734B2 (en) | 2003-03-26 | 2011-03-01 | Novo Nordisk Healthcare Ag | Method for the production of proteins |
EP1628677B1 (de) | 2003-05-23 | 2010-01-13 | Novo Nordisk Health Care AG | Stabilisierung von proteinen in lösung |
PE20050627A1 (es) * | 2003-05-30 | 2005-08-10 | Wyeth Corp | Anticuerpos humanizados que reconocen el peptido beta amiloideo |
WO2004112828A1 (en) | 2003-06-25 | 2004-12-29 | Novo Nordisk Health Care Ag | Liquid composition of factor vii polypeptides |
BRPI0413518A (pt) | 2003-08-14 | 2006-10-10 | Novo Nordisk Healthcare Ag | composição farmacêutica lìquida aquosa, método para preparar e uso da mesma, método para tratar uma sìndrome responsiva ao fator vii, e, recipiente hermético |
KR20140093711A (ko) | 2003-12-19 | 2014-07-28 | 노보 노르디스크 헬스 케어 악티엔게젤샤프트 | 인자 vii 폴리펩티드의 안정화된 조성물 |
JP2008505119A (ja) * | 2004-06-30 | 2008-02-21 | ネクター セラピューティクス アラバマ,コーポレイション | 高分子−第ix因子部分の抱合体 |
US20060051347A1 (en) | 2004-09-09 | 2006-03-09 | Winter Charles M | Process for concentration of antibodies and therapeutic products thereof |
AR052051A1 (es) * | 2004-12-15 | 2007-02-28 | Neuralab Ltd | Anticuerpos ab humanizados usados en mejorar la cognicion |
WO2006066171A1 (en) * | 2004-12-15 | 2006-06-22 | Neuralab Limited | Amyloid βετα antibodies for use in improving cognition |
ES2396555T3 (es) * | 2004-12-15 | 2013-02-22 | Janssen Alzheimer Immunotherapy | Anticuerpos que reconocen péptido beta amiloide |
GT200600031A (es) * | 2005-01-28 | 2006-08-29 | Formulacion anticuerpo anti a beta | |
TW200638943A (en) * | 2005-01-28 | 2006-11-16 | Wyeth Corp | Stabilized liquid polypeptide formulations |
ES2439709T3 (es) | 2005-06-21 | 2014-01-24 | Xoma (Us) Llc | Anticuerpos y fragmentos de los mismos que se unen a la IL-1beta |
AU2006308921C1 (en) | 2005-11-01 | 2013-01-24 | Wyeth Llc | Sodium chloride solution for drug reconstitution or dilution |
CA2630115A1 (en) * | 2005-11-22 | 2007-05-31 | Wyeth | Immunoglobulin fusion protein formulations |
US8784810B2 (en) * | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
EP2094306A2 (de) | 2006-12-20 | 2009-09-02 | XOMA Technology Ltd. | Behandlung von il-1-beta-bedingten erkrankungen |
MX2009011127A (es) * | 2007-04-18 | 2010-03-10 | Janssen Alzheimer Immunotherap | Metodo de prevencion y tratamiento de angiopatia amiloide cerebral. |
US8003097B2 (en) * | 2007-04-18 | 2011-08-23 | Janssen Alzheimer Immunotherapy | Treatment of cerebral amyloid angiopathy |
CA2687246A1 (en) * | 2007-06-01 | 2008-12-11 | Acologix, Inc. | High temperature stable peptide formulation |
PL2182983T3 (pl) | 2007-07-27 | 2014-10-31 | Janssen Alzheimer Immunotherap | Leczenie chorób amyloidowych z wykorzystaniem humanizowanych przeciwciał specyficznych względem Abeta |
JO3076B1 (ar) * | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
JP5536666B2 (ja) | 2007-12-20 | 2014-07-02 | ゾーマ (ユーエス) リミテッド ライアビリティ カンパニー | 痛風の治療のための方法 |
WO2009082648A1 (en) * | 2007-12-21 | 2009-07-02 | Inspiration Biopharmaceuticals, Inc. | Stabilized factor ix formulations containing trehalose |
US9067981B1 (en) | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
MX2011006347A (es) * | 2008-12-16 | 2011-09-06 | Genzyme Corp | Conjugados de oligosacaridos-proteinas. |
WO2012092539A2 (en) | 2010-12-31 | 2012-07-05 | Takeda Pharmaceutical Company Limited | Antibodies to dll4 and uses thereof |
JP5828909B2 (ja) | 2011-01-10 | 2015-12-09 | シーティー アトランティック リミテッド | 腫瘍関連抗原結合抗体を含む併用療法 |
US20140093514A1 (en) | 2011-06-03 | 2014-04-03 | University Of Zurich | Magea3 binding antibodies |
US20140186363A1 (en) | 2011-06-03 | 2014-07-03 | University Of Zurich | Magea3 binding antibodies |
EP3050900A1 (de) | 2011-12-19 | 2016-08-03 | Xoma (Us) Llc | Verfahren zur behandlung von akne |
JP2015509091A (ja) | 2012-01-09 | 2015-03-26 | ザ スクリプス リサーチ インスティテュート | ヒト化抗体 |
US20140050720A1 (en) | 2012-01-09 | 2014-02-20 | The Scripps Research Institute | Ultralong complementarity determining regions and uses thereof |
WO2014052490A1 (en) | 2012-09-25 | 2014-04-03 | Biogen Idec Ma Inc. | Methods of using fix polypeptides |
CA2890848C (en) | 2012-11-09 | 2020-11-17 | Puget Sound Blood Center | Protein stabilizing factors apolipoprotein a-1 or high density lipoprotein |
CA2904586A1 (en) | 2013-03-08 | 2014-09-12 | The Curators Of The University Of Missouri | Methods and compositions for the treatment and/or prevention of type 1 diabetes |
EP2968498A4 (de) | 2013-03-15 | 2016-09-07 | Biogen Ma Inc | Faktor-ix-polypeptidformulierungen |
EP3019533B1 (de) | 2013-07-11 | 2020-01-08 | The Scripps Research Institute | Doppelwendel-immunglobulinfusionsproteine und zusammensetzungen daraus |
EP3022224A2 (de) | 2013-07-18 | 2016-05-25 | Fabrus, Inc. | Antikörper mit ultralangen komplementaritätsbestimmenden regionen |
AU2014290361B2 (en) | 2013-07-18 | 2019-04-18 | Taurus Biosciences, Llc | Humanized antibodies with ultralong complementarity determining regions |
CA2924109A1 (en) | 2013-09-13 | 2015-03-19 | The California Institute For Biomedical Research | Modified therapeutic agents and compositions thereof |
US9913818B2 (en) | 2013-10-09 | 2018-03-13 | Nestec S.A. | Compositions comprising citrulline and leucine and their use in the treatment of diabetes and metabolic syndrome |
WO2015057834A1 (en) | 2013-10-15 | 2015-04-23 | The California Institute For Biomedical Research | Peptidic chimeric antigen receptor t cell switches and uses thereof |
JP6637415B2 (ja) | 2013-10-15 | 2020-01-29 | ザ スクリプス リサーチ インスティテュート | キメラ抗原受容体t細胞スイッチおよびその使用 |
JP6572497B2 (ja) | 2013-12-18 | 2019-09-11 | ザ・スクリップス・リサーチ・インスティテュート | 修飾された治療剤、ステープル留めされたペプチド脂質複合体、及びそれらの組成物 |
SG10201913735SA (en) | 2014-03-24 | 2020-03-30 | Bioverativ Therapeutics Inc | Lyophilized factor ix formulations |
WO2016154621A1 (en) | 2015-03-26 | 2016-09-29 | The California Institute For Biomedical Research | SWITCHABLE NON-scFv CHIMERIC RECEPTORS, SWITCHES, AND USES THEREOF |
EP3283113A4 (de) | 2015-04-15 | 2018-12-05 | The California Institute for Biomedical Research | Optimierte pne-basierte chimäre t-zell-rezeptor-schalter und verwendungen davon |
JP2018517711A (ja) | 2015-06-01 | 2018-07-05 | メディジーン イミュノテラピーズ ゲーエムベーハー | 細胞表面タンパク質に対する抗体を作製する方法 |
NZ737851A (en) | 2015-06-01 | 2019-08-30 | Medigene Immunotherapies Gmbh | T-cell receptor specific antibodies |
WO2016193299A1 (en) | 2015-06-01 | 2016-12-08 | Medigene Immunotherapies Gmbh | T cell receptor library |
US20190000928A1 (en) | 2015-06-17 | 2019-01-03 | The California Institute For Biomedical Research | Modified therapeutic agents and compositions thereof |
UA124616C2 (uk) | 2015-07-06 | 2021-10-20 | Юсб Біофарма Срл | Зв'язуюче тау-білок антитіло |
CN108348581B (zh) | 2015-09-04 | 2022-07-01 | 斯克利普斯研究所 | 胰岛素免疫球蛋白融合蛋白 |
EP3387019B1 (de) | 2015-12-09 | 2021-10-20 | The Scripps Research Institute | Relaxin-immunglobulin-fusionsproteine und verfahren zur verwendung |
BR112018012826A2 (pt) | 2015-12-23 | 2018-12-04 | Medigene Immunotherapies Gmbh | método para gerar linfócitos, para gerar um tcr e tcr específico para gage-1 |
ES3030503T3 (en) | 2016-10-19 | 2025-06-30 | Scripps Research Inst | Chimeric antigen receptor effector cell switches with humanized targeting moieties and/or optimized chimeric antigen receptor interacting domains and uses thereof |
CA3149494A1 (en) | 2019-08-12 | 2021-02-18 | Purinomia Biotech, Inc. | Methods and compositions for promoting and potentiating t-cell mediated immune responses through adcc targeting of cd39 expressing cells |
CA3158893A1 (en) | 2019-10-24 | 2021-04-29 | Minotaur Therapeutics, Inc. | Chimeric cytokine modified antibodies and methods of use thereof |
CN118251420A (zh) | 2021-04-28 | 2024-06-25 | 米诺陶治疗公司 | 人源化嵌合牛抗体和使用方法 |
WO2022257979A1 (en) | 2021-06-09 | 2022-12-15 | The Scripps Research Institute | Long-acting dual gip/glp-1 peptide conjugates and methods of use |
US20250108109A1 (en) | 2021-12-01 | 2025-04-03 | UCB Biopharma SRL | Formulations comprising fab-peg |
CN118354793A (zh) | 2022-04-29 | 2024-07-16 | 普瑞诺生物科技公司 | 用于治疗嗜酸性粒细胞驱动的疾病和病症的方法和组合物 |
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JPS5480406A (en) * | 1977-12-09 | 1979-06-27 | Tanabe Seiyaku Co Ltd | Preparation of urokinase for injection |
DE3045153A1 (de) * | 1980-11-29 | 1982-07-08 | Behringwerke Ag, 3550 Marburg | Verfahren zur herstellung von blutgerinnungsfaktoren und danach hergestellte praeparation der faktoren ix und x |
US4495278A (en) | 1981-04-27 | 1985-01-22 | Baxter Travenol Laboratories, Inc. | Process for making novel blood clotting enzyme compositions |
US4470968A (en) * | 1983-01-13 | 1984-09-11 | Miles Laboratories, Inc. | Pasteurized therapeutically active blood coagulation factor concentrates |
AT376881B (de) * | 1983-05-02 | 1985-01-10 | Immuno Ag | Verfahren zur inaktivierung von vermehrungsfaehigen krankheitserregern |
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US4952675A (en) * | 1985-02-01 | 1990-08-28 | New York University | Method for purifying antihemophilic factor |
ATE74164T1 (de) | 1985-04-22 | 1992-04-15 | Genetics Inst | Herstellung mit hoher leistung des aktivfaktors ix. |
DE3729863A1 (de) * | 1987-09-05 | 1989-03-16 | Boehringer Mannheim Gmbh | Stabilisierte erythropoietin-lyophilisate |
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ES2045167T5 (es) | 1987-10-23 | 1996-07-01 | Centre Regional De Transfusion | Preparacion de concentrado de factor ix humano de elevada pureza y de otras proteinas plasmaticas. |
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DE4001451A1 (de) * | 1990-01-19 | 1991-08-01 | Octapharma Ag | Stabile injizierbare loesungen von faktor viii und faktor ix |
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US6372716B1 (en) * | 1994-04-26 | 2002-04-16 | Genetics Institute, Inc. | Formulations for factor IX |
-
1994
- 1994-04-26 US US08/233,663 patent/US6372716B1/en not_active Expired - Lifetime
-
1995
- 1995-04-06 DK DK95915040T patent/DK0758248T3/da active
- 1995-04-06 DE DE69531204T patent/DE69531204T2/de not_active Expired - Lifetime
- 1995-04-06 CA CA002182200A patent/CA2182200C/en not_active Expired - Lifetime
- 1995-04-06 AU AU22075/95A patent/AU695084B2/en not_active Expired
- 1995-04-06 AT AT95915040T patent/ATE244015T1/de active
- 1995-04-06 JP JP7527660A patent/JPH09512267A/ja not_active Withdrawn
- 1995-04-06 ES ES95915040T patent/ES2202356T3/es not_active Expired - Lifetime
- 1995-04-06 WO PCT/US1995/004263 patent/WO1995028954A1/en active IP Right Grant
- 1995-04-06 PT PT95915040T patent/PT758248E/pt unknown
- 1995-04-06 EP EP95915040A patent/EP0758248B1/de not_active Expired - Lifetime
-
2006
- 2006-05-22 JP JP2006141780A patent/JP4789698B2/ja not_active Expired - Lifetime
-
2007
- 2007-06-13 JP JP2007156252A patent/JP2007224052A/ja not_active Withdrawn
-
2009
- 2009-11-25 JP JP2009267797A patent/JP2010077148A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
CA2182200C (en) | 1999-02-02 |
JP2010077148A (ja) | 2010-04-08 |
CA2182200A1 (en) | 1995-11-02 |
ES2202356T3 (es) | 2004-04-01 |
JP2006219500A (ja) | 2006-08-24 |
AU2207595A (en) | 1995-11-16 |
JP2007224052A (ja) | 2007-09-06 |
DE69531204D1 (de) | 2003-08-07 |
AU695084B2 (en) | 1998-08-06 |
JPH09512267A (ja) | 1997-12-09 |
DK0758248T3 (da) | 2003-10-27 |
WO1995028954A1 (en) | 1995-11-02 |
JP4789698B2 (ja) | 2011-10-12 |
DE69531204T2 (de) | 2004-04-22 |
US6372716B1 (en) | 2002-04-16 |
PT758248E (pt) | 2003-11-28 |
EP0758248B1 (de) | 2003-07-02 |
EP0758248A1 (de) | 1997-02-19 |
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