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DK0937456T3 - Liposomal dispersion af erytropoietin - Google Patents

Liposomal dispersion af erytropoietin

Info

Publication number
DK0937456T3
DK0937456T3 DK98103111T DK98103111T DK0937456T3 DK 0937456 T3 DK0937456 T3 DK 0937456T3 DK 98103111 T DK98103111 T DK 98103111T DK 98103111 T DK98103111 T DK 98103111T DK 0937456 T3 DK0937456 T3 DK 0937456T3
Authority
DK
Denmark
Prior art keywords
erythropoietin
cholesterol
cholesterols
lecithin
liposome based
Prior art date
Application number
DK98103111T
Other languages
Danish (da)
English (en)
Inventor
Rainer Naeff
Sandro Delmenico
Andre Wetter
Frank-Ulrich Floether
Original Assignee
Cilag Ag Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cilag Ag Int filed Critical Cilag Ag Int
Application granted granted Critical
Publication of DK0937456T3 publication Critical patent/DK0937456T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1816—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
DK98103111T 1998-02-23 1998-02-23 Liposomal dispersion af erytropoietin DK0937456T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98103111A EP0937456B1 (en) 1998-02-23 1998-02-23 Erythropoietin liposomal dispersion

Publications (1)

Publication Number Publication Date
DK0937456T3 true DK0937456T3 (da) 2004-11-08

Family

ID=8231466

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98103111T DK0937456T3 (da) 1998-02-23 1998-02-23 Liposomal dispersion af erytropoietin

Country Status (23)

Country Link
US (2) US6645522B2 (pt)
EP (1) EP0937456B1 (pt)
JP (1) JP4613294B2 (pt)
KR (1) KR100591871B1 (pt)
CN (1) CN1184958C (pt)
AT (1) ATE271376T1 (pt)
AU (1) AU750481B2 (pt)
BR (1) BR9908202A (pt)
CA (1) CA2320072C (pt)
CZ (1) CZ296415B6 (pt)
DE (1) DE69825137T2 (pt)
DK (1) DK0937456T3 (pt)
ES (1) ES2224299T3 (pt)
HU (1) HUP0101026A2 (pt)
IL (2) IL137808A0 (pt)
NO (1) NO20004186L (pt)
NZ (1) NZ506429A (pt)
PL (1) PL194502B1 (pt)
PT (1) PT937456E (pt)
RU (1) RU2218914C2 (pt)
SI (1) SI0937456T1 (pt)
SK (1) SK284036B6 (pt)
WO (1) WO1999042085A1 (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0937456B1 (en) * 1998-02-23 2004-07-21 Cilag AG International Erythropoietin liposomal dispersion
US7345019B1 (en) * 1999-04-13 2008-03-18 The Kenneth S. Warren Institute, Inc. Modulation of excitable tissue function by peripherally administered erythropoietin
ES2280170T3 (es) * 1999-12-22 2007-09-16 Dade Behring Marburg Gmbh Soluciones de procalcitonina humana.
US7767643B2 (en) 2000-12-29 2010-08-03 The Kenneth S. Warren Institute, Inc. Protection, restoration, and enhancement of erythropoietin-responsive cells, tissues and organs
US20030072737A1 (en) 2000-12-29 2003-04-17 Michael Brines Tissue protective cytokines for the protection, restoration, and enhancement of responsive cells, tissues and organs
DE10219545A1 (de) * 2002-04-26 2003-11-06 Lang Florian Regulation der Apoptose
AU2003263552A1 (en) * 2002-09-09 2004-03-29 Nautilus Biotech Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
JP2004115397A (ja) * 2002-09-25 2004-04-15 Fuji Photo Film Co Ltd 血管疾患治療薬を含むリポソーム
DE04708802T1 (de) * 2003-02-07 2006-06-22 Prometic Biosciences Inc., Montreal Fettsäuren mittlerer kettenlänge, glyceride und analoga als stimulatoren der erythropoiese
JP4728805B2 (ja) * 2003-07-17 2011-07-20 大塚製薬株式会社 配糖体含有リポソーム
ZA200603396B (en) * 2003-09-29 2007-11-28 Warren Pharmaceuticals Inc Tissue protective cytokines for the treatment and prevention of sepsis and the formation of adhesions
EP1537876A1 (en) * 2003-12-01 2005-06-08 BioGeneriX AG Erythropoietin solution formulation
EP1748760B1 (en) * 2004-05-24 2009-12-23 Polymun Scientific Immunbiologische Forschung GmbH Superloaded liposomes for drug delivery
KR100684380B1 (ko) 2005-05-24 2007-02-20 한국화학연구원 빗살형 폴리에틸렌글리콜을 결합한 리포솜 및 이의 제조방법
US9119782B2 (en) 2006-03-20 2015-09-01 Mary P. McCourt Drug delivery means
EP2120998B1 (en) 2006-11-28 2013-08-07 HanAll Biopharma Co., Ltd. Modified erythropoietin polypeptides and uses thereof for treatment
WO2009044406A2 (en) * 2007-05-09 2009-04-09 Claris Lifesciences Limited Stearically stabilized unilamilar vesicles, process for preparation thereof and use thereof
US20100003322A1 (en) * 2008-07-03 2010-01-07 Lai Felix S Enteric coated hydrophobic matrix formulation
US20110070294A1 (en) * 2009-09-23 2011-03-24 Javeri Indu Methods for the Administration of Drugs Using Liposomes
JP6189749B2 (ja) * 2010-06-23 2017-08-30 ブライトサイド イノベーションズ，インコーポレイティド レシチン担体小胞とその作製方法
EA018472B1 (ru) * 2010-09-15 2013-08-30 Открытое Акционерное Общество "Протек" Частицы, содержащие эритропоэтин, для лечения и профилактики неврологических и гематологических заболеваний и нарушений
WO2014152795A2 (en) 2013-03-14 2014-09-25 Schentag Jerome J Cholestosome vesicles for incorporation of molecules into chylomicrons
CN108066288A (zh) * 2014-01-03 2018-05-25 广州市鼍龙生物技术开发有限公司 一种鳄鱼油纳米脂质体及其制备方法
JP6155387B2 (ja) * 2014-04-30 2017-06-28 富士フイルム株式会社 リポソームの製造方法
US11198831B2 (en) 2019-01-31 2021-12-14 Kvi Llc Lubricant for a device

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ210501A (en) 1983-12-13 1991-08-27 Kirin Amgen Inc Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence
JPS6197229A (ja) * 1984-10-18 1986-05-15 Chugai Pharmaceut Co Ltd 安定なエリトロポエチン製剤
AU598002B2 (en) * 1986-07-15 1990-06-14 Cilag Ltd. Method of preparing single bilayered liposomes
JPH087219B2 (ja) 1992-04-27 1996-01-29 雪印乳業株式会社 リポソーム封入生理活性蛋白質の定量方法
JPH06228012A (ja) 1993-01-29 1994-08-16 Dai Ichi Seiyaku Co Ltd リポソーム製剤
CA2120197A1 (en) * 1993-04-02 1994-10-03 Kenji Endo Stable aqueous dispersions containing liposomes
US5874075A (en) * 1993-10-06 1999-02-23 Amgen Inc. Stable protein: phospholipid compositions and methods
US6214388B1 (en) * 1994-11-09 2001-04-10 The Regents Of The University Of California Immunoliposomes that optimize internalization into target cells
JP3850468B2 (ja) * 1994-12-28 2006-11-29 中外製薬株式会社 エリスロポエチンのリポソーム製剤
US5858397A (en) * 1995-10-11 1999-01-12 University Of British Columbia Liposomal formulations of mitoxantrone
EP0937456B1 (en) * 1998-02-23 2004-07-21 Cilag AG International Erythropoietin liposomal dispersion

Also Published As

Publication number Publication date
PT937456E (pt) 2004-10-29
NO20004186D0 (no) 2000-08-22
ES2224299T3 (es) 2005-03-01
RU2218914C2 (ru) 2003-12-20
KR100591871B1 (ko) 2006-06-23
US20020028236A1 (en) 2002-03-07
IL137808A0 (en) 2001-10-31
AU2180899A (en) 1999-09-06
CN1184958C (zh) 2005-01-19
ATE271376T1 (de) 2004-08-15
CZ296415B6 (cs) 2006-03-15
SK12222000A3 (sk) 2001-11-06
JP4613294B2 (ja) 2011-01-12
BR9908202A (pt) 2000-10-24
NZ506429A (en) 2003-03-28
NO20004186L (no) 2000-08-22
CA2320072A1 (en) 1999-08-26
DE69825137D1 (de) 2004-08-26
IL137808A (en) 2007-07-24
HUP0101026A2 (hu) 2001-08-28
PL194502B1 (pl) 2007-06-29
PL342514A1 (en) 2001-06-18
EP0937456A1 (en) 1999-08-25
AU750481B2 (en) 2002-07-18
SI0937456T1 (en) 2004-12-31
CZ20002959A3 (cs) 2001-10-17
CN1298296A (zh) 2001-06-06
DE69825137T2 (de) 2005-07-21
EP0937456B1 (en) 2004-07-21
WO1999042085A1 (en) 1999-08-26
US6645522B2 (en) 2003-11-11
JP2002503685A (ja) 2002-02-05
KR20010041152A (ko) 2001-05-15
SK284036B6 (sk) 2004-08-03
US20040052838A1 (en) 2004-03-18
CA2320072C (en) 2009-04-07

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