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PT1295890E - Novos derivados de pirazina ou os seus sais, composicoes farmaceuticas que os contem, e compostos intermedios utilizados na sua producao - Google Patents

Novos derivados de pirazina ou os seus sais, composicoes farmaceuticas que os contem, e compostos intermedios utilizados na sua producao

Info

Publication number
PT1295890E
PT1295890E PT02028152T PT02028152T PT1295890E PT 1295890 E PT1295890 E PT 1295890E PT 02028152 T PT02028152 T PT 02028152T PT 02028152 T PT02028152 T PT 02028152T PT 1295890 E PT1295890 E PT 1295890E
Authority
PT
Portugal
Prior art keywords
salts
production
contain
pyrazine derivatives
compounds
Prior art date
Application number
PT02028152T
Other languages
English (en)
Inventor
Egawa Hiroyuki
Furuta Yousuke
Jun Sugita
Uehara Sayuri
Hamamoto Shoichi
Yonezawa Kenji
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Publication of PT1295890E publication Critical patent/PT1295890E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT02028152T 2000-02-16 2001-02-14 Novos derivados de pirazina ou os seus sais, composicoes farmaceuticas que os contem, e compostos intermedios utilizados na sua producao PT1295890E (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2000037486 2000-02-16
JP2000040439 2000-02-18
JP2000090071 2000-03-29

Publications (1)

Publication Number Publication Date
PT1295890E true PT1295890E (pt) 2005-06-30

Family

ID=27342371

Family Applications (2)

Application Number Title Priority Date Filing Date
PT01904434T PT1256588E (pt) 2000-02-16 2001-02-14 Derivados de pirazina originais ou os seus sais, preparacoes farmaceuticas, contendo os derivados ou os seus sais e produtos intermedios para a preparacao de ambos
PT02028152T PT1295890E (pt) 2000-02-16 2001-02-14 Novos derivados de pirazina ou os seus sais, composicoes farmaceuticas que os contem, e compostos intermedios utilizados na sua producao

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PT01904434T PT1256588E (pt) 2000-02-16 2001-02-14 Derivados de pirazina originais ou os seus sais, preparacoes farmaceuticas, contendo os derivados ou os seus sais e produtos intermedios para a preparacao de ambos

Country Status (15)

Country Link
US (1) US6800629B2 (pt)
EP (2) EP1256588B1 (pt)
JP (2) JP4379767B2 (pt)
KR (3) KR100604955B1 (pt)
CN (1) CN1239511C (pt)
AT (2) ATE294185T1 (pt)
AU (1) AU2001232287A1 (pt)
BR (2) BRPI0108374B8 (pt)
CA (1) CA2398620C (pt)
DE (2) DE60110415T2 (pt)
DK (1) DK1295890T3 (pt)
ES (2) ES2240645T3 (pt)
MX (1) MXPA02007890A (pt)
PT (2) PT1256588E (pt)
WO (1) WO2001060834A1 (pt)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003015798A1 (en) * 2001-08-14 2003-02-27 Toyama Chemical Co., Ltd. Novel virus proliferation inhibition/virucidal method and novel pyradine nucleotide/pyradine nucleoside analogue
AU2005289517A1 (en) * 2004-09-24 2006-04-06 Centre National De La Recherche Scientifique Methods and compositions for treating flaviviruses, pestiviruses and hepacivirus
EP1962864A4 (en) * 2005-12-22 2010-02-17 Alchemia Ltd ANTIBACTERIAL AGENTS
NZ573108A (en) * 2006-05-31 2011-02-25 Toyama Chemical Co Ltd Anti-foot-and-mouth disease virus agent for animal belonging to family suidae or sheep, and method for prevention or treatment of foot-and-mouth disease in animal belonging to family suidae or sheep
CA2700490C (en) * 2007-09-27 2015-10-27 Toyama Chemical Co. Ltd. Organic amine salt of 6-fluoro-3-hydroxy-2-pyrazinecarbonitrile and method for producing the same
JP5364327B2 (ja) * 2008-09-26 2013-12-11 富士フイルム株式会社 ハロピラジンカルボキサミド化合物の製造方法
WO2010087117A1 (ja) * 2009-01-28 2010-08-05 日本曹達株式会社 ジクロロピラジン誘導体の製造方法
JP5559604B2 (ja) * 2009-05-27 2014-07-23 富山化学工業株式会社 ３，６−ジクロロ−２−ピラジンカルボニトリルの製造法
ES2554630T3 (es) 2010-09-30 2015-12-22 Toyama Chemical Co., Ltd. Sal sódica de 6-fluoro-3-hidroxi-2-pirazinocarboxamida
JP5936546B2 (ja) 2010-09-30 2016-06-22 富山化学工業株式会社 ６−フルオロ−３−ヒドロキシ−２−ピラジンカルボキサミドのメグルミン塩
AU2011327111B2 (en) * 2010-11-12 2015-04-23 Fujifilm Toyama Chemical Co., Ltd. Pyrazino[2,3-d]isoxazole Derivative
CN102846617B (zh) * 2011-07-01 2016-01-13 中国人民解放军军事医学科学院毒物药物研究所 3－(丁基氧基)－2－吡嗪甲酰氨的制备方法和用途
WO2013004141A1 (zh) * 2011-07-01 2013-01-10 中国人民解放军军事医学科学院毒物药物研究所 3－烷氧基取代－2－吡嗪甲酰氨类化合物及其用途
CN105732748B (zh) * 2014-12-12 2019-01-01 浙江医药股份有限公司新昌制药厂 一种核苷酸类似物及其制备方法、以及含有核苷酸类似物的药物组合物及其应用
WO2016172205A1 (en) * 2015-04-20 2016-10-27 Emory University Managing ebola viral infections
CN107635976A (zh) 2015-06-09 2018-01-26 富山化学工业株式会社 6‑溴‑3‑羟基‑2‑吡嗪甲酰胺的结晶及其制造方法
CN104961690A (zh) * 2015-07-11 2015-10-07 长沙深橙生物科技有限公司 3-(4-氟苯氧基)吡嗪-2-羧酸的制备方法
CN104961691A (zh) * 2015-07-11 2015-10-07 长沙深橙生物科技有限公司 3-(2-氟苯氧基)吡嗪-2-羧酸的制备方法
CN105037281A (zh) * 2015-07-11 2015-11-11 长沙深橙生物科技有限公司 3-(3-氟苯氧基)吡嗪-2-羧酸的制备方法
CN105017166A (zh) * 2015-07-11 2015-11-04 长沙深橙生物科技有限公司 3-(3-溴苯氧基)吡嗪-2-羧酸的制备方法
CN107641106A (zh) * 2016-07-22 2018-01-30 大连鸿凯化工科技发展有限公司 法匹拉韦中间体以及法匹拉韦的合成方法
JPWO2018199048A1 (ja) * 2017-04-25 2020-05-07 大原薬品工業株式会社 ヌクレオシド系抗がん剤または抗ウィルス剤の５’位モノ燐酸ジベンジルエステル誘導体
CN111265528A (zh) * 2020-01-21 2020-06-12 中国人民解放军军事科学院军事医学研究院 法匹拉韦在治疗冠状病毒感染方面的应用
CN113248450B (zh) * 2020-02-07 2024-04-12 北京四环制药有限公司 一种法匹拉韦的制备方法
CN113735784A (zh) * 2020-05-28 2021-12-03 南京桦冠生物技术有限公司 6-氟-3-羟基吡嗪-2-甲酰胺的制备方法
WO2021255681A1 (en) * 2020-06-17 2021-12-23 Hikal Limited A simple process for the preparation of favipiravir and its intermediates thereof
CN111704582B (zh) * 2020-06-23 2021-06-11 杭州煌森生物科技有限公司 一种法匹拉韦及其衍生物的制备方法
WO2022009036A1 (en) * 2020-07-06 2022-01-13 Optimus Drugs (P) Ltd Synthesis of favipiravir
CN114656412A (zh) * 2020-12-22 2022-06-24 山东特珐曼药业有限公司 一种法匹拉韦的合成方法
CN112552245B (zh) * 2020-12-29 2022-08-02 苏州正济药业有限公司 法匹拉韦的合成方法
CN112851589B (zh) * 2021-01-25 2022-10-11 山东邹平大展新材料有限公司 一种法匹拉韦中间体6-溴-3-羟基吡嗪-2-甲酰胺的制备方法
AU2022422584A1 (en) 2021-12-23 2024-05-30 Subintro Limited Novel antiviral compositions comprising oleic acid
CN114478404A (zh) * 2022-03-17 2022-05-13 浙江海正药业股份有限公司 一种法维拉韦中间体羟基物的纯化方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990002125A1 (en) * 1988-08-22 1990-03-08 Idemitsu Kosan Co. Ltd. Oxirane derivatives and herbicides containing same as active ingredients
DE59209008D1 (de) * 1991-08-17 1997-12-11 Hoechst Ag 2-Fluorpyrazine, Verfahren zu ihrer Herstellung und ihre Verwendung in flüssigkristallinen Mischungen
RU2224520C2 (ru) * 1998-08-20 2004-02-27 Тояма Кемикал Ко., Лтд. Азотсодержащие гетероциклические производные карбоксамида или их соли и противовирусные средства, включающие их

Also Published As

Publication number Publication date
CN1418220A (zh) 2003-05-14
CN1239511C (zh) 2006-02-01
KR20030032918A (ko) 2003-04-26
EP1295890A1 (en) 2003-03-26
ATE294185T1 (de) 2005-05-15
KR20030034120A (ko) 2003-05-01
BRPI0116967B1 (pt) 2018-05-22
EP1256588B1 (en) 2005-02-02
ES2240645T3 (es) 2005-10-16
KR100604955B1 (ko) 2006-07-26
WO2001060834A1 (fr) 2001-08-23
DE60110415D1 (de) 2005-06-02
JP4379767B2 (ja) 2009-12-09
DE60110415T2 (de) 2005-09-29
DE60108724D1 (de) 2005-03-10
EP1256588A4 (en) 2003-03-26
ES2237550T3 (es) 2005-08-01
JP2009161553A (ja) 2009-07-23
AU2001232287A1 (en) 2001-08-27
KR20030048108A (ko) 2003-06-18
BRPI0108374B1 (pt) 2017-10-10
BRPI0116967B8 (pt) 2021-05-25
KR100589935B1 (ko) 2006-06-15
PT1256588E (pt) 2005-05-31
BRPI0116967A2 (pt) 2009-07-14
JP5038345B2 (ja) 2012-10-03
US20030130213A1 (en) 2003-07-10
EP1256588A1 (en) 2002-11-13
DE60108724T2 (de) 2005-06-23
MXPA02007890A (es) 2002-10-31
CA2398620A1 (en) 2001-08-23
US6800629B2 (en) 2004-10-05
EP1295890B1 (en) 2005-04-27
DK1295890T3 (da) 2005-05-17
CA2398620C (en) 2009-06-23
BRPI0108374B8 (pt) 2021-05-25
ATE288443T1 (de) 2005-02-15
BR0108374A (pt) 2003-03-18

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