PT1105382E - Metodo para a preparacao de citalopran - Google Patents

Metodo para a preparacao de citalopran

Info

Publication number: PT1105382E
Authority: PT; Portugal
Prior art keywords: citalopran; preparation
Prior art date: 1999-06-25

Application number

PT99968206T

Other languages

English (en)

Inventor

Hans Petersen

Michael Harold Rock

Original Assignee

Lundbeck & Co As H

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-06-25

Filing date

1999-11-19

Publication date

2002-07-31

1999-11-19 Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H

2002-07-31 Publication of PT1105382E publication Critical patent/PT1105382E/pt

Classifications

- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/22—Organic complexes
- B01J31/2282—Unsaturated compounds used as ligands
- B01J31/2295—Cyclic compounds, e.g. cyclopentadienyls
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
- B01J31/2404—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
- B01J2231/40—Substitution reactions at carbon centres, e.g. C-C or C-X, i.e. carbon-hetero atom, cross-coupling, C-H activation or ring-opening reactions
- B01J2231/42—Catalytic cross-coupling, i.e. connection of previously not connected C-atoms or C- and X-atoms without rearrangement
- B01J2231/4205—C-C cross-coupling, e.g. metal catalyzed or Friedel-Crafts type
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
- B01J2531/80—Complexes comprising metals of Group VIII as the central metal
- B01J2531/84—Metals of the iron group
- B01J2531/847—Nickel

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Inorganic Chemistry (AREA)
Materials Engineering (AREA)
Neurology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Steroid Compounds (AREA)
Furan Compounds (AREA)

PT99968206T 1999-06-25 1999-11-19 Metodo para a preparacao de citalopran PT1105382E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DKPA199900921		1999-06-25

Publications (1)

Publication Number	Publication Date
PT1105382E true PT1105382E (pt)	2002-07-31

Family

ID=8099044

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT99968206T PT1105382E (pt)	1999-06-25	1999-11-19	Metodo para a preparacao de citalopran

Country Status (36)

Country	Link
US (1)	US6750358B2 (pt)
EP (1)	EP1105382B1 (pt)
JP (1)	JP3389571B2 (pt)
KR (1)	KR100491369B1 (pt)
CN (1)	CN1129593C (pt)
AR (1)	AR020573A1 (pt)
AT (3)	ATE213237T1 (pt)
AU (2)	AU1374800A (pt)
BG (1)	BG106190A (pt)
BR (1)	BR9917367A (pt)
CA (1)	CA2290125C (pt)
CH (1)	CH691304A5 (pt)
CZ (1)	CZ292174B6 (pt)
DE (2)	DE19983486C2 (pt)
DK (1)	DK1105382T3 (pt)
EA (1)	EA002661B1 (pt)
ES (1)	ES2172356T3 (pt)
FI (1)	FI108538B (pt)
GB (1)	GB2354240B (pt)
HK (1)	HK1047745B (pt)
HU (1)	HUP0103417A3 (pt)
IL (1)	IL145960A0 (pt)
IS (1)	IS5862A (pt)
IT (1)	ITMI991579A1 (pt)
MX (1)	MXPA01010986A (pt)
NO (1)	NO20010318L (pt)
NZ (1)	NZ514982A (pt)
PL (1)	PL345971A1 (pt)
PT (1)	PT1105382E (pt)
SE (1)	SE516689C2 (pt)
SI (1)	SI1105382T1 (pt)
SK (1)	SK18412001A3 (pt)
TR (1)	TR200103700T2 (pt)
UA (1)	UA62023C2 (pt)
WO (1)	WO2000011926A2 (pt)
ZA (1)	ZA200108855B (pt)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR100454008B1 (ko)	1998-12-23	2004-10-20	하. 룬트벡 아크티에 셀스카브	5-시아노프탈리드의 제조방법
AR022329A1 (es)	1999-01-29	2002-09-04	Lundbeck & Co As H	Metodo para la preparacion de 5-cianoftalida
SI1173431T2 (sl)	1999-04-14	2009-12-31	Lundbeck & Co As H	Postopek za pripravo citaloprama
ITMI991581A1 (it) *	1999-06-25	2001-01-15	Lundbeck & Co As H	Metodo per la preparazione di citalopram
ITMI991579A1 (it)	1999-06-25	2001-01-15	Lundbeck & Co As H	Metodo per la preparazione di citalopram
HUP0200169A3 (en)	1999-10-25	2002-11-28	Lundbeck & Co As H	Method for the preparation of citalopram
TR200101874T1 (tr)	1999-10-25	2002-02-21	H. Lundbeck A/S	Sitalopram hazırlanması için yöntem
AR026063A1 (es)	1999-11-01	2002-12-26	Lundbeck & Co As H	Metodo para la preparacion de 5-carboxiftalida.
SI1246812T1 (en)	1999-12-28	2004-08-31	H. Lundbeck A/S	Method for the preparation of citalopram
SI1246813T1 (en)	1999-12-30	2004-08-31	H. Lundbeck A/S	Method for the preparation of citalopram
CZ20022601A3 (cs)	2000-01-14	2002-10-16	H. Lundbeck A/S	Způsob výroby 5-kyanoftalidu
FR2805812A1 (fr)	2000-02-24	2001-09-07	Lundbeck & Co As H	Procede de preparation du citalopram
NL1017417C1 (nl)	2000-03-03	2001-03-16	Lundbeck & Co As H	Werkwijze voor de bereiding van Citalopram.
GB0005477D0 (en)	2000-03-07	2000-04-26	Resolution Chemicals Limited	Process for the preparation of citalopram
IES20010206A2 (en)	2000-03-13	2002-03-06	Lundbeck & Co As H	Method for the preparation of citalopram
NZ521201A (en)	2000-03-13	2004-02-27	H	Method for the preparation of citalopram
GB2357762B (en)	2000-03-13	2002-01-30	Lundbeck & Co As H	Crystalline base of citalopram
TR200202195T2 (tr)	2000-03-13	2002-12-23	H. Lundbeck A/S	5-Yer değiştirmiş 1-(4-florofenil)-1,3- dihidroizobenzofuran'ın adım adım alkillenmesi
PL360107A1 (en)	2000-03-14	2004-09-06	H.Lundbeck A/S	Method for the preparation of citalopram
WO2001068632A1 (en) *	2000-03-16	2001-09-20	H. Lundbeck A/S	Method for the preparation of 5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
AR032455A1 (es)	2000-05-12	2003-11-12	Lundbeck & Co As H	Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
CZ2002832A3 (cs) *	2000-07-06	2002-05-15	H. Lundbeck A/S	Způsob výroby citalopramu
IL144816A (en) *	2000-08-18	2005-09-25	Lundbeck & Co As H	Method for the preparation of citalopram
ES2228824T3 (es) *	2000-12-22	2005-04-16	H. Lundbeck A/S	Metodo de preparacion de citalopram puro.
ATE222899T1 (de)	2000-12-28	2002-09-15	Lundbeck & Co As H	Verfahren zur herstellung von reinem citalopram
EP1355897A1 (en)	2001-01-30	2003-10-29	Orion Corporation Fermion	Process for the preparation of 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
GB0105627D0 (en) *	2001-03-07	2001-04-25	Cipla Ltd	Preparation of phthalanes
WO2002072565A1 (en) *	2001-03-09	2002-09-19	Ranbaxy Laboratories Limited	Process for the preparation of citalopram
EA006213B1 (ru) *	2001-07-31	2005-10-27	Х. Лундбекк А/С	Кристаллическая композиция, содержащая эсциталопрам
WO2003057132A2 (en)	2002-01-07	2003-07-17	Sun Pharmaceutical Industries Limited	Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofuran carbonitrile
AR040970A1 (es)	2002-08-12	2005-04-27	Lundbeck & Co As H	Metodo para la separacion de intermediarios que pueden ser utilizados para la preparacion de escitalopram
WO2004085416A1 (en) *	2003-03-24	2004-10-07	Hetero Drugs Limited	Novel crystalline forms of (s)-citalopram oxalate
US7019153B2 (en)	2003-06-10	2006-03-28	Sun Pharmaceutical Industries Limited	Process for hydrogenolysis of [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran acetamido-3-substituted-3-cephem-4-carboxylic acid
TWI339651B (en)	2004-02-12	2011-04-01	Lundbeck & Co As H	Method for the separation of intermediates which may be used for the preparation of escitalopram
JP2006008603A (ja) *	2004-06-25	2006-01-12	Sumitomo Chemical Co Ltd	光学活性シタロプラムの製造方法、その中間体およびその製造方法
KR101166280B1 (ko)	2004-08-23	2013-11-27	썬 파마 글로벌 에프제트이	시탈로프램 및 에난티오머의 제조 방법
WO2006103550A1 (en) *	2005-03-31	2006-10-05	Ranbaxy Laboratories Limited	Processes for the preparation of citalopram and its intermediate 5-aminophthalide
US7834201B2 (en)	2005-06-22	2010-11-16	H. Lundbeck A/S	Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
TWI358407B (en)	2005-06-22	2012-02-21	Lundbeck & Co As H	Crystalline base of escitalopram and orodispersibl
EP2017271A1 (en)	2007-07-06	2009-01-21	Aurobindo Pharma Limited	Process for the preparation of escitalopram

Family Cites Families (24)

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Publication number	Priority date	Publication date	Assignee	Title
GB1143702A (pt)	1965-03-18
GB1526331A (en) *	1976-01-14	1978-09-27	Kefalas As	Phthalanes
GB8419963D0 (en)	1984-08-06	1984-09-12	Lundbeck & Co As H	Intermediate compound and method
GB8814057D0 (en)	1988-06-14	1988-07-20	Lundbeck & Co As H	New enantiomers & their isolation
CA2010159A1 (en)	1989-02-21	1990-08-21	James J. Maul	Cyanation of haloaromatics utilizing catalysts generated in situ starting with nic1 or nic1 6h 0
US5296507A (en)	1990-09-06	1994-03-22	H.Lundbeck A/S	Treatment of cerbrovascular disorders
DE19626659A1 (de)	1996-07-03	1998-01-08	Basf Ag	Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de)	1996-07-10	1998-01-15	Basf Ag	Verfahren zur Herstellung von Phthaliden
DE19706648A1 (de)	1997-02-20	1998-08-27	Bayer Ag	Verfahren zur Herstellung von aromatischen Nitrilen
DK1015416T3 (da)	1997-07-08	2001-11-05	Lundbeck & Co As H	Fremgangsmåde til fremstilling af citalopram
UA62985C2 (en)	1997-11-10	2004-01-15	Lunnbeck As H	A method for the preparation of citalopram
SK283907B6 (sk)	1997-11-11	2004-04-06	H. Lundbeck A/S	Spôsob výroby citalopramu a medziprodukty
ES2189502T3 (es)	1998-10-20	2003-07-01	Lundbeck & Co As H	Metodo para la prevencion de citalopram.
KR100454008B1 (ko)	1998-12-23	2004-10-20	하. 룬트벡 아크티에 셀스카브	5-시아노프탈리드의 제조방법
AR022329A1 (es)	1999-01-29	2002-09-04	Lundbeck & Co As H	Metodo para la preparacion de 5-cianoftalida
US6331628B1 (en)	1999-03-29	2001-12-18	Nissan Chemical Industries, Ltd.	Process for the preparation of benzonitrile compounds
SI1173431T2 (sl)	1999-04-14	2009-12-31	Lundbeck & Co As H	Postopek za pripravo citaloprama
ITMI991581A1 (it)	1999-06-25	2001-01-15	Lundbeck & Co As H	Metodo per la preparazione di citalopram
ITMI991579A1 (it)	1999-06-25	2001-01-15	Lundbeck & Co As H	Metodo per la preparazione di citalopram
TR200101874T1 (tr)	1999-10-25	2002-02-21	H. Lundbeck A/S	Sitalopram hazırlanması için yöntem
US6310222B1 (en)	1999-11-01	2001-10-30	Sumika Fine Chemicals Co., Ltd.	Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
GB0005477D0 (en)	2000-03-07	2000-04-26	Resolution Chemicals Limited	Process for the preparation of citalopram
ES2228824T3 (es)	2000-12-22	2005-04-16	H. Lundbeck A/S	Metodo de preparacion de citalopram puro.
ATE222899T1 (de)	2000-12-28	2002-09-15	Lundbeck & Co As H	Verfahren zur herstellung von reinem citalopram

1999
- 1999-07-15 IT IT1999MI001579A patent/ITMI991579A1/it unknown
- 1999-11-19 EP EP99968206A patent/EP1105382B1/en not_active Expired - Lifetime
- 1999-11-19 PT PT99968206T patent/PT1105382E/pt unknown
- 1999-11-19 BR BR9917367-0A patent/BR9917367A/pt not_active IP Right Cessation
- 1999-11-19 CH CH00307/01A patent/CH691304A5/de not_active IP Right Cessation
- 1999-11-19 IL IL14596099A patent/IL145960A0/xx unknown
- 1999-11-19 AT AT99968206T patent/ATE213237T1/de not_active IP Right Cessation
- 1999-11-19 CN CN99816768A patent/CN1129593C/zh not_active Expired - Fee Related
- 1999-11-19 ES ES99968206T patent/ES2172356T3/es not_active Expired - Lifetime
- 1999-11-19 NZ NZ514982A patent/NZ514982A/xx unknown
- 1999-11-19 MX MXPA01010986A patent/MXPA01010986A/es not_active IP Right Cessation
- 1999-11-19 KR KR10-2001-7013971A patent/KR100491369B1/ko not_active Expired - Fee Related
- 1999-11-19 JP JP2000567065A patent/JP3389571B2/ja not_active Expired - Fee Related
- 1999-11-19 AU AU13748/00A patent/AU1374800A/en active Pending
- 1999-11-19 AT AT0904099A patent/AT409960B/de not_active IP Right Cessation
- 1999-11-19 AU AU2001100433A patent/AU2001100433B4/en not_active Ceased
- 1999-11-19 TR TR2001/03700T patent/TR200103700T2/xx unknown
- 1999-11-19 SI SI9930039T patent/SI1105382T1/xx unknown
- 1999-11-19 DE DE19983486T patent/DE19983486C2/de not_active Expired - Fee Related
- 1999-11-19 PL PL99345971A patent/PL345971A1/xx not_active Application Discontinuation
- 1999-11-19 DE DE69900891T patent/DE69900891D1/de not_active Expired - Lifetime
- 1999-11-19 SK SK1841-2001A patent/SK18412001A3/sk unknown
- 1999-11-19 EA EA200101071A patent/EA002661B1/ru not_active IP Right Cessation
- 1999-11-19 DK DK99968206T patent/DK1105382T3/da active
- 1999-11-19 WO PCT/DK1999/000643 patent/WO2000011926A2/en not_active Ceased
- 1999-11-19 GB GB0101508A patent/GB2354240B/en not_active Expired - Fee Related
- 1999-11-19 CZ CZ2001319A patent/CZ292174B6/cs not_active IP Right Cessation
- 1999-11-19 HK HK02109330.8A patent/HK1047745B/zh not_active IP Right Cessation
- 1999-11-19 UA UA2001117897A patent/UA62023C2/uk unknown
- 1999-11-19 HU HU0103417A patent/HUP0103417A3/hu unknown
- 1999-11-22 CA CA002290125A patent/CA2290125C/en not_active Expired - Fee Related
2000
- 2000-06-21 AR ARP000103080A patent/AR020573A1/es unknown
2001
- 2001-01-19 NO NO20010318A patent/NO20010318L/no unknown
- 2001-01-24 SE SE0100194A patent/SE516689C2/sv not_active IP Right Cessation
- 2001-01-25 FI FI20010154A patent/FI108538B/fi not_active IP Right Cessation
- 2001-02-23 IS IS5862A patent/IS5862A/is unknown
- 2001-03-13 AT AT0018501U patent/AT4366U1/de not_active IP Right Cessation
- 2001-10-26 ZA ZA200108855A patent/ZA200108855B/xx unknown
- 2001-11-06 US US10/012,025 patent/US6750358B2/en not_active Expired - Fee Related
- 2001-12-07 BG BG106190A patent/BG106190A/xx unknown

Also Published As

Publication number	Publication date
ATE213237T1 (de)	2002-02-15
CN1356993A (zh)	2002-07-03
AT4366U1 (de)	2001-06-25
CH691304A5 (de)	2001-06-29
NO20010318D0 (no)	2001-01-19
IS5862A (is)	2001-02-23
BR9917367A (pt)	2002-03-05
WO2000011926A2 (en)	2000-03-09
DE19983486C2 (de)	2002-09-05
HK1047745A1 (en)	2003-03-07
CZ2001319A3 (en)	2001-05-16
ATA904099A (de)	2002-05-15
EP1105382B1 (en)	2002-02-13
DE69900891D1 (de)	2002-03-21
ITMI991579A0 (it)	1999-07-15
HUP0103417A3 (en)	2003-01-28
KR100491369B1 (ko)	2005-05-24
ZA200108855B (en)	2002-08-28
EA200101071A1 (ru)	2002-02-28
GB2354240A (en)	2001-03-21
FI20010154L (fi)	2001-02-09
JP3389571B2 (ja)	2003-03-24
ES2172356T3 (es)	2002-09-16
SE516689C2 (sv)	2002-02-12
TR200103700T2 (tr)	2002-05-21
MXPA01010986A (es)	2002-06-04
GB2354240B (en)	2001-05-23
SK18412001A3 (sk)	2002-05-09
DK1105382T3 (da)	2002-05-27
CN1129593C (zh)	2003-12-03
AU2001100433B4 (en)	2002-01-17
SI1105382T1 (en)	2002-06-30
UA62023C2 (en)	2003-12-15
BG106190A (en)	2002-08-30
IL145960A0 (en)	2002-07-25
HK1047745B (zh)	2004-09-10
EP1105382A2 (en)	2001-06-13
SE0100194L (sv)	2001-04-25
HUP0103417A2 (hu)	2002-01-28
PL345971A1 (en)	2002-01-14
JP2002523432A (ja)	2002-07-30
SE0100194D0 (sv)	2001-01-24
KR20020011982A (ko)	2002-02-09
AT409960B (de)	2002-12-27
WO2000011926A3 (en)	2000-06-29
CZ292174B6 (cs)	2003-08-13
CA2290125C (en)	2004-08-10
CA2290125A1 (en)	2000-12-25
ITMI991579A1 (it)	2001-01-15
AU1374800A (en)	2000-03-21
FI108538B (fi)	2002-02-15
US6750358B2 (en)	2004-06-15
GB0101508D0 (en)	2001-03-07
US20020061925A1 (en)	2002-05-23
NZ514982A (en)	2004-01-30
DE19983486T1 (de)	2001-10-18
NO20010318L (no)	2001-02-20
EA002661B1 (ru)	2002-08-29
AR020573A1 (es)	2002-05-15
AU2001100433A4 (en)	2001-11-01

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