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PT101627A - Polipeptideo trombopoietina isolado e substancialmente homogeneo, dna que o codifica e metodos recombinantes ou de sintese para a sua preparacao e purificacao - Google Patents

Polipeptideo trombopoietina isolado e substancialmente homogeneo, dna que o codifica e metodos recombinantes ou de sintese para a sua preparacao e purificacao

Info

Publication number
PT101627A
PT101627A PT101627A PT10162794A PT101627A PT 101627 A PT101627 A PT 101627A PT 101627 A PT101627 A PT 101627A PT 10162794 A PT10162794 A PT 10162794A PT 101627 A PT101627 A PT 101627A
Authority
PT
Portugal
Prior art keywords
polympeptidee
purification
synthesis
isolated
preparation
Prior art date
Application number
PT101627A
Other languages
English (en)
Other versions
PT101627B (pt
Inventor
Dan L Eaton
Frederic J De Sauvage
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/196,689 external-priority patent/US8357513B1/en
Priority claimed from US08/249,376 external-priority patent/US8192955B1/en
Priority claimed from US08/348,657 external-priority patent/US6660256B1/en
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of PT101627A publication Critical patent/PT101627A/pt
Publication of PT101627B publication Critical patent/PT101627B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/524—Thrombopoietin, i.e. C-MPL ligand
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Vehicle Body Suspensions (AREA)
  • Information Transfer Systems (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
PT101627A 1994-01-03 1994-12-30 Polipeptideo trombopoietina isolado e substancialmente homogeneo, dna que o codifica e metodos recombinantes ou de sintese para a sua preparacao e purificacao PT101627B (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US17655394A 1994-01-03 1994-01-03
US18560794A 1994-01-21 1994-01-21
US08/196,689 US8357513B1 (en) 1994-01-03 1994-02-15 Nucleic acids encoding mpl ligand (thrombopoietin) and fragments thereof
US22326394A 1994-04-04 1994-04-04
US08/249,376 US8192955B1 (en) 1994-01-03 1994-05-25 Nucleic acids encoding MPL ligand (thrombopoietin), variants, and fragments thereof
US34865894A 1994-12-02 1994-12-02
US08/348,657 US6660256B1 (en) 1994-01-03 1994-12-02 Porcine mpl ligand

Publications (2)

Publication Number Publication Date
PT101627A true PT101627A (pt) 1995-11-30
PT101627B PT101627B (pt) 1996-11-29

Family

ID=27569151

Family Applications (1)

Application Number Title Priority Date Filing Date
PT101627A PT101627B (pt) 1994-01-03 1994-12-30 Polipeptideo trombopoietina isolado e substancialmente homogeneo, dna que o codifica e metodos recombinantes ou de sintese para a sua preparacao e purificacao

Country Status (28)

Country Link
EP (1) EP0738323A1 (pt)
JP (2) JPH09508262A (pt)
CN (1) CN1134539C (pt)
AU (1) AU704266B2 (pt)
BG (1) BG63639B1 (pt)
CA (1) CA2178482C (pt)
CZ (1) CZ296130B6 (pt)
DK (1) DK149194A (pt)
ES (1) ES2114786B1 (pt)
FI (1) FI121573B (pt)
FR (1) FR2714670B1 (pt)
GB (1) GB2285446B (pt)
HR (1) HRP941020A2 (pt)
HU (1) HUT75657A (pt)
IE (1) IE72517B1 (pt)
IL (1) IL112184A (pt)
IT (1) IT1283770B1 (pt)
LU (1) LU88573A1 (pt)
LV (1) LV11632B (pt)
NL (1) NL9500010A (pt)
NO (1) NO326903B1 (pt)
NZ (1) NZ278726A (pt)
PT (1) PT101627B (pt)
RO (1) RO117110B1 (pt)
SG (1) SG47030A1 (pt)
SI (1) SI9420079A (pt)
SK (1) SK282265B6 (pt)
WO (1) WO1995018858A1 (pt)

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US6270989B1 (en) 1991-11-05 2001-08-07 Transkaryotic Therapies, Inc. Protein production and delivery
SK100896A3 (en) * 1994-02-14 1997-10-08 Zymogenetics Inc Hematopoietic protein and materials and methods for making it
DK0690127T3 (da) * 1994-03-31 1999-05-03 Amgen Inc Sammensætninger og fremgangsmåder til stimulering af megakaryocytvækst og -differentiering
US5795569A (en) * 1994-03-31 1998-08-18 Amgen Inc. Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation
US5986049A (en) * 1994-12-30 1999-11-16 Zymogenetics, Inc. Purified thrombopoietin and method of making it
TW387940B (en) * 1995-01-17 2000-04-21 Kirin Brewery Anti-tpo monodonal antibody
WO1996023888A1 (en) 1995-02-03 1996-08-08 G.D. Searle & Co. NOVEL c-MPL LIGANDS
US5989538A (en) * 1995-02-15 1999-11-23 Amgen Inc. Mpl ligand analogs
US5696250A (en) * 1995-02-15 1997-12-09 Amgen Inc. DNA encoding megakaryocyte growth and development factor analogs
DE69636052T2 (de) * 1995-02-15 2007-04-12 Amgen Inc., Thousand Oaks Mpl-liganden analoga
TW434020B (en) * 1995-03-15 2001-05-16 Kirin Brewery Methods for preventing adsorption of thrombopoietin (TPO), and stable top-containing compositions
TW434021B (en) * 1995-03-15 2001-05-16 Kirin Brewery Methods for preventing adsorption of thrombopoietin (TPO), and stable TPO-containing compositions
ZA964382B (en) * 1995-06-06 1997-12-01 Genentech Inc Lymphotoxin and thrombopoietin for use in the treatment of cancer.
EP2055712A1 (en) * 1995-06-07 2009-05-06 Glaxo Group Limited Peptides and compounds that bind to a thrombopoietin receptor
US5869451A (en) * 1995-06-07 1999-02-09 Glaxo Group Limited Peptides and compounds that bind to a receptor
US6251864B1 (en) 1995-06-07 2001-06-26 Glaxo Group Limited Peptides and compounds that bind to a receptor
TW497972B (en) * 1995-06-08 2002-08-11 Kirin Brewery Stable thrombopoietin (TPO)-containing lyophilized compositions
US6066318A (en) 1995-10-05 2000-05-23 G.D. Searle & Co. Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors
US6031071A (en) * 1996-01-24 2000-02-29 Biophage, Inc. Methods of generating novel peptides
US5879673A (en) * 1996-01-25 1999-03-09 Genentech, Inc. Administration of thrombopoietin on a single day only
US7091311B2 (en) 1996-06-07 2006-08-15 Smithkline Beecham Corporation Peptides and compounds that bind to a receptor
AU728881B2 (en) * 1996-08-13 2001-01-18 Zymogenetics Inc. Expression vectors, cells, and methods for preparing thrombopoietin polypeptides
JP4562815B2 (ja) * 1997-05-21 2010-10-13 ジェネンテック， インコーポレイテッド トロンボポエチンの新規な投与
US5980893A (en) * 1997-07-17 1999-11-09 Beth Israel Deaconess Medical Center, Inc. Agonist murine monoclonal antibody as a stimulant for megakaryocytopoiesis
US6342220B1 (en) 1997-08-25 2002-01-29 Genentech, Inc. Agonist antibodies
US20030228666A1 (en) 1998-06-30 2003-12-11 Daewoong Pharmaceutical Co., Ltd. Novel human thrombopoietin mutein
KR20000006549A (ko) * 1998-06-30 2000-01-25 윤재승 생체내혈소판증식효능이향상된신규한트롬보포이에틴유도체
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
IL142023A0 (en) 1998-10-23 2002-03-10 Amgen Inc Dimeric thrombopoietin peptide mimetics binding to mpi receptor and having thrombopoietic activity
CY2010012I2 (el) * 2000-05-25 2020-05-29 Novartis Ag Μιμητικα θρομβοποιητινης
UY26317A1 (es) * 2000-08-30 2000-10-31 Alfonso Cayota Carlos Pritsch Sistema de produccion de trombopoyetina humana por celulas de mamiferos en cultivo
US6673580B2 (en) 2000-10-27 2004-01-06 Genentech, Inc. Identification and modification of immunodominant epitopes in polypeptides
US7332474B2 (en) 2001-10-11 2008-02-19 Amgen Inc. Peptides and related compounds having thrombopoietic activity
EP1452093A4 (en) 2001-11-15 2007-08-15 Kirin Brewery CHIMESE NON-MENTAL ANIMAL
KR100467750B1 (ko) * 2001-11-29 2005-01-24 씨제이 주식회사 생체내 에리스로포이에틴 활성이 증진된 융합단백질
US20030191056A1 (en) 2002-04-04 2003-10-09 Kenneth Walker Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins
MXPA05003057A (es) 2002-09-18 2006-04-18 Johnson & Johnson Metodos para aumentar la produccion de celulas madre hematopoyeticas y plaquetas.
UA82710C2 (uk) 2003-08-28 2008-05-12 Орто-Макнейл Фармацевтикал, Инк. Пептид, що зв'язується з тромбопоетиновим рецептором (варіанти), та спосіб лікування тромбоциторенії (варіанти)
US7723295B2 (en) 2003-08-28 2010-05-25 Ortho-Mcneil Pharmaceutical, Inc. Peptides and compounds that bind to a receptor
ES2603062T3 (es) 2004-05-18 2017-02-23 Intrexon Corporation Métodos de ensamblaje dinámico de vectores para la clonación de ADN de vectores plasmídicos
MX2007000216A (es) 2004-07-08 2007-03-15 Amgen Inc Peptidos terapeuticos.
US8008453B2 (en) 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules
US9012605B2 (en) 2006-01-23 2015-04-21 Amgen Inc. Crystalline polypeptides
WO2007098547A1 (en) * 2006-03-01 2007-09-07 Apollo Life Sciences Limited A molecule and chimeric molecules thereof
US7981425B2 (en) 2006-06-19 2011-07-19 Amgen Inc. Thrombopoietic compounds
WO2008011664A1 (en) 2006-07-24 2008-01-31 The University Of Queensland Method of producing a population of cells
TW200902708A (en) 2007-04-23 2009-01-16 Wyeth Corp Methods of protein production using anti-senescence compounds
US8420779B2 (en) 2007-05-22 2013-04-16 Amgen Inc. Compositions and methods for producing bioactive fusion proteins
WO2010085086A2 (ko) 2009-01-20 2010-07-29 한올바이오파마 주식회사 변형된 인간 트롬보포이에틴 폴리펩타이드 절편 및 그의 제조방법
WO2014089478A1 (en) * 2012-12-07 2014-06-12 University Of Tennessee Research Foundation Methods of numerical analysis for platelet disorders and computer-readable media and systems for performing the same
WO2014100779A1 (en) 2012-12-21 2014-06-26 Advanced Cell Technology, Inc. Methods ofr production of platelets from pluripotent stem cells and compositions thereof
CN103555760B (zh) * 2013-10-18 2015-05-20 江苏康禾生物制药有限公司 一种重组人血小板生成素的制备方法及其制剂
CN110279845B (zh) * 2015-12-21 2021-08-20 保脑稳有限公司 记忆力、学习力、认知力提高用组合物
GB201700621D0 (en) 2017-01-13 2017-03-01 Guest Ryan Dominic Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue
AU2020349991A1 (en) * 2019-09-20 2022-04-07 Ractigen Therapeutics Nucleic acid molecule for treating immune thrombocytopenia and application thereof
IL294098A (en) 2019-12-20 2022-08-01 Instil Bio Uk Ltd Devices and methods for isolating tumor infiltrating lymphocytes and uses thereof

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US5260417A (en) 1989-04-03 1993-11-09 Genetics Institute, Inc. Megakaryocyte growth promoting activity protein
WO1990012877A1 (en) * 1989-04-19 1990-11-01 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
US5223408A (en) * 1991-07-11 1993-06-29 Genentech, Inc. Method for making variant secreted proteins with altered properties
CA2123430C (en) * 1991-12-06 2004-02-10 Cornelia M. Gorman Prohormone convertase transformed cells
IL139335A (en) 1994-01-03 2005-08-31 Genentech Inc Mpl ligand polypeptides, nucleic acids encoding them, vectors and host cells comprising such nucleic acids, processes for producing such polypeptides pharmaceutical compositions containing them and use thereof in the preparation of medicaments for treating thrombocytopenia

Also Published As

Publication number Publication date
ES2114786B1 (es) 1999-01-01
WO1995018858A1 (en) 1995-07-13
ES2114786A1 (es) 1998-06-01
CZ296130B6 (cs) 2006-01-11
SI9420079A (en) 1997-02-28
FR2714670A1 (fr) 1995-07-07
IE950002A1 (en) 1995-07-12
AU1514695A (en) 1995-08-01
HUT75657A (en) 1997-05-28
EP0738323A1 (en) 1996-10-23
PT101627B (pt) 1996-11-29
SK87596A3 (en) 1997-11-05
NO962783D0 (no) 1996-07-02
FI121573B (fi) 2011-01-14
IL112184A (en) 2004-07-25
ITTO950002A1 (it) 1995-07-03
JPH09508262A (ja) 1997-08-26
SK282265B6 (sk) 2001-12-03
SG47030A1 (en) 1998-03-20
LV11632A (lv) 1996-12-20
IT1283770B1 (it) 1998-04-30
GB2285446B (en) 1999-07-28
GB2285446A (en) 1995-07-12
DK149194A (da) 1995-07-04
HRP941020A2 (en) 1997-04-30
FR2714670B1 (fr) 1997-01-10
NL9500010A (nl) 1995-08-01
RO117110B1 (ro) 2001-10-30
GB9425831D0 (en) 1995-02-22
IE72517B1 (en) 1997-04-23
FI962723A (fi) 1996-09-03
CZ192296A3 (en) 1997-05-14
IL112184A0 (en) 1995-03-15
AU704266B2 (en) 1999-04-15
BG63639B1 (bg) 2002-07-31
NO326903B1 (no) 2009-03-16
LV11632B (en) 1997-04-20
LU88573A1 (de) 1995-06-01
CA2178482C (en) 2012-01-03
CN1134539C (zh) 2004-01-14
CN1141061A (zh) 1997-01-22
HU9601805D0 (en) 1996-08-28
NO962783L (no) 1996-09-03
ITTO950002A0 (it) 1995-01-02
NZ278726A (en) 1998-06-26
JPH10113186A (ja) 1998-05-06
FI962723A0 (fi) 1996-07-02
CA2178482A1 (en) 1995-07-13
BG100693A (en) 1998-01-30

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Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19960820

MM4A Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: MAXIMUM VALIDITY LIMIT REACHED

Effective date: 20141230