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PT101627A - ISOLATED AND SUBSTANTIALLY HOMOGENEOUS POLYMPEPTIDEE, CODIFYING DNA AND RECOMBINANT METHODS OR SYNTHESIS FOR PREPARATION AND PURIFICATION - Google Patents

ISOLATED AND SUBSTANTIALLY HOMOGENEOUS POLYMPEPTIDEE, CODIFYING DNA AND RECOMBINANT METHODS OR SYNTHESIS FOR PREPARATION AND PURIFICATION

Info

Publication number
PT101627A
PT101627A PT101627A PT10162794A PT101627A PT 101627 A PT101627 A PT 101627A PT 101627 A PT101627 A PT 101627A PT 10162794 A PT10162794 A PT 10162794A PT 101627 A PT101627 A PT 101627A
Authority
PT
Portugal
Prior art keywords
polympeptidee
purification
synthesis
isolated
preparation
Prior art date
Application number
PT101627A
Other languages
Portuguese (pt)
Other versions
PT101627B (en
Inventor
Dan L Eaton
Frederic J De Sauvage
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/196,689 external-priority patent/US8357513B1/en
Priority claimed from US08/249,376 external-priority patent/US8192955B1/en
Priority claimed from US08/348,657 external-priority patent/US6660256B1/en
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of PT101627A publication Critical patent/PT101627A/en
Publication of PT101627B publication Critical patent/PT101627B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/524—Thrombopoietin, i.e. C-MPL ligand
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Vehicle Body Suspensions (AREA)
  • Information Transfer Systems (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
PT101627A 1994-01-03 1994-12-30 ISOLATED AND SUBSTANTIALLY HOMOGENEOUS POLYMPEPTIDEE, CODIFYING DNA AND RECOMBINANT METHODS OR SYNTHESIS FOR PREPARATION AND PURIFICATION PT101627B (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US17655394A 1994-01-03 1994-01-03
US18560794A 1994-01-21 1994-01-21
US08/196,689 US8357513B1 (en) 1994-01-03 1994-02-15 Nucleic acids encoding mpl ligand (thrombopoietin) and fragments thereof
US22326394A 1994-04-04 1994-04-04
US08/249,376 US8192955B1 (en) 1994-01-03 1994-05-25 Nucleic acids encoding MPL ligand (thrombopoietin), variants, and fragments thereof
US34865894A 1994-12-02 1994-12-02
US08/348,657 US6660256B1 (en) 1994-01-03 1994-12-02 Porcine mpl ligand

Publications (2)

Publication Number Publication Date
PT101627A true PT101627A (en) 1995-11-30
PT101627B PT101627B (en) 1996-11-29

Family

ID=27569151

Family Applications (1)

Application Number Title Priority Date Filing Date
PT101627A PT101627B (en) 1994-01-03 1994-12-30 ISOLATED AND SUBSTANTIALLY HOMOGENEOUS POLYMPEPTIDEE, CODIFYING DNA AND RECOMBINANT METHODS OR SYNTHESIS FOR PREPARATION AND PURIFICATION

Country Status (28)

Country Link
EP (1) EP0738323A1 (en)
JP (2) JPH09508262A (en)
CN (1) CN1134539C (en)
AU (1) AU704266B2 (en)
BG (1) BG63639B1 (en)
CA (1) CA2178482C (en)
CZ (1) CZ296130B6 (en)
DK (1) DK149194A (en)
ES (1) ES2114786B1 (en)
FI (1) FI121573B (en)
FR (1) FR2714670B1 (en)
GB (1) GB2285446B (en)
HR (1) HRP941020A2 (en)
HU (1) HUT75657A (en)
IE (1) IE72517B1 (en)
IL (1) IL112184A (en)
IT (1) IT1283770B1 (en)
LU (1) LU88573A1 (en)
LV (1) LV11632B (en)
NL (1) NL9500010A (en)
NO (1) NO326903B1 (en)
NZ (1) NZ278726A (en)
PT (1) PT101627B (en)
RO (1) RO117110B1 (en)
SG (1) SG47030A1 (en)
SI (1) SI9420079A (en)
SK (1) SK282265B6 (en)
WO (1) WO1995018858A1 (en)

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US5733761A (en) 1991-11-05 1998-03-31 Transkaryotic Therapies, Inc. Protein production and protein delivery
US6270989B1 (en) 1991-11-05 2001-08-07 Transkaryotic Therapies, Inc. Protein production and delivery
SK100896A3 (en) * 1994-02-14 1997-10-08 Zymogenetics Inc Hematopoietic protein and materials and methods for making it
DK0690127T3 (en) * 1994-03-31 1999-05-03 Amgen Inc Compositions and Methods for Stimulating Megakaryocyte Growth and Differentiation
US5795569A (en) * 1994-03-31 1998-08-18 Amgen Inc. Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation
US5986049A (en) * 1994-12-30 1999-11-16 Zymogenetics, Inc. Purified thrombopoietin and method of making it
TW387940B (en) * 1995-01-17 2000-04-21 Kirin Brewery Anti-tpo monodonal antibody
WO1996023888A1 (en) 1995-02-03 1996-08-08 G.D. Searle & Co. NOVEL c-MPL LIGANDS
US5989538A (en) * 1995-02-15 1999-11-23 Amgen Inc. Mpl ligand analogs
US5696250A (en) * 1995-02-15 1997-12-09 Amgen Inc. DNA encoding megakaryocyte growth and development factor analogs
DE69636052T2 (en) * 1995-02-15 2007-04-12 Amgen Inc., Thousand Oaks MPL-LIGAND ANALOGUE
TW434020B (en) * 1995-03-15 2001-05-16 Kirin Brewery Methods for preventing adsorption of thrombopoietin (TPO), and stable top-containing compositions
TW434021B (en) * 1995-03-15 2001-05-16 Kirin Brewery Methods for preventing adsorption of thrombopoietin (TPO), and stable TPO-containing compositions
ZA964382B (en) * 1995-06-06 1997-12-01 Genentech Inc Lymphotoxin and thrombopoietin for use in the treatment of cancer.
EP2055712A1 (en) * 1995-06-07 2009-05-06 Glaxo Group Limited Peptides and compounds that bind to a thrombopoietin receptor
US5869451A (en) * 1995-06-07 1999-02-09 Glaxo Group Limited Peptides and compounds that bind to a receptor
US6251864B1 (en) 1995-06-07 2001-06-26 Glaxo Group Limited Peptides and compounds that bind to a receptor
TW497972B (en) * 1995-06-08 2002-08-11 Kirin Brewery Stable thrombopoietin (TPO)-containing lyophilized compositions
US6066318A (en) 1995-10-05 2000-05-23 G.D. Searle & Co. Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors
US6031071A (en) * 1996-01-24 2000-02-29 Biophage, Inc. Methods of generating novel peptides
US5879673A (en) * 1996-01-25 1999-03-09 Genentech, Inc. Administration of thrombopoietin on a single day only
US7091311B2 (en) 1996-06-07 2006-08-15 Smithkline Beecham Corporation Peptides and compounds that bind to a receptor
AU728881B2 (en) * 1996-08-13 2001-01-18 Zymogenetics Inc. Expression vectors, cells, and methods for preparing thrombopoietin polypeptides
JP4562815B2 (en) * 1997-05-21 2010-10-13 ジェネンテック， インコーポレイテッド New administration of thrombopoietin
US5980893A (en) * 1997-07-17 1999-11-09 Beth Israel Deaconess Medical Center, Inc. Agonist murine monoclonal antibody as a stimulant for megakaryocytopoiesis
US6342220B1 (en) 1997-08-25 2002-01-29 Genentech, Inc. Agonist antibodies
US20030228666A1 (en) 1998-06-30 2003-12-11 Daewoong Pharmaceutical Co., Ltd. Novel human thrombopoietin mutein
KR20000006549A (en) * 1998-06-30 2000-01-25 윤재승 A novel human thrombopoietin mutein
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
IL142023A0 (en) 1998-10-23 2002-03-10 Amgen Inc Dimeric thrombopoietin peptide mimetics binding to mpi receptor and having thrombopoietic activity
CY2010012I2 (en) * 2000-05-25 2020-05-29 Novartis Ag THROMBOPOIETIN MIMETICS
UY26317A1 (en) * 2000-08-30 2000-10-31 Alfonso Cayota Carlos Pritsch PRODUCTION SYSTEM OF HUMAN THROMBOPOYETINE BY CELLS OF MAMMALS IN CULTIVATION
US6673580B2 (en) 2000-10-27 2004-01-06 Genentech, Inc. Identification and modification of immunodominant epitopes in polypeptides
US7332474B2 (en) 2001-10-11 2008-02-19 Amgen Inc. Peptides and related compounds having thrombopoietic activity
EP1452093A4 (en) 2001-11-15 2007-08-15 Kirin Brewery CHIMERIC ANIMALS
KR100467750B1 (en) * 2001-11-29 2005-01-24 씨제이 주식회사 Fusion protein having the enhanced in vivo activity of erythropoietin
US20030191056A1 (en) 2002-04-04 2003-10-09 Kenneth Walker Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins
MXPA05003057A (en) 2002-09-18 2006-04-18 Johnson & Johnson Methods of increasing platelet and hematopoietic stem cell production.
UA82710C2 (en) 2003-08-28 2008-05-12 Орто-Макнейл Фармацевтикал, Инк. Peptide that binds the thrombopoietin receptor (variants) and method for treatment of thrombocytopenia (variants)
US7723295B2 (en) 2003-08-28 2010-05-25 Ortho-Mcneil Pharmaceutical, Inc. Peptides and compounds that bind to a receptor
ES2603062T3 (en) 2004-05-18 2017-02-23 Intrexon Corporation Dynamic vector assembly methods for DNA cloning of plasmid vectors
MX2007000216A (en) 2004-07-08 2007-03-15 Amgen Inc Therapeutic peptides.
US8008453B2 (en) 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules
US9012605B2 (en) 2006-01-23 2015-04-21 Amgen Inc. Crystalline polypeptides
WO2007098547A1 (en) * 2006-03-01 2007-09-07 Apollo Life Sciences Limited A molecule and chimeric molecules thereof
US7981425B2 (en) 2006-06-19 2011-07-19 Amgen Inc. Thrombopoietic compounds
WO2008011664A1 (en) 2006-07-24 2008-01-31 The University Of Queensland Method of producing a population of cells
TW200902708A (en) 2007-04-23 2009-01-16 Wyeth Corp Methods of protein production using anti-senescence compounds
US8420779B2 (en) 2007-05-22 2013-04-16 Amgen Inc. Compositions and methods for producing bioactive fusion proteins
WO2010085086A2 (en) 2009-01-20 2010-07-29 한올바이오파마 주식회사 Modified human thrombopoietin polypeptide fragment and manufacturing method thereof
WO2014089478A1 (en) * 2012-12-07 2014-06-12 University Of Tennessee Research Foundation Methods of numerical analysis for platelet disorders and computer-readable media and systems for performing the same
WO2014100779A1 (en) 2012-12-21 2014-06-26 Advanced Cell Technology, Inc. Methods ofr production of platelets from pluripotent stem cells and compositions thereof
CN103555760B (en) * 2013-10-18 2015-05-20 江苏康禾生物制药有限公司 Preparation method and preparation of recombinant human thrombopoietin
CN110279845B (en) * 2015-12-21 2021-08-20 保脑稳有限公司 Composition for improving memory, learning ability and cognitive ability
GB201700621D0 (en) 2017-01-13 2017-03-01 Guest Ryan Dominic Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue
AU2020349991A1 (en) * 2019-09-20 2022-04-07 Ractigen Therapeutics Nucleic acid molecule for treating immune thrombocytopenia and application thereof
IL294098A (en) 2019-12-20 2022-08-01 Instil Bio Uk Ltd Devices and methods for isolating lymphocytes infiltrating tumors and their use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260417A (en) 1989-04-03 1993-11-09 Genetics Institute, Inc. Megakaryocyte growth promoting activity protein
WO1990012877A1 (en) * 1989-04-19 1990-11-01 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
US5223408A (en) * 1991-07-11 1993-06-29 Genentech, Inc. Method for making variant secreted proteins with altered properties
CA2123430C (en) * 1991-12-06 2004-02-10 Cornelia M. Gorman Prohormone convertase transformed cells
IL139335A (en) 1994-01-03 2005-08-31 Genentech Inc Mpl ligand polypeptides, nucleic acids encoding them, vectors and host cells comprising such nucleic acids, processes for producing such polypeptides pharmaceutical compositions containing them and use thereof in the preparation of medicaments for treating thrombocytopenia

Also Published As

Publication number Publication date
ES2114786B1 (en) 1999-01-01
WO1995018858A1 (en) 1995-07-13
ES2114786A1 (en) 1998-06-01
CZ296130B6 (en) 2006-01-11
SI9420079A (en) 1997-02-28
FR2714670A1 (en) 1995-07-07
IE950002A1 (en) 1995-07-12
AU1514695A (en) 1995-08-01
HUT75657A (en) 1997-05-28
EP0738323A1 (en) 1996-10-23
PT101627B (en) 1996-11-29
SK87596A3 (en) 1997-11-05
NO962783D0 (en) 1996-07-02
FI121573B (en) 2011-01-14
IL112184A (en) 2004-07-25
ITTO950002A1 (en) 1995-07-03
JPH09508262A (en) 1997-08-26
SK282265B6 (en) 2001-12-03
SG47030A1 (en) 1998-03-20
LV11632A (en) 1996-12-20
IT1283770B1 (en) 1998-04-30
GB2285446B (en) 1999-07-28
GB2285446A (en) 1995-07-12
DK149194A (en) 1995-07-04
HRP941020A2 (en) 1997-04-30
FR2714670B1 (en) 1997-01-10
NL9500010A (en) 1995-08-01
RO117110B1 (en) 2001-10-30
GB9425831D0 (en) 1995-02-22
IE72517B1 (en) 1997-04-23
FI962723A (en) 1996-09-03
CZ192296A3 (en) 1997-05-14
IL112184A0 (en) 1995-03-15
AU704266B2 (en) 1999-04-15
BG63639B1 (en) 2002-07-31
NO326903B1 (en) 2009-03-16
LV11632B (en) 1997-04-20
LU88573A1 (en) 1995-06-01
CA2178482C (en) 2012-01-03
CN1134539C (en) 2004-01-14
CN1141061A (en) 1997-01-22
HU9601805D0 (en) 1996-08-28
NO962783L (en) 1996-09-03
ITTO950002A0 (en) 1995-01-02
NZ278726A (en) 1998-06-26
JPH10113186A (en) 1998-05-06
FI962723A0 (en) 1996-07-02
CA2178482A1 (en) 1995-07-13
BG100693A (en) 1998-01-30

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Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19960820

MM4A Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: MAXIMUM VALIDITY LIMIT REACHED

Effective date: 20141230