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PL443538A1 - 8-Bromo-6-chloro-4'-O-β-D-(4"-O-methylglucopyranosyl)-flavan-4-ol and method for producing 8-bromo-6-chloro-4'-O-β-D -(4"O-methylglucopyranosyl)-flavan-4-ol - Google Patents

8-Bromo-6-chloro-4'-O-β-D-(4"-O-methylglucopyranosyl)-flavan-4-ol and method for producing 8-bromo-6-chloro-4'-O-β-D -(4"O-methylglucopyranosyl)-flavan-4-ol

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Publication number
PL443538A1
PL443538A1 PL443538A PL44353823A PL443538A1 PL 443538 A1 PL443538 A1 PL 443538A1 PL 443538 A PL443538 A PL 443538A PL 44353823 A PL44353823 A PL 44353823A PL 443538 A1 PL443538 A1 PL 443538A1
Authority
PL
Poland
Prior art keywords
bromo
methylglucopyranosyl
flavan
chloro
producing
Prior art date
Application number
PL443538A
Other languages
Polish (pl)
Inventor
Martyna Perz
Edyta Kostrzewa-Susłow
Monika Dymarska
Tomasz Janeczko
Original Assignee
Uniwersytet Przyrodniczy we Wrocławiu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Przyrodniczy we Wrocławiu filed Critical Uniwersytet Przyrodniczy we Wrocławiu
Priority to PL443538A priority Critical patent/PL443538A1/en
Publication of PL443538A1 publication Critical patent/PL443538A1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Przedmiotem zgłoszenia jest 8-bromo-6-chloro-4'-O-β-D-(4"-O-metyloglukopiranozylo)-flawan-4-ol o wzorze 2 oraz sposób wytwarzania 8-bromo-6-chloro-4'-O-β-D-(4"-O-metyloglukopiranozylo)-flawan-4-olu, charakteryzujący się tym, że do podłoża odpowiedniego dla grzybów strzępkowych wprowadza się szczep Isaria fumosorosea KCH J2, następnie po upływie co najmniej 72 godzin do hodowli wprowadza się substrat, którym jest 8-bromo-6-chloroflawanon o wzorze 1, rozpuszczony w rozpuszczalniku organicznym mieszającym się z wodą, transformację prowadzi się w temperaturze od 20 do 30 stopni Celsjusza, przy ciągłym wstrząsaniu, co najmniej 96 godzin, po czym produkt ekstrahuje się rozpuszczalnikiem organicznym niemieszającym się z wodą i oczyszcza chromatograficznie.The subject of the application is 8-bromo-6-chloro-4'-O-β-D-(4"-O-methylglucopyranosyl)-flavan-4-ol of formula 2 and a method for producing 8-bromo-6-chloro-4'-O-β-D-(4"-O-methylglucopyranosyl)-flavan-4-ol, characterized in that the strain Isaria fumosorosea KCH J2 is introduced into a medium suitable for filamentous fungi, then after at least 72 hours a substrate is introduced into the culture, which is 8-bromo-6-chloroflavanone of formula 1, dissolved in an organic solvent miscible with water, the transformation is carried out at a temperature of 20 to 30 degrees Celsius, with continuous shaking, for at least 96 hours, after which the product is extracted with an organic solvent immiscible with water and purified chromatographically.

PL443538A 2023-01-20 2023-01-20 8-Bromo-6-chloro-4'-O-β-D-(4"-O-methylglucopyranosyl)-flavan-4-ol and method for producing 8-bromo-6-chloro-4'-O-β-D -(4"O-methylglucopyranosyl)-flavan-4-ol PL443538A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL443538A PL443538A1 (en) 2023-01-20 2023-01-20 8-Bromo-6-chloro-4'-O-β-D-(4"-O-methylglucopyranosyl)-flavan-4-ol and method for producing 8-bromo-6-chloro-4'-O-β-D -(4"O-methylglucopyranosyl)-flavan-4-ol

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL443538A PL443538A1 (en) 2023-01-20 2023-01-20 8-Bromo-6-chloro-4'-O-β-D-(4"-O-methylglucopyranosyl)-flavan-4-ol and method for producing 8-bromo-6-chloro-4'-O-β-D -(4"O-methylglucopyranosyl)-flavan-4-ol

Publications (1)

Publication Number Publication Date
PL443538A1 true PL443538A1 (en) 2024-07-22

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Family Applications (1)

Application Number Title Priority Date Filing Date
PL443538A PL443538A1 (en) 2023-01-20 2023-01-20 8-Bromo-6-chloro-4'-O-β-D-(4"-O-methylglucopyranosyl)-flavan-4-ol and method for producing 8-bromo-6-chloro-4'-O-β-D -(4"O-methylglucopyranosyl)-flavan-4-ol

Country Status (1)

Country Link
PL (1) PL443538A1 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL238969B1 (en) * 2018-09-10 2021-10-25 Wrocław University Of Environmental And Life Sciences 3'-O-β-D-(4"-O-methylglucopyranosyl)-flavan-4-ol and method of preparing 3'-O-β-D-(4"-O-methylglucopyranosyl)-flavan-4-ol
PL238968B1 (en) * 2018-09-10 2021-10-25 Wrocław University Of Environmental And Life Sciences 2'-O-β-D-(4''-O-methylglucopyranosyl)-flavan-4-ol and method of preparing 2'-O-β-D-(4"-O-methylglucopyranosyl)-flavan-4-ol

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL238969B1 (en) * 2018-09-10 2021-10-25 Wrocław University Of Environmental And Life Sciences 3'-O-β-D-(4"-O-methylglucopyranosyl)-flavan-4-ol and method of preparing 3'-O-β-D-(4"-O-methylglucopyranosyl)-flavan-4-ol
PL238968B1 (en) * 2018-09-10 2021-10-25 Wrocław University Of Environmental And Life Sciences 2'-O-β-D-(4''-O-methylglucopyranosyl)-flavan-4-ol and method of preparing 2'-O-β-D-(4"-O-methylglucopyranosyl)-flavan-4-ol

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