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PL443910A1 - 2'-Hydroxy-5'-chloro-3-O-β-D-(4''-O-methylglucopyranosyl)-chalcone and method for preparing 2'-hydroxy-5'-chloro-3-O-β-D-(4''-O-methylglucopyranosyl)-chalcone - Google Patents

2'-Hydroxy-5'-chloro-3-O-β-D-(4''-O-methylglucopyranosyl)-chalcone and method for preparing 2'-hydroxy-5'-chloro-3-O-β-D-(4''-O-methylglucopyranosyl)-chalcone

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Publication number
PL443910A1
PL443910A1 PL443910A PL44391023A PL443910A1 PL 443910 A1 PL443910 A1 PL 443910A1 PL 443910 A PL443910 A PL 443910A PL 44391023 A PL44391023 A PL 44391023A PL 443910 A1 PL443910 A1 PL 443910A1
Authority
PL
Poland
Prior art keywords
hydroxy
methylglucopyranosyl
chalcone
chloro
formula
Prior art date
Application number
PL443910A
Other languages
Polish (pl)
Inventor
Agnieszka Krawczyk-Łebek
Edyta Kostrzewa-Susłow
Monika Dymarska
Tomasz Janeczko
Original Assignee
Uniwersytet Przyrodniczy we Wrocławiu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Przyrodniczy we Wrocławiu filed Critical Uniwersytet Przyrodniczy we Wrocławiu
Priority to PL443910A priority Critical patent/PL443910A1/en
Publication of PL443910A1 publication Critical patent/PL443910A1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Przedmiotem zgłoszenia jest 2'-hydroksy-5'-chloro-3-O-β-D-(4"-O-metyloglukopiranozylo)-chalkon o wzorze 2 oraz sposób wytwarzania 2'-hydroksy-5'-chloro-3-O-β-D-(4"-O-metyloglukopiranozylo)-chalkonu charakteryzujący się tym, że do podłoża odpowiedniego dla grzybów strzępkowych wprowadza się szczep Beauveria bassiana KCH J1.5, następnie po upływie co najmniej 72 godzin do hodowli wprowadza się substrat, którym jest 2'-hydroksy-5'chlorochalkon o wzorze 1, rozpuszczony w rozpuszczalniku organicznym mieszającym się z wodą, transformację prowadzi się w temperaturze od 20 do 30 stopni Celsjusza, przy ciągłym wstrząsaniu, co najmniej 96 godzin, po czym produkt ekstrahuje się rozpuszczalnikiem organicznym niemieszającym się z wodą i oczyszcza chromatograficznie, przy czym 2'-hydroksy-5'-chloro-3-O-β-D-(4"-O-metyloglukopiranozylo)-chalkon o wzorze 2 znajduje się we frakcji o pośredniej polarności, w drugim paśmie od linii startu.The subject of the application is 2'-hydroxy-5'-chloro-3-O-β-D-(4"-O-methylglucopyranosyl)-chalcone of formula 2 and a method for producing 2'-hydroxy-5'-chloro-3-O-β-D-(4"-O-methylglucopyranosyl)-chalcone characterized in that the Beauveria bassiana KCH J1.5 strain is introduced into a medium suitable for filamentous fungi, then after at least 72 hours a substrate is introduced into the culture, which is 2'-hydroxy-5'-chlorochalcone of formula 1, dissolved in an organic solvent miscible with water, the transformation is carried out at a temperature of 20 to 30 degrees Celsius, with continuous shaking, for at least 96 hours, after which the product is extracted with an organic solvent immiscible with water and purified chromatographically, wherein 2'-Hydroxy-5'-chloro-3-O-β-D-(4"-O-methylglucopyranosyl)-chalcone of formula 2 is located in the fraction of intermediate polarity, in the second band from the starting line.

PL443910A 2023-02-28 2023-02-28 2'-Hydroxy-5'-chloro-3-O-β-D-(4''-O-methylglucopyranosyl)-chalcone and method for preparing 2'-hydroxy-5'-chloro-3-O-β-D-(4''-O-methylglucopyranosyl)-chalcone PL443910A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL443910A PL443910A1 (en) 2023-02-28 2023-02-28 2'-Hydroxy-5'-chloro-3-O-β-D-(4''-O-methylglucopyranosyl)-chalcone and method for preparing 2'-hydroxy-5'-chloro-3-O-β-D-(4''-O-methylglucopyranosyl)-chalcone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL443910A PL443910A1 (en) 2023-02-28 2023-02-28 2'-Hydroxy-5'-chloro-3-O-β-D-(4''-O-methylglucopyranosyl)-chalcone and method for preparing 2'-hydroxy-5'-chloro-3-O-β-D-(4''-O-methylglucopyranosyl)-chalcone

Publications (1)

Publication Number Publication Date
PL443910A1 true PL443910A1 (en) 2024-09-02

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Family Applications (1)

Application Number Title Priority Date Filing Date
PL443910A PL443910A1 (en) 2023-02-28 2023-02-28 2'-Hydroxy-5'-chloro-3-O-β-D-(4''-O-methylglucopyranosyl)-chalcone and method for preparing 2'-hydroxy-5'-chloro-3-O-β-D-(4''-O-methylglucopyranosyl)-chalcone

Country Status (1)

Country Link
PL (1) PL443910A1 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL241534B1 (en) * 2020-02-20 2022-10-17 Wrocław University Of Environmental And Life Sciences 2′-Hydroxy-5'-methyl-3-O-β-D-(4''-O-methylglucopyranosyl)-chalcone and method for the preparation of 2'-hydroxy-5'-methyl-3-O-β-D- (4''-O-methylglucopyranosyl)-chalcone
PL438352A1 (en) * 2021-07-05 2023-01-09 Uniwersytet Przyrodniczy we Wrocławiu 2',3-Dihydroxy-2-methyl-3'-O-β-D-(4''-O-methylglucopyranosyl)-dihydrochalcone and method for the preparation of 2',3-dihydroxy-2-methyl-3'-O- β-D-(4''-O-methylglucopyranosyl)-dihydrochalcone

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL241534B1 (en) * 2020-02-20 2022-10-17 Wrocław University Of Environmental And Life Sciences 2′-Hydroxy-5'-methyl-3-O-β-D-(4''-O-methylglucopyranosyl)-chalcone and method for the preparation of 2'-hydroxy-5'-methyl-3-O-β-D- (4''-O-methylglucopyranosyl)-chalcone
PL438352A1 (en) * 2021-07-05 2023-01-09 Uniwersytet Przyrodniczy we Wrocławiu 2',3-Dihydroxy-2-methyl-3'-O-β-D-(4''-O-methylglucopyranosyl)-dihydrochalcone and method for the preparation of 2',3-dihydroxy-2-methyl-3'-O- β-D-(4''-O-methylglucopyranosyl)-dihydrochalcone

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