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PL439088A1 - 4'-Methylene-O-β-D-(4''-O-methylglucopyranosyl)-flavanone and method for preparing 4'-methylene-O-β-D-(4''-O-methylglucopyranosyl)-flavanone - Google Patents

4'-Methylene-O-β-D-(4''-O-methylglucopyranosyl)-flavanone and method for preparing 4'-methylene-O-β-D-(4''-O-methylglucopyranosyl)-flavanone

Info

Publication number
PL439088A1
PL439088A1 PL439088A PL43908821A PL439088A1 PL 439088 A1 PL439088 A1 PL 439088A1 PL 439088 A PL439088 A PL 439088A PL 43908821 A PL43908821 A PL 43908821A PL 439088 A1 PL439088 A1 PL 439088A1
Authority
PL
Poland
Prior art keywords
methylglucopyranosyl
flavanone
methylene
formula
hours
Prior art date
Application number
PL439088A
Other languages
Polish (pl)
Inventor
Agnieszka Krawczyk-Łebek
Edyta Kostrzewa-Susłow
Monika Dymarska
Tomasz Janeczko
Original Assignee
Uniwersytet Przyrodniczy we Wrocławiu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Przyrodniczy we Wrocławiu filed Critical Uniwersytet Przyrodniczy we Wrocławiu
Priority to PL439088A priority Critical patent/PL439088A1/en
Publication of PL439088A1 publication Critical patent/PL439088A1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Przedmiotem zgłoszenia jest 4'-metyleno-O-β-D-(4"-O-metyloglukopiranozylo)-flawanon o wzorze 2 oraz sposób wytwarzania 4'-metyleno-O-β-D-(4"-O-metyloglukopiranozylo)-flawanonu, charakteryzujący się tym, że do podłoża odpowiedniego dla grzybów strzępkowych wprowadza się szczep Isaria fumosorosea KCH J2, następnie po upływie co najmniej 72 godzin do hodowli wprowadza się substrat, którym jest 4'-metyloflawanon o wzorze 1, rozpuszczony w rozpuszczalniku organicznym mieszającym się z wodą, transformację prowadzi się w temperaturze od 20 do 30 stopni Celsjusza, przy ciągłym wstrząsaniu, co najmniej 96 godzin, po czym produkt ekstrahuje się rozpuszczalnikiem organicznym niemieszającym się z wodą i oczyszcza chromatograficznie, przy czym 4'-metyleno-O-β-D-(4"-O-metyloglukopiranozylo)-flawanon o wzorze 2 znajduje się we frakcji o pośredniej polarności, w drugim paśmie od linii startu.The subject of the application is 4'-methylene-O-β-D-(4"-O-methylglucopyranosyl)-flavanone of formula 2 and a method for the production of 4'-methylene-O-β-D-(4"-O-methylglucopyranosyl)- flavanone, characterized in that the strain Isaria fumosorosea KCH J2 is introduced into the medium suitable for filamentous fungi, then, after at least 72 hours, the substrate is introduced into the culture, which is 4'-methylflavanone of the formula 1, dissolved in an organic solvent miscible with water, the transformation is carried out at a temperature of 20 to 30 degrees Celsius with continuous shaking for at least 96 hours, after which the product is extracted with a water-immiscible organic solvent and purified by chromatography, the 4'-methylene-O-β- D-(4"-O-methylglucopyranosyl)-flavanone of formula 2 is found in the fraction of intermediate polarity, in the second band from the starting line.

PL439088A 2021-09-30 2021-09-30 4'-Methylene-O-β-D-(4''-O-methylglucopyranosyl)-flavanone and method for preparing 4'-methylene-O-β-D-(4''-O-methylglucopyranosyl)-flavanone PL439088A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL439088A PL439088A1 (en) 2021-09-30 2021-09-30 4'-Methylene-O-β-D-(4''-O-methylglucopyranosyl)-flavanone and method for preparing 4'-methylene-O-β-D-(4''-O-methylglucopyranosyl)-flavanone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL439088A PL439088A1 (en) 2021-09-30 2021-09-30 4'-Methylene-O-β-D-(4''-O-methylglucopyranosyl)-flavanone and method for preparing 4'-methylene-O-β-D-(4''-O-methylglucopyranosyl)-flavanone

Publications (1)

Publication Number Publication Date
PL439088A1 true PL439088A1 (en) 2023-04-03

Family

ID=85783964

Family Applications (1)

Application Number Title Priority Date Filing Date
PL439088A PL439088A1 (en) 2021-09-30 2021-09-30 4'-Methylene-O-β-D-(4''-O-methylglucopyranosyl)-flavanone and method for preparing 4'-methylene-O-β-D-(4''-O-methylglucopyranosyl)-flavanone

Country Status (1)

Country Link
PL (1) PL439088A1 (en)

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