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PL436247A1 - 7-Methoxy-4'-O-β-D-(4"-O-methylglucopyranosyl)-flavanone and method of preparing 7-methoxy-4'-O-β-D-(4"-O-methylglucopyranosyl)-flavanone - Google Patents

7-Methoxy-4'-O-β-D-(4"-O-methylglucopyranosyl)-flavanone and method of preparing 7-methoxy-4'-O-β-D-(4"-O-methylglucopyranosyl)-flavanone

Info

Publication number
PL436247A1
PL436247A1 PL436247A PL43624720A PL436247A1 PL 436247 A1 PL436247 A1 PL 436247A1 PL 436247 A PL436247 A PL 436247A PL 43624720 A PL43624720 A PL 43624720A PL 436247 A1 PL436247 A1 PL 436247A1
Authority
PL
Poland
Prior art keywords
methylglucopyranosyl
flavanone
methoxy
formula
hours
Prior art date
Application number
PL436247A
Other languages
Polish (pl)
Other versions
PL244215B1 (en
Inventor
Monika Dymarska
Edyta Kostrzewa-Susłow
Tomasz Janeczko
Original Assignee
Uniwersytet Przyrodniczy we Wrocławiu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Przyrodniczy we Wrocławiu filed Critical Uniwersytet Przyrodniczy we Wrocławiu
Priority to PL436247A priority Critical patent/PL244215B1/en
Publication of PL436247A1 publication Critical patent/PL436247A1/en
Publication of PL244215B1 publication Critical patent/PL244215B1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Przedmiotem zgłoszenia jest 7-metoksy-4'-O-β-D-(4"-O-metyloglukopiranozylo)-flawanon o wzorze 2. Zgłoszenie obejmuje także sposób wytwarzania 7-metoksy-4'-O-β-D-(4"-O-metyloglukopiranozylo)-flawanonu charakteryzujący się tym, że do podłoża odpowiedniego dla grzybów strzępkowych wprowadza się szczep Isaria fumosorosea KCH J2, następnie po upływie co najmniej 72 godzin do hodowli wprowadza się substrat, którym jest 7-metoksyflawanon o wzorze 1, rozpuszczony w rozpuszczalniku organicznym mieszającym się z wodą, dalej transformację prowadzi się w temperaturze od 20 do 30 stopni Celsjusza, przy ciągłym wstrząsaniu, co najmniej 96 godzin, po czym produkt ekstrahuje się rozpuszczalnikiem organicznym niemieszającym się z wodą i oczyszcza chromatograficznie, przy czym 7-metoksy-4'-O-β-D-(4"-O-metyloglukopiranozylo)-flawanon o wzorze 2 znajduje się we frakcji o wyższej polarności, w drugim paśmie od linii startu.The subject of the application is 7-methoxy-4'-O-β-D- (4 "-O-methylglucopyranosyl) -flavanone of the formula 2. The application also covers the production process of 7-methoxy-4'-O-β-D- (4 "-O-methylglucopyranosyl) -flavanone, characterized in that the Isaria fumosorosea KCH J2 strain is introduced into a medium suitable for filamentous fungi, then, after at least 72 hours, the substrate is introduced into the culture, which is 7-methoxyflavanone of formula 1, dissolved in a water-miscible organic solvent, further transformation is carried out at a temperature of 20 to 30 degrees Celsius with continuous shaking for at least 96 hours, then the product is extracted with a water-immiscible organic solvent and purified by chromatography, the 7-methoxy -4'-O-β-D- (4 "-O-methylglucopyranosyl) -flavanone of formula 2 is found in the higher polarity fraction in the second band from the starting line.

PL436247A 2020-12-06 2020-12-06 7-Methoxy-4'-O-β-D-(4''-O-methylglucopyranosyl)-flavanone and method of producing 7-methoxy-4'-O-β-D-(4''-O-methylglucopyranosyl)- flavanone PL244215B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL436247A PL244215B1 (en) 2020-12-06 2020-12-06 7-Methoxy-4'-O-β-D-(4''-O-methylglucopyranosyl)-flavanone and method of producing 7-methoxy-4'-O-β-D-(4''-O-methylglucopyranosyl)- flavanone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL436247A PL244215B1 (en) 2020-12-06 2020-12-06 7-Methoxy-4'-O-β-D-(4''-O-methylglucopyranosyl)-flavanone and method of producing 7-methoxy-4'-O-β-D-(4''-O-methylglucopyranosyl)- flavanone

Publications (2)

Publication Number Publication Date
PL436247A1 true PL436247A1 (en) 2022-06-13
PL244215B1 PL244215B1 (en) 2023-12-18

Family

ID=81943638

Family Applications (1)

Application Number Title Priority Date Filing Date
PL436247A PL244215B1 (en) 2020-12-06 2020-12-06 7-Methoxy-4'-O-β-D-(4''-O-methylglucopyranosyl)-flavanone and method of producing 7-methoxy-4'-O-β-D-(4''-O-methylglucopyranosyl)- flavanone

Country Status (1)

Country Link
PL (1) PL244215B1 (en)

Also Published As

Publication number Publication date
PL244215B1 (en) 2023-12-18

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