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PL439095A1 - 4'-Methyl-3-O-β-D-(4''-O-methylglucopyranosyl)-flavone and method of production of 4'-methyl-3-O-β-D-(4''-O-methylglucopyranosyl)-flavone - Google Patents

4'-Methyl-3-O-β-D-(4''-O-methylglucopyranosyl)-flavone and method of production of 4'-methyl-3-O-β-D-(4''-O-methylglucopyranosyl)-flavone

Info

Publication number
PL439095A1
PL439095A1 PL439095A PL43909521A PL439095A1 PL 439095 A1 PL439095 A1 PL 439095A1 PL 439095 A PL439095 A PL 439095A PL 43909521 A PL43909521 A PL 43909521A PL 439095 A1 PL439095 A1 PL 439095A1
Authority
PL
Poland
Prior art keywords
methylglucopyranosyl
flavone
methyl
formula
hours
Prior art date
Application number
PL439095A
Other languages
Polish (pl)
Inventor
Agnieszka Krawczyk-Łebek
Edyta Kostrzewa-Susłow
Monika Dymarska
Tomasz Janeczko
Original Assignee
Uniwersytet Przyrodniczy we Wrocławiu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Przyrodniczy we Wrocławiu filed Critical Uniwersytet Przyrodniczy we Wrocławiu
Priority to PL439095A priority Critical patent/PL439095A1/en
Publication of PL439095A1 publication Critical patent/PL439095A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/06—Benzopyran radicals
    • C07H17/065—Benzo[b]pyrans
    • C07H17/07—Benzo[b]pyran-4-ones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Przedmiotem zgłoszenia jest 4'-metylo-3-O-β-D-(4"-O-metyloglukopiranozylo)-flawon o wzorze 2 oraz sposób wytwarzania 4'-metylo-3-O-β-D-(4"-O-metyloglukopiranozylo)-flawonu, który polega na tym, że do podłoża odpowiedniego dla grzybów strzępkowych wprowadza się szczep Isaria fumosorosea KCH J2, następnie po upływie co najmniej 72 godzin do hodowli wprowadza się substrat, którym jest 4'-metyloflawon o wzorze 1, rozpuszczony w rozpuszczalniku organicznym mieszającym się z wodą, transformację prowadzi się w temperaturze od 20 do 30 stopni Celsjusza, przy ciągłym wstrząsaniu, co najmniej 96 godzin, po czym produkt ekstrahuje się rozpuszczalnikiem organicznym niemieszającym się z wodą i oczyszcza chromatograficznie, przy czym 4'-metylo-3-O-β-D-(4"-O-metyloglukopiranozylo)-flawon o wzorze 2 znajduje się we frakcji o pośredniej polarności, w piątym paśmie od linii startu.The subject of the application is 4'-methyl-3-O-β-D-(4"-O-methylglucopyranosyl)-flavone of the formula 2 and a method for producing 4'-methyl-3-O-β-D-(4"-O -methylglucopyranosyl)-flavone, which consists in introducing the Isaria fumosorosea KCH J2 strain into the substrate suitable for filamentous fungi, then, after at least 72 hours, the substrate is introduced into the culture, which is 4'-methylflavone of the formula 1, dissolved in a water-miscible organic solvent, transformation is carried out at a temperature of 20 to 30 degrees Celsius, with continuous shaking, for at least 96 hours, after which the product is extracted with a water-immiscible organic solvent and purified by chromatography, 4'-methyl -3-O-β-D-(4"-O-methylglucopyranosyl)-flavone of formula 2 is found in the fraction of intermediate polarity, in the fifth band from the starting line.

PL439095A 2021-09-30 2021-09-30 4'-Methyl-3-O-β-D-(4''-O-methylglucopyranosyl)-flavone and method of production of 4'-methyl-3-O-β-D-(4''-O-methylglucopyranosyl)-flavone PL439095A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL439095A PL439095A1 (en) 2021-09-30 2021-09-30 4'-Methyl-3-O-β-D-(4''-O-methylglucopyranosyl)-flavone and method of production of 4'-methyl-3-O-β-D-(4''-O-methylglucopyranosyl)-flavone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL439095A PL439095A1 (en) 2021-09-30 2021-09-30 4'-Methyl-3-O-β-D-(4''-O-methylglucopyranosyl)-flavone and method of production of 4'-methyl-3-O-β-D-(4''-O-methylglucopyranosyl)-flavone

Publications (1)

Publication Number Publication Date
PL439095A1 true PL439095A1 (en) 2023-04-03

Family

ID=85783962

Family Applications (1)

Application Number Title Priority Date Filing Date
PL439095A PL439095A1 (en) 2021-09-30 2021-09-30 4'-Methyl-3-O-β-D-(4''-O-methylglucopyranosyl)-flavone and method of production of 4'-methyl-3-O-β-D-(4''-O-methylglucopyranosyl)-flavone

Country Status (1)

Country Link
PL (1) PL439095A1 (en)

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