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PL443539A1 - 8-Bromo-6-chloro-4'-O-β-D-(4"-O-methylglucopyranosyl)-flavone and method for preparing 8-bromo-6-chloro-4'-O-β-D-(4"-O-methylglucopyranosyl)-flavone - Google Patents

8-Bromo-6-chloro-4'-O-β-D-(4"-O-methylglucopyranosyl)-flavone and method for preparing 8-bromo-6-chloro-4'-O-β-D-(4"-O-methylglucopyranosyl)-flavone

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Publication number
PL443539A1
PL443539A1 PL443539A PL44353923A PL443539A1 PL 443539 A1 PL443539 A1 PL 443539A1 PL 443539 A PL443539 A PL 443539A PL 44353923 A PL44353923 A PL 44353923A PL 443539 A1 PL443539 A1 PL 443539A1
Authority
PL
Poland
Prior art keywords
bromo
methylglucopyranosyl
flavone
chloro
preparing
Prior art date
Application number
PL443539A
Other languages
Polish (pl)
Inventor
Martyna Perz
Edyta Kostrzewa-Susłow
Monika Dymarska
Tomasz Janeczko
Original Assignee
Uniwersytet Przyrodniczy we Wrocławiu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Przyrodniczy we Wrocławiu filed Critical Uniwersytet Przyrodniczy we Wrocławiu
Priority to PL443539A priority Critical patent/PL443539A1/en
Publication of PL443539A1 publication Critical patent/PL443539A1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

Przedmiotem zgłoszenia jest 8-bromo-6-chloro-4'-O-β-D-(4"-O-metyloglukopiranozylo)-flawon o wzorze 2 oraz Sposób wytwarzania 8-bromo-6-chloro-4'-O-β-D-(4"-O-metyloglukopiranozylo)-flawonu charakteryzujący się tym, że do podłoża odpowiedniego dla grzybów strzępkowych wprowadza się szczep Isaria farinosa KCH J2.6, następnie po upływie co najmniej 72 godzin do hodowli wprowadza się substrat, którym jest 8-bromo-6-chloroflawon o wzorze 1, rozpuszczony w rozpuszczalniku organicznym mieszającym się z wodą, transformację prowadzi się w temperaturze od 20 do 30 stopni Celsjusza, przy ciągłym wstrząsaniu, co najmniej 96 godzin, po czym produkt ekstrahuje się rozpuszczalnikiem organicznym niemieszającym się z wodą i oczyszcza chromatograficznie.The subject of the application is 8-bromo-6-chloro-4'-O-β-D-(4"-O-methylglucopyranosyl)-flavone of formula 2 and a method for producing 8-bromo-6-chloro-4'-O-β-D-(4"-O-methylglucopyranosyl)-flavone characterized in that the strain Isaria farinosa KCH J2.6 is introduced into a medium suitable for filamentous fungi, then after at least 72 hours a substrate is introduced into the culture, which is 8-bromo-6-chloroflavone of formula 1, dissolved in an organic solvent miscible with water, the transformation is carried out at a temperature of 20 to 30 degrees Celsius, with continuous shaking, for at least 96 hours, after which the product is extracted with an organic solvent immiscible with water and purified chromatographically.

PL443539A 2023-01-20 2023-01-20 8-Bromo-6-chloro-4'-O-β-D-(4"-O-methylglucopyranosyl)-flavone and method for preparing 8-bromo-6-chloro-4'-O-β-D-(4"-O-methylglucopyranosyl)-flavone PL443539A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL443539A PL443539A1 (en) 2023-01-20 2023-01-20 8-Bromo-6-chloro-4'-O-β-D-(4"-O-methylglucopyranosyl)-flavone and method for preparing 8-bromo-6-chloro-4'-O-β-D-(4"-O-methylglucopyranosyl)-flavone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL443539A PL443539A1 (en) 2023-01-20 2023-01-20 8-Bromo-6-chloro-4'-O-β-D-(4"-O-methylglucopyranosyl)-flavone and method for preparing 8-bromo-6-chloro-4'-O-β-D-(4"-O-methylglucopyranosyl)-flavone

Publications (1)

Publication Number Publication Date
PL443539A1 true PL443539A1 (en) 2024-07-22

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Family Applications (1)

Application Number Title Priority Date Filing Date
PL443539A PL443539A1 (en) 2023-01-20 2023-01-20 8-Bromo-6-chloro-4'-O-β-D-(4"-O-methylglucopyranosyl)-flavone and method for preparing 8-bromo-6-chloro-4'-O-β-D-(4"-O-methylglucopyranosyl)-flavone

Country Status (1)

Country Link
PL (1) PL443539A1 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL238971B1 (en) * 2019-09-16 2021-10-25 Wrocław University Of Environmental And Life Sciences 6-Chloro-4'-0-β-D-(4"-O-methylglucopyranosyl)-flavone and method of producing 6-chloro-4'-O-β-D-(4"-O-methylglucopyranosyl)-flavone
PL238972B1 (en) * 2019-09-16 2021-10-25 Wrocław University Of Environmental And Life Sciences 6,8-Dichloro-4'-O-β-D-(4"-O-methylglucopyranosyl)-flavone and method of producing 6,8-dichloro-4'-O-β-D-(4"-O-methylglucopyranosyl)-flavone

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL238971B1 (en) * 2019-09-16 2021-10-25 Wrocław University Of Environmental And Life Sciences 6-Chloro-4'-0-β-D-(4"-O-methylglucopyranosyl)-flavone and method of producing 6-chloro-4'-O-β-D-(4"-O-methylglucopyranosyl)-flavone
PL238972B1 (en) * 2019-09-16 2021-10-25 Wrocław University Of Environmental And Life Sciences 6,8-Dichloro-4'-O-β-D-(4"-O-methylglucopyranosyl)-flavone and method of producing 6,8-dichloro-4'-O-β-D-(4"-O-methylglucopyranosyl)-flavone

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