PL3450434T3 - Deuterowane pochodne ruksolitynibu - Google Patents
Deuterowane pochodne ruksolitynibuInfo
- Publication number
- PL3450434T3 PL3450434T3 PL18188152T PL18188152T PL3450434T3 PL 3450434 T3 PL3450434 T3 PL 3450434T3 PL 18188152 T PL18188152 T PL 18188152T PL 18188152 T PL18188152 T PL 18188152T PL 3450434 T3 PL3450434 T3 PL 3450434T3
- Authority
- PL
- Poland
- Prior art keywords
- russolitinb
- deuterated
- derivatives
- russolitinb derivatives
- deuterated russolitinb
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
- A61K31/5685—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261660428P | 2012-06-15 | 2012-06-15 | |
| US201261678795P | 2012-08-02 | 2012-08-02 | |
| EP13732046.1A EP2861600A1 (en) | 2012-06-15 | 2013-06-14 | Deuterated derivatives of ruxolitinib |
| EP18188152.5A EP3450434B1 (en) | 2012-06-15 | 2013-06-14 | Deuterated derivatives of ruxolitinib |
| PCT/US2013/045919 WO2013188783A1 (en) | 2012-06-15 | 2013-06-14 | Deuterated derivatives of ruxolitinib |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3450434T3 true PL3450434T3 (pl) | 2021-10-04 |
Family
ID=48699982
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL18188152T PL3450434T3 (pl) | 2012-06-15 | 2013-06-14 | Deuterowane pochodne ruksolitynibu |
Country Status (12)
| Country | Link |
|---|---|
| US (7) | US20150197525A1 (pl) |
| EP (3) | EP3450434B1 (pl) |
| AU (3) | AU2013274030B2 (pl) |
| BR (1) | BR122023027277A2 (pl) |
| CA (1) | CA2876306C (pl) |
| DK (1) | DK3450434T3 (pl) |
| EA (1) | EA201492287A1 (pl) |
| ES (1) | ES2867048T3 (pl) |
| IN (1) | IN2014DN10670A (pl) |
| MX (2) | MX360495B (pl) |
| PL (1) | PL3450434T3 (pl) |
| WO (1) | WO2013188783A1 (pl) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2543904T3 (es) | 2005-12-13 | 2015-08-25 | Incyte Corporation | Pirrolo[2,3-b]piridinas y pirrolo[2,3-b]pirimidinas sustituidas con heteroarilo como inhibidores de quinasas Janus |
| NZ602313A (en) | 2010-03-10 | 2014-08-29 | Incyte Corp | Piperidin-4-yl azetidine derivatives as jak1 inhibitors |
| CN103797010B (zh) | 2011-06-20 | 2016-02-24 | 因塞特控股公司 | 作为jak抑制剂的氮杂环丁烷基苯基、吡啶基或吡嗪基甲酰胺衍生物 |
| DK3450434T3 (da) | 2012-06-15 | 2021-05-03 | Concert Pharmaceuticals Inc | Deutererede derivater af ruxolitinib |
| US10166191B2 (en) | 2012-11-15 | 2019-01-01 | Incyte Corporation | Sustained-release dosage forms of ruxolitinib |
| CN116036089A (zh) | 2013-08-07 | 2023-05-02 | 因赛特控股公司 | Jak1抑制剂的持续释放剂型 |
| EP4233870A3 (en) | 2014-05-28 | 2024-01-24 | Onco Tracker, Inc. | Anti-cancer effects of jak2 inhibitors in combination with thalidomide derivatives and glucocorticoids |
| US10865203B2 (en) | 2015-06-03 | 2020-12-15 | Uwm Research Foundation, Inc. | Ligands selective to alpha 6 subunit-containing GABAA receptors and their methods of use |
| CA3013123A1 (en) | 2016-02-04 | 2017-08-10 | Cinrx Pharma, Llc | Deuterated domperidone compositions and methods for therapy of disorders |
| WO2017139569A1 (en) * | 2016-02-12 | 2017-08-17 | Concert Pharmaceuticals, Inc. | Deuterium-modified cftr modulators |
| HRP20241345T1 (hr) * | 2016-05-04 | 2024-12-20 | Sun Pharmaceutical Industries, Inc. | Liječenje poremećaja gubitka kose deuteriranim inhibitorima jak |
| CA3045666A1 (en) * | 2016-12-14 | 2018-06-21 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a jak inhibitor and devices |
| US11364226B2 (en) | 2017-06-30 | 2022-06-21 | Cinrx Pharma, Llc | Deuterated domperidone compositions, methods, and preparation |
| WO2019104214A1 (en) | 2017-11-22 | 2019-05-31 | Dauntless 2, Inc. | Membrane emulsification device for microsphere creation |
| EP3713545A1 (en) | 2017-11-22 | 2020-09-30 | Dauntless 1, Inc. | Therapeutic compound formulations |
| US11179412B2 (en) * | 2017-12-04 | 2021-11-23 | University of Pittsburgh—of the Commonwealth System of Higher Education | Methods of treating conditions involving elevated inflammatory response |
| WO2019113487A1 (en) * | 2017-12-08 | 2019-06-13 | Incyte Corporation | Low dose combination therapy for treatment of myeloproliferative neoplasms |
| CA3092931A1 (en) | 2018-03-08 | 2019-09-12 | Novartis Ag | Use of an anti-p-selectin antibody |
| AU2019245420B2 (en) | 2018-03-30 | 2024-10-10 | Incyte Corporation | Treatment of hidradenitis suppurativa using JAK inhibitors |
| JP7565798B2 (ja) | 2018-03-30 | 2024-10-11 | インサイト・コーポレイション | 炎症性皮膚疾患のバイオマーカー |
| JP7378420B2 (ja) | 2018-04-13 | 2023-11-13 | インサイト・コーポレイション | 移植片対宿主病のバイオマーカー |
| WO2020039401A1 (en) | 2018-08-24 | 2020-02-27 | Novartis Ag | Treatment comprising il-1βeta binding antibodies and combinations thereof |
| KR20210124345A (ko) * | 2019-02-06 | 2021-10-14 | 콘서트 파마슈티컬즈, 인크. | 거울상 이성질체 풍부한 jak 억제제를 제조하는 방법 |
| CA3132371A1 (en) | 2019-03-05 | 2020-09-10 | Incyte Corporation | Jak1 pathway inhibitors for the treatment of chronic lung allograft dysfunction |
| TW202102222A (zh) | 2019-03-19 | 2021-01-16 | 美商英塞特公司 | 白斑病之生物標記物 |
| US11731947B2 (en) | 2019-04-10 | 2023-08-22 | University Of Notre Dame Du Lac | Deuterated antimicrobial compounds |
| WO2020223640A1 (en) | 2019-05-02 | 2020-11-05 | Intel Corporation | Quality of service (qos) in information centric networking (icn) |
| WO2020236950A1 (en) | 2019-05-21 | 2020-11-26 | Dauntless 1, Inc. | Therapeutic microsphere formulations containing charged polymers |
| JP2022547311A (ja) | 2019-09-16 | 2022-11-11 | ノバルティス アーゲー | 骨髄線維症の治療のためのｍｄｍ２阻害剤の使用 |
| US20220306737A1 (en) | 2019-09-16 | 2022-09-29 | Novartis Ag | Use of high-affinity, ligand-blocking, humanized anti-t-cell immunoglobulin domain and mucin domain-3 (tim-3) igg4 antibody for the treatment of myelofibrosis |
| WO2021072116A1 (en) | 2019-10-10 | 2021-04-15 | Incyte Corporation | Biomarkers for graft-versus-host disease |
| WO2021072098A1 (en) | 2019-10-10 | 2021-04-15 | Incyte Corporation | Biomarkers for graft-versus-host disease |
| US11992490B2 (en) | 2019-10-16 | 2024-05-28 | Incyte Corporation | Use of JAK1 inhibitors for the treatment of cutaneous lupus erythematosus and Lichen planus (LP) |
| WO2021076124A1 (en) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Use of jak1 inhibitors for the treatment of cutaneous lupus erythematosus and lichen planus (lp) |
| CR20220280A (es) | 2019-11-22 | 2022-09-02 | Incyte Corp | Terapia de combinación que comprende un inhibidor de alk2 y un inhibidor de jak2 |
| WO2021236139A1 (en) | 2020-05-21 | 2021-11-25 | Concert Pharmaceuticals, Inc. | Novel deuterated jak inhibitor and uses thereof |
| US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
| CN116348467A (zh) | 2020-08-12 | 2023-06-27 | 康塞特医药品有限公司 | 用于制备对映异构体富集的jak抑制剂的方法 |
| US20240000777A1 (en) | 2020-10-08 | 2024-01-04 | Novartis Ag | Use of an erk inhibitor for the treatment of myelofibrosis |
| PE20231945A1 (es) | 2020-10-28 | 2023-12-05 | Sun Pharmaceutical Ind Inc | Regimenes para el tratamiento de los trastornos de la perdida de cabello con inhibidores de jak deuterados |
| US20230404917A1 (en) * | 2020-11-19 | 2023-12-21 | Sol-Gel Technologies Ltd. | Ruxolitinib or deuterated ruxolitinib composition and uses thereof |
| JP2023552424A (ja) | 2020-12-04 | 2023-12-15 | インサイト・コーポレイション | 皮膚疾患の治療のためのビタミンｄ類似体を有するｊａｋ阻害剤 |
| US11918581B2 (en) | 2021-01-11 | 2024-03-05 | Incyte Corporation | Combination therapy comprising JAK pathway inhibitor and rock inhibitor |
| CN114853760A (zh) * | 2021-02-03 | 2022-08-05 | 南京正大天晴制药有限公司 | 一种芦可替尼中间体的制备方法 |
| CN118159272A (zh) | 2021-08-11 | 2024-06-07 | 太阳医药工业公司 | 用氘化的jak抑制剂来治疗脱发病症 |
| WO2023018954A1 (en) | 2021-08-12 | 2023-02-16 | Concert Pharmaceuticals, Inc. | Treatment of jak-inhibition-responsive disorders with prodrugs of jak inhibitors |
| CN113820413B (zh) * | 2021-09-17 | 2023-04-07 | 重庆华邦胜凯制药有限公司 | 高效液相色谱法分离测定磷酸芦可替尼及杂质的方法 |
| KR20250022668A (ko) | 2022-05-04 | 2025-02-17 | 썬 파마슈티칼 인더스트리즈 인코포레이티드 | 중수소화된 jak 억제제를 이용해 치료하기 위한 투여 요법 |
| CN117384163A (zh) * | 2022-07-05 | 2024-01-12 | 盛世泰科生物医药技术(苏州)股份有限公司 | 一种含偕二氟基的化合物及其制备方法和用途 |
| WO2024196761A1 (en) * | 2023-03-17 | 2024-09-26 | Mayo Foundation For Medical Education And Research | Use of oral jak kinase inhibitors to treat lichen planus |
| WO2024194352A1 (en) | 2023-03-23 | 2024-09-26 | Glaxosmithkline Intellectual Property (No.3) Limited | Deuterated p2x3 modulators |
| US12247034B1 (en) | 2024-04-19 | 2025-03-11 | Sun Pharmaceutical Industries, Inc. | Crystalline form of deuruxolitinib phosphate |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5304121A (en) | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
| US5886026A (en) | 1993-07-19 | 1999-03-23 | Angiotech Pharmaceuticals Inc. | Anti-angiogenic compositions and methods of use |
| US6221335B1 (en) * | 1994-03-25 | 2001-04-24 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| AU707748B2 (en) | 1994-03-25 | 1999-07-22 | Isotechnika Inc. | Enhancement of the efficacy of drugs by deuteration |
| US6099562A (en) | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
| US6440710B1 (en) * | 1998-12-10 | 2002-08-27 | The Scripps Research Institute | Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds |
| GB9925962D0 (en) | 1999-11-02 | 1999-12-29 | Novartis Ag | Organic compounds |
| DE60001623T2 (de) * | 1999-12-03 | 2003-12-18 | Pfizer Products Inc., Groton | Sulfamoylheteroarylpyrazolverbindungen zur Verwendung als analgetisches/entzündungshemmendes Mittel |
| CN1255185C (zh) | 2001-05-03 | 2006-05-10 | 弗·哈夫曼-拉罗切有限公司 | 无定形甲磺酸奈非那韦的药物剂型 |
| US6737042B2 (en) | 2001-05-24 | 2004-05-18 | Alexza Molecular Delivery Corporation | Delivery of drug esters through an inhalation route |
| TW200413273A (en) * | 2002-11-15 | 2004-08-01 | Wako Pure Chem Ind Ltd | Heavy hydrogenation method of heterocyclic rings |
| CN101076319A (zh) | 2004-09-29 | 2007-11-21 | 科迪斯公司 | 稳定的非晶形雷帕霉素样化合物的药物剂型 |
| US7598273B2 (en) * | 2005-10-06 | 2009-10-06 | Auspex Pharmaceuticals, Inc | Inhibitors of the gastric H+, K+-ATPase with enhanced therapeutic properties |
| ES2543904T3 (es) * | 2005-12-13 | 2015-08-25 | Incyte Corporation | Pirrolo[2,3-b]piridinas y pirrolo[2,3-b]pirimidinas sustituidas con heteroarilo como inhibidores de quinasas Janus |
| US7750168B2 (en) * | 2006-02-10 | 2010-07-06 | Sigma-Aldrich Co. | Stabilized deuteroborane-tetrahydrofuran complex |
| JO2630B1 (en) | 2006-04-13 | 2012-06-17 | نوفارتيس ايه جي | Organic compounds |
| JP2010502702A (ja) * | 2006-09-05 | 2010-01-28 | シェーリング コーポレイション | 脂質管理およびアテローム性動脈硬化症および脂肪肝の治療治療において使用される医薬組成物 |
| CL2008001709A1 (es) | 2007-06-13 | 2008-11-03 | Incyte Corp | Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras. |
| WO2009094216A1 (en) | 2008-01-22 | 2009-07-30 | Concert Pharmaceuticals Inc. | Derivatives of gefitinib |
| JOP20190230A1 (ar) | 2009-01-15 | 2017-06-16 | Incyte Corp | طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به |
| DK3450434T3 (da) | 2012-06-15 | 2021-05-03 | Concert Pharmaceuticals Inc | Deutererede derivater af ruxolitinib |
| US10166191B2 (en) * | 2012-11-15 | 2019-01-01 | Incyte Corporation | Sustained-release dosage forms of ruxolitinib |
-
2013
- 2013-06-14 DK DK18188152.5T patent/DK3450434T3/da active
- 2013-06-14 WO PCT/US2013/045919 patent/WO2013188783A1/en active Application Filing
- 2013-06-14 EP EP18188152.5A patent/EP3450434B1/en active Active
- 2013-06-14 PL PL18188152T patent/PL3450434T3/pl unknown
- 2013-06-14 EP EP21156398.6A patent/EP3882249A1/en active Pending
- 2013-06-14 EP EP13732046.1A patent/EP2861600A1/en not_active Withdrawn
- 2013-06-14 AU AU2013274030A patent/AU2013274030B2/en active Active
- 2013-06-14 CA CA2876306A patent/CA2876306C/en active Active
- 2013-06-14 MX MX2014015185A patent/MX360495B/es active IP Right Grant
- 2013-06-14 BR BR122023027277-3A patent/BR122023027277A2/pt not_active Application Discontinuation
- 2013-06-14 IN IN10670DEN2014 patent/IN2014DN10670A/en unknown
- 2013-06-14 ES ES18188152T patent/ES2867048T3/es active Active
- 2013-06-14 EA EA201492287A patent/EA201492287A1/ru unknown
-
2014
- 2014-12-10 MX MX2018013542A patent/MX373123B/es unknown
- 2014-12-15 US US14/570,954 patent/US20150197525A1/en not_active Abandoned
-
2015
- 2015-05-08 US US14/707,912 patent/US9249149B2/en active Active
-
2016
- 2016-10-05 AU AU2016238877A patent/AU2016238877B2/en active Active
-
2017
- 2017-03-09 US US15/454,844 patent/US20170239254A1/en not_active Abandoned
-
2018
- 2018-11-26 AU AU2018271227A patent/AU2018271227B2/en active Active
-
2019
- 2019-03-11 US US16/298,795 patent/US20190308976A1/en not_active Abandoned
-
2020
- 2020-12-10 US US17/118,050 patent/US20210330674A1/en not_active Abandoned
-
2022
- 2022-12-09 US US18/078,571 patent/US20230355629A1/en active Pending
-
2024
- 2024-10-03 US US18/905,925 patent/US20250025467A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2016238877A1 (en) | 2016-10-27 |
| AU2013274030A1 (en) | 2015-01-22 |
| AU2013274030B2 (en) | 2016-07-07 |
| WO2013188783A8 (en) | 2014-02-27 |
| EP3450434B1 (en) | 2021-02-24 |
| CA2876306C (en) | 2024-02-20 |
| WO2013188783A1 (en) | 2013-12-19 |
| US20190308976A1 (en) | 2019-10-10 |
| BR112014031204A2 (pt) | 2017-06-27 |
| US20170239254A1 (en) | 2017-08-24 |
| US20230355629A1 (en) | 2023-11-09 |
| AU2018271227A1 (en) | 2018-12-13 |
| EP3882249A1 (en) | 2021-09-22 |
| IN2014DN10670A (pl) | 2015-08-28 |
| MX373123B (es) | 2025-03-04 |
| US20210330674A1 (en) | 2021-10-28 |
| AU2018271227B2 (en) | 2020-08-27 |
| EP3450434A1 (en) | 2019-03-06 |
| US20150239896A1 (en) | 2015-08-27 |
| AU2016238877B2 (en) | 2018-08-30 |
| US9249149B2 (en) | 2016-02-02 |
| US20150197525A1 (en) | 2015-07-16 |
| MX360495B (es) | 2018-11-06 |
| BR122023027277A2 (pt) | 2024-01-23 |
| EA201492287A1 (ru) | 2015-07-30 |
| DK3450434T3 (da) | 2021-05-03 |
| CA2876306A1 (en) | 2013-12-19 |
| EP2861600A1 (en) | 2015-04-22 |
| MX2014015185A (es) | 2015-02-17 |
| ES2867048T3 (es) | 2021-10-20 |
| US20250025467A1 (en) | 2025-01-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY2022027I1 (el) | Παραγωγα βενζιμιδαζολο-προλινης | |
| PL3450434T3 (pl) | Deuterowane pochodne ruksolitynibu | |
| BR112015003153A2 (pt) | baricitinib deuterado | |
| DK2859055T3 (da) | Polymercoatings | |
| DK2825087T3 (da) | Otoscanner | |
| EP2809145A4 (en) | CHLOROPLAST TRANSIT PEPTIDES | |
| DK2839013T3 (da) | Ikke-disruptiv-gen-targetering | |
| EP2814472A4 (en) | DITHIOAMINE REDUCING AGENTS | |
| EP2805877A4 (en) | UNDER HOOD | |
| DK2873977T3 (da) | Dobbeltdækker-rørdispenser | |
| DK2854722T3 (da) | Stomipose | |
| EP2941099A4 (en) | SWITCHING DEVICE | |
| EP2831482A4 (en) | Flange gasket | |
| EP2899849A4 (en) | STATOR FASTENING STRUCTURE | |
| DK2825157T3 (da) | Aminosyrelipider | |
| EP2812047A4 (en) | ACCESS SYSTEM VIA AN OCCLUSION | |
| DK2831122T3 (da) | Anthocyanidin-kompleks | |
| FI20125510L (fi) | Laitteisto | |
| EP2801315A4 (en) | SCANNING ENDOSCOPE DEVICE | |
| DE112012006214T8 (de) | Wulstringwickler | |
| DK2885638T3 (da) | Molekylenet | |
| DK2858657T3 (da) | Feijoafrugtekstrakt | |
| ES1077590Y (es) | Columbario | |
| DE102013212400A8 (de) | Abdeckplattenstützbaugruppe | |
| DK2897570T3 (da) | Spin-elueringsrør |