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DK2825157T3 - Aminosyrelipider - Google Patents

Aminosyrelipider Download PDF

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Publication number
DK2825157T3
DK2825157T3 DK13710787.6T DK13710787T DK2825157T3 DK 2825157 T3 DK2825157 T3 DK 2825157T3 DK 13710787 T DK13710787 T DK 13710787T DK 2825157 T3 DK2825157 T3 DK 2825157T3
Authority
DK
Denmark
Prior art keywords
aminosyrelipider
Prior art date
Application number
DK13710787.6T
Other languages
English (en)
Inventor
Michael Wilhelm Platscher
Raymond Behrendt
Simone Rachel Hoertner
Marco Silvio Passafaro
Finn Bauer
Viola Groehn
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Application granted granted Critical
Publication of DK2825157T3 publication Critical patent/DK2825157T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/30Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/08Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/10Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/08Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/185Saturated compounds having only one carboxyl group and containing keto groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/02Ortho- or ortho- and peri-condensed systems
    • C07C2603/04Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18Fluorenes; Hydrogenated fluorenes
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK13710787.6T 2012-03-16 2013-03-11 Aminosyrelipider DK2825157T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12001793 2012-03-16
PCT/EP2013/000699 WO2013135360A1 (en) 2012-03-16 2013-03-11 Aminoacid lipids

Publications (1)

Publication Number Publication Date
DK2825157T3 true DK2825157T3 (da) 2019-01-02

Family

ID=47901939

Family Applications (1)

Application Number Title Priority Date Filing Date
DK13710787.6T DK2825157T3 (da) 2012-03-16 2013-03-11 Aminosyrelipider

Country Status (22)

Country Link
US (1) US9796666B2 (da)
EP (1) EP2825157B1 (da)
JP (1) JP6457816B2 (da)
KR (1) KR102081046B1 (da)
CN (1) CN104168887B (da)
AU (1) AU2013231819B2 (da)
BR (1) BR112014022847B1 (da)
CA (1) CA2867184C (da)
DK (1) DK2825157T3 (da)
ES (1) ES2700742T3 (da)
HK (1) HK1199819A1 (da)
HU (1) HUE040256T2 (da)
MX (1) MX359736B (da)
NZ (1) NZ630990A (da)
PL (1) PL2825157T3 (da)
PT (1) PT2825157T (da)
RU (1) RU2670618C2 (da)
SG (2) SG10201610402VA (da)
SI (1) SI2825157T1 (da)
TW (1) TWI606030B (da)
WO (1) WO2013135360A1 (da)
ZA (1) ZA201407491B (da)

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* Cited by examiner, † Cited by third party
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SG11201405552VA (en) * 2012-03-16 2014-10-30 Merck Patent Gmbh Targeting aminoacid lipids
JP2016507671A (ja) 2013-02-14 2016-03-10 ナノパレイル,エルエルシー 電界紡糸ナノファイバーのハイブリッドフェルト
WO2014152211A1 (en) 2013-03-14 2014-09-25 Moderna Therapeutics, Inc. Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions
US11633355B2 (en) 2014-12-12 2023-04-25 Clemson University Research Foundation Multi-functional particles and methods of using the same
US10232050B1 (en) 2014-12-12 2019-03-19 Clemson University Multi-functional particles and methods of using the same
EP3375538A4 (en) * 2015-11-11 2019-06-19 The Yokohama Rubber Co., Ltd. TIRE CLEANING SYSTEM
CN106083637B (zh) * 2016-06-06 2018-11-23 大连民族大学 味精类脂、味精脂质体的合成方法及其应用
JP6883034B2 (ja) * 2016-06-24 2021-06-02 エーザイ・アール・アンド・ディー・マネジメント株式会社 カチオン性脂質
EP3493814A4 (en) * 2016-08-03 2020-07-22 Neuropore Therapies, Inc. LIPID-SUBSTITUTED AMINO-1,2 AND 1,3-DIOL COMPOUNDS AS MODULATORS OF TLR2 DIMERIZATION
WO2019131580A1 (ja) 2017-12-27 2019-07-04 エーザイ・アール・アンド・ディー・マネジメント株式会社 カチオン性脂質
BR112021022182A2 (pt) * 2019-05-07 2021-12-21 Univ Do Minho Método para produção de lipossomas.
CN112010995A (zh) * 2019-05-30 2020-12-01 株式会社大赛璐 壳聚糖衍生物及光学异构体用分离剂
CN114177136B (zh) * 2020-09-12 2023-08-01 苏州优诺康医药科技有限公司 一种可注射用的两亲性嵌段共聚物纳米载药胶束
CN113185421B (zh) * 2020-11-27 2022-01-25 广州市锐博生物科技有限公司 脂质化合物及其组合物
WO2023232148A1 (zh) 2022-06-02 2023-12-07 厦门赛诺邦格生物科技股份有限公司 一种含有不饱和键的氨基酸阳离子脂质

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WO1979000515A1 (en) 1978-01-16 1979-08-09 Univ Boston Method of effecting cellular uptake of molecules
US4144034A (en) * 1978-03-27 1979-03-13 Texaco Inc. Polyether-maleic anhydride reaction product containing motor fuel composition
US4144036A (en) 1978-03-27 1979-03-13 Texaco Inc. Detergent fuel composition
US5108921A (en) 1989-04-03 1992-04-28 Purdue Research Foundation Method for enhanced transmembrane transport of exogenous molecules
US6030954A (en) 1991-09-05 2000-02-29 University Of Connecticut Targeted delivery of poly- or oligonucleotides to cells
US6335434B1 (en) 1998-06-16 2002-01-01 Isis Pharmaceuticals, Inc., Nucleosidic and non-nucleosidic folate conjugates
IT1254135B (it) 1992-01-16 1995-09-08 Sigma Tau Ind Farmaceuti Esteri di acil carnitine con alcooli alifatici a lunga catena e composizioni farmaceutiche che li contengono, ad attivita' antibatterica.
US6214388B1 (en) 1994-11-09 2001-04-10 The Regents Of The University Of California Immunoliposomes that optimize internalization into target cells
DE19521412A1 (de) * 1995-06-14 1996-12-19 Boehringer Mannheim Gmbh Neue kationische und polykationische Amphiphile, diese enthaltende Reagenzien und deren Verwendung
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JP5093547B2 (ja) 2001-08-24 2012-12-12 日本ケミカルリサーチ株式会社 両イオン性脂質およびその用途
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Also Published As

Publication number Publication date
BR112014022847A2 (da) 2017-06-20
CA2867184C (en) 2020-09-01
ES2700742T3 (es) 2019-02-19
TWI606030B (zh) 2017-11-21
NZ630990A (en) 2016-04-29
BR112014022847B1 (pt) 2022-08-23
MX359736B (es) 2018-10-09
AU2013231819A1 (en) 2014-10-30
SG11201405536YA (en) 2014-10-30
RU2014141547A (ru) 2016-05-10
CA2867184A1 (en) 2013-09-19
EP2825157A1 (en) 2015-01-21
TW201343615A (zh) 2013-11-01
US20150030670A1 (en) 2015-01-29
AU2013231819B2 (en) 2017-07-20
US9796666B2 (en) 2017-10-24
JP2015514692A (ja) 2015-05-21
SI2825157T1 (sl) 2019-01-31
CN104168887B (zh) 2018-09-04
RU2670618C2 (ru) 2018-10-24
PL2825157T3 (pl) 2019-05-31
WO2013135360A1 (en) 2013-09-19
HK1199819A1 (en) 2015-07-24
KR102081046B1 (ko) 2020-02-25
CN104168887A (zh) 2014-11-26
MX2014010810A (es) 2014-12-08
ZA201407491B (en) 2015-12-23
SG10201610402VA (en) 2017-02-27
PT2825157T (pt) 2018-12-14
HUE040256T2 (hu) 2019-02-28
JP6457816B2 (ja) 2019-01-23
KR20140135832A (ko) 2014-11-26
EP2825157B1 (en) 2018-09-05

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