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PE20211911A1 - Compuestos heterociclicos como inmunomoduladores - Google Patents

Compuestos heterociclicos como inmunomoduladores

Info

Publication number
PE20211911A1
PE20211911A1 PE2020001506A PE2020001506A PE20211911A1 PE 20211911 A1 PE20211911 A1 PE 20211911A1 PE 2020001506 A PE2020001506 A PE 2020001506A PE 2020001506 A PE2020001506 A PE 2020001506A PE 20211911 A1 PE20211911 A1 PE 20211911A1
Authority
PE
Peru
Prior art keywords
methyl
hydroxy
ethylamino
hydroxypyrrolidin
methylpyrrolidin
Prior art date
Application number
PE2020001506A
Other languages
English (en)
Inventor
Liangxing Wu
Jingwei Li
Wenqing Yao
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of PE20211911A1 publication Critical patent/PE20211911A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Esta referido a compuestos de Formula I', en donde: Anillo A es azetidinilo, pirrolidinilo o piperidinilo; X1 es CH o N; R1 es metilo o halo; R2 es alquilo, alcoxi, haloalquilo, haloalcoxi, entre otros; R3 es (R)-3-hidroxi-3-metilpirrolidin-1-ilo, (S)-3-hidroxi-3-metilpirrolidin-1-ilo, (R)-3-hidroxipirrolidin-1-ilo, (S)-3-hidroxipirrolidin-1-ilo, (R)-2-hidroxi-2-metil-etilamino, (S)-2-hidroxi-2-metil-etilamino, (R)-2-hidroxi-1-metil-etilamino y (S)-2-hidroxi-1-metil-etilamino; R4 es H, alquilo; R5 es COOH, CON(Ch3)2, entre otros. Entre los compuestos preferidos tenemos los siguientes: acido (R)-1-((7-ciano-2-(3'-(7-((3-hidroxipirrolidin-1-il)metil)-2-metilpirido[3,2-d]pirimidin-4-ilamino)-2,2'-dimetilbifenil-3-il)benzo[d]oxazol-5-il)metil)piperidin-4-carboxilico; acido (R)-1-((7-ciano-2-(3'-(7-((3-hidroxi-3-metilpirrolidin-1-il)metil)-2-metilpirido[3,2-d]pirimidin-4-ilamino)-2,2'-dimetilbifenil-3-il)benzo[d]oxazol-5-il)metil)piperidin-4-carboxilico; entre otros. Estos compuestos modulan la interaccion proteina/proteina PD-1/PD-L1 y son utiles en el tratamiento de diversas enfermedades que incluyen enfermedades infecciosas y cancer.
PE2020001506A 2018-03-30 2019-03-29 Compuestos heterociclicos como inmunomoduladores PE20211911A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862650821P 2018-03-30 2018-03-30
US201862687964P 2018-06-21 2018-06-21
PCT/US2019/025036 WO2019191707A1 (en) 2018-03-30 2019-03-29 Heterocyclic compounds as immunomodulators

Publications (1)

Publication Number Publication Date
PE20211911A1 true PE20211911A1 (es) 2021-09-28

Family

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PE2024002663A PE20251288A1 (es) 2018-03-30 2019-03-29 Compuestos heterociclicos como inmunomoduladores

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Country Status (34)

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US (4) US10669271B2 (es)
EP (3) EP4212529B1 (es)
JP (2) JP7372255B2 (es)
KR (2) KR102815634B1 (es)
CN (2) CN119613400A (es)
AU (2) AU2019245288C1 (es)
BR (1) BR112020019700A2 (es)
CA (1) CA3095758A1 (es)
CL (1) CL2020002511A1 (es)
CO (1) CO2020013601A2 (es)
CR (1) CR20200520A (es)
DK (2) DK4212529T3 (es)
EC (1) ECSP20069418A (es)
ES (2) ES3030010T3 (es)
FI (2) FI4212529T3 (es)
HR (2) HRP20250421T1 (es)
HU (1) HUE061258T2 (es)
IL (2) IL313101A (es)
LT (2) LT4212529T (es)
MA (1) MA64121B1 (es)
MD (1) MD3774791T2 (es)
MX (2) MX2020010321A (es)
PE (2) PE20211911A1 (es)
PH (1) PH12020551572A1 (es)
PL (2) PL3774791T3 (es)
PT (2) PT4212529T (es)
RS (2) RS66699B1 (es)
SG (1) SG11202009440WA (es)
SI (2) SI3774791T1 (es)
SM (2) SMT202300065T1 (es)
TW (1) TWI851563B (es)
UA (1) UA128453C2 (es)
WO (1) WO2019191707A1 (es)
ZA (1) ZA202403923B (es)

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