[go: up one dir, main page]

PE20140375A1 - Composiciones farmaceuticas que contienen un inhibidor de dgat1 - Google Patents

Composiciones farmaceuticas que contienen un inhibidor de dgat1

Info

Publication number
PE20140375A1
PE20140375A1 PE2013000837A PE2013000837A PE20140375A1 PE 20140375 A1 PE20140375 A1 PE 20140375A1 PE 2013000837 A PE2013000837 A PE 2013000837A PE 2013000837 A PE2013000837 A PE 2013000837A PE 20140375 A1 PE20140375 A1 PE 20140375A1
Authority
PE
Peru
Prior art keywords
mixture
acid
starch
composition
pyridin
Prior art date
Application number
PE2013000837A
Other languages
English (en)
Inventor
Hong Wen
Natrajan Kumaraperumal
Richard Nause
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44908106&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20140375(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20140375A1 publication Critical patent/PE20140375A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38Cellulose; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2009Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • A61K9/2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2027Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2095Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806Coating materials
    • A61K9/2813Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Inorganic Chemistry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

REFERIDA A UNA COMPOSICION FARMACEUTICA, QUE COMPRENDE: a) UN COMPUESTO DE FORMULA (I) TAL COMO EL ACIDO (4-{4-[5-(6-TRIFLUORO-METIL-PIRIDIN-3-IL-AMINO)-PIRIDIN-2-IL]-FENIL}-CICLOHEXIL)-ACETICO O UNA SAL DEL MISMO, b) UNO O MAS TENSOACTIVOS CON PROPIEDADES LUBRICANTES TALES COMO LAURIL-SULFATO DE SODIO, ACIDO ESTEARICO, ACIDO PALMITICO, ENTRE OTROS, EN UNA CANTIDAD DE 0.1% A 5% EN PESO DE LA COMPOSICION, c) UNO O MAS AGLUTINANTES SECOS CON PROPIEDADES DESINTEGRANTES TALES COMO POLIETILENGLICOLES, ALMIDON PREGELATINIZADO, QUITOSANO, ALMIDON, ENTRE OTROS, EN UNA CANTIDAD DE 5% A 15% EN PESO DE LA COMPOSICION, d) UNO O MAS RELLENOS TALES COMO UNA MEZCLA DE CELULOSA MICROCRISTALINA Y LACTOSA ANHIDRA, DONDE LA PROPORCION DE CELULOSA MICROCRIATALINA A LACTOSA ES ENTRE 1:5 Y 1:1, e) UNO O MAS DESINTEGRANTES TALES COMO CROSCARMELOSA DE SODIO, POLIVINIL-PIRROLIDONA RETICULADA, GLICOLATO DE ALMIDON DE SODIO. TAMBIEN ESTA REFERIDA A UN PROCESO DE PREPARACION QUE COMPRENDE LOS PASOS DE: MEZCLAR EL COMPUESTO DE FORMULA (I) CON UN EXCIPIENTE, COMPACTAR CON RODILLO, MOLER LA MEZCLA, LUBRICAR LA MEZCLA RESULTANTE Y COMPRIMIR LA MEZCLA RESULTANTE EN UNA FORMA DE DOSIFICACION ORAL SOLIDA
PE2013000837A 2010-10-14 2011-10-14 Composiciones farmaceuticas que contienen un inhibidor de dgat1 PE20140375A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39310310P 2010-10-14 2010-10-14

Publications (1)

Publication Number Publication Date
PE20140375A1 true PE20140375A1 (es) 2014-03-19

Family

ID=44908106

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2013000837A PE20140375A1 (es) 2010-10-14 2011-10-14 Composiciones farmaceuticas que contienen un inhibidor de dgat1

Country Status (30)

Country Link
US (5) US20130190354A1 (es)
EP (1) EP2627319B1 (es)
JP (1) JP6060081B2 (es)
KR (1) KR20130100311A (es)
CN (1) CN103179957B (es)
AR (1) AR083417A1 (es)
AU (1) AU2011316003B2 (es)
BR (1) BR112013008757A2 (es)
CA (1) CA2813781C (es)
CL (1) CL2013001001A1 (es)
CO (1) CO6710915A2 (es)
DK (1) DK2627319T3 (es)
EC (1) ECSP13012755A (es)
ES (1) ES2712064T3 (es)
GT (1) GT201300096A (es)
HU (1) HUE043524T2 (es)
IL (1) IL225434A0 (es)
MA (1) MA34599B1 (es)
MX (1) MX2013004162A (es)
NZ (1) NZ608558A (es)
PE (1) PE20140375A1 (es)
PH (1) PH12013500695A1 (es)
PL (1) PL2627319T3 (es)
PT (1) PT2627319T (es)
RU (1) RU2595866C2 (es)
SG (1) SG189078A1 (es)
SI (1) SI2627319T1 (es)
TR (1) TR201902435T4 (es)
WO (1) WO2012051488A1 (es)
ZA (1) ZA201302108B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR083417A1 (es) 2010-10-14 2013-02-21 Novartis Ag Composiciones farmaceuticas que contienen un dgat1 inhibidor
WO2013055910A1 (en) 2011-10-12 2013-04-18 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
US9108956B2 (en) * 2012-04-27 2015-08-18 Novartis Ag Cyclic ether DGAT1 inhibitorscyclic ether DGAT1 inhibitors
WO2013169648A1 (en) * 2012-05-07 2013-11-14 Novartis Ag Pharmaceutical combinations comprising a dgat1 inhibtor and a triglyceride lowering drug
WO2014074668A1 (en) 2012-11-08 2014-05-15 Arena Pharmaceuticals, Inc. Modulators of gpr119 and the treatment of disorders related thereto
CN114099496A (zh) 2015-03-13 2022-03-01 艾斯柏伦治疗公司 含etc1002和依泽替米贝的组合及治疗方法
MA41793A (fr) 2015-03-16 2018-01-23 Esperion Therapeutics Inc Associations de doses fixes comprenant du etc1002 et une ou plusieurs statines permettant de traiter ou de réduire un risque cardiovasculaire
JP2018534323A (ja) 2015-11-19 2018-11-22 シニュー・ファーマ・インコーポレイテッドSiNew Pharma Inc. 脂肪肝の予防または処置用医薬組成物
US11975002B2 (en) 2016-03-04 2024-05-07 Taiho Pharmaceutical Co., Ltd. Preparation and composition for treatment of malignant tumors
US11883404B2 (en) 2016-03-04 2024-01-30 Taiho Pharmaceuticals Co., Ltd. Preparation and composition for treatment of malignant tumors
US20180338922A1 (en) * 2017-05-26 2018-11-29 Esperion Therapeutics, Inc. Fixed dose formulations
US10632092B2 (en) 2017-08-30 2020-04-28 First Fruits Business Ministry, Llc Composition for and method to increase serum adiponectin and reduce body fat
CN111936137B (zh) * 2018-03-16 2023-09-08 安济药业公司 用于治疗严重便秘的组合物和方法
AU2019239404B2 (en) * 2018-03-19 2021-12-23 Taiho Pharmaceutical Co., Ltd. Pharmaceutical composition including sodium alkyl sulfate

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE271863T1 (de) 1995-11-14 2004-08-15 Abbott Gmbh & Co Kg Schilddrüsenhormone enthaltende stabilisierte arzneimittel und verfahren
GB9613470D0 (en) * 1996-06-27 1996-08-28 Ciba Geigy Ag Small solid oral dosage form
DE19816070A1 (de) * 1998-04-09 1999-10-14 Aventis Res & Tech Gmbh & Co Retardtablette hergestellt aus linearen wasserunlöslichen Polysacchariden
WO2003053416A1 (en) * 2001-12-21 2003-07-03 Pfizer Products Inc. Directly compressible formulations of azithromycin
CN101198333A (zh) * 2005-04-19 2008-06-11 拜尔药品公司 芳烷基酸衍生物及其用途
KR101219042B1 (ko) * 2005-12-06 2013-01-07 삼성디스플레이 주식회사 반투과형 액정 표시 장치
CN101365432B (zh) * 2005-12-16 2011-06-22 默沙东公司 二肽基肽酶-4抑制剂与二甲双胍的组合的药物组合物
AU2007223278A1 (en) * 2006-03-06 2007-09-13 Wyeth Tablet formulations and processes
US20070224258A1 (en) 2006-03-22 2007-09-27 Bunick Frank J Dosage forms having a randomized coating
PL2004607T3 (pl) * 2006-03-31 2012-03-30 Novartis Ag Pochodne kwasu (4-(4-[6-(trifluorometylopirydyn-3-yloamino)-N-zawierające-heteroarylo]-fenylo)-cykloheksylo)-octowego i ich farmaceutyczne zastosowania
BRPI0719352A2 (pt) 2006-11-29 2017-10-24 Abbott Lab inibidores de enzima diacilglicerol o-aciltransferase tipo 1
US20080145425A1 (en) * 2006-12-15 2008-06-19 Pliva Research & Development Limited Pharmaceutical composition of zolpidem
NZ580660A (en) 2007-04-30 2012-02-24 Abbott Lab Inhibitors of diacylglycerol o-acyltransferase type 1 enzyme
US8283331B2 (en) * 2007-10-09 2012-10-09 Children's Medical Center Corporation Methods to regulate miRNA processing by targeting Lin-28
SMT201700416T1 (it) * 2009-03-31 2017-11-15 Ligand Pharm Inc Antagonista di bifenilsolfonammide del recettore di endotelina ed angiotensina ii per il trattamento della glomerulosclerosi
ES2586127T3 (es) * 2010-03-30 2016-10-11 Novartis Ag Usos de inhibidores de DGAT1
AR083417A1 (es) 2010-10-14 2013-02-21 Novartis Ag Composiciones farmaceuticas que contienen un dgat1 inhibidor

Also Published As

Publication number Publication date
MX2013004162A (es) 2014-12-08
RU2013121795A (ru) 2014-11-20
CA2813781C (en) 2018-08-07
SI2627319T1 (sl) 2019-04-30
CN103179957B (zh) 2016-05-18
AU2011316003A1 (en) 2013-04-11
SG189078A1 (en) 2013-05-31
PL2627319T3 (pl) 2019-05-31
US20200230062A1 (en) 2020-07-23
PH12013500695A1 (en) 2017-08-09
BR112013008757A2 (pt) 2020-09-01
RU2595866C2 (ru) 2016-08-27
NZ608558A (en) 2015-03-27
EP2627319B1 (en) 2018-11-21
CL2013001001A1 (es) 2013-10-25
CN103179957A (zh) 2013-06-26
GT201300096A (es) 2014-07-08
AU2011316003B2 (en) 2015-03-19
CA2813781A1 (en) 2012-04-19
PT2627319T (pt) 2019-02-27
DK2627319T3 (en) 2019-03-18
US20150320687A1 (en) 2015-11-12
AR083417A1 (es) 2013-02-21
IL225434A0 (en) 2013-06-27
ES2712064T3 (es) 2019-05-09
US20180243222A1 (en) 2018-08-30
US20130190354A1 (en) 2013-07-25
CO6710915A2 (es) 2013-07-15
HUE043524T2 (hu) 2019-08-28
JP6060081B2 (ja) 2017-01-11
US20160374947A1 (en) 2016-12-29
WO2012051488A1 (en) 2012-04-19
ZA201302108B (en) 2013-11-27
US10646446B2 (en) 2020-05-12
JP2013539794A (ja) 2013-10-28
MA34599B1 (fr) 2013-10-02
ECSP13012755A (es) 2014-01-31
US11304907B2 (en) 2022-04-19
EP2627319A1 (en) 2013-08-21
KR20130100311A (ko) 2013-09-10
TR201902435T4 (tr) 2019-03-21

Similar Documents

Publication Publication Date Title
PE20140375A1 (es) Composiciones farmaceuticas que contienen un inhibidor de dgat1
CL2011003072A1 (es) Compuestos derivados de 4´-(isoxazol-5-il)-bifenil-4-il-cicloalquil(c3-8), antagonistas del receptor de acido lisofosfatidico; composicion farmaceutica que los comprende; y sus usos en el tratamiento del cancer, problemas pulmonares, entre otras.
IN2012DN03337A (es)
AU2016202535B2 (en) Fused heterocyclic compounds as sodium channel modulators
NZ601121A (en) 5-alkynyl-pyrimidines
PE20142448A1 (es) Compuestos de n-alquiltriazol como antagonistas de lpar
NZ727015A (en) Formulations of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid
CL2012003546A1 (es) Compuestos especifico acido 2-(3-(4-cianonaftalen-1-il)piridin-4-iltio)-2-metilprpanoico, en su uso fromula markush; composicion y combinacion farmaceutica que lo comprende; y uso del compuesto y de la combinacion farmaceutica en la preparacion de medicamentos para tratar enfermedades originadas por altos niveles de acido urico.
MY167791A (en) 2-(1,2,3-triazol-2-yl)benzamide and 3-(1,2,3-triazol-2-yl)picolinamide derivatives as orexin receptor antagonists
UY33614A (es) Lactamas sustituidas por piperidinilo como moduladores de gpr119
MX339252B (es) Derivados de acido carboxilico de pirrolidina o tiazolidina, composicion farmaceutica y metodos para su uso en el tratamiento de transtornos metabolicos, como agonistas del receptor 43 acoplado por proteina-g (gpr43).
PE20120316A1 (es) Composiciones farmaceuticas solidas y procesos para su produccion
PE20151335A1 (es) Composicion farmaceutica con biodisponibilidad mejorada
MX390726B (es) Procesos para preparar compuestos de quinolina y composiciones farmaceuticas que contienen tales compuestos.
MX358961B (es) Compuestos de tetraciclina sustituidos con fluor en c7.
PE20080186A1 (es) Derivados 4,6-disustituidos de 2-metoxi-6-etilamino-pirimidina como antagonistas del receptor de prostaglandina d2
MX2011013884A (es) Sulfonamidas heterociclicas, usos y composiciones farmaceuticas de las mismas.
BR112014000471A2 (pt) processo para preparo de derivados de diamida de ácido antranílico substituídos com tetrazol por meio da reação de ácidos pirazóis com ésteres antranílicos
AR077642A1 (es) Moduladores del metabolismo y el tratamiento de trastornos relacionados con el mismo
MX2013006420A (es) Derivados de aminotriazol hidrolixado como agonistas del receptor de alx.
MX2011008360A (es) Derivados de piridazinona sustituida con heteroarilo.
TR201902057T4 (tr) Tetrasiklin bileşikleri.
PE20142399A1 (es) Compuestos de pirazol como inhibidores de sglt1
NZ610614A (en) Substituted sodium-1h-pyrazole-5-olate
ES2584556T3 (es) Composiciones novedosas que contienen carbodiimida, un procedimiento para su preparación y su uso

Legal Events

Date Code Title Description
FD Application declared void or lapsed