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PE20010754A1 - Uso de inhibidores de 3',5'-guanosinmonofosfato ciclico fosfodiesterasa para el tratamiento de neuropatia - Google Patents

Uso de inhibidores de 3',5'-guanosinmonofosfato ciclico fosfodiesterasa para el tratamiento de neuropatia

Info

Publication number
PE20010754A1
PE20010754A1 PE2000001133A PE0011332000A PE20010754A1 PE 20010754 A1 PE20010754 A1 PE 20010754A1 PE 2000001133 A PE2000001133 A PE 2000001133A PE 0011332000 A PE0011332000 A PE 0011332000A PE 20010754 A1 PE20010754 A1 PE 20010754A1
Authority
PE
Peru
Prior art keywords
cyclic
treatment
neuropathy
guanosimmonophosphate
phosphodiesterase inhibitors
Prior art date
Application number
PE2000001133A
Other languages
English (en)
Inventor
Nandan Parmanand Koppiker
Steven B Leichter
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9924958.3A external-priority patent/GB9924958D0/en
Priority claimed from GB0021520A external-priority patent/GB0021520D0/en
Application filed by Pfizer filed Critical Pfizer
Publication of PE20010754A1 publication Critical patent/PE20010754A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

SE REFIERE AL USO DE 3`,5'-GUANOSINMONOFOSFATO CICLICO FOSFODIESTERASA TIPO 5 TAL COMO SILDENAFIL PARA EL TRATAMIENTO DE NEUROPATIA DIABETICA PERIFERICA; CON LA CONDICION QUE EL INHIBIDOR NO SEA i)5-(3-PIRIDIL)PIRAZOLO[4,3-d]PIRIMIDIN-7-ONA SUSTITUIDA; ii)2-(3-PIRIDIL)-4a,5-DIHIDROIMIDAZO[5,1-f][1,2,4]TRIAZIN-4(3H)-ONA SUSTITUIDA; iii)2-FENILPURIN-6-ONA SUSTITUIDA, 2-(3-PIRIDIL)PURIN-6-ONA SUSTITUIDA; UTILIZANDOSE DE 5 mg A 500 mg
PE2000001133A 1999-10-21 2000-10-20 Uso de inhibidores de 3',5'-guanosinmonofosfato ciclico fosfodiesterasa para el tratamiento de neuropatia PE20010754A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9924958.3A GB9924958D0 (en) 1999-10-21 1999-10-21 Treatment of neuropathy
GB0021520A GB0021520D0 (en) 2000-09-01 2000-09-01 Treatment of neuropathy

Publications (1)

Publication Number Publication Date
PE20010754A1 true PE20010754A1 (es) 2001-07-18

Family

ID=26244947

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2000001133A PE20010754A1 (es) 1999-10-21 2000-10-20 Uso de inhibidores de 3',5'-guanosinmonofosfato ciclico fosfodiesterasa para el tratamiento de neuropatia

Country Status (16)

Country Link
US (2) US20030162782A1 (es)
EP (2) EP1129706A3 (es)
JP (2) JP2001122803A (es)
KR (1) KR20010051181A (es)
AT (1) ATE380049T1 (es)
AU (1) AU781550B2 (es)
CA (1) CA2323839C (es)
CO (1) CO5271711A1 (es)
CY (1) CY1107285T1 (es)
DE (1) DE60037347T2 (es)
DK (1) DK1440709T3 (es)
ES (1) ES2295726T3 (es)
HU (1) HUP0004120A3 (es)
IL (2) IL139073A0 (es)
PE (1) PE20010754A1 (es)
PT (1) PT1440709E (es)

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Also Published As

Publication number Publication date
DE60037347D1 (de) 2008-01-17
HU0004120D0 (es) 2001-01-29
ATE380049T1 (de) 2007-12-15
JP2001122803A (ja) 2001-05-08
HUP0004120A2 (hu) 2002-11-28
HUP0004120A3 (en) 2003-11-28
IL152925A (en) 2010-04-15
CO5271711A1 (es) 2003-04-30
CY1107285T1 (el) 2012-11-21
EP1129706A3 (en) 2002-01-02
US20040122010A1 (en) 2004-06-24
EP1440709A3 (en) 2004-12-08
PT1440709E (pt) 2008-02-06
AU781550B2 (en) 2005-05-26
KR20010051181A (ko) 2001-06-25
EP1129706A2 (en) 2001-09-05
ES2295726T3 (es) 2008-04-16
EP1440709A2 (en) 2004-07-28
CA2323839C (en) 2008-03-18
CA2323839A1 (en) 2001-04-21
JP2003119131A (ja) 2003-04-23
IL139073A0 (en) 2001-11-25
AU6665000A (en) 2001-04-26
DE60037347T2 (de) 2008-11-27
EP1440709B1 (en) 2007-12-05
DK1440709T3 (da) 2008-03-17
US20030162782A1 (en) 2003-08-28

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