ATE380049T1 - Kombinationen enthaltend cgmp-pde5-hemmer. - Google Patents
Kombinationen enthaltend cgmp-pde5-hemmer.Info
- Publication number
- ATE380049T1 ATE380049T1 AT04010436T AT04010436T ATE380049T1 AT E380049 T1 ATE380049 T1 AT E380049T1 AT 04010436 T AT04010436 T AT 04010436T AT 04010436 T AT04010436 T AT 04010436T AT E380049 T1 ATE380049 T1 AT E380049T1
- Authority
- AT
- Austria
- Prior art keywords
- combinations containing
- pde5 inhibitors
- containing cgmp
- cgmp
- pde5
- Prior art date
Links
- 229940123333 Phosphodiesterase 5 inhibitor Drugs 0.000 title abstract 2
- 239000002590 phosphodiesterase V inhibitor Substances 0.000 title abstract 2
- UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 abstract 2
- 229960002870 gabapentin Drugs 0.000 abstract 1
- 201000001119 neuropathy Diseases 0.000 abstract 1
- 230000007823 neuropathy Effects 0.000 abstract 1
- 208000033808 peripheral neuropathy Diseases 0.000 abstract 1
- 229960001233 pregabalin Drugs 0.000 abstract 1
- AYXYPKUFHZROOJ-ZETCQYMHSA-N pregabalin Chemical compound CC(C)C[C@H](CN)CC(O)=O AYXYPKUFHZROOJ-ZETCQYMHSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9924958.3A GB9924958D0 (en) | 1999-10-21 | 1999-10-21 | Treatment of neuropathy |
GB0021520A GB0021520D0 (en) | 2000-09-01 | 2000-09-01 | Treatment of neuropathy |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE380049T1 true ATE380049T1 (de) | 2007-12-15 |
Family
ID=26244947
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04010436T ATE380049T1 (de) | 1999-10-21 | 2000-10-17 | Kombinationen enthaltend cgmp-pde5-hemmer. |
Country Status (16)
Country | Link |
---|---|
US (2) | US20030162782A1 (de) |
EP (2) | EP1129706A3 (de) |
JP (2) | JP2001122803A (de) |
KR (1) | KR20010051181A (de) |
AT (1) | ATE380049T1 (de) |
AU (1) | AU781550B2 (de) |
CA (1) | CA2323839C (de) |
CO (1) | CO5271711A1 (de) |
CY (1) | CY1107285T1 (de) |
DE (1) | DE60037347T2 (de) |
DK (1) | DK1440709T3 (de) |
ES (1) | ES2295726T3 (de) |
HU (1) | HUP0004120A3 (de) |
IL (2) | IL152925A (de) |
PE (1) | PE20010754A1 (de) |
PT (1) | PT1440709E (de) |
Families Citing this family (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1630532A (zh) * | 2000-04-19 | 2005-06-22 | 约翰斯霍普金斯大学 | 预防和治疗胃肠疾病的方法 |
FR2809623B1 (fr) * | 2000-06-05 | 2003-09-05 | Sanjuan Benito Arranz | Dans le traitement des maladies neurodegeneratives : (notamment alzheimer et parkinson), utilisation pour un medicament : du sildenafil (ou de ses derives) |
DE10135815A1 (de) * | 2001-07-23 | 2003-02-06 | Bayer Ag | Verwendung von 2-Alkoxyphenyl-substituierten Imidazotriazinonen |
ES2429132T3 (es) | 2001-08-31 | 2013-11-13 | The Rockefeller University | Atividad de fosfodiesterasa y regulación de la señalización mediada por fosfodiesterasa 1-B en el cerebro |
GB0129274D0 (en) * | 2001-12-06 | 2002-01-23 | Pfizer Ltd | Novel kit |
CN1638775A (zh) * | 2002-01-04 | 2005-07-13 | 亨利福尔德健康组织 | 治疗疾病和损伤用的氧化氮供体 |
US7419981B2 (en) | 2002-08-15 | 2008-09-02 | Pfizer Inc. | Synergistic combinations of an alpha-2-delta ligand and a cGMP phosphodieterse 5 inhibitor |
GB0219024D0 (en) * | 2002-08-15 | 2002-09-25 | Pfizer Ltd | Synergistic combinations |
US7659305B2 (en) | 2002-10-31 | 2010-02-09 | Pfizer Inc. | Therapeutic proline derivatives |
BR0316572A (pt) * | 2002-12-13 | 2005-10-04 | Warner Lambert Co | Ligando alfa-2-delta para o tratamento de sintomas do trato variáveis inferior, utilização e produto deste |
CN101723921A (zh) | 2003-04-23 | 2010-06-09 | 日本烟草产业株式会社 | CaSR拮抗剂 |
DE10325813B4 (de) * | 2003-06-06 | 2007-12-20 | Universitätsklinikum Freiburg | Prophylaxe und/oder Therapie bei der portalen Hypertonie |
WO2005089766A1 (en) | 2004-03-05 | 2005-09-29 | Altana Pharma Ag | Novel use for pde5 inhibitors |
US8273750B2 (en) | 2005-06-06 | 2012-09-25 | Takeda Pharmaceutical Company Limited | Organic compounds |
US20080194592A1 (en) * | 2005-08-23 | 2008-08-14 | Intra-Cellular Therapies, Inc. | Organic Compounds |
US9255099B2 (en) * | 2006-06-06 | 2016-02-09 | Intra-Cellular Therapies, Inc. | Pyrazolo[3,4-D]pyrimidine-4,6(5H,7H)-diones as phosphodiesterase 1 inhibitors |
EP2081431B1 (de) * | 2006-11-13 | 2013-01-16 | Intra-Cellular Therapies, Inc. | Organische verbindungen |
US9006258B2 (en) | 2006-12-05 | 2015-04-14 | Intra-Cellular Therapies, Inc. | Method of treating female sexual dysfunction with a PDE1 inhibitor |
US7638541B2 (en) | 2006-12-28 | 2009-12-29 | Metabolex Inc. | 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine |
WO2008131256A1 (en) * | 2007-04-19 | 2008-10-30 | Trinity Laboratories Inc. | Improved treatments for premature ejaculation in humans |
JP5489997B2 (ja) | 2007-07-19 | 2014-05-14 | シマベイ セラピューティクス, インコーポレーテッド | 糖尿病および代謝疾患の治療のためのRUP3またはGPRl19受容体のアゴニストとしてのN−アザ環状置換ピロール、ピラゾール、イミダゾール、トリアゾールおよびテトラゾール誘導体 |
ES2436780T3 (es) | 2007-12-06 | 2014-01-07 | Takeda Pharmaceutical Company Limited | Compuestos orgánicos |
CA2707218A1 (en) * | 2007-12-06 | 2009-06-11 | Intra-Cellular Therapies, Inc. | Organic compounds |
EA201170768A1 (ru) | 2008-12-06 | 2012-05-30 | Интра-Селлулар Терапиз, Инк. | Органические соединения |
PE20110944A1 (es) | 2008-12-06 | 2012-01-25 | Intra Cellular Therapies Inc | DERIVADOS DE PIRAZOLO[3,4-d]PIRIMIDINA COMO INHIBIDORES PDE1 |
KR20110096032A (ko) | 2008-12-06 | 2011-08-26 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 유기 화합물 |
AU2009322900A1 (en) * | 2008-12-06 | 2010-06-10 | Intra-Cellular Therapies, Inc. | Organic compounds |
KR20110095881A (ko) | 2008-12-06 | 2011-08-25 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 유기 화합물 |
MA32941B1 (fr) | 2008-12-06 | 2012-01-02 | Intra Cellular Therapies Inc | Composes organiques |
US11464781B2 (en) | 2009-02-25 | 2022-10-11 | Intra-Cellular Therapies, Inc. | PDE1 inhibitors for ophthalmic disorders |
US9468637B2 (en) | 2009-05-13 | 2016-10-18 | Intra-Cellular Therapies, Inc. | Organic compounds |
SG178279A1 (en) | 2009-08-05 | 2012-03-29 | Intra Cellular Therapies Inc | Novel regulatory proteins and inhibitors |
EP2483281B1 (de) | 2009-10-01 | 2014-06-04 | Cymabay Therapeutics, Inc. | Substituierte tetrazol-1-yl-phenoxymethyl-thiazol-2-yl-piperidinyl-pyrimidinsalze |
US20130065936A1 (en) * | 2010-05-14 | 2013-03-14 | The Regents Of The University Of California | Modulation of bioactive epoxy-fatty acid levels by phosphodiesterase inhibitors |
WO2011153138A1 (en) | 2010-05-31 | 2011-12-08 | Intra-Cellular Therapies, Inc. | Organic compounds |
EP2575817A4 (de) | 2010-05-31 | 2014-01-08 | Intra Cellular Therapies Inc | Organische verbindungen |
TW201206937A (en) | 2010-05-31 | 2012-02-16 | Intra Cellular Therapies Inc | Organic compounds |
US9371327B2 (en) | 2010-05-31 | 2016-06-21 | Intra-Cellular Therapies, Inc. | PDE1 inhibitor compounds |
US20130143894A1 (en) * | 2010-06-07 | 2013-06-06 | vadel Pharma Inc. | Oral spray formulations ad methods for administration of sildenafil |
CN109674753A (zh) | 2010-06-23 | 2019-04-26 | 希玛贝治疗股份有限公司 | 固态分散体 |
WO2012171016A1 (en) | 2011-06-10 | 2012-12-13 | Intra-Cellular Therapies, Inc. | Organic compounds |
CN102276511A (zh) * | 2011-06-20 | 2011-12-14 | 兰州博实生化科技有限责任公司 | 1-叔丁氧羰基-3-碘氮杂环丁烷的合成方法 |
US8449565B2 (en) | 2011-07-21 | 2013-05-28 | Francis Duhay | Approaches to venous occlusion for embolus management |
JP6549040B2 (ja) | 2013-02-17 | 2019-07-24 | イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. | 新規使用 |
AU2014234990B2 (en) | 2013-03-15 | 2017-11-16 | Intra-Cellular Therapies, Inc. | Organic compounds |
ES2717688T3 (es) | 2013-03-15 | 2019-06-24 | Intra Cellular Therapies Inc | Inhibidores de la PDE1 para uso en el tratamiento y/o prevención de lesiones de SNC, y enfermedades, trastornos o lesiones de SNP |
RU2549459C2 (ru) * | 2013-08-20 | 2015-04-27 | Константин Александрович Корейба | Способ лечения нейропатических трофических язв при синдроме диабетической стопы |
EP3091983B1 (de) | 2014-01-08 | 2019-10-02 | Intra-Cellular Therapies, Inc. | Pharmazeutische zusammensetzungen enthaltend einen pde-1-hemmer und einen pde-2-hemmer |
JP6810613B2 (ja) | 2014-06-20 | 2021-01-06 | イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. | 有機化合物 |
US9546175B2 (en) | 2014-08-07 | 2017-01-17 | Intra-Cellular Therapies, Inc. | Organic compounds |
US10285992B2 (en) | 2014-08-07 | 2019-05-14 | Intra-Cellular Therapies, Inc. | Combinations of PDE1 inhibitors and NEP inhibitors and associated methods |
ES2745819T3 (es) | 2014-08-07 | 2020-03-03 | Intra Cellular Therapies Inc | Derivados de imidazo[1,2-a]-pirazolo[4,3-e]-pirimidin-4-ona con actividad inhibidora de la PDE1 |
EP3725789B1 (de) | 2014-09-17 | 2022-03-09 | Intra-Cellular Therapies, Inc. | 7,8-dihydro-[2h]-imidazo-[1,2-a]pyrazolo[4,3-e]pyrimidin-4(5h)-on-derivate als phosphodiesterase 1 (pde1) inhibitoren zur behandlung von erkrankungen, störungen oder verletzungen des zentralen nervensystems (zns) |
CN107205999B (zh) | 2014-12-06 | 2021-08-03 | 细胞内治疗公司 | 有机化合物 |
AU2015357498B2 (en) | 2014-12-06 | 2019-09-12 | Intra-Cellular Therapies, Inc. | Organic compounds |
WO2016133788A1 (en) | 2015-02-20 | 2016-08-25 | The Regents Of The University Of California | Methods of inhibiting pain |
US10682354B2 (en) | 2016-03-28 | 2020-06-16 | Intra-Cellular Therapies, Inc. | Compositions and methods |
CN109862896A (zh) | 2016-08-03 | 2019-06-07 | 西玛贝医药公司 | 用于治疗炎症性胃肠疾病或胃肠病症的氧亚甲基芳基化合物 |
WO2018049152A1 (en) | 2016-09-09 | 2018-03-15 | Incyte Corporation | Pyrazolopyrimidine derivatives as hpk1 modulators and uses thereof for the treatment of cancer |
CN115819417A (zh) | 2016-09-09 | 2023-03-21 | 因赛特公司 | 作为hpk1调节剂的吡唑并吡啶衍生物及其用于治疗癌症的用途 |
WO2018049214A1 (en) | 2016-09-09 | 2018-03-15 | Incyte Corporation | Pyrazolopyridine derivatives as hpk1 modulators and uses thereof for the treatment of cancer |
EP3970719A1 (de) | 2016-09-12 | 2022-03-23 | Intra-Cellular Therapies, Inc. | Pde1-inhibitor zur verwendung in einem verfahren zur behandlung oder prophylaxe von entzündungen und/oder einer entzündlichen krankheit oder störung |
WO2018152220A1 (en) | 2017-02-15 | 2018-08-23 | Incyte Corporation | Pyrazolopyridine compounds and uses thereof |
US10722495B2 (en) | 2017-09-08 | 2020-07-28 | Incyte Corporation | Cyanoindazole compounds and uses thereof |
MX2017016930A (es) * | 2017-12-19 | 2019-06-20 | Malesil Research & Tech Llc | Uso del maleato de sildenafil en el tratamiento de ulceras de pie diabetico. |
EP3746081A4 (de) | 2018-01-31 | 2021-10-27 | Intra-Cellular Therapies, Inc. | Neuartige verwendungen |
WO2019164847A1 (en) | 2018-02-20 | 2019-08-29 | Incyte Corporation | Indazole compounds and uses thereof |
PE20210397A1 (es) | 2018-02-20 | 2021-03-02 | Incyte Corp | Derivados de n-(fenil)-2-(fenil)pirimidina-4-carboxamida y compuestos relacionados como inhibidores hpki para tratar el cancer |
US10745388B2 (en) | 2018-02-20 | 2020-08-18 | Incyte Corporation | Indazole compounds and uses thereof |
US11299473B2 (en) | 2018-04-13 | 2022-04-12 | Incyte Corporation | Benzimidazole and indole compounds and uses thereof |
US10899755B2 (en) | 2018-08-08 | 2021-01-26 | Incyte Corporation | Benzothiazole compounds and uses thereof |
JP7399968B2 (ja) | 2018-09-25 | 2023-12-18 | インサイト・コーポレイション | Alk2及び/またはfgfr調節剤としてのピラゾロ[4,3-d]ピリミジン化合物 |
CR20220097A (es) | 2019-08-06 | 2022-06-01 | Incyte Corp | Formas sólidas de un inhibidor de hpk1 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT100905A (pt) * | 1991-09-30 | 1994-02-28 | Eisai Co Ltd | Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem |
WO1997024334A1 (fr) * | 1995-12-28 | 1997-07-10 | Fujisawa Pharmaceutical Co., Ltd. | Derives du benzimidazole |
NZ332762A (en) * | 1996-07-24 | 2000-09-29 | Warner Lambert Co | Isobutylgaba and its derivatives for the treatment of pain |
US6127418A (en) * | 1997-08-20 | 2000-10-03 | Warner-Lambert Company | GABA analogs to prevent and treat gastrointestinal damage |
SI1073658T1 (en) * | 1998-04-20 | 2003-12-31 | Pfizer Inc. | Pyrazolopyrimidinone cgmp pde5 inhibitors for the treatment of sexual dysfunction |
US6331171B1 (en) * | 1998-06-04 | 2001-12-18 | Alcon Laboratories, Inc. | Tip for a liquefracture handpiece |
GB9823103D0 (en) * | 1998-10-23 | 1998-12-16 | Pfizer Ltd | Pharmaceutically active compounds |
GB9823101D0 (en) * | 1998-10-23 | 1998-12-16 | Pfizer Ltd | Pharmaceutically active compounds |
PT1123296E (pt) * | 1998-10-23 | 2003-12-31 | Pfizer | Inibidores de cgmp pdes derivados da pirazolopirimidinona para tratamento da disfuncao sexual |
US6453237B1 (en) * | 1999-04-23 | 2002-09-17 | Global Locate, Inc. | Method and apparatus for locating and providing services to mobile devices |
US6411892B1 (en) * | 2000-07-13 | 2002-06-25 | Global Locate, Inc. | Method and apparatus for locating mobile receivers using a wide area reference network for propagating ephemeris |
IL137429A0 (en) * | 1999-07-28 | 2001-07-24 | Pfizer Prod Inc | Methods and compsitions for treating diseases and conditions of the eye |
ATE341329T1 (de) * | 1999-10-12 | 2006-10-15 | Lilly Icos Llc | Arzneimittel zur behandlung von neuropathien |
US6560534B2 (en) * | 2001-06-06 | 2003-05-06 | Global Locate, Inc. | Method and apparatus for distributing satellite tracking information |
US7196660B2 (en) * | 2000-11-17 | 2007-03-27 | Global Locate, Inc | Method and system for determining time in a satellite positioning system |
-
2000
- 2000-10-16 IL IL152925A patent/IL152925A/en not_active IP Right Cessation
- 2000-10-16 IL IL13907300A patent/IL139073A0/xx unknown
- 2000-10-17 DE DE60037347T patent/DE60037347T2/de not_active Expired - Fee Related
- 2000-10-17 DK DK04010436T patent/DK1440709T3/da active
- 2000-10-17 AT AT04010436T patent/ATE380049T1/de not_active IP Right Cessation
- 2000-10-17 PT PT04010436T patent/PT1440709E/pt unknown
- 2000-10-17 EP EP00309129A patent/EP1129706A3/de not_active Withdrawn
- 2000-10-17 EP EP04010436A patent/EP1440709B1/de not_active Expired - Lifetime
- 2000-10-17 ES ES04010436T patent/ES2295726T3/es not_active Expired - Lifetime
- 2000-10-19 CA CA002323839A patent/CA2323839C/en not_active Expired - Fee Related
- 2000-10-20 PE PE2000001133A patent/PE20010754A1/es not_active Application Discontinuation
- 2000-10-20 HU HU0004120A patent/HUP0004120A3/hu unknown
- 2000-10-20 AU AU66650/00A patent/AU781550B2/en not_active Withdrawn - After Issue
- 2000-10-20 CO CO00080163A patent/CO5271711A1/es not_active Application Discontinuation
- 2000-10-21 KR KR1020000062129A patent/KR20010051181A/ko not_active Application Discontinuation
- 2000-10-23 JP JP2000322510A patent/JP2001122803A/ja active Pending
-
2002
- 2002-07-26 US US10/206,615 patent/US20030162782A1/en not_active Abandoned
- 2002-10-10 JP JP2002297617A patent/JP2003119131A/ja active Pending
-
2003
- 2003-12-10 US US10/731,905 patent/US20040122010A1/en not_active Abandoned
-
2008
- 2008-02-18 CY CY20081100193T patent/CY1107285T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
HU0004120D0 (de) | 2001-01-29 |
EP1129706A2 (de) | 2001-09-05 |
DE60037347D1 (de) | 2008-01-17 |
PE20010754A1 (es) | 2001-07-18 |
IL152925A (en) | 2010-04-15 |
JP2001122803A (ja) | 2001-05-08 |
EP1440709A3 (de) | 2004-12-08 |
DK1440709T3 (da) | 2008-03-17 |
US20030162782A1 (en) | 2003-08-28 |
ES2295726T3 (es) | 2008-04-16 |
HUP0004120A2 (hu) | 2002-11-28 |
DE60037347T2 (de) | 2008-11-27 |
EP1129706A3 (de) | 2002-01-02 |
KR20010051181A (ko) | 2001-06-25 |
CA2323839C (en) | 2008-03-18 |
EP1440709A2 (de) | 2004-07-28 |
JP2003119131A (ja) | 2003-04-23 |
US20040122010A1 (en) | 2004-06-24 |
HUP0004120A3 (en) | 2003-11-28 |
EP1440709B1 (de) | 2007-12-05 |
IL139073A0 (en) | 2001-11-25 |
CO5271711A1 (es) | 2003-04-30 |
CY1107285T1 (el) | 2012-11-21 |
CA2323839A1 (en) | 2001-04-21 |
PT1440709E (pt) | 2008-02-06 |
AU781550B2 (en) | 2005-05-26 |
AU6665000A (en) | 2001-04-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE380049T1 (de) | Kombinationen enthaltend cgmp-pde5-hemmer. | |
GB0206711D0 (en) | HIF Inhibitor | |
BR0108750A (pt) | Variantes da xilanase que apresentam sensibilidade alterada para inibidores da xilanase | |
MXPA03008968A (es) | Fuente de iluminacion lineal. | |
RS22104A (en) | Herbicide and safening combinations | |
GB2379798B (en) | Light emitting diode and method for manufacturing the same | |
DE60135387D1 (de) | 7,9 substituierte tetracyclinverbindungen | |
BR0102059B1 (pt) | segmento retentor para conjunto turbilhonador. | |
BR0110143A (pt) | Derivados de ácido heptenóico de 2-amino-5,6 halogenado úteis como inibidores de sintase de óxido nìtrico | |
WO2002014925A3 (en) | Lamp structure, having elliptical reflectors, for uniformly irradiating surfaces of optical fiber and method of use thereof | |
ITTO20021024A1 (it) | Trattamento di superficie per componenti ferrosi. | |
DK1273299T3 (da) | Minoxidilinindeholdende praparater | |
GB0011358D0 (en) | Novel use | |
TNSN06246A1 (fr) | Nouvelle combinaison d'un agent antiemetique et d'un inhibiteur de l'encephalinase | |
BR0204620B1 (pt) | processo para o tratamento de condensados que contÊm compostos. | |
NZ320259A (en) | Deodorizing preparations containing cationic biopolymers, aluminium hydrochlorate and esterase inhibitors | |
MY138266A (en) | Treatment of neuropathy | |
DK1188681T3 (da) | Beskyttelsesemballage til en cylindrisk genstand, forsynet med et fastgörelsesmiddel | |
TW499049U (en) | Light source assembly | |
MY140504A (en) | Statin-mmp inhibitor combinations | |
BR0210678A (pt) | Carbamatos de 2-heterocìclicos-1,2-etanodióis | |
TWI319707B (en) | Method of purifying pravastatin | |
RU2001103824A (ru) | Средство для лечения острого мышьяковистого периодонтита | |
ATE214207T1 (de) | Lichtquelle, mit einem ein gas einschliessenden hohlraum | |
GB0111551D0 (en) | F.R.at source |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
Ref document number: 1440709 Country of ref document: EP |
|
REN | Ceased due to non-payment of the annual fee |